Nlrp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nlrp5
Entrez Gene ID	308325
Full Name	NLR family, pyrin domain containing 5
Synonyms	Nalp5
General protein information	Preferred Names NLR family, pyrin domain containing 5 Names NACHT, LRR and PYD domains-containing protein 5 NACHT, leucine rich repeat and PYD containing 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107474.1	NP_001100944.1	NACHT, LRR and PYD domains-containing protein 5
XM_017589108.1	XP_017444597.1	NACHT, LRR and PYD domains-containing protein 5 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NLRP5	XP_001139299.2
	NLRP5	NP_001121103.1
Canis lupus familiaris (dog)	NLRP5	XP_005616898.1
Bos taurus (cattle)	NLRP5	NP_001007815.1
Rattus norvegicus (Norway rat)	Nlrp5	NP_001100944.1
Homo sapiens (human)	NLRP5	NP_703148.4
Mus musculus (house mouse)	Nlrp5	NP_035990.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O, Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel M, Paquet C, Croisile B, Thomas-Ant?rion C, Vercelletto M, L?vy R, Fr?bourg T, Hannequin D, Campion D,
European journal of human genetics : EJHG20(6)613-7(2012 Jun)

Potential role for MATER in cytoplasmic lattice formation in murine oocytes.
Kim B, Kan R, Anguish L, Nelson LM, Coonrod SA
PloS one5(9)e12587(2010 Sep)

Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
Zheng P, Dean J
Proceedings of the National Academy of Sciences of the United States of America106(18)7473-8(2009 May)

A subcortical maternal complex essential for preimplantation mouse embryogenesis.
Li L, Baibakov B, Dean J
Developmental cell15(3)416-25(2008 Sep)

Induced expression of death domain genes NALP1 and NALP5 following neuronal injury.
Frederick Lo C, Ning X, Gonzales C, Ozenberger BA
Biochemical and biophysical research communications366(3)664-9(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that NALP1 and NALP5 may regulate caspase activation and apoptosis in injured neurons.
Title: Induced expression of death domain genes NALP1 and NALP5 following neuronal injury.

The following Nlrp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nlrp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00149	NM_001107474.1 Latest version!	Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa56566	XM_017589108.1 Latest version!	Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nlrp5 ( NM_001107474.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100944.1 Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), mRNA.

Price & Availability↑

CloneID	ORa00149
Clone ID Related Accession (Same CDS sequence)	NM_001107474.1
Accession Version	NM_001107474.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2643bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	NACHT, LRR and PYD domains-containing protein 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474102.2. On or before Oct 4, 2007 this sequence version replaced XM_001069546.1, XM_218237.4. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689601 [ECO:0000350] ##Evidence-Data-END##

ATGAAAGTAT TGTCTGATGC TTTTAAACCA CACCAGAAAA CCTTCAGGCC GCACACCATT 
ATCCTACATG GAAGACCAGG AGTTGGGAAG TCGGCTTTGG CCAGAAGTAT CATTCTGGGC 
TGGGCACAGG GTAAACTCTA CCAAGACATG TCCTATGTCT TCCTCTTCTC TGTCAGAGAA 
ATGAAGTGGA CAGAAAAGAG TAGTTTGGCA CAGCTGATGG CCAACGAGTG GCCACACTCC 
CAGGCTCCAG TGACAAAGAT CATGTCCCAA CCAGAAAGAC TCTTGTTTGT CATAGATGGT 
TTGGACGATA TGGACTCTGC CCTCCAACAT GACGATATGA CACTCTCCAG AGACTGGAAG 
GACAAACAGC CCATATACAT CCTGGTGTAC AGCCTCCTGA GGAAGGCCCT CCTATCCCAG 
TCCTTTCTCA TCATTACCAC CAGAAACACA GGCTTAGAAA ACCTCAGGTC GATGGTGGTG 
TCCCCCCTCT ACATACTGGT TGAAGGACTA TCTGCATCAA GGAGATCTCA ACTAGTCCTC 
GAGAACATCC CCGATGACCA TCAAAAAATA CAAGTCTTCC ATTCTGTGAT AGAAAATCAC 
CAGCTATTTG ACCAAAGCCA GGCCCCCTCC TTTTGCTCGC TGGTCTGTGA GGCTCTACAG 
CTGCAAGAGA AGCTGGGTAA GAGATGCACC CTACCCTGCC AGACTCTCAC TGATTTATAT 
GCCACCTTGG TGTTCCACCA GCTCACCTCA AGAGGGCCTT CCCAGAGGGC ACTCAGTAAG 
GAAGAGCAAA TTACCCTAGT GGGTTTGTGC AGGATGGCAC TGGAGGGAGT GTGGACCATG 
AGGTCGGTGT TCTATGATGA TGACCTGAAG AGCTACAGTC TAAAGCAGTC TGAGATCTCA 
GCCCTCTTTC ACGTGAACAT CCTTCTCCAG GTTGGCCACA GCAGTGAGCA GTGTTATGTT 
TTCTTCGACC TCAGCCTGCA GGATTTCTTT GCTGCCTTAT ATTATGTTTT AGAAGGGCTG 
GGGGAATGGA ATCAGTATTT TTCCTACATT ACAAACCAAA GGAACATCAT GGAGGTGAAG 
AGATCCAGCG ACTCTCACCT CCTCGAGATG AAGCGTTTCT TATTTGGCCT CATGAACAAG 
GATACCTTGA AGACTGTGGA GGTTCTGTTT CGATGTCCCG TGACCCCGCC TATTAAGCAG 
AAGCTCCAAC ACTGCCTCTC TCTGATAGGT CAGCAGGTCA ATGGCTCCAG CCCAATGGAT 
ACCCTGGATG CCTTCTACTA TCTCTTTGAG TCTCAGGATG AAGAGTTTGT TCACATGGCT 
CTCAAAAGCT TCCAAGAAGT GTGGCTTCTG ATTAACCAGA AGATGGACTT GATGGTATCT 
TCCTACTGTC TCCAGCAGTG TCAGAACTTG AAGGCAATCC GGGTGGATAT CAGTGACCTC 
TTCTCAGTGG ATAATACTCC CAAGCTGTGC CCTGTCGCTC TCCAGAAGAC ACAATGCAAG 
CCCCTCATCA TAGAGTGGTG GGAAAACTTC TGCACTGTGC TCAGCACCCA TCCGAACTTG 
AAGACACTGG ACTTGGGCCA CAGCATCTTG AATGAATGGT CCATGAAGAT TCTATGCCTC 
AAGCTGAGGA ATTCATCCTG CAGCATACAG AATCTAACGT TTAAGAATTC AGAGGTAGTT 
TCTGGCCTGC AATATCTCTG GATGCTCCTT GTTAGCAATC GGAACTTAAA GTACCTCAAT 
CTAGGGAACA CGCCCATGAA GGACGATGAC ATCAAGTTAG CCTGTGAAGC ACTGAAACAT 
CCAAGCTGTT CCCTGGAGAC CCTGAGGTTG GATTCCTGTG AGTTAACCCT CACTGGTTAT 
GAGCTGATCT CCAAGCTCCT TCTTTCAGCC AGCAGCCTAA AGTGTCTCAG CCTGGCCAGA 
AATAAGGTGG GGGTAAAGAG TATGACATCC CTTGGGGAAG CCTTGAGTAG CTCTACATGT 
ACACTGCAGA AGCTGATACT GAATCATTGC AACATTATCA AGGATGCCTA CGGCTTCCTG 
GCGTTGATAC TGGCAAACAA CAGAAAGCTG ACGCACCTGA GCCTGACCAT GAACCCTGTA 
GGAAATAGTG CAATGAAGCT ACTGTGTGAA GCTTTAAAGG AGCCAACTTG CTACCTTCAA 
GACCTGGAAC TAGTGGACTG CCAGCTCACG GAGAACTGCT GTGAAGACCT GGCCTGTATG 
ATCACAACAA CCAAGCACTT ACAAAGCTTG GATCTTGGGA ACAATGCCCT CGGTGACAAA 
GGAGTCATAA CCCTGTGCAA AGGACTGAAG CAAAGTAGCA GCTCCCTGAG GAGACTTGGG 
TTGGCAGCAT GTGGGTTGAC TTCCAAATGC TGTGAGGTAT TGTCATCGGC CCTCTCTTGC 
AACCCGTACC TGAACAGCCT GAACCTAGTA AGAAATGACT TCAATACATC AGGGATGTTG 
AAGCTCTGCT CTGCGTTCCA AAACCCTGCC TCTAACCTGT GGATAATTGG CCTGTGGAAG 
CAGCAGTTCT ATGCCCAGGT GAGAAGACAG CTGGAAGAAG TGCAGTTTAT CAAGCCCCAC 
GTGGTGATTG ATGGTGACTG GTATTCTATT GATGAAGATG ACCGTAACTG GTGGAAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100944.1
CDS	289..2931
Translation	MKVLSDAFKPHQKTFRPHTIILHGRPGVGKSALARSIILGWAQGKLYQDMSYVFLFSVREMKWTEKSSLAQLMANEWPHSQAPVTKIMSQPERLLFVIDGLDDMDSALQHDDMTLSRDWKDKQPIYILVYSLLRKALLSQSFLIITTRNTGLENLRSMVVSPLYILVEGLSASRRSQLVLENIPDDHQKIQVFHSVIENHQLFDQSQAPSFCSLVCEALQLQEKLGKRCTLPCQTLTDLYATLVFHQLTSRGPSQRALSKEEQITLVGLCRMALEGVWTMRSVFYDDDLKSYSLKQSEISALFHVNILLQVGHSSEQCYVFFDLSLQDFFAALYYVLEGLGEWNQYFSYITNQRNIMEVKRSSDSHLLEMKRFLFGLMNKDTLKTVEVLFRCPVTPPIKQKLQHCLSLIGQQVNGSSPMDTLDAFYYLFESQDEEFVHMALKSFQEVWLLINQKMDLMVSSYCLQQCQNLKAIRVDISDLFSVDNTPKLCPVALQKTQCKPLIIEWWENFCTVLSTHPNLKTLDLGHSILNEWSMKILCLKLRNSSCSIQNLTFKNSEVVSGLQYLWMLLVSNRNLKYLNLGNTPMKDDDIKLACEALKHPSCSLETLRLDSCELTLTGYELISKLLLSASSLKCLSLARNKVGVKSMTSLGEALSSSTCTLQKLILNHCNIIKDAYGFLALILANNRKLTHLSLTMNPVGNSAMKLLCEALKEPTCYLQDLELVDCQLTENCCEDLACMITTTKHLQSLDLGNNALGDKGVITLCKGLKQSSSSLRRLGLAACGLTSKCCEVLSSALSCNPYLNSLNLVRNDFNTSGMLKLCSAFQNPASNLWIIGLWKQQFYAQVRRQLEEVQFIKPHVVIDGDWYSIDEDDRNWWKN

Target ORF information:

RefSeq Version	NM_001107474.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107474.1

ORF Insert Sequence:

ATGAAAGTAT TGTCTGATGC TTTTAAACCA CACCAGAAAA CCTTCAGGCC GCACACCATT 
ATCCTACATG GAAGACCAGG AGTTGGGAAG TCGGCTTTGG CCAGAAGTAT CATTCTGGGC 
TGGGCACAGG GTAAACTCTA CCAAGACATG TCCTATGTCT TCCTCTTCTC TGTCAGAGAA 
ATGAAGTGGA CAGAAAAGAG TAGTTTGGCA CAGCTGATGG CCAACGAGTG GCCACACTCC 
CAGGCTCCAG TGACAAAGAT CATGTCCCAA CCAGAAAGAC TCTTGTTTGT CATAGATGGT 
TTGGACGATA TGGACTCTGC CCTCCAACAT GACGATATGA CACTCTCCAG AGACTGGAAG 
GACAAACAGC CCATATACAT CCTGGTGTAC AGCCTCCTGA GGAAGGCCCT CCTATCCCAG 
TCCTTTCTCA TCATTACCAC CAGAAACACA GGCTTAGAAA ACCTCAGGTC GATGGTGGTG 
TCCCCCCTCT ACATACTGGT TGAAGGACTA TCTGCATCAA GGAGATCTCA ACTAGTCCTC 
GAGAACATCC CCGATGACCA TCAAAAAATA CAAGTCTTCC ATTCTGTGAT AGAAAATCAC 
CAGCTATTTG ACCAAAGCCA GGCCCCCTCC TTTTGCTCGC TGGTCTGTGA GGCTCTACAG 
CTGCAAGAGA AGCTGGGTAA GAGATGCACC CTACCCTGCC AGACTCTCAC TGATTTATAT 
GCCACCTTGG TGTTCCACCA GCTCACCTCA AGAGGGCCTT CCCAGAGGGC ACTCAGTAAG 
GAAGAGCAAA TTACCCTAGT GGGTTTGTGC AGGATGGCAC TGGAGGGAGT GTGGACCATG 
AGGTCGGTGT TCTATGATGA TGACCTGAAG AGCTACAGTC TAAAGCAGTC TGAGATCTCA 
GCCCTCTTTC ACGTGAACAT CCTTCTCCAG GTTGGCCACA GCAGTGAGCA GTGTTATGTT 
TTCTTCGACC TCAGCCTGCA GGATTTCTTT GCTGCCTTAT ATTATGTTTT AGAAGGGCTG 
GGGGAATGGA ATCAGTATTT TTCCTACATT ACAAACCAAA GGAACATCAT GGAGGTGAAG 
AGATCCAGCG ACTCTCACCT CCTCGAGATG AAGCGTTTCT TATTTGGCCT CATGAACAAG 
GATACCTTGA AGACTGTGGA GGTTCTGTTT CGATGTCCCG TGACCCCGCC TATTAAGCAG 
AAGCTCCAAC ACTGCCTCTC TCTGATAGGT CAGCAGGTCA ATGGCTCCAG CCCAATGGAT 
ACCCTGGATG CCTTCTACTA TCTCTTTGAG TCTCAGGATG AAGAGTTTGT TCACATGGCT 
CTCAAAAGCT TCCAAGAAGT GTGGCTTCTG ATTAACCAGA AGATGGACTT GATGGTATCT 
TCCTACTGTC TCCAGCAGTG TCAGAACTTG AAGGCAATCC GGGTGGATAT CAGTGACCTC 
TTCTCAGTGG ATAATACTCC CAAGCTGTGC CCTGTCGCTC TCCAGAAGAC ACAATGCAAG 
CCCCTCATCA TAGAGTGGTG GGAAAACTTC TGCACTGTGC TCAGCACCCA TCCGAACTTG 
AAGACACTGG ACTTGGGCCA CAGCATCTTG AATGAATGGT CCATGAAGAT TCTATGCCTC 
AAGCTGAGGA ATTCATCCTG CAGCATACAG AATCTAACGT TTAAGAATTC AGAGGTAGTT 
TCTGGCCTGC AATATCTCTG GATGCTCCTT GTTAGCAATC GGAACTTAAA GTACCTCAAT 
CTAGGGAACA CGCCCATGAA GGACGATGAC ATCAAGTTAG CCTGTGAAGC ACTGAAACAT 
CCAAGCTGTT CCCTGGAGAC CCTGAGGTTG GATTCCTGTG AGTTAACCCT CACTGGTTAT 
GAGCTGATCT CCAAGCTCCT TCTTTCAGCC AGCAGCCTAA AGTGTCTCAG CCTGGCCAGA 
AATAAGGTGG GGGTAAAGAG TATGACATCC CTTGGGGAAG CCTTGAGTAG CTCTACATGT 
ACACTGCAGA AGCTGATACT GAATCATTGC AACATTATCA AGGATGCCTA CGGCTTCCTG 
GCGTTGATAC TGGCAAACAA CAGAAAGCTG ACGCACCTGA GCCTGACCAT GAACCCTGTA 
GGAAATAGTG CAATGAAGCT ACTGTGTGAA GCTTTAAAGG AGCCAACTTG CTACCTTCAA 
GACCTGGAAC TAGTGGACTG CCAGCTCACG GAGAACTGCT GTGAAGACCT GGCCTGTATG 
ATCACAACAA CCAAGCACTT ACAAAGCTTG GATCTTGGGA ACAATGCCCT CGGTGACAAA 
GGAGTCATAA CCCTGTGCAA AGGACTGAAG CAAAGTAGCA GCTCCCTGAG GAGACTTGGG 
TTGGCAGCAT GTGGGTTGAC TTCCAAATGC TGTGAGGTAT TGTCATCGGC CCTCTCTTGC 
AACCCGTACC TGAACAGCCT GAACCTAGTA AGAAATGACT TCAATACATC AGGGATGTTG 
AAGCTCTGCT CTGCGTTCCA AAACCCTGCC TCTAACCTGT GGATAATTGG CCTGTGGAAG 
CAGCAGTTCT ATGCCCAGGT GAGAAGACAG CTGGAAGAAG TGCAGTTTAT CAAGCCCCAC 
GTGGTGATTG ATGGTGACTG GTATTCTATT GATGAAGATG ACCGTAACTG GTGGAAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nlrp5 ( XM_017589108.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444597.1 Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56566
Clone ID Related Accession (Same CDS sequence)	XM_017589108.1
Accession Version	XM_017589108.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3069bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NACHT, LRR and PYD domains-containing protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END##

ATGAGATTCG GGGATCACAG GCACAGCGAC TCAGAGGAGA GGATAGTTAC TCCAGAAAAA 
CATGATAAAG CAACCCAGAA GGACCAAGGA TCAGAGGAGG AACAGATACC AGAAAGCACA 
ACGACTCCTC CAGAAAAAGA TGATGAAGCA ATCCCAAAGG ACGAAGGATC AGAGGAGGAA 
CAGATATCAG ACTACAAGGC CCACGTGATC GCTAAATTCG ACACAAGTGT GGATCTGCAC 
TGTGACGGCC CAGAGATGAA AGTATTGTCT GATGCTTTTA AACCACACCA GAAAACCTTC 
AGGCCGCACA CCATTATCCT ACATGGAAGA CCAGGAGTTG GGAAGTCGGC TTTGGCCAGA 
AGTATCATTC TGGGCTGGGC ACAGGGTAAA CTCTACCAAG ACATGTCCTA TGTCTTCCTC 
TTCTCTGTCA GAGAAATGAA GTGGACAGAA AAGAGTAGTT TGGCACAGCT GATGGCCAAC 
GAGTGGCCAC ACTCCCAGGC TCCAGTGACA AAGATCATGT CCCAACCAGA AAGACTCTTG 
TTTGTCATAG ATGGTTTGGA CGATATGGAC TCTGCCCTCC AACATGACGA TATGACACTC 
TCCAGAGACT GGAAGGACAA ACAGCCCATA TACATCCTGG TGTACAGCCT CCTGAGGAAG 
GCCCTCCTAT CCCAGTCCTT TCTCATCATT ACCACCAGAA ACACAGGCTT AGAAAACCTC 
AGGTCGATGG TGGTGTCCCC CCTCTACATA CTGGTTGAAG GACTATCTGC ATCAAGGAGA 
TCTCAACTAG TCCTCGAGAA CATCCCCGAT GACCATCAAA AAATACAAGT CTTCCATTCT 
GTGATAGAAA ATCACCAGCT ATTTGACCAA AGCCAGGCCC CCTCCTTTTG CTCGCTGGTC 
TGTGAGGCTC TACAGCTGCA AGAGAAGCTG GGTAAGAGAT GCACCCTACC CTGCCAGACT 
CTCACTGATT TATATGCCAC CTTGGTGTTC CACCAGCTCA CCTCAAGAGG GCCTTCCCAG 
AGGGCACTCA GTAAGGAAGA GCAAATTACC CTAGTGGGTT TGTGCAGGAT GGCACTGGAG 
GGAGTGTGGA CCATGAGGTC GGTGTTCTAT GATGATGACC TGAAGAGCTA CAGTCTAAAG 
CAGTCTGAGA TCTCAGCCCT CTTTCACGTG AACATCCTTC TCCAGGTTGG CCACAGCAGT 
GAGCAGTGTT ATGTTTTCTT CGACCTCAGC CTGCAGGATT TCTTTGCTGC CTTATATTAT 
GTTTTAGAAG GGCTGGGGGA ATGGAATCAG TATTTTTCCT ACATTACAAA CCAAAGGAAC 
ATCATGGAGG TGAAGAGATC CAGCGACTCT CACCTCCTCG AGATGAAGCG TTTCTTATTT 
GGCCTCATGA ACAAGGATAC CTTGAAGACT GTGGAGGTTC TGTTTCGATG TCCCGTGACC 
CCGCCTATTA AGCAGAAGCT CCAACACTGC CTCTCTCTGA TAGGTCAGCA GGTCAATGGC 
TCCAGCCCAA TGGATACCCT GGATGCCTTC TACTATCTCT TTGAGTCTCA GGATGAAGAG 
TTTGTTCACA TGGCTCTCAA AAGCTTCCAA GAAGTGTGGC TTCTGATTAA CCAGAAGATG 
GACTTGATGG TATCTTCCTA CTGTCTCCAG CAGTGTCAGA ACTTGAAGGC AATCCGGGTG 
GATATCAGTG ACCTCTTCTC AGTGGATAAT ACTCCCAAGC TGTGCCCTGT CGCTCTCCAG 
AAGACACAAT GCAAGCCCCT CATCATAGAG TGGTGGGAAA ACTTCTGCAC TGTGCTCAGC 
ACCCATCCGA ACTTGAAGAC ACTGGACTTG GGCCACAGCA TCTTGAATGA ATGGTCCATG 
AAGATTCTAT GCCTCAAGCT GAGGAATTCA TCCTGCAGCA TACAGAATCT AACGTTTAAG 
AATTCAGAGG TAGTTTCTGG CCTGCAATAT CTCTGGATGC TCCTTGTTAG CAATCGGAAC 
TTAAAGTACC TCAATCTAGG GAACACGCCC ATGAAGGACG ATGACATCAA GTTAGCCTGT 
GAAGCACTGA AACATCCAAG CTGTTCCCTG GAGACCCTGA GGTTGGATTC CTGTGAGTTA 
ACCCTCACTG GTTATGAGCT GATCTCCAAG CTCCTTCTTT CAGCCAGCAG CCTAAAGTGT 
CTCAGCCTGG CCAGAAATAA GGTGGGGGTA AAGAGTATGA CATCCCTTGG GGAAGCCTTG 
AGTAGCTCTA CATGTACACT GCAGAAGCTG ATACTGGACG GCTGTGACCT CATACCTGTC 
AGCTGCCACA TGCTGACCTC CGCCCTCTCC AGCAACCGGA ACTTGACTCA CCTGTGCCTG 
TCAAACAACA GCTTGGGGAC TGAAGAAGTG CAACAGCTGT GTCAGTTCCT GAAGAAACCA 
GAATGTGCTC TCCGGCGGCT GATACTGAAT CATTGCAACA TTATCAAGGA TGCCTACGGC 
TTCCTGGCGT TGATACTGGC AAACAACAGA AAGCTGACGC ACCTGAGCCT GACCATGAAC 
CCTGTAGGAA ATAGTGCAAT GAAGCTACTG TGTGAAGCTT TAAAGGAGCC AACTTGCTAC 
CTTCAAGACC TGGAACTAGT GGACTGCCAG CTCACGGAGA ACTGCTGTGA AGACCTGGCC 
TGTATGATCA CAACAACCAA GCACTTACAA AGCTTGGATC TTGGGAACAA TGCCCTCGGT 
GACAAAGGAG TCATAACCCT GTGCAAAGGA CTGAAGCAAA GTAGCAGCTC CCTGAGGAGA 
CTTGGGTTGG CAGCATGTGG GTTGACTTCC AAATGCTGTG AGGTATTGTC ATCGGCCCTC 
TCTTGCAACC CGTACCTGAA CAGCCTGAAC CTAGTAAGAA ATGACTTCAA TACATCAGGG 
ATGTTGAAGC TCTGCTCTGC GTTCCAAAAC CCTGCCTCTA ACCTGTGGAT AATTGGCCTG 
TGGAAGCAGC AGTTCTATGC CCAGGTGAGA AGACAGCTGG AAGAAGTGCA GTTTATCAAG 
CCCCACGTGG TGATTGATGG TGACTGGTAT TCTATTGATG AAGATGACCG TAACTGGTGG 
AAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444597.1
CDS	1..3069
Translation	MRFGDHRHSDSEERIVTPEKHDKATQKDQGSEEEQIPESTTTPPEKDDEAIPKDEGSEEEQISDYKAHVIAKFDTSVDLHCDGPEMKVLSDAFKPHQKTFRPHTIILHGRPGVGKSALARSIILGWAQGKLYQDMSYVFLFSVREMKWTEKSSLAQLMANEWPHSQAPVTKIMSQPERLLFVIDGLDDMDSALQHDDMTLSRDWKDKQPIYILVYSLLRKALLSQSFLIITTRNTGLENLRSMVVSPLYILVEGLSASRRSQLVLENIPDDHQKIQVFHSVIENHQLFDQSQAPSFCSLVCEALQLQEKLGKRCTLPCQTLTDLYATLVFHQLTSRGPSQRALSKEEQITLVGLCRMALEGVWTMRSVFYDDDLKSYSLKQSEISALFHVNILLQVGHSSEQCYVFFDLSLQDFFAALYYVLEGLGEWNQYFSYITNQRNIMEVKRSSDSHLLEMKRFLFGLMNKDTLKTVEVLFRCPVTPPIKQKLQHCLSLIGQQVNGSSPMDTLDAFYYLFESQDEEFVHMALKSFQEVWLLINQKMDLMVSSYCLQQCQNLKAIRVDISDLFSVDNTPKLCPVALQKTQCKPLIIEWWENFCTVLSTHPNLKTLDLGHSILNEWSMKILCLKLRNSSCSIQNLTFKNSEVVSGLQYLWMLLVSNRNLKYLNLGNTPMKDDDIKLACEALKHPSCSLETLRLDSCELTLTGYELISKLLLSASSLKCLSLARNKVGVKSMTSLGEALSSSTCTLQKLILDGCDLIPVSCHMLTSALSSNRNLTHLCLSNNSLGTEEVQQLCQFLKKPECALRRLILNHCNIIKDAYGFLALILANNRKLTHLSLTMNPVGNSAMKLLCEALKEPTCYLQDLELVDCQLTENCCEDLACMITTTKHLQSLDLGNNALGDKGVITLCKGLKQSSSSLRRLGLAACGLTSKCCEVLSSALSCNPYLNSLNLVRNDFNTSGMLKLCSAFQNPASNLWIIGLWKQQFYAQVRRQLEEVQFIKPHVVIDGDWYSIDEDDRNWWKN

Target ORF information:

RefSeq Version	XM_017589108.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589108.1

ORF Insert Sequence:

ATGAGATTCG GGGATCACAG GCACAGCGAC TCAGAGGAGA GGATAGTTAC TCCAGAAAAA 
CATGATAAAG CAACCCAGAA GGACCAAGGA TCAGAGGAGG AACAGATACC AGAAAGCACA 
ACGACTCCTC CAGAAAAAGA TGATGAAGCA ATCCCAAAGG ACGAAGGATC AGAGGAGGAA 
CAGATATCAG ACTACAAGGC CCACGTGATC GCTAAATTCG ACACAAGTGT GGATCTGCAC 
TGTGACGGCC CAGAGATGAA AGTATTGTCT GATGCTTTTA AACCACACCA GAAAACCTTC 
AGGCCGCACA CCATTATCCT ACATGGAAGA CCAGGAGTTG GGAAGTCGGC TTTGGCCAGA 
AGTATCATTC TGGGCTGGGC ACAGGGTAAA CTCTACCAAG ACATGTCCTA TGTCTTCCTC 
TTCTCTGTCA GAGAAATGAA GTGGACAGAA AAGAGTAGTT TGGCACAGCT GATGGCCAAC 
GAGTGGCCAC ACTCCCAGGC TCCAGTGACA AAGATCATGT CCCAACCAGA AAGACTCTTG 
TTTGTCATAG ATGGTTTGGA CGATATGGAC TCTGCCCTCC AACATGACGA TATGACACTC 
TCCAGAGACT GGAAGGACAA ACAGCCCATA TACATCCTGG TGTACAGCCT CCTGAGGAAG 
GCCCTCCTAT CCCAGTCCTT TCTCATCATT ACCACCAGAA ACACAGGCTT AGAAAACCTC 
AGGTCGATGG TGGTGTCCCC CCTCTACATA CTGGTTGAAG GACTATCTGC ATCAAGGAGA 
TCTCAACTAG TCCTCGAGAA CATCCCCGAT GACCATCAAA AAATACAAGT CTTCCATTCT 
GTGATAGAAA ATCACCAGCT ATTTGACCAA AGCCAGGCCC CCTCCTTTTG CTCGCTGGTC 
TGTGAGGCTC TACAGCTGCA AGAGAAGCTG GGTAAGAGAT GCACCCTACC CTGCCAGACT 
CTCACTGATT TATATGCCAC CTTGGTGTTC CACCAGCTCA CCTCAAGAGG GCCTTCCCAG 
AGGGCACTCA GTAAGGAAGA GCAAATTACC CTAGTGGGTT TGTGCAGGAT GGCACTGGAG 
GGAGTGTGGA CCATGAGGTC GGTGTTCTAT GATGATGACC TGAAGAGCTA CAGTCTAAAG 
CAGTCTGAGA TCTCAGCCCT CTTTCACGTG AACATCCTTC TCCAGGTTGG CCACAGCAGT 
GAGCAGTGTT ATGTTTTCTT CGACCTCAGC CTGCAGGATT TCTTTGCTGC CTTATATTAT 
GTTTTAGAAG GGCTGGGGGA ATGGAATCAG TATTTTTCCT ACATTACAAA CCAAAGGAAC 
ATCATGGAGG TGAAGAGATC CAGCGACTCT CACCTCCTCG AGATGAAGCG TTTCTTATTT 
GGCCTCATGA ACAAGGATAC CTTGAAGACT GTGGAGGTTC TGTTTCGATG TCCCGTGACC 
CCGCCTATTA AGCAGAAGCT CCAACACTGC CTCTCTCTGA TAGGTCAGCA GGTCAATGGC 
TCCAGCCCAA TGGATACCCT GGATGCCTTC TACTATCTCT TTGAGTCTCA GGATGAAGAG 
TTTGTTCACA TGGCTCTCAA AAGCTTCCAA GAAGTGTGGC TTCTGATTAA CCAGAAGATG 
GACTTGATGG TATCTTCCTA CTGTCTCCAG CAGTGTCAGA ACTTGAAGGC AATCCGGGTG 
GATATCAGTG ACCTCTTCTC AGTGGATAAT ACTCCCAAGC TGTGCCCTGT CGCTCTCCAG 
AAGACACAAT GCAAGCCCCT CATCATAGAG TGGTGGGAAA ACTTCTGCAC TGTGCTCAGC 
ACCCATCCGA ACTTGAAGAC ACTGGACTTG GGCCACAGCA TCTTGAATGA ATGGTCCATG 
AAGATTCTAT GCCTCAAGCT GAGGAATTCA TCCTGCAGCA TACAGAATCT AACGTTTAAG 
AATTCAGAGG TAGTTTCTGG CCTGCAATAT CTCTGGATGC TCCTTGTTAG CAATCGGAAC 
TTAAAGTACC TCAATCTAGG GAACACGCCC ATGAAGGACG ATGACATCAA GTTAGCCTGT 
GAAGCACTGA AACATCCAAG CTGTTCCCTG GAGACCCTGA GGTTGGATTC CTGTGAGTTA 
ACCCTCACTG GTTATGAGCT GATCTCCAAG CTCCTTCTTT CAGCCAGCAG CCTAAAGTGT 
CTCAGCCTGG CCAGAAATAA GGTGGGGGTA AAGAGTATGA CATCCCTTGG GGAAGCCTTG 
AGTAGCTCTA CATGTACACT GCAGAAGCTG ATACTGGACG GCTGTGACCT CATACCTGTC 
AGCTGCCACA TGCTGACCTC CGCCCTCTCC AGCAACCGGA ACTTGACTCA CCTGTGCCTG 
TCAAACAACA GCTTGGGGAC TGAAGAAGTG CAACAGCTGT GTCAGTTCCT GAAGAAACCA 
GAATGTGCTC TCCGGCGGCT GATACTGAAT CATTGCAACA TTATCAAGGA TGCCTACGGC 
TTCCTGGCGT TGATACTGGC AAACAACAGA AAGCTGACGC ACCTGAGCCT GACCATGAAC 
CCTGTAGGAA ATAGTGCAAT GAAGCTACTG TGTGAAGCTT TAAAGGAGCC AACTTGCTAC 
CTTCAAGACC TGGAACTAGT GGACTGCCAG CTCACGGAGA ACTGCTGTGA AGACCTGGCC 
TGTATGATCA CAACAACCAA GCACTTACAA AGCTTGGATC TTGGGAACAA TGCCCTCGGT 
GACAAAGGAG TCATAACCCT GTGCAAAGGA CTGAAGCAAA GTAGCAGCTC CCTGAGGAGA 
CTTGGGTTGG CAGCATGTGG GTTGACTTCC AAATGCTGTG AGGTATTGTC ATCGGCCCTC 
TCTTGCAACC CGTACCTGAA CAGCCTGAAC CTAGTAAGAA ATGACTTCAA TACATCAGGG 
ATGTTGAAGC TCTGCTCTGC GTTCCAAAAC CCTGCCTCTA ACCTGTGGAT AATTGGCCTG 
TGGAAGCAGC AGTTCTATGC CCAGGTGAGA AGACAGCTGG AAGAAGTGCA GTTTATCAAG 
CCCCACGTGG TGATTGATGG TGACTGGTAT TCTATTGATG AAGATGACCG TAACTGGTGG 
AAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
European journal of human genetics : EJHG20(6)613-7(2012 Jun)
Rovelet-Lecrux A,Legallic S,Wallon D,Flaman JM,Martinaud O,Bombois S,Rollin-Sillaire A,Michon A,Le Ber I,Pariente J,Puel M,Paquet C,Croisile B,Thomas-Ant?rion C,Vercelletto M,L?vy R,Fr?bourg T,Hannequin D,Campion D,

Potential role for MATER in cytoplasmic lattice formation in murine oocytes.
PloS one5(9)e12587(2010 Sep)
Kim B,Kan R,Anguish L,Nelson LM,Coonrod SA

Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America106(18)7473-8(2009 May)
Zheng P,Dean J

A subcortical maternal complex essential for preimplantation mouse embryogenesis.
Developmental cell15(3)416-25(2008 Sep)
Li L,Baibakov B,Dean J

Induced expression of death domain genes NALP1 and NALP5 following neuronal injury.
Biochemical and biophysical research communications366(3)664-9(2008 Feb)
Frederick Lo C,Ning X,Gonzales C,Ozenberger BA