Pla2g10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pla2g10
Entrez Gene ID	29359
Full Name	phospholipase A2, group X
Synonyms	PLA2GX,sPLA2-X
General protein information	Preferred Names phospholipase A2, group X Names group 10 secretory phospholipase A2 GX sPLA2 group X phospholipase A2 group X secretory phospholipase A2 phosphatidylcholine 2-acylhydrolase 10 phosphatidylcholine 2-acylhydrolase GX phospholipase A2, group 10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q11
Summary	mouse homolog has phospholipase A2 activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017176.2	NP_058872.1	group 10 secretory phospholipase A2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLA2G10	NP_003552.1
Pan troglodytes (chimpanzee)	PLA2G10	XP_001143002.1
	LOC717517	XP_001109076.2
Gallus gallus (chicken)	LOC418356	XP_003640502.1
Xenopus tropicalis (tropical clawed frog)	LOC100492785	XP_002935521.1
Canis lupus familiaris (dog)	PLA2G10	XP_005622132.1
Danio rerio (zebrafish)	zgc:92162	NP_001002350.1
Bos taurus (cattle)	PLA2G10	XP_002698051.2
Mus musculus (house mouse)	Pla2g10	NP_036117.1
Rattus norvegicus (Norway rat)	Pla2g10	NP_058872.1
Gallus gallus (chicken)	PLA2G10	NP_001171686.1

Gene Ontology
Bibliography

Related articles in PubMed

Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection.
Fornander L, Ghafouri B, Kihlstr?m E, Akerlind B, Sch?n T, Tagesson C, Lindahl M
Proteomics. Clinical applications5(9-10)513-22(2011 Oct)

Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR
Arteriosclerosis, thrombosis, and vascular biology30(10)2014-21(2010 Oct)

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)

Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.
Curfs DM, Ghesquiere SA, Vergouwe MN, van der Made I, Gijbels MJ, Greaves DR, Verbeek JS, Hofker MH, de Winther MP
The Journal of biological chemistry283(31)21640-8(2008 Aug)

Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M
The Journal of biological chemistry280(30)28044-52(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

group X secreted phospholipase A2 is expressed in neural cells and has neuritogenic action
Title: Neuronal expression and neuritogenic action of group X secreted phospholipase A2.

The following Pla2g10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pla2g10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03132	NM_017176.2 Latest version!	Rattus norvegicus phospholipase A2, group X (Pla2g10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pla2g10 ( NM_017176.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058872.1 Rattus norvegicus phospholipase A2, group X (Pla2g10), mRNA.

Price & Availability↑

CloneID	ORa03132
Clone ID Related Accession (Same CDS sequence)	NM_017176.2
Accession Version	NM_017176.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	group 10 secretory phospholipase A2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF166100.1. On Aug 31, 2012 this sequence version replaced NM_017176.1. ##Evidence-Data-START## Transcript exon combination :: AF166100.1, AY651029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642708 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCTGC TACTGCTGCT GTTGCTACTG GGACCTGGAT CCTGTCTCAG CGAAGCAACC 
AGGAGGTCAC ATGTGTACAA GCGTGGACTC CTGGAACTGG CAGGGACCTT GGATTGTGTT 
GGTCCTCGAT CGCCGATGGC TTACATGAAC TATGGTTGTT ATTGTGGCCT TGGTGGCCAC 
GGAGAGCCAC GTGATGCCAT TGACTGGTGC TGCTACTACC ATGACTGCTG CTACTCTCAG 
GCTCAGGATG CCGGCTGCAG CCCCAAGCTA TACCGATACC CGTGGAAGTG CATGGACCAT 
CGCATCCTGT GTGGACCGGC AGAGAACAAA TGCCAAGAAC TCCTATGCAG GTGTGATGAG 
ACGCTCGCAT ACTGCCTGGC AGACACAGAG TACCACCTGA AATACCTCTT CTTCCCCTCG 
GTTTTATGTG AGAAGGACTC ACCCAAGTGC AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058872.1
CDS	47..502
Translation	MLLLLLLLLLGPGSCLSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYYHDCCYSQAQDAGCSPKLYRYPWKCMDHRILCGPAENKCQELLCRCDETLAYCLADTEYHLKYLFFPSVLCEKDSPKCN

Target ORF information:

RefSeq Version	NM_017176.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phospholipase A2, group X (Pla2g10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017176.2

ORF Insert Sequence:

ATGCTGCTGC TACTGCTGCT GTTGCTACTG GGACCTGGAT CCTGTCTCAG CGAAGCAACC 
AGGAGGTCAC ATGTGTACAA GCGTGGACTC CTGGAACTGG CAGGGACCTT GGATTGTGTT 
GGTCCTCGAT CGCCGATGGC TTACATGAAC TATGGTTGTT ATTGTGGCCT TGGTGGCCAC 
GGAGAGCCAC GTGATGCCAT TGACTGGTGC TGCTACTACC ATGACTGCTG CTACTCTCAG 
GCTCAGGATG CCGGCTGCAG CCCCAAGCTA TACCGATACC CGTGGAAGTG CATGGACCAT 
CGCATCCTGT GTGGACCGGC AGAGAACAAA TGCCAAGAAC TCCTATGCAG GTGTGATGAG 
ACGCTCGCAT ACTGCCTGGC AGACACAGAG TACCACCTGA AATACCTCTT CTTCCCCTCG 
GTTTTATGTG AGAAGGACTC ACCCAAGTGC AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection.
Proteomics. Clinical applications5(9-10)513-22(2011 Oct)
Fornander L,Ghafouri B,Kihlstr?m E,Akerlind B,Sch?n T,Tagesson C,Lindahl M

Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Arteriosclerosis, thrombosis, and vascular biology30(10)2014-21(2010 Oct)
Shridas P,Bailey WM,Gizard F,Oslund RC,Gelb MH,Bruemmer D,Webb NR

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)
Tarantino C,Paolella G,Cozzuto L,Minopoli G,Pastore L,Parisi S,Russo T

Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.
The Journal of biological chemistry283(31)21640-8(2008 Aug)
Curfs DM,Ghesquiere SA,Vergouwe MN,van der Made I,Gijbels MJ,Greaves DR,Verbeek JS,Hofker MH,de Winther MP

Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
The Journal of biological chemistry280(30)28044-52(2005 Jul)
Ikeno Y,Konno N,Cheon SH,Bolchi A,Ottonello S,Kitamoto K,Arioka M