Serpina6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina6
Entrez Gene ID	299270
Full Name	serpin family A member 6
Synonyms	Cbg
General protein information	Preferred Names serpin family A member 6 Names corticosteroid-binding globulin Corticosteroid binding globulin serine (or cysteine) peptidase inhibitor, clade A, member 6 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 serpin A6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 serpin peptidase inhibitor, clade A, member 6 transcortin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009663.1	NP_001009663.1	corticosteroid-binding globulin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpina6	NP_031644.1
Canis lupus familiaris (dog)	SERPINA6	XP_005623821.1
Homo sapiens (human)	SERPINA6	NP_001747.2
Pan troglodytes (chimpanzee)	SERPINA6	XP_510143.2
	SERPINA6	XP_002805222.1
Bos taurus (cattle)	SERPINA6	XP_005222338.1
Rattus norvegicus (Norway rat)	Serpina6	NP_001009663.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional Implications of Corticosteroid-binding Globulin N-Glycosylation.
Simard M, Underhill C, Hammond GL
Journal of molecular endocrinology(2017 Dec)

Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats.
Hill LA, Bodnar TS, Weinberg J, Hammond GL
The Journal of endocrinology230(2)215-25(2016 Aug)

Differences in colocalization of corticosteroid-binding globulin and glucocorticoid receptor immunoreactivity in the rat brain.
Sivukhina E, Sch?fer HH, Jirikowski GF
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft195(3)219-24(2013 May)

Expression of corticosteroid binding globulin in the rat olfactory system.
D?lz W, Eitner A, Caldwell JD, Jirikowski GF
Acta histochemica115(4)376-81(2013 May)

Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats.
Ogias D, de Andrade S? ER, Kasai A, Moisan MP, Alvares EP, Gama P
American journal of physiology. Gastrointestinal and liver physiology298(1)G117-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

levels and integrity of plasma CBG are biomarkers of the onset and severity of inflammation
Title: Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats.

It is most likely that CBG in the brain may be involved in the response to changing systemic glucocorticoid levels.
Title: Differences in colocalization of corticosteroid-binding globulin and glucocorticoid receptor immunoreactivity in the rat brain.

corticosteroid binding globulin
Title: Expression of corticosteroid binding globulin in the rat olfactory system.

Food restriction induced higher corticosterone plasma concentration at both ages, but only in pups did CBG binding increase after short- and long-term treatments
Title: Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats.

analysis of the structural basis for steroid transport and proteinase-triggered release of CBG
Title: Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release.

The following Serpina6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00758	NM_001009663.1 Latest version!	Rattus norvegicus serpin family A member 6 (Serpina6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina6 ( NM_001009663.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001009663.1 Rattus norvegicus serpin family A member 6 (Serpina6), mRNA.

Price & Availability↑

CloneID	ORa00758
Clone ID Related Accession (Same CDS sequence)	NM_001009663.1
Accession Version	NM_001009663.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Rattus norvegicus(Norway rat)
Product	corticosteroid-binding globulin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088300.1. On Jan 13, 2005 this sequence version replaced XM_216777.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088300.1, FQ209977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGTCACTCG CCCTGTATAC CTGCCTCCTC TGGCTCTGCA CCAGTGGCCT CTGGACTGCC 
CAAGCCAGCA CTAATGAGAG TTCAAATTCT CACCGAGGCC TGGCTCCCAC CAATGTTGAC 
TTTGCCTTCA ACTTGTACCA ACGCCTAGTG GCCCTAAATC CAGACAAGAA CACCTTAATC 
TCCCCAGTGA GCATCTCCAT GGCTCTGGCC ATGGTATCCC TTGGCTCTGC CCAGACTCAG 
TCTCTCCAGA GTCTAGGCTT CAACCTCACA GAGACCTCTG AAGCTGAGAT CCACCAGAGT 
TTCCAGTACC TCAATTACCT TCTCAAGCAG TCCGATACTG GCTTAGAGAT GAACATGGGC 
AATGCCATGT TCCTCCTCCA GAAGCTGAAG CTGAAGGACT CGTTCTTAGC AGACGTCAAA 
CAATACTATG AGTCAGAGGC CTTGGCCATC GATTTCGAGG ACTGGACTAA AGCCAGCCAA 
CAGATCAACC AGCATGTCAA GGATAAGACA CAGGGGAAAA TTGAGCATGT GTTCTCAGAC 
CTGGATAGTC CAGCCTCCTT CATCCTGGTC AACTACATCT TCCTCAGAGG CATATGGGAA 
CTTCCCTTCA GCCCAGAAAA TACTAGAGAG GAGGACTTCT ATGTGAATGA GACAAGCACC 
GTGAAGGTGC CCATGATGGT CCAGTCAGGC AGCATTGGTT ACTTTCGTGA CTCAGTCTTC 
CCCTGCCAGC TGATACAGAT GGACTATGTG GGAAATGGAA CTGCCTTCTT CATTCTTCCA 
GACCAGGGCC AGATGGACAC TGTCATCGCT GCACTTAGTC GGGACACAAT TGATAGGTGG 
GGCAAGCTTA TGACCCCAAG GCAGGTGAAC CTATACATCC CGAAATTCTC CATATCTGAT 
ACCTATGACC TTAAAGACAT GCTGGAAGAC CTGAACATTA AGGACTTGCT CACCAACCAA 
TCAGATTTCT CAGGCAACAC CAAAGATGTT CCCTTGACAT TAACGATGGT CCACAAGGCC 
ATGCTACAAC TGGATGAAGG GAATGTGTTG CCTAATTCTA CCAACGGGGC TCCCCTACAC 
CTGCGCTCTG AACCACTTGA CATCAAGTTC AACAAGCCCT TCATCCTCCT GCTCTTTGAC 
AAGTTCACAT GGAGCAGCCT GATGATGAGC CAAGTGGTCA ATCCAGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009663.1
CDS	72..1262
Translation	MSLALYTCLLWLCTSGLWTAQASTNESSNSHRGLAPTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSAQTQSLQSLGFNLTETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSISDTYDLKDMLEDLNIKDLLTNQSDFSGNTKDVPLTLTMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFDKFTWSSLMMSQVVNPA

Target ORF information:

RefSeq Version	NM_001009663.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family A member 6 (Serpina6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009663.1

ORF Insert Sequence:

ATGTCACTCG CCCTGTATAC CTGCCTCCTC TGGCTCTGCA CCAGTGGCCT CTGGACTGCC 
CAAGCCAGCA CTAATGAGAG TTCAAATTCT CACCGAGGCC TGGCTCCCAC CAATGTTGAC 
TTTGCCTTCA ACTTGTACCA ACGCCTAGTG GCCCTAAATC CAGACAAGAA CACCTTAATC 
TCCCCAGTGA GCATCTCCAT GGCTCTGGCC ATGGTATCCC TTGGCTCTGC CCAGACTCAG 
TCTCTCCAGA GTCTAGGCTT CAACCTCACA GAGACCTCTG AAGCTGAGAT CCACCAGAGT 
TTCCAGTACC TCAATTACCT TCTCAAGCAG TCCGATACTG GCTTAGAGAT GAACATGGGC 
AATGCCATGT TCCTCCTCCA GAAGCTGAAG CTGAAGGACT CGTTCTTAGC AGACGTCAAA 
CAATACTATG AGTCAGAGGC CTTGGCCATC GATTTCGAGG ACTGGACTAA AGCCAGCCAA 
CAGATCAACC AGCATGTCAA GGATAAGACA CAGGGGAAAA TTGAGCATGT GTTCTCAGAC 
CTGGATAGTC CAGCCTCCTT CATCCTGGTC AACTACATCT TCCTCAGAGG CATATGGGAA 
CTTCCCTTCA GCCCAGAAAA TACTAGAGAG GAGGACTTCT ATGTGAATGA GACAAGCACC 
GTGAAGGTGC CCATGATGGT CCAGTCAGGC AGCATTGGTT ACTTTCGTGA CTCAGTCTTC 
CCCTGCCAGC TGATACAGAT GGACTATGTG GGAAATGGAA CTGCCTTCTT CATTCTTCCA 
GACCAGGGCC AGATGGACAC TGTCATCGCT GCACTTAGTC GGGACACAAT TGATAGGTGG 
GGCAAGCTTA TGACCCCAAG GCAGGTGAAC CTATACATCC CGAAATTCTC CATATCTGAT 
ACCTATGACC TTAAAGACAT GCTGGAAGAC CTGAACATTA AGGACTTGCT CACCAACCAA 
TCAGATTTCT CAGGCAACAC CAAAGATGTT CCCTTGACAT TAACGATGGT CCACAAGGCC 
ATGCTACAAC TGGATGAAGG GAATGTGTTG CCTAATTCTA CCAACGGGGC TCCCCTACAC 
CTGCGCTCTG AACCACTTGA CATCAAGTTC AACAAGCCCT TCATCCTCCT GCTCTTTGAC 
AAGTTCACAT GGAGCAGCCT GATGATGAGC CAAGTGGTCA ATCCAGCCTA A