Gdf15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdf15
Entrez Gene ID	29455
Full Name	growth differentiation factor 15
General protein information	Preferred Names growth differentiation factor 15 Names growth/differentiation factor 15 GDF-15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	member of the TGF-beta superfamily of growth factors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019216.2	NP_062089.1	growth/differentiation factor 15 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gdf15	NP_062089.1
Homo sapiens (human)	GDF15	NP_004855.2
	GDF15	XP_001114375.1
Bos taurus (cattle)	GDF15	NP_001193227.1
Pan troglodytes (chimpanzee)	GDF15	XP_003953462.1
Canis lupus familiaris (dog)	GDF15	XP_541938.1
Mus musculus (house mouse)	Gdf15	NP_035949.2

Gene Ontology
Bibliography

Related articles in PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkj?r SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, N?rgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, J?rgensen SB
Nature medicine23(10)1158-1166(2017 Oct)

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
Xiong Y, Walker K, Min X, Hale C, Tran T, Komorowski R, Yang J, Davda J, Nuanmanee N, Kemp D, Wang X, Liu H, Miller S, Lee KJ, Wang Z, V?niant MM
Science translational medicine9(412)(2017 Oct)

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB
Nature550(7675)255-259(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation.
Title: High-dose Radiation Induced Heart Damage in a Rat Model.

findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells
Title: The nuclear receptor REV-ERB? represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.

the time course of the expression of growth differentiation factor15 (GDF15) in rat ischemic myocardium with increasing durations of reperfusion, and to elucidate its physiopathological role in the noreflow phenomenon, is reported.
Title: Growth differentiation factor 15 may protect the myocardium from no?reflow by inhibiting the inflammatory?like response that predominantly involves neutrophil infiltration.

Expression levels of GDF-15, BMP6, and HJV genes increased in rats exposed to ischemia and reperfusion, but this increase was not statistically significant.
Title: The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion.

GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage
Title: Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes.

The following Gdf15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdf15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04054	NM_019216.2 Latest version!	Rattus norvegicus growth differentiation factor 15 (Gdf15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdf15 ( NM_019216.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062089.1 Rattus norvegicus growth differentiation factor 15 (Gdf15), mRNA.

Price & Availability↑

CloneID	ORa04054
Clone ID Related Accession (Same CDS sequence)	NM_019216.2
Accession Version	NM_019216.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Rattus norvegicus(Norway rat)
Product	growth/differentiation factor 15 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ011969.1. On Sep 3, 2009 this sequence version replaced NM_019216.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTGC GCGCGCTCCA TGCCCAGCCT ACAGGCGGTC CTCAGCTGAG GTTCCTGCTG 
TTCCTGCTGC TCTTGCTGCT TCTGCTGTCA TGGCCATCTC AGGGGGACGC CCTGGCATTG 
CCTGAGCAGC GACGCTCCCT CTCTGAGTCC CAACTCAACC CGGACGAGCT ACGGGGTCGC 
TTCCAGGACC TGCTGAGCCG ACTGCATGCC AACCAGAGCC GGGAGGACTC GAACTCAGAA 
CCAACCCCTG ACCCAGCTGT CCGGATACTC AGTCCAGAGG TGCGATTGGG GTCCCACGGC 
CGGCTGCTGC TCCGCGTCAA CCGGGCGTCG CTGACTCAGG GTCTCCCCGA AGCCTACCGC 
GTGCACCGAG CGCTGCTCCT GCTGACGCCT TCGTCCAGGC CCTGGGACAT CACCAGGCCC 
CTGCAACGTG CGATCAGCCT CCAGGGACCC CACGCTCGCG CACTGCGCTT GCGCCTGGCG 
CCGCCTCCCG ACCTAGCCGT GCTGCCCTCT GGCGGCGCGC GCCTGGAACT GCACTTACGA 
TCGGCCGCCG GCAGGGGGCG CCGAAGCGCG CATTTGCACC CAAGAGACTC GTGCCCGCTG 
GGTCCCGGGC GCTGCTGTCA CCTGGAGACT GTGCAGGCAA CTCTCGAGGA CCTAGGTTGG 
AGCGACTGGG TACTGTCCCC GCGTCAGCTG CAACTGAGCA TGTGCGTGGG CGAGTGCCCC 
CACCTCTACC GGTCGGCCAA CACGCATGCG CTGATCAAAG CACGCCTGCA TGGCCTGCAG 
CCCGACAGAG TGCCGGCCCC GTGCTGTGTC CCCTCCAGCT ACACCCCGGT GGTTCTTATG 
CACAGGACAG ACAGCGGCGT GTCACTGCAG ACTTATGATG ATCTGGTAGC CCAGGGCTGC 
CACTGCGCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062089.1
CDS	1..912
Translation	MALRALHAQPTGGPQLRFLLFLLLLLLLLSWPSQGDALALPEQRRSLSESQLNPDELRGRFQDLLSRLHANQSREDSNSEPTPDPAVRILSPEVRLGSHGRLLLRVNRASLTQGLPEAYRVHRALLLLTPSSRPWDITRPLQRAISLQGPHARALRLRLAPPPDLAVLPSGGARLELHLRSAAGRGRRSAHLHPRDSCPLGPGRCCHLETVQATLEDLGWSDWVLSPRQLQLSMCVGECPHLYRSANTHALIKARLHGLQPDRVPAPCCVPSSYTPVVLMHRTDSGVSLQTYDDLVAQGCHCA

Target ORF information:

RefSeq Version	NM_019216.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth differentiation factor 15 (Gdf15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019216.2

ORF Insert Sequence:

ATGGCCCTGC GCGCGCTCCA TGCCCAGCCT ACAGGCGGTC CTCAGCTGAG GTTCCTGCTG 
TTCCTGCTGC TCTTGCTGCT TCTGCTGTCA TGGCCATCTC AGGGGGACGC CCTGGCATTG 
CCTGAGCAGC GACGCTCCCT CTCTGAGTCC CAACTCAACC CGGACGAGCT ACGGGGTCGC 
TTCCAGGACC TGCTGAGCCG ACTGCATGCC AACCAGAGCC GGGAGGACTC GAACTCAGAA 
CCAACCCCTG ACCCAGCTGT CCGGATACTC AGTCCAGAGG TGCGATTGGG GTCCCACGGC 
CGGCTGCTGC TCCGCGTCAA CCGGGCGTCG CTGACTCAGG GTCTCCCCGA AGCCTACCGC 
GTGCACCGAG CGCTGCTCCT GCTGACGCCT TCGTCCAGGC CCTGGGACAT CACCAGGCCC 
CTGCAACGTG CGATCAGCCT CCAGGGACCC CACGCTCGCG CACTGCGCTT GCGCCTGGCG 
CCGCCTCCCG ACCTAGCCGT GCTGCCCTCT GGCGGCGCGC GCCTGGAACT GCACTTACGA 
TCGGCCGCCG GCAGGGGGCG CCGAAGCGCG CATTTGCACC CAAGAGACTC GTGCCCGCTG 
GGTCCCGGGC GCTGCTGTCA CCTGGAGACT GTGCAGGCAA CTCTCGAGGA CCTAGGTTGG 
AGCGACTGGG TACTGTCCCC GCGTCAGCTG CAACTGAGCA TGTGCGTGGG CGAGTGCCCC 
CACCTCTACC GGTCGGCCAA CACGCATGCG CTGATCAAAG CACGCCTGCA TGGCCTGCAG 
CCCGACAGAG TGCCGGCCCC GTGCTGTGTC CCCTCCAGCT ACACCCCGGT GGTTCTTATG 
CACAGGACAG ACAGCGGCGT GTCACTGCAG ACTTATGATG ATCTGGTAGC CCAGGGCTGC 
CACTGCGCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Nature medicine23(10)1158-1166(2017 Oct)
Yang L,Chang CC,Sun Z,Madsen D,Zhu H,Padkj?r SB,Wu X,Huang T,Hultman K,Paulsen SJ,Wang J,Bugge A,Frantzen JB,N?rgaard P,Jeppesen JF,Yang Z,Secher A,Chen H,Li X,John LM,Shan B,He Z,Gao X,Su J,Hansen KT,Yang W,J?rgensen SB

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
Science translational medicine9(412)(2017 Oct)
Xiong Y,Walker K,Min X,Hale C,Tran T,Komorowski R,Yang J,Davda J,Nuanmanee N,Kemp D,Wang X,Liu H,Miller S,Lee KJ,Wang Z,V?niant MM

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature550(7675)255-259(2017 Oct)
Hsu JY,Crawley S,Chen M,Ayupova DA,Lindhout DA,Higbee J,Kutach A,Joo W,Gao Z,Fu D,To C,Mondal K,Li B,Kekatpure A,Wang M,Laird T,Horner G,Chan J,McEntee M,Lopez M,Lakshminarasimhan D,White A,Wang SP,Yao J,Yie J,Matern H,Solloway M,Haldankar R,Parsons T,Tang J,Shen WD,Alice Chen Y,Tian H,Allan BB

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Gdf15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

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見積依頼

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電話

FAX

オンラインフォーム