Kcnmb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnmb2
Entrez Gene ID	294961
Full Name	potassium calcium-activated channel subfamily M regulatory beta subunit 2
Synonyms	Kcmb2
General protein information	Preferred Names potassium calcium-activated channel subfamily M regulatory beta subunit 2 Names calcium-activated potassium channel subunit beta-2 BK channel subunit beta-2 BKbeta2 calcium-activated potassium channel beta 2 calcium-activated potassium channel, subfamily M subunit beta-2 charybdotoxin receptor subunit beta-2 k(VCA)beta-2 maxi K channel subunit beta-2 potassium channel subfamily M regulatory beta subunit 2 potassium large conductance calcium-activated channel, subfamily M, beta member 2 rbeta3 slo-beta-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q24
Summary	a Ca(2+)-activated K(+) (BK) channel responsible for the large K(+) conductance in inner hair cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_176861.1	NP_789831.1	calcium-activated potassium channel subunit beta-2
XM_017590735.1	XP_017446224.1	calcium-activated potassium channel subunit beta-2 isoform X2
XM_017590734.1	XP_017446223.1	calcium-activated potassium channel subunit beta-2 isoform X1
XM_017590737.1	XP_017446226.1	calcium-activated potassium channel subunit beta-2 isoform X2
XM_017590736.1	XP_017446225.1	calcium-activated potassium channel subunit beta-2 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNMB2	NP_001265840.1
Pan troglodytes (chimpanzee)	KCNMB2	XP_516884.1
Bos taurus (cattle)	KCNMB2	NP_001073769.1
Mus musculus (house mouse)	Kcnmb2	NP_082507.1
Danio rerio (zebrafish)	LOC796753	XP_005172908.1
Canis lupus familiaris (dog)	KCNMB2	XP_545302.3
Xenopus tropicalis (tropical clawed frog)	kcnmb2	XP_002931599.2
	KCNMB2	XP_001109372.1
Rattus norvegicus (Norway rat)	Kcnmb2	NP_789831.1
Danio rerio (zebrafish)	kcnmb2	NP_001013543.1
Gallus gallus (chicken)	KCNMB2	XP_004943515.1

Gene Ontology
Bibliography

Related articles in PubMed

Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel ?1-subunit by a novel nonsteroidal agent.
Bukiya AN, McMillan JE, Fedinec AL, Patil SA, Miller DD, Leffler CW, Parrill AL, Dopico AM
Molecular pharmacology83(5)1030-44(2013 May)

Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.
Li W, Gao SB, Lv CX, Wu Y, Guo ZH, Ding JP, Xu T
Journal of cellular physiology212(2)348-57(2007 Aug)

Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.
Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y
Molecular pharmacology71(4)1075-88(2007 Apr)

Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea.
Langer P, Gr?nder S, R?sch A
The Journal of comparative neurology455(2)198-209(2003 Jan)

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.
Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW
The Journal of biological chemistry275(9)6453-61(2000 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kcnmb2 is responsible for inactivating large-conductance calcium-dependent potassium currents in small sensory dorsal root ganglion neurons.
Title: Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.

DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed.
Title: Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.

The following Kcnmb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnmb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04011	NM_176861.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa59667	XM_017590734.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa59668	XM_017590737.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa59668	XM_017590735.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa59668	XM_017590736.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnmb2 ( NM_176861.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_789831.1 Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), mRNA.

Price & Availability↑

CloneID	ORa04011
Clone ID Related Accession (Same CDS sequence)	NM_176861.1
Accession Version	NM_176861.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	calcium-activated potassium channel subunit beta-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY191836.1. ##Evidence-Data-START## Transcript exon combination :: AY191836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGAG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGC GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789831.1
CDS	1..708
Translation	MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQRALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

Target ORF information:

RefSeq Version	NM_176861.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176861.1

ORF Insert Sequence:

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGAG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGC GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnmb2 ( XM_017590734.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446223.1 Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59667
Clone ID Related Accession (Same CDS sequence)	XM_017590734.1
Accession Version	XM_017590734.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcium-activated potassium channel subunit beta-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCACCC CGCACCAAAG GTCTTTCCGC CACTCCCCCA GGACTTCCAC AGCAAGGACA 
GGAGCTGCAG GACCAACATC CTCTAAGATG TTTATATGGA CCAGTGGCCG GACCTCTTCA 
TCTTACAGAC ACGACGAGAA AAGAAATATC TACCAGAAAA TCAGGGACCA TGACCTCCTG 
GACAAAAGGA AAACTGTGAC AGCTCTGAAG GCTGGGGAGG ACCGGGCCAT CCTGCTTGGA 
CTGGCCATGA TGGTGTGCTC CATCATGATG TACTTCCTAC TGGGAATCAC ACTGCTGCGC 
TCGTACATGC AGAGTGTATG GACAGAAGAA GCCCAGTGTG CCCTGCTGAA TGTGTCAATC 
ACAGAAACAT TTAACTGTTC CTTCAGCTGT GGGCCTGACT GCTGGAAGCT CTCTCAGTAC 
CCTTGCCTGC AGGTATACGT GAACCTGACA TCTTCTGGGG AGAAGCTCCT CCTCTACCAC 
ACAGAAGAGA CCATGAAGAT CAATCAAAAG TGCTCCTATA TTCCTAAGTG TGGAAACAAC 
TTTGAGGAGT CCATGTCCCT TGTGAGTGTC GTCATGGAAA ACTTCAGGAG ACACCAACAC 
TTCCCCTGCT ATTCTGACCC AGAAGGGAAC CAAAAGAGCG TCATCCTGAC CAAACTCTAT 
AGCTCCAATG TGCTGTTCCA TTCTCTCTTC TGGCCAACGT GTATGATGGC TGGGGGTGTG 
GCAATCGTTG CTATGGTGAA ACTAACTCAG TACCTCTCCC TGCTTTGTGA GAGGATCCAA 
CGGATCAACA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446223.1
CDS	648..1442
Translation	MATPHQRSFRHSPRTSTARTGAAGPTSSKMFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

Target ORF information:

RefSeq Version	XM_017590734.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590734.1

ORF Insert Sequence:

ATGGCCACCC CGCACCAAAG GTCTTTCCGC CACTCCCCCA GGACTTCCAC AGCAAGGACA 
GGAGCTGCAG GACCAACATC CTCTAAGATG TTTATATGGA CCAGTGGCCG GACCTCTTCA 
TCTTACAGAC ACGACGAGAA AAGAAATATC TACCAGAAAA TCAGGGACCA TGACCTCCTG 
GACAAAAGGA AAACTGTGAC AGCTCTGAAG GCTGGGGAGG ACCGGGCCAT CCTGCTTGGA 
CTGGCCATGA TGGTGTGCTC CATCATGATG TACTTCCTAC TGGGAATCAC ACTGCTGCGC 
TCGTACATGC AGAGTGTATG GACAGAAGAA GCCCAGTGTG CCCTGCTGAA TGTGTCAATC 
ACAGAAACAT TTAACTGTTC CTTCAGCTGT GGGCCTGACT GCTGGAAGCT CTCTCAGTAC 
CCTTGCCTGC AGGTATACGT GAACCTGACA TCTTCTGGGG AGAAGCTCCT CCTCTACCAC 
ACAGAAGAGA CCATGAAGAT CAATCAAAAG TGCTCCTATA TTCCTAAGTG TGGAAACAAC 
TTTGAGGAGT CCATGTCCCT TGTGAGTGTC GTCATGGAAA ACTTCAGGAG ACACCAACAC 
TTCCCCTGCT ATTCTGACCC AGAAGGGAAC CAAAAGAGCG TCATCCTGAC CAAACTCTAT 
AGCTCCAATG TGCTGTTCCA TTCTCTCTTC TGGCCAACGT GTATGATGGC TGGGGGTGTG 
GCAATCGTTG CTATGGTGAA ACTAACTCAG TACCTCTCCC TGCTTTGTGA GAGGATCCAA 
CGGATCAACA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnmb2 ( XM_017590735.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446224.1 Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa59668
Clone ID Related Accession (Same CDS sequence)	XM_017590735.1 , XM_017590737.1 , XM_017590736.1
Accession Version	XM_017590735.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcium-activated potassium channel subunit beta-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446224.1
CDS	3731..4438
Translation	MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

Target ORF information:

RefSeq Version	XM_017590735.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590735.1

ORF Insert Sequence:

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnmb2 ( XM_017590737.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446226.1 Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa59668
Clone ID Related Accession (Same CDS sequence)	XM_017590735.1 , XM_017590737.1 , XM_017590736.1
Accession Version	XM_017590737.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcium-activated potassium channel subunit beta-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446226.1
CDS	3001..3708
Translation	MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

Target ORF information:

RefSeq Version	XM_017590737.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590737.1

ORF Insert Sequence:

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnmb2 ( XM_017590736.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446225.1 Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X3, mRNA.

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CloneID	ORa59668
Clone ID Related Accession (Same CDS sequence)	XM_017590735.1 , XM_017590737.1 , XM_017590736.1
Accession Version	XM_017590736.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcium-activated potassium channel subunit beta-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446225.1
CDS	811..1518
Translation	MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

Target ORF information:

RefSeq Version	XM_017590736.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 2 (Kcnmb2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590736.1

ORF Insert Sequence:

ATGTTTATAT GGACCAGTGG CCGGACCTCT TCATCTTACA GACACGACGA GAAAAGAAAT 
ATCTACCAGA AAATCAGGGA CCATGACCTC CTGGACAAAA GGAAAACTGT GACAGCTCTG 
AAGGCTGGGG AGGACCGGGC CATCCTGCTT GGACTGGCCA TGATGGTGTG CTCCATCATG 
ATGTACTTCC TACTGGGAAT CACACTGCTG CGCTCGTACA TGCAGAGTGT ATGGACAGAA 
GAAGCCCAGT GTGCCCTGCT GAATGTGTCA ATCACAGAAA CATTTAACTG TTCCTTCAGC 
TGTGGGCCTG ACTGCTGGAA GCTCTCTCAG TACCCTTGCC TGCAGGTATA CGTGAACCTG 
ACATCTTCTG GGGAGAAGCT CCTCCTCTAC CACACAGAAG AGACCATGAA GATCAATCAA 
AAGTGCTCCT ATATTCCTAA GTGTGGAAAC AACTTTGAGG AGTCCATGTC CCTTGTGAGT 
GTCGTCATGG AAAACTTCAG GAGACACCAA CACTTCCCCT GCTATTCTGA CCCAGAAGGG 
AACCAAAAGA GCGTCATCCT GACCAAACTC TATAGCTCCA ATGTGCTGTT CCATTCTCTC 
TTCTGGCCAA CGTGTATGAT GGCTGGGGGT GTGGCAATCG TTGCTATGGT GAAACTAACT 
CAGTACCTCT CCCTGCTTTG TGAGAGGATC CAACGGATCA ACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel ?1-subunit by a novel nonsteroidal agent.
Molecular pharmacology83(5)1030-44(2013 May)
Bukiya AN,McMillan JE,Fedinec AL,Patil SA,Miller DD,Leffler CW,Parrill AL,Dopico AM

Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.
Journal of cellular physiology212(2)348-57(2007 Aug)
Li W,Gao SB,Lv CX,Wu Y,Guo ZH,Ding JP,Xu T

Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.
Molecular pharmacology71(4)1075-88(2007 Apr)
Morimoto T,Sakamoto K,Sade H,Ohya S,Muraki K,Imaizumi Y

Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea.
The Journal of comparative neurology455(2)198-209(2003 Jan)
Langer P,Gr?nder S,R?sch A

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.
The Journal of biological chemistry275(9)6453-61(2000 Mar)
Brenner R,Jegla TJ,Wickenden A,Liu Y,Aldrich RW