Rgs11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs11
Entrez Gene ID	54291
Full Name	regulator of G-protein signaling 11
General protein information	Preferred Names regulator of G-protein signaling 11 Names regulator of G-protein signaling 11
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	activates G-protein alpha GTPase activity; regulates G-protein signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019338.1	NP_062211.1	regulator of G-protein signaling 11

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RGS11	XP_003314940.2
	RGS11	XP_001083719.1
Canis lupus familiaris (dog)	RGS11	XP_854319.3
Bos taurus (cattle)	RGS11	NP_001069282.2
Rattus norvegicus (Norway rat)	Rgs11	NP_062211.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000232	XP_310900.5
Xenopus tropicalis (tropical clawed frog)	rgs9	NP_001096497.1
Homo sapiens (human)	RGS11	NP_899180.1
Mus musculus (house mouse)	Rgs11	NP_001074538.1
Gallus gallus (chicken)	RGS11	XP_001231808.2
Danio rerio (zebrafish)	rgs11	NP_001104631.1

Gene Ontology
Bibliography

Related articles in PubMed

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.
Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA
The Journal of cell biology197(6)711-9(2012 Jun)

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Lyssand JS, DeFino MC, Tang XB, Hertz AL, Feller DB, Wacker JL, Adams ME, Hague C
The Journal of biological chemistry283(27)18792-800(2008 Jul)

Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3.
Zhou JY, Toth PT, Miller RJ
The Journal of pharmacology and experimental therapeutics305(2)460-6(2003 May)

Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ
The Journal of neuroscience : the official journal of the Society for Neuroscience17(20)8024-37(1997 Oct)

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
Koelle MR, Horvitz HR
Cell84(1)115-25(1996 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rgs11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04472	NM_019338.1 Latest version!	Rattus norvegicus regulator of G-protein signaling 11 (Rgs11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs11 ( NM_019338.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062211.1 Rattus norvegicus regulator of G-protein signaling 11 (Rgs11), mRNA.

Price & Availability↑

CloneID	ORa04472
Clone ID Related Accession (Same CDS sequence)	NM_019338.1
Accession Version	NM_019338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AAHX01062955.1, CB786483.1, CB605941.1 and DY471398.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data based on alignments of orthologous transcripts, including mouse AF061934.1. The complete splice pattern has not been confirmed in rat, and alternatively spliced transcripts suggest this locus may be an evolving pseudogene. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCACGG TTAGAGGCTG CACACCCCAT CGCGGGTGCT CCCGAATGCA GAGACCACAT 
CTCAGCAAGA TGGAACGGGT GGTCGTGAGT ATGCAGGACC CTGACCAGGG CGTGAAGATG 
CGGAGCCAGC GCCTTCTGAT CACCGTCATT CCCCACGCGG TGGCGGGCAG AGACATCGTG 
GAATGGCTGG TCCAGAAGTT CTGCATCTCG GAGGAGGAAG CCCTGCACCT GGGCACACTC 
CTGACACAGC ACGGCTACAT CTACCCACTG CGTGAGTCCC GAGACCTGAC GCTCAGGCCG 
GACGAGACCC CCTACAGGTT CCAGACACCC TACTTTTGGA CAAGCACTCT GTGGCCAGCT 
GCTGAACTGG ACTATGCCAT CTACCTGGCT AAGAAGAACA TCCAAAAACA AGGGGCCTTG 
GTGGACTATG AGAAGGAACA TTACACCCTG CTGCACAAGA AGATCAACCA TGCGTGGGAT 
CTAGTATTGA TGCAGGCTCG AGAGCAGCTG CGGGCTGCTA AGCAGCGCAG GAAGGGAGAC 
AGGCTGGTCA TTTCGTGTCA GGAGCAGACA TACTGGCTGG TGAACAAACC CCCTCCTGGG 
GCACCTAATG TTCTGGAGCA GGGTCCTGAG AGGGGTTCTG ATAACCCCAG TCAAGTGCAG 
ATGAGCTCGG ATTTCTATAA GTGTGAGATC GAGTGCTTCA GGAAGGCGCT GAGCAGGAAC 
CGGGTGAAGT CCTCTGTCTG CCTCGAGGCG TACCTGAAGT TCAGCAGCCA GCATGGGCCG 
CACGATCCCA TCCTGTCAGG GTGCCTGCCC AGCAACCCCT GGATCACAGA CGATGTCACC 
TACTGGGTCA TGAATGCGCC CAATGTGGCT GCCCCGACAA AGCTCCGCGT CGAGCGATGG 
AGCTTCAGCT TCCGGGAGCT CCTGGATGAC CCCGTGGGGC GTATCCACTT CATGGACTTT 
CTGCAGAAGG AATTCAGTGC GGAAAACCTC AGCTTCTGGG AGGCGTGTGA GGAGCTGCGC 
TTTGGCGGAC AGGCCCAGGT CCCCACCCTG GTGGACTCTG TTTACCAGCA GTTCCTGGCC 
CCTGGAGCTG CCCGCTGGAT CAACATTGAC AGCAGAACAA TGGAGTGGAC CCTGGAGGGG 
CTGCGCCAGC CACACCGCTA TGTCCTAGAT GCAGCACAAC TGCACATCTA CATGCTCATG 
AAGAAGGACT CCTATCCAAG GTTCCTAAAG TCTGATATCT ACAGAGGGCT GCTGGAGGAA 
GCTGTGATTC CGCTGGAGAC CAAGCGCTGG CCATTCCCAT TCTTGCGGAA GCCTCTGCAC 
TCAAGTCCCA GCCCTGCTCT CCAGTCGACC TCTGGGGAGC CTGCAGCTAC CAGCTCCCCT 
GCAGGTGGCA ATGAGGAGGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062211.1
CDS	11..1414
Translation	MATVRGCTPHRGCSRMQRPHLSKMERVVVSMQDPDQGVKMRSQRLLITVIPHAVAGRDIVEWLVQKFCISEEEALHLGTLLTQHGYIYPLRESRDLTLRPDETPYRFQTPYFWTSTLWPAAELDYAIYLAKKNIQKQGALVDYEKEHYTLLHKKINHAWDLVLMQAREQLRAAKQRRKGDRLVISCQEQTYWLVNKPPPGAPNVLEQGPERGSDNPSQVQMSSDFYKCEIECFRKALSRNRVKSSVCLEAYLKFSSQHGPHDPILSGCLPSNPWITDDVTYWVMNAPNVAAPTKLRVERWSFSFRELLDDPVGRIHFMDFLQKEFSAENLSFWEACEELRFGGQAQVPTLVDSVYQQFLAPGAARWINIDSRTMEWTLEGLRQPHRYVLDAAQLHIYMLMKKDSYPRFLKSDIYRGLLEEAVIPLETKRWPFPFLRKPLHSSPSPALQSTSGEPAATSSPAGGNEED

Target ORF information:

RefSeq Version	NM_019338.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 11 (Rgs11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019338.1

ORF Insert Sequence:

ATGGCCACGG TTAGAGGCTG CACACCCCAT CGCGGGTGCT CCCGAATGCA GAGACCACAT 
CTCAGCAAGA TGGAACGGGT GGTCGTGAGT ATGCAGGACC CTGACCAGGG CGTGAAGATG 
CGGAGCCAGC GCCTTCTGAT CACCGTCATT CCCCACGCGG TGGCGGGCAG AGACATCGTG 
GAATGGCTGG TCCAGAAGTT CTGCATCTCG GAGGAGGAAG CCCTGCACCT GGGCACACTC 
CTGACACAGC ACGGCTACAT CTACCCACTG CGTGAGTCCC GAGACCTGAC GCTCAGGCCG 
GACGAGACCC CCTACAGGTT CCAGACACCC TACTTTTGGA CAAGCACTCT GTGGCCAGCT 
GCTGAACTGG ACTATGCCAT CTACCTGGCT AAGAAGAACA TCCAAAAACA AGGGGCCTTG 
GTGGACTATG AGAAGGAACA TTACACCCTG CTGCACAAGA AGATCAACCA TGCGTGGGAT 
CTAGTATTGA TGCAGGCTCG AGAGCAGCTG CGGGCTGCTA AGCAGCGCAG GAAGGGAGAC 
AGGCTGGTCA TTTCGTGTCA GGAGCAGACA TACTGGCTGG TGAACAAACC CCCTCCTGGG 
GCACCTAATG TTCTGGAGCA GGGTCCTGAG AGGGGTTCTG ATAACCCCAG TCAAGTGCAG 
ATGAGCTCGG ATTTCTATAA GTGTGAGATC GAGTGCTTCA GGAAGGCGCT GAGCAGGAAC 
CGGGTGAAGT CCTCTGTCTG CCTCGAGGCG TACCTGAAGT TCAGCAGCCA GCATGGGCCG 
CACGATCCCA TCCTGTCAGG GTGCCTGCCC AGCAACCCCT GGATCACAGA CGATGTCACC 
TACTGGGTCA TGAATGCGCC CAATGTGGCT GCCCCGACAA AGCTCCGCGT CGAGCGATGG 
AGCTTCAGCT TCCGGGAGCT CCTGGATGAC CCCGTGGGGC GTATCCACTT CATGGACTTT 
CTGCAGAAGG AATTCAGTGC GGAAAACCTC AGCTTCTGGG AGGCGTGTGA GGAGCTGCGC 
TTTGGCGGAC AGGCCCAGGT CCCCACCCTG GTGGACTCTG TTTACCAGCA GTTCCTGGCC 
CCTGGAGCTG CCCGCTGGAT CAACATTGAC AGCAGAACAA TGGAGTGGAC CCTGGAGGGG 
CTGCGCCAGC CACACCGCTA TGTCCTAGAT GCAGCACAAC TGCACATCTA CATGCTCATG 
AAGAAGGACT CCTATCCAAG GTTCCTAAAG TCTGATATCT ACAGAGGGCT GCTGGAGGAA 
GCTGTGATTC CGCTGGAGAC CAAGCGCTGG CCATTCCCAT TCTTGCGGAA GCCTCTGCAC 
TCAAGTCCCA GCCCTGCTCT CCAGTCGACC TCTGGGGAGC CTGCAGCTAC CAGCTCCCCT 
GCAGGTGGCA ATGAGGAGGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.
The Journal of cell biology197(6)711-9(2012 Jun)
Orlandi C,Posokhova E,Masuho I,Ray TA,Hasan N,Gregg RG,Martemyanov KA

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
The Journal of biological chemistry283(27)18792-800(2008 Jul)
Lyssand JS,DeFino MC,Tang XB,Hertz AL,Feller DB,Wacker JL,Adams ME,Hague C

Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3.
The Journal of pharmacology and experimental therapeutics305(2)460-6(2003 May)
Zhou JY,Toth PT,Miller RJ

Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience17(20)8024-37(1997 Oct)
Gold SJ,Ni YG,Dohlman HG,Nestler EJ

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
Cell84(1)115-25(1996 Jan)
Koelle MR,Horvitz HR