Gpr182 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr182
Entrez Gene ID	29307
Full Name	G protein-coupled receptor 182
Synonyms	Admr
General protein information	Preferred Names G protein-coupled receptor 182 Names G-protein coupled receptor 182 G10D NOW adrenomedullin receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	seven-transmembrane receptor that binds adrenomedullin, a potent vasodilator peptide [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053302.3	NP_445754.2	G-protein coupled receptor 182
XM_008765379.2	XP_008763601.1	G-protein coupled receptor 182 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpr182	NP_445754.2
Danio rerio (zebrafish)	gpr182	NP_001018314.1
Homo sapiens (human)	GPR182	NP_009195.1
Canis lupus familiaris (dog)	GPR182	XP_538241.1
Bos taurus (cattle)	GPR182	NP_001193346.1
Pan troglodytes (chimpanzee)	GPR182	XP_003952198.1
Gallus gallus (chicken)	GPR182	XP_004950283.1
	GPR182	XP_001115515.1
Mus musculus (house mouse)	Gpr182	NP_031438.2
Xenopus tropicalis (tropical clawed frog)	LOC100498373	XP_002939752.1

Gene Ontology
Bibliography

Related articles in PubMed

Adrenomedullin promotes rat trophoblast stem cell differentiation.
Gao H, Liebenthal DA, Yallampalli U, Yallampalli C
Biology of reproduction91(3)65(2014 Sep)

Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis.
Geissler B, Plank C, Hartner A, Amann K, Struwe FG, Hilgers KF, Rascher W, D?tsch J
Nephron. Experimental nephrology115(3)e80-8(2010)

Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary.
Li YY, Li L, Hwang IS, Tang F, O WS
Biology of reproduction79(2)200-8(2008 Aug)

Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery.
Ross GR, Yallampalli U, Yallampalli C
Journal of vascular research45(1)33-44(2008)

Up-regulation of adrenomedullin receptor gene expression in activated local stem cells during rat adrenal regeneration.
Rebuffat P, Macchi C, Malendowicz LK, Nussdorfer GG
International journal of molecular medicine20(6)855-8(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2).
Title: Adrenomedullin promotes rat trophoblast stem cell differentiation.

study demonstrates that glomerular gene expression of ADM and its receptors are downregulated during anti-Thy1 glomerulonephritis
Title: Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis.

The presence of ADM and the gene expression of ADM and its receptor components in the female reproductive system suggest a paracrine effect of ADM on ovarian steroidogenesis.
Title: Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary.

Adrenomedullin inhibits CaCl(2)-induced contraction, without affecting calcium influx, through a CGRP(8-37)-sensitive receptor, but not using the cyclic adenosine monophosphate pathway, probably through activation of protein phosphatases.
Title: Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery.

Data indicate that the adrenomedullin receptor subtypes AM1-R and AM2-R are up-regulated in enucleated adrenals, and that this effect depends on the increased local production of AM.
Title: Up-regulation of adrenomedullin receptor gene expression in activated local stem cells during rat adrenal regeneration.

The following Gpr182 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr182 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09215	NM_053302.3 Latest version!	Rattus norvegicus G protein-coupled receptor 182 (Gpr182), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa09215	XM_008765379.2 Latest version!	Rattus norvegicus G protein-coupled receptor 182 (Gpr182), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr182 ( NM_053302.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445754.2 Rattus norvegicus G protein-coupled receptor 182 (Gpr182), mRNA.

Price & Availability↑

CloneID	ORa09215
Clone ID Related Accession (Same CDS sequence)	NM_053302.3 , XM_008765379.2
Accession Version	NM_053302.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	G-protein coupled receptor 182
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129072.1. On Jan 10, 2007 this sequence version replaced NM_053302.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC129072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906351 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGTCA TACCCAGCTC CAGGCCGGTC TCCACCTTGG CACCTGACAA TGATTTTAGA 
GAGATCCACA ACTGGACAGA GCTGCTCCAT CTCTTCAACC AAACCTTTTC TGATTGCCAC 
ATGGAACTCA ATGAGAACAC CAAACAAGTG GTCCTCTTTG TCTTCTACCT GGCCATCTTT 
GTGGTAGGGT TAGTGGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG CTCAGGCCGG 
GTGGGGATGC TGAACTTATA CATCCTCAAC ATGGCCGTCG CGGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CCTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GCCAACATGT ACAGCAGCAT CTTCTTCCTC 
ACCTGCCTCA GCATTGACCG CTACGTCACC CTCACCAATA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATCATC 
CCACTGCCTG AGGTGGTACA TATCCAGCTG CTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCTACCATC 
CTGGGCTTCC TACTGCCTTT TCCTCTCATC GCAGTGTTTA ATATCCTGTC AGCCTGCCGG 
CTTCGGAGGC AAGGGCAGAC AGAGAGCAGG CGCCACTGTC TGTTGATGTG GGCTTACATA 
GCTGTCTTTG TCATCTGCTG GCTGCCCTAC CACGTGACTA TGCTGCTGCT CACTCTGCAC 
ACAACCCACA TCTTCCTTCA CTGCAACCTG GTTAACTTCC TCTACTTCTT CTACGAAATC 
ATTGACTGCT TCTCCATGCT ACACTGTGTC GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GCGGTCGAGC CTCCTCTTCA TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTGCACACCC ACGCCATCAG AAACGTGCAG 
GCCTCCTCTC TGCCTCCGAA CACCTCACCT ACACTCTGCA ATTCCATAGC CAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445754.2
CDS	156..1352
Translation	MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIAVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHAIRNVQASSLPPNTSPTLCNSIAS

Target ORF information:

RefSeq Version	NM_053302.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 182 (Gpr182), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053302.3

ORF Insert Sequence:

ATGTCAGTCA TACCCAGCTC CAGGCCGGTC TCCACCTTGG CACCTGACAA TGATTTTAGA 
GAGATCCACA ACTGGACAGA GCTGCTCCAT CTCTTCAACC AAACCTTTTC TGATTGCCAC 
ATGGAACTCA ATGAGAACAC CAAACAAGTG GTCCTCTTTG TCTTCTACCT GGCCATCTTT 
GTGGTAGGGT TAGTGGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG CTCAGGCCGG 
GTGGGGATGC TGAACTTATA CATCCTCAAC ATGGCCGTCG CGGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CCTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GCCAACATGT ACAGCAGCAT CTTCTTCCTC 
ACCTGCCTCA GCATTGACCG CTACGTCACC CTCACCAATA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATCATC 
CCACTGCCTG AGGTGGTACA TATCCAGCTG CTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCTACCATC 
CTGGGCTTCC TACTGCCTTT TCCTCTCATC GCAGTGTTTA ATATCCTGTC AGCCTGCCGG 
CTTCGGAGGC AAGGGCAGAC AGAGAGCAGG CGCCACTGTC TGTTGATGTG GGCTTACATA 
GCTGTCTTTG TCATCTGCTG GCTGCCCTAC CACGTGACTA TGCTGCTGCT CACTCTGCAC 
ACAACCCACA TCTTCCTTCA CTGCAACCTG GTTAACTTCC TCTACTTCTT CTACGAAATC 
ATTGACTGCT TCTCCATGCT ACACTGTGTC GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GCGGTCGAGC CTCCTCTTCA TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTGCACACCC ACGCCATCAG AAACGTGCAG 
GCCTCCTCTC TGCCTCCGAA CACCTCACCT ACACTCTGCA ATTCCATAGC CAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpr182 ( XM_008765379.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008763601.1 Rattus norvegicus G protein-coupled receptor 182 (Gpr182), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09215
Clone ID Related Accession (Same CDS sequence)	NM_053302.3 , XM_008765379.2
Accession Version	XM_008765379.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	G-protein coupled receptor 182 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008765379.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGTCA TACCCAGCTC CAGGCCGGTC TCCACCTTGG CACCTGACAA TGATTTTAGA 
GAGATCCACA ACTGGACAGA GCTGCTCCAT CTCTTCAACC AAACCTTTTC TGATTGCCAC 
ATGGAACTCA ATGAGAACAC CAAACAAGTG GTCCTCTTTG TCTTCTACCT GGCCATCTTT 
GTGGTAGGGT TAGTGGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG CTCAGGCCGG 
GTGGGGATGC TGAACTTATA CATCCTCAAC ATGGCCGTCG CGGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CCTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GCCAACATGT ACAGCAGCAT CTTCTTCCTC 
ACCTGCCTCA GCATTGACCG CTACGTCACC CTCACCAATA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATCATC 
CCACTGCCTG AGGTGGTACA TATCCAGCTG CTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCTACCATC 
CTGGGCTTCC TACTGCCTTT TCCTCTCATC GCAGTGTTTA ATATCCTGTC AGCCTGCCGG 
CTTCGGAGGC AAGGGCAGAC AGAGAGCAGG CGCCACTGTC TGTTGATGTG GGCTTACATA 
GCTGTCTTTG TCATCTGCTG GCTGCCCTAC CACGTGACTA TGCTGCTGCT CACTCTGCAC 
ACAACCCACA TCTTCCTTCA CTGCAACCTG GTTAACTTCC TCTACTTCTT CTACGAAATC 
ATTGACTGCT TCTCCATGCT ACACTGTGTC GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GCGGTCGAGC CTCCTCTTCA TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTGCACACCC ACGCCATCAG AAACGTGCAG 
GCCTCCTCTC TGCCTCCGAA CACCTCACCT ACACTCTGCA ATTCCATAGC CAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008763601.1
CDS	489..1685
Translation	MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIAVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHAIRNVQASSLPPNTSPTLCNSIAS

Target ORF information:

RefSeq Version	XM_008765379.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 182 (Gpr182), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008765379.2

ORF Insert Sequence:

ATGTCAGTCA TACCCAGCTC CAGGCCGGTC TCCACCTTGG CACCTGACAA TGATTTTAGA 
GAGATCCACA ACTGGACAGA GCTGCTCCAT CTCTTCAACC AAACCTTTTC TGATTGCCAC 
ATGGAACTCA ATGAGAACAC CAAACAAGTG GTCCTCTTTG TCTTCTACCT GGCCATCTTT 
GTGGTAGGGT TAGTGGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG CTCAGGCCGG 
GTGGGGATGC TGAACTTATA CATCCTCAAC ATGGCCGTCG CGGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CCTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GCCAACATGT ACAGCAGCAT CTTCTTCCTC 
ACCTGCCTCA GCATTGACCG CTACGTCACC CTCACCAATA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATCATC 
CCACTGCCTG AGGTGGTACA TATCCAGCTG CTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCTACCATC 
CTGGGCTTCC TACTGCCTTT TCCTCTCATC GCAGTGTTTA ATATCCTGTC AGCCTGCCGG 
CTTCGGAGGC AAGGGCAGAC AGAGAGCAGG CGCCACTGTC TGTTGATGTG GGCTTACATA 
GCTGTCTTTG TCATCTGCTG GCTGCCCTAC CACGTGACTA TGCTGCTGCT CACTCTGCAC 
ACAACCCACA TCTTCCTTCA CTGCAACCTG GTTAACTTCC TCTACTTCTT CTACGAAATC 
ATTGACTGCT TCTCCATGCT ACACTGTGTC GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GCGGTCGAGC CTCCTCTTCA TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTGCACACCC ACGCCATCAG AAACGTGCAG 
GCCTCCTCTC TGCCTCCGAA CACCTCACCT ACACTCTGCA ATTCCATAGC CAGCTAA