Cln8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cln8
Entrez Gene ID	306619
Full Name	CLN8, transmembrane ER and ERGIC protein
General protein information	Preferred Names CLN8, transmembrane ER and ERGIC protein Names protein CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5

mRNA and Protein(s)

mRNA	Protein	Name
XM_006253394.3	XP_006253456.1	protein CLN8 isoform X1
NM_001007686.1	NP_001007687.1	protein CLN8

Pathways from BioSystems

Homologies

	CLN8	XP_001096231.1
Bos taurus (cattle)	CLN8	NP_001069409.2
Xenopus tropicalis (tropical clawed frog)	cln8	XP_004914543.1
Homo sapiens (human)	CLN8	NP_061764.2
Canis lupus familiaris (dog)	CLN8	NP_001012343.1
Mus musculus (house mouse)	Cln8	NP_036130.1
Gallus gallus (chicken)	CLN8	NP_001026258.1
Pan troglodytes (chimpanzee)	CLN8	XP_519584.2
Rattus norvegicus (Norway rat)	Cln8	NP_001007687.1
Danio rerio (zebrafish)	cln8	NP_001108060.1

Gene Ontology
Bibliography

Related articles in PubMed

Mouse model resources for vision research.
Won J, Shi LY, Hicks W, Wang J, Hurd R, Naggert JK, Chang B, Nishina PM
Journal of ophthalmology2011391384(2011)

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins.
Lyly A, von Schantz C, Heine C, Schmiedt ML, Sipil? T, Jalanko A, Kytt?l? A
BMC cell biology1083(2009 Nov)

Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study.
Hermansson M, K?kel? R, Bergh?ll M, Lehesjoki AE, Somerharju P, Lahtinen U
Journal of neurochemistry95(3)609-17(2005 Nov)

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.
Cho SK, Gao N, Pearce DA, Lehrman MA, Hofmann SL
Glycobiology15(6)637-48(2005 Jun)

Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze.
Wendt KD, Lei B, Schachtman TR, Tullis GE, Ibe ME, Katz ML
Behavioural brain research161(2)175-82(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cln8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cln8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11606	NM_001007686.1 Latest version!	Rattus norvegicus CLN8, transmembrane ER and ERGIC protein (Cln8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa11606	XM_006253394.3 Latest version!	Rattus norvegicus ceroid-lipofuscinosis, neuronal 8 (Cln8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cln8 ( NM_001007686.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007687.1 Rattus norvegicus CLN8, transmembrane ER and ERGIC protein (Cln8), mRNA.

Price & Availability↑

CloneID	ORa11606
Clone ID Related Accession (Same CDS sequence)	XM_006253394.3 , NM_001007686.1
Accession Version	NM_001007686.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	protein CLN8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078982.1. On Nov 29, 2004 this sequence version replaced XM_225033.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078982.1, CK469209.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACTCCTG TGAGCAACCA TGGCGTTGCG GAGAGCATTT TTGACCTGGA CTATGCTTCC 
TGGAAGATTC GATCAACTCT AGCAGTAGCT GGCTTTGTCT TCTACCTGGG CGTCTTTGTG 
GTCTGCCACC AGCTTTCGTC CTCCCTGAAT GCCACCTACC GCTCTCTGTT GGCCAAAGAG 
AAGGTCTTCT GGAACCTGGC TGCGACGCGC GCTGTCTTCG GCATCCAGAG CACAGCCGCA 
GGCCTGTGGG CGCTGCTGGG AGACCCCGTG CTCTACTCTA ACAAGGCTCT CGGGCAGCAG 
AACTGGTGCT GGTTCCACAT CACCACTGCC ACGGGATTCT TCTTCTTCGA GAATGCGGCC 
GTTCACCTGT CCAACCTGTT CTTCCGTACT TTTGACCTGT TTCTGGTCGT CCACCACCTC 
TTTGCCTTTC TTGGGTTCCT TGGGTCAGCG GTCAATCTCA GAGCTGGCCA CTACCTAGCC 
ATGACCACTT TGCTCCTAGA GATGAGCACG CCCTTCACCT GCGTTTCCTG GATGCTCCTG 
AAGGCTGGCT GGTCACACTC CCTGTTCTGG AAGGTGAACC AGTGGCTGAT GATCCACATG 
TTTCACTGCA GAATGATCCT TACCTACCAC ATGTGGTGGG TGTGCTTCCA GCACTGGGAC 
GCCCTCGCCA GCAGCCTGTA CCTGCCCCAC TTGGCGCTGT TCCTCTTCGG GCTGGCCCTG 
CTCACAGTCA TCATTAACCC TTACTGGACA CACAAGAAGA CCCAGCAGCT TCTCAATCCC 
GTGGATTGGA ACTTTGCACA GCCGGAAGCC AAGGGCGACC GGCAAGAAAG GACCAATGGC 
CAGGTGCCTC GGAAAAAGAG GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007687.1
CDS	162..1028
Translation	MTPVSNHGVAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLLAKEKVFWNLAATRAVFGIQSTAAGLWALLGDPVLYSNKALGQQNWCWFHITTATGFFFFENAAVHLSNLFFRTFDLFLVVHHLFAFLGFLGSAVNLRAGHYLAMTTLLLEMSTPFTCVSWMLLKAGWSHSLFWKVNQWLMIHMFHCRMILTYHMWWVCFQHWDALASSLYLPHLALFLFGLALLTVIINPYWTHKKTQQLLNPVDWNFAQPEAKGDRQERTNGQVPRKKRL

Target ORF information:

RefSeq Version	NM_001007686.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CLN8, transmembrane ER and ERGIC protein (Cln8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007686.1

ORF Insert Sequence:

ATGACTCCTG TGAGCAACCA TGGCGTTGCG GAGAGCATTT TTGACCTGGA CTATGCTTCC 
TGGAAGATTC GATCAACTCT AGCAGTAGCT GGCTTTGTCT TCTACCTGGG CGTCTTTGTG 
GTCTGCCACC AGCTTTCGTC CTCCCTGAAT GCCACCTACC GCTCTCTGTT GGCCAAAGAG 
AAGGTCTTCT GGAACCTGGC TGCGACGCGC GCTGTCTTCG GCATCCAGAG CACAGCCGCA 
GGCCTGTGGG CGCTGCTGGG AGACCCCGTG CTCTACTCTA ACAAGGCTCT CGGGCAGCAG 
AACTGGTGCT GGTTCCACAT CACCACTGCC ACGGGATTCT TCTTCTTCGA GAATGCGGCC 
GTTCACCTGT CCAACCTGTT CTTCCGTACT TTTGACCTGT TTCTGGTCGT CCACCACCTC 
TTTGCCTTTC TTGGGTTCCT TGGGTCAGCG GTCAATCTCA GAGCTGGCCA CTACCTAGCC 
ATGACCACTT TGCTCCTAGA GATGAGCACG CCCTTCACCT GCGTTTCCTG GATGCTCCTG 
AAGGCTGGCT GGTCACACTC CCTGTTCTGG AAGGTGAACC AGTGGCTGAT GATCCACATG 
TTTCACTGCA GAATGATCCT TACCTACCAC ATGTGGTGGG TGTGCTTCCA GCACTGGGAC 
GCCCTCGCCA GCAGCCTGTA CCTGCCCCAC TTGGCGCTGT TCCTCTTCGG GCTGGCCCTG 
CTCACAGTCA TCATTAACCC TTACTGGACA CACAAGAAGA CCCAGCAGCT TCTCAATCCC 
GTGGATTGGA ACTTTGCACA GCCGGAAGCC AAGGGCGACC GGCAAGAAAG GACCAATGGC 
CAGGTGCCTC GGAAAAAGAG GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cln8 ( XM_006253394.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253456.1 Rattus norvegicus ceroid-lipofuscinosis, neuronal 8 (Cln8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa11606
Clone ID Related Accession (Same CDS sequence)	XM_006253394.3 , NM_001007686.1
Accession Version	XM_006253394.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein CLN8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253394.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTCCTG TGAGCAACCA TGGCGTTGCG GAGAGCATTT TTGACCTGGA CTATGCTTCC 
TGGAAGATTC GATCAACTCT AGCAGTAGCT GGCTTTGTCT TCTACCTGGG CGTCTTTGTG 
GTCTGCCACC AGCTTTCGTC CTCCCTGAAT GCCACCTACC GCTCTCTGTT GGCCAAAGAG 
AAGGTCTTCT GGAACCTGGC TGCGACGCGC GCTGTCTTCG GCATCCAGAG CACAGCCGCA 
GGCCTGTGGG CGCTGCTGGG AGACCCCGTG CTCTACTCTA ACAAGGCTCT CGGGCAGCAG 
AACTGGTGCT GGTTCCACAT CACCACTGCC ACGGGATTCT TCTTCTTCGA GAATGCGGCC 
GTTCACCTGT CCAACCTGTT CTTCCGTACT TTTGACCTGT TTCTGGTCGT CCACCACCTC 
TTTGCCTTTC TTGGGTTCCT TGGGTCAGCG GTCAATCTCA GAGCTGGCCA CTACCTAGCC 
ATGACCACTT TGCTCCTAGA GATGAGCACG CCCTTCACCT GCGTTTCCTG GATGCTCCTG 
AAGGCTGGCT GGTCACACTC CCTGTTCTGG AAGGTGAACC AGTGGCTGAT GATCCACATG 
TTTCACTGCA GAATGATCCT TACCTACCAC ATGTGGTGGG TGTGCTTCCA GCACTGGGAC 
GCCCTCGCCA GCAGCCTGTA CCTGCCCCAC TTGGCGCTGT TCCTCTTCGG GCTGGCCCTG 
CTCACAGTCA TCATTAACCC TTACTGGACA CACAAGAAGA CCCAGCAGCT TCTCAATCCC 
GTGGATTGGA ACTTTGCACA GCCGGAAGCC AAGGGCGACC GGCAAGAAAG GACCAATGGC 
CAGGTGCCTC GGAAAAAGAG GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253456.1
CDS	433..1299
Translation	MTPVSNHGVAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLLAKEKVFWNLAATRAVFGIQSTAAGLWALLGDPVLYSNKALGQQNWCWFHITTATGFFFFENAAVHLSNLFFRTFDLFLVVHHLFAFLGFLGSAVNLRAGHYLAMTTLLLEMSTPFTCVSWMLLKAGWSHSLFWKVNQWLMIHMFHCRMILTYHMWWVCFQHWDALASSLYLPHLALFLFGLALLTVIINPYWTHKKTQQLLNPVDWNFAQPEAKGDRQERTNGQVPRKKRL

Target ORF information:

RefSeq Version	XM_006253394.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ceroid-lipofuscinosis, neuronal 8 (Cln8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253394.3

ORF Insert Sequence:

ATGACTCCTG TGAGCAACCA TGGCGTTGCG GAGAGCATTT TTGACCTGGA CTATGCTTCC 
TGGAAGATTC GATCAACTCT AGCAGTAGCT GGCTTTGTCT TCTACCTGGG CGTCTTTGTG 
GTCTGCCACC AGCTTTCGTC CTCCCTGAAT GCCACCTACC GCTCTCTGTT GGCCAAAGAG 
AAGGTCTTCT GGAACCTGGC TGCGACGCGC GCTGTCTTCG GCATCCAGAG CACAGCCGCA 
GGCCTGTGGG CGCTGCTGGG AGACCCCGTG CTCTACTCTA ACAAGGCTCT CGGGCAGCAG 
AACTGGTGCT GGTTCCACAT CACCACTGCC ACGGGATTCT TCTTCTTCGA GAATGCGGCC 
GTTCACCTGT CCAACCTGTT CTTCCGTACT TTTGACCTGT TTCTGGTCGT CCACCACCTC 
TTTGCCTTTC TTGGGTTCCT TGGGTCAGCG GTCAATCTCA GAGCTGGCCA CTACCTAGCC 
ATGACCACTT TGCTCCTAGA GATGAGCACG CCCTTCACCT GCGTTTCCTG GATGCTCCTG 
AAGGCTGGCT GGTCACACTC CCTGTTCTGG AAGGTGAACC AGTGGCTGAT GATCCACATG 
TTTCACTGCA GAATGATCCT TACCTACCAC ATGTGGTGGG TGTGCTTCCA GCACTGGGAC 
GCCCTCGCCA GCAGCCTGTA CCTGCCCCAC TTGGCGCTGT TCCTCTTCGG GCTGGCCCTG 
CTCACAGTCA TCATTAACCC TTACTGGACA CACAAGAAGA CCCAGCAGCT TCTCAATCCC 
GTGGATTGGA ACTTTGCACA GCCGGAAGCC AAGGGCGACC GGCAAGAAAG GACCAATGGC 
CAGGTGCCTC GGAAAAAGAG GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mouse model resources for vision research.
Journal of ophthalmology2011391384(2011)
Won J,Shi LY,Hicks W,Wang J,Hurd R,Naggert JK,Chang B,Nishina PM

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins.
BMC cell biology1083(2009 Nov)
Lyly A,von Schantz C,Heine C,Schmiedt ML,Sipil? T,Jalanko A,Kytt?l? A

Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study.
Journal of neurochemistry95(3)609-17(2005 Nov)
Hermansson M,K?kel? R,Bergh?ll M,Lehesjoki AE,Somerharju P,Lahtinen U

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.
Glycobiology15(6)637-48(2005 Jun)
Cho SK,Gao N,Pearce DA,Lehrman MA,Hofmann SL

Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze.
Behavioural brain research161(2)175-82(2005 Jun)
Wendt KD,Lei B,Schachtman TR,Tullis GE,Ibe ME,Katz ML