Npsr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npsr1
Entrez Gene ID	300458
Full Name	neuropeptide S receptor 1
Synonyms	RGD1564154
General protein information	Preferred Names neuropeptide S receptor 1 Names neuropeptide S receptor G-protein coupled receptor 154
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106808.1	NP_001100278.1	neuropeptide S receptor
XM_008766049.1	XP_008764271.1	neuropeptide S receptor isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NPSR1	XP_001168820.1
Bos taurus (cattle)	NPSR1	NP_001179906.1
Rattus norvegicus (Norway rat)	Npsr1	NP_001100278.1
Homo sapiens (human)	NPSR1	NP_997055.1
	NPSR1	NP_001028114.1
Drosophila melanogaster (fruit fly)	CcapR	NP_996297.3
Canis lupus familiaris (dog)	NPSR1	XP_539511.2
Gallus gallus (chicken)	NPSR1	XP_426022.2
Anopheles gambiae (African malaria mosquito)	GPRVPR1	XP_321100.4
Mus musculus (house mouse)	Npsr1	NP_783609.1
Xenopus tropicalis (tropical clawed frog)	npsr1	XP_002937035.2

Gene Ontology
Bibliography

Related articles in PubMed

Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.
Cohen H, Vainer E, Zeev K, Zohar J, Math? AA
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology28(1)159-170(2018 Jan)

Neuroleptics Affect Neuropeptide S and NPSR mRNA Levels in the Rat Brain.
Pa?asz A, Rojczyk E
Journal of molecular neuroscience : MN57(3)352-7(2015 Nov)

Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.
Parks GS, Wang L, Wang Z, Civelli O
The Journal of comparative neurology522(17)3817-33(2014 Dec)

Nasal application of neuropeptide S inhibits arthritis pain-related behaviors through an action in the amygdala.
Medina G, Ji G, Gr?goire S, Neugebauer V
Molecular pain1032(2014 May)

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M
The Journal of neuroscience : the official journal of the Society for Neuroscience33(24)10132-42(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPSR expression decreased after single-dose and chronic chlorpromazine administration in the hypothalamus, as well as after chronic olanzapine and chlorpromazine administration in the striatum and hippocampus.
Title: Neuroleptics Affect Neuropeptide S and NPSR mRNA Levels in the Rat Brain.

This study demonistrated that neuropeptide S receptor and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain.
Title: Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.

These results demonstrated that morphine dependence induction led to changes in NPSR mRNA expression.
Title: Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain.

The distribution of NPSR protein provides further insight into the organization of the NPS system and may guide future studies of the role of the NPSR in the brain.
Title: Immunohistochemical localization of the neuropeptide S receptor in the rat central nervous system.

Neuropeptide S receptor messenger ribonucleic acid (mRNA) expression is increased in different brain regions of postdependent alcoholic rats.
Title: Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats.

The following Npsr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npsr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12774	NM_001106808.1 Latest version!	Rattus norvegicus neuropeptide S receptor 1 (Npsr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa12774	XM_008766049.1 Latest version!	Rattus norvegicus neuropeptide S receptor 1 (Npsr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npsr1 ( NM_001106808.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100278.1 Rattus norvegicus neuropeptide S receptor 1 (Npsr1), mRNA.

Price & Availability↑

CloneID	ORa12774
Clone ID Related Accession (Same CDS sequence)	NM_001106808.1 , XM_008766049.1
Accession Version	NM_001106808.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Rattus norvegicus(Norway rat)
Product	neuropeptide S receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474007.2. On or before Oct 4, 2007 this sequence version replaced XM_001053598.1, XM_235968.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689595 [ECO:0000350] ##Evidence-Data-END##

ATGCCGGCCA ACCTCACAGA GGGCAGCTTT CATGCCAACC AGACTGTGCC GATGCTAGAT 
TCTTCCCCTG TAGCTTGCAC TGAAATTGTG ACTTTCACTG AAGCGCTGGA GGCTGAGGAG 
TGGGGCTCCT TCTACTCGTC CTTTAAGACA GAGCAGCTGA TAACCCTGTG GGTCCTGTTT 
GTCTTCACTA TTGTGGGAAA CTCGGTCGTG CTGTTCTCCA CATGGAGAAG AAAAAGAAAG 
TCCAGAATGA CCTTCTTTGT GACTCAATTG GCCATCACAG ACTCCTTCAC AGGCCTGATC 
AACATCCTGA CAGACATTAT TTGGCGATTC ACGGGAGACT TCATGGCCCC TGACCTGGTC 
TGCAGAATCG TCCGCTACTT ACAGGTTGTC CTGCTTTATG CCTCTACCTA TGTCCTGGTG 
TCCCTCAGCA TAGACAGATA CCATGCCATC GTTTACCCCA TGAAATTCCT TCAAGGAGAG 
AAGCAAGCCA AAGTCCTCAT CGGAATAGCA TGGAGCCTCT CCTTCCTGTT CTCCATCCCC 
ACACTGATCA TATTTGGGAA AAGGACACTT TCCAATGGTG AGGTACAGTG CTGGGCACTG 
TGGCCAGACG ACTCCTACTG GACCCCATAT ATGACCATCG TTGCCTTTCT GGTGTACTTC 
ATCCCCTTGA CAATTATCAG CGTCATCTAT GGCCTTGTGA TCCGAACTAT TTGGATTAAA 
AGCAAAGCCC ATGAGACGGT GATTTCCAAC TGCTCAGATG GAGAACTATG CTGCAGCTAC 
AACCGAGGCC TCATCTCAAA AGCAAAAATC AAGGCCATCA AGTACAGCAT CGTCATAATC 
CTTGCTTTCA TCTGCTGCTG GAGTCCATAC TTCCTCTTTG ACATGTTAGA CAACTTCAAC 
CTCCTTCCAG ACACCAAGGA GCGTTTCTAT GCCTCTGTGA TTATCCAGAA CCTGCCTGCC 
TTGAACAGTG CCATTAACCC CCTCATCTAC TGCATCTTCA GCGGCTCCCT CTGCTCCCCC 
TGCAAGGTGC AAAGATCCCA GGATTCCAGA ATGACGTACC GAGAGAGAAG CGAGAGGCAT 
GAGATGCAGA TTCTCTCCAA GCCTGAATTC ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100278.1
CDS	86..1201
Translation	MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALEAEEWGSFYSSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRIVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGELCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPLIYCIFSGSLCSPCKVQRSQDSRMTYRERSERHEMQILSKPEFI

Target ORF information:

RefSeq Version	NM_001106808.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuropeptide S receptor 1 (Npsr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106808.1

ORF Insert Sequence:

ATGCCGGCCA ACCTCACAGA GGGCAGCTTT CATGCCAACC AGACTGTGCC GATGCTAGAT 
TCTTCCCCTG TAGCTTGCAC TGAAATTGTG ACTTTCACTG AAGCGCTGGA GGCTGAGGAG 
TGGGGCTCCT TCTACTCGTC CTTTAAGACA GAGCAGCTGA TAACCCTGTG GGTCCTGTTT 
GTCTTCACTA TTGTGGGAAA CTCGGTCGTG CTGTTCTCCA CATGGAGAAG AAAAAGAAAG 
TCCAGAATGA CCTTCTTTGT GACTCAATTG GCCATCACAG ACTCCTTCAC AGGCCTGATC 
AACATCCTGA CAGACATTAT TTGGCGATTC ACGGGAGACT TCATGGCCCC TGACCTGGTC 
TGCAGAATCG TCCGCTACTT ACAGGTTGTC CTGCTTTATG CCTCTACCTA TGTCCTGGTG 
TCCCTCAGCA TAGACAGATA CCATGCCATC GTTTACCCCA TGAAATTCCT TCAAGGAGAG 
AAGCAAGCCA AAGTCCTCAT CGGAATAGCA TGGAGCCTCT CCTTCCTGTT CTCCATCCCC 
ACACTGATCA TATTTGGGAA AAGGACACTT TCCAATGGTG AGGTACAGTG CTGGGCACTG 
TGGCCAGACG ACTCCTACTG GACCCCATAT ATGACCATCG TTGCCTTTCT GGTGTACTTC 
ATCCCCTTGA CAATTATCAG CGTCATCTAT GGCCTTGTGA TCCGAACTAT TTGGATTAAA 
AGCAAAGCCC ATGAGACGGT GATTTCCAAC TGCTCAGATG GAGAACTATG CTGCAGCTAC 
AACCGAGGCC TCATCTCAAA AGCAAAAATC AAGGCCATCA AGTACAGCAT CGTCATAATC 
CTTGCTTTCA TCTGCTGCTG GAGTCCATAC TTCCTCTTTG ACATGTTAGA CAACTTCAAC 
CTCCTTCCAG ACACCAAGGA GCGTTTCTAT GCCTCTGTGA TTATCCAGAA CCTGCCTGCC 
TTGAACAGTG CCATTAACCC CCTCATCTAC TGCATCTTCA GCGGCTCCCT CTGCTCCCCC 
TGCAAGGTGC AAAGATCCCA GGATTCCAGA ATGACGTACC GAGAGAGAAG CGAGAGGCAT 
GAGATGCAGA TTCTCTCCAA GCCTGAATTC ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npsr1 ( XM_008766049.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764271.1 Rattus norvegicus neuropeptide S receptor 1 (Npsr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12774
Clone ID Related Accession (Same CDS sequence)	NM_001106808.1 , XM_008766049.1
Accession Version	XM_008766049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neuropeptide S receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGCCA ACCTCACAGA GGGCAGCTTT CATGCCAACC AGACTGTGCC GATGCTAGAT 
TCTTCCCCTG TAGCTTGCAC TGAAATTGTG ACTTTCACTG AAGCGCTGGA GGCTGAGGAG 
TGGGGCTCCT TCTACTCGTC CTTTAAGACA GAGCAGCTGA TAACCCTGTG GGTCCTGTTT 
GTCTTCACTA TTGTGGGAAA CTCGGTCGTG CTGTTCTCCA CATGGAGAAG AAAAAGAAAG 
TCCAGAATGA CCTTCTTTGT GACTCAATTG GCCATCACAG ACTCCTTCAC AGGCCTGATC 
AACATCCTGA CAGACATTAT TTGGCGATTC ACGGGAGACT TCATGGCCCC TGACCTGGTC 
TGCAGAATCG TCCGCTACTT ACAGGTTGTC CTGCTTTATG CCTCTACCTA TGTCCTGGTG 
TCCCTCAGCA TAGACAGATA CCATGCCATC GTTTACCCCA TGAAATTCCT TCAAGGAGAG 
AAGCAAGCCA AAGTCCTCAT CGGAATAGCA TGGAGCCTCT CCTTCCTGTT CTCCATCCCC 
ACACTGATCA TATTTGGGAA AAGGACACTT TCCAATGGTG AGGTACAGTG CTGGGCACTG 
TGGCCAGACG ACTCCTACTG GACCCCATAT ATGACCATCG TTGCCTTTCT GGTGTACTTC 
ATCCCCTTGA CAATTATCAG CGTCATCTAT GGCCTTGTGA TCCGAACTAT TTGGATTAAA 
AGCAAAGCCC ATGAGACGGT GATTTCCAAC TGCTCAGATG GAGAACTATG CTGCAGCTAC 
AACCGAGGCC TCATCTCAAA AGCAAAAATC AAGGCCATCA AGTACAGCAT CGTCATAATC 
CTTGCTTTCA TCTGCTGCTG GAGTCCATAC TTCCTCTTTG ACATGTTAGA CAACTTCAAC 
CTCCTTCCAG ACACCAAGGA GCGTTTCTAT GCCTCTGTGA TTATCCAGAA CCTGCCTGCC 
TTGAACAGTG CCATTAACCC CCTCATCTAC TGCATCTTCA GCGGCTCCCT CTGCTCCCCC 
TGCAAGGTGC AAAGATCCCA GGATTCCAGA ATGACGTACC GAGAGAGAAG CGAGAGGCAT 
GAGATGCAGA TTCTCTCCAA GCCTGAATTC ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764271.1
CDS	329..1444
Translation	MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALEAEEWGSFYSSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRIVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGELCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPLIYCIFSGSLCSPCKVQRSQDSRMTYRERSERHEMQILSKPEFI

Target ORF information:

RefSeq Version	XM_008766049.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuropeptide S receptor 1 (Npsr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766049.1

ORF Insert Sequence:

ATGCCGGCCA ACCTCACAGA GGGCAGCTTT CATGCCAACC AGACTGTGCC GATGCTAGAT 
TCTTCCCCTG TAGCTTGCAC TGAAATTGTG ACTTTCACTG AAGCGCTGGA GGCTGAGGAG 
TGGGGCTCCT TCTACTCGTC CTTTAAGACA GAGCAGCTGA TAACCCTGTG GGTCCTGTTT 
GTCTTCACTA TTGTGGGAAA CTCGGTCGTG CTGTTCTCCA CATGGAGAAG AAAAAGAAAG 
TCCAGAATGA CCTTCTTTGT GACTCAATTG GCCATCACAG ACTCCTTCAC AGGCCTGATC 
AACATCCTGA CAGACATTAT TTGGCGATTC ACGGGAGACT TCATGGCCCC TGACCTGGTC 
TGCAGAATCG TCCGCTACTT ACAGGTTGTC CTGCTTTATG CCTCTACCTA TGTCCTGGTG 
TCCCTCAGCA TAGACAGATA CCATGCCATC GTTTACCCCA TGAAATTCCT TCAAGGAGAG 
AAGCAAGCCA AAGTCCTCAT CGGAATAGCA TGGAGCCTCT CCTTCCTGTT CTCCATCCCC 
ACACTGATCA TATTTGGGAA AAGGACACTT TCCAATGGTG AGGTACAGTG CTGGGCACTG 
TGGCCAGACG ACTCCTACTG GACCCCATAT ATGACCATCG TTGCCTTTCT GGTGTACTTC 
ATCCCCTTGA CAATTATCAG CGTCATCTAT GGCCTTGTGA TCCGAACTAT TTGGATTAAA 
AGCAAAGCCC ATGAGACGGT GATTTCCAAC TGCTCAGATG GAGAACTATG CTGCAGCTAC 
AACCGAGGCC TCATCTCAAA AGCAAAAATC AAGGCCATCA AGTACAGCAT CGTCATAATC 
CTTGCTTTCA TCTGCTGCTG GAGTCCATAC TTCCTCTTTG ACATGTTAGA CAACTTCAAC 
CTCCTTCCAG ACACCAAGGA GCGTTTCTAT GCCTCTGTGA TTATCCAGAA CCTGCCTGCC 
TTGAACAGTG CCATTAACCC CCTCATCTAC TGCATCTTCA GCGGCTCCCT CTGCTCCCCC 
TGCAAGGTGC AAAGATCCCA GGATTCCAGA ATGACGTACC GAGAGAGAAG CGAGAGGCAT 
GAGATGCAGA TTCTCTCCAA GCCTGAATTC ATCTAA