Clcn7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clcn7
Entrez Gene ID	29233
Full Name	chloride voltage-gated channel 7
Synonyms	ClC-7
General protein information	Preferred Names chloride voltage-gated channel 7 Names H(+)/Cl(-) exchange transporter 7 chloride channel 7 alpha subunit chloride channel protein 7 chloride channel, voltage-sensitive 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	putative voltage-gated chloride channel; mutation in human and mouse homologs is associated with osteopetrosis and retinal degeneration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597168.1	XP_017452657.1	H(+)/Cl(-) exchange transporter 7 isoform X1
NM_031568.2	NP_113756.1	H(+)/Cl(-) exchange transporter 7

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CLCN7	NP_001025815.1
Homo sapiens (human)	CLCN7	NP_001278.1
Pan troglodytes (chimpanzee)	CLCN7	XP_001159424.1
	CLCN7	XP_002802404.1
Drosophila melanogaster (fruit fly)	ClC-b	NP_610798.1
Arabidopsis thaliana (thale cress)	AT5G33280	NP_198313.2
Canis lupus familiaris (dog)	CLCN7	XP_537014.2
Rattus norvegicus (Norway rat)	Clcn7	NP_113756.1
Danio rerio (zebrafish)	clcn7	NP_001071005.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007499	XP_308378.4
Arabidopsis thaliana (thale cress)	CLC-C	NP_199800.1
Xenopus tropicalis (tropical clawed frog)	clcn7	NP_001041533.1
Bos taurus (cattle)	CLCN7	NP_001020502.1
Mus musculus (house mouse)	Clcn7	NP_036060.1
Caenorhabditis elegans (roundworm)	clh-6	NP_506022.1

Gene Ontology
Bibliography

Related articles in PubMed

The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.
Schulz P, Werner J, Stauber T, Henriksen K, Fendler K
PloS one5(9)e12585(2010 Sep)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Integral and associated lysosomal membrane proteins.
Schr?der B, Wrocklage C, Pan C, J?ger R, K?sters B, Sch?fer H, Els?sser HP, Mann M, Hasilik A
Traffic (Copenhagen, Denmark)8(12)1676-86(2007 Dec)

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells.
Auzanneau C, Thoreau V, Kitzis A, Becq F
The Journal of biological chemistry278(21)19230-6(2003 May)

Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis.
Diewald L, Rupp J, Dreger M, Hucho F, Gillen C, Nawrath H
Biochemical and biophysical research communications291(2)421-4(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

G213R mutation prevents ClC-7 from being correctly targeted to the lysosomal membrane.
Title: The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.

The following Clcn7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clcn7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08122	NM_031568.2 Latest version!	Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa57273	XM_017597168.1 Latest version!	Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clcn7 ( NM_031568.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113756.1 Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), mRNA.

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CloneID	ORa08122
Clone ID Related Accession (Same CDS sequence)	NM_031568.2
Accession Version	NM_031568.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	H(+)/Cl(-) exchange transporter 7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z67744.1. On Aug 31, 2012 this sequence version replaced NM_031568.1. ##Evidence-Data-START## Transcript exon combination :: Z67744.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAACG TTTCTAAGAA AGTGTCTTGG TCCGGCCGAG ATCGCGATGA CGAGGAGGGG 
GCGCCGCTGC TTCGAAGGAC GGGGCAACCT GACGAGGAGA CGCCGCTGCT GAACGGAGCC 
GGGCCGGGCG CGCGCCAGTC TCATTCTGCA CTTTTCCGAA TTGGACAGAT GAACAACGTG 
GAGCTGGATG ATGAACTCCT GGACCCGGAA GTGGACCCTC CTCACACCTT CCCCAAGGAG 
ATTCCACACA ACGAGAAGCT CCTCTCCCTC AAGTATGAGA GCCTGGACTA TGACAATAGT 
GAGAATCAGC TCTTCCTGGA GGAGGAAAGA CGAATCAACC ACACGGCTTT CCGGACAGTG 
GAGATCAAGC GCTGGGTTAT CTGTGCCCTC ATTGGAATCC TCACAGGCCT AGTAGCCTGC 
TTCATTGACA TTGTAGTGGA GAACCTGGCA GGCCTCAAGT ACCGAGTCAT CAAGGACAAC 
ATCGACAAGT TCACAGAGAA GGGCGGCCTG TCCTTCTCCC TCCTGCTGTG GGCCACACTG 
AACTCTGCCT TCGTGCTCGT GGGGTCTGTG ATTGTGGCCT TCATAGAGCC AGTTGCTGCT 
GGCAGCGGAA TCCCTCAGAT CAAGTGCTTC CTCAATGGGG TGAAGATCCC CCACGTGGTG 
CGGCTCAAGA CGCTGGTGAT CAAGGTGTCT GGCGTGATTC TGTCTGTGGT AGGGGGACTG 
GCTGTGGGAA AGGAAGGGCC AATGATCCAC TCAGGATCCG TGATTGCTGC AGGGATTTCA 
CAGGGAAGGT CGACGTCACT CAAGCGAGAT TTTAAGATCT TTGAATATTT CCGCAGAGAT 
ACAGAGAAGC GGGATTTTGT CTCAGCTGGA GCTGCAGCTG GAGTGTCTGC TGCGTTTGGA 
GCACCTGTGG GTGGGGTCCT GTTCAGCCTG GAAGAGGGCG CCTCCTTCTG GAATCAGTTC 
CTGACATGGA GAATTTTCTT TGCTTCCATG ATTTCGACCT TTACACTGAA TTTTGTTCTG 
AGCATCTACC ATGGAAACAT GTGGGACCTG TCCAGCCCTG GCCTCATAAA TTTTGGAAGA 
TTCGACTCAG AGAAAATGGC CTACACAATC CATGAGATTC CTGTCTTCAT CGCCATGGGT 
GTGGTGGGTG GCATTCTTGG AGCCGTGTTC AATGCCTTGA ATTACTGGCT AACTATGTTT 
CGAATCAGGT ACATCCACCG GCCCTGCCTC CAAGTGATTG AGGCCATGCT GGTGGCAGCT 
GTCACAGCCA CAGTTGCATT TGTCTTGATT TACTCGTCTC GAGATTGCCA GCCCCTGCAG 
GGGAGCTCCA TGTCCTACCC ACTCCAGCTC TTCTGTGCAG ATGGCGAATA CAACTCAATG 
GCCGCAGCCT TCTTTAACAC CCCTGAGAAG AGCGTCGTCA GCCTGTTCCA CGACCCACCA 
GGCTCCTATA ATCCCATGAC TCTCGGCCTG TTCACCCTGG TCTACTTCTT CCTGGCCTGC 
TGGACCTATG GCCTCACAGT ATCTGCTGGT GTCTTCATCC CATCCCTGCT CATTGGGGCT 
GCCTGGGGCC GACTCTTTGG CATCTCCATG TCCTACCTCA CAGGAGCAGC GATCTGGGCA 
GATCCGGGTA AATACGCCCT GATGGGAGCT GCTGCTCAGC TTGGTGGGAT CGTGAGGATG 
ACCCTTAGCC TGACAGTCAT CATGATGGAG GCCACCAGCA ACGTGACCTA CGGTTTTCCC 
ATCATGTTGG TGCTGATGAC TGCCAAGATT GTGGGTGATG TCTTCATTGA GGGCCTCTAT 
GACATGCACA TCCAGCTGCA AAGTGTGCCC TTCCTACACT GGGAAGCCCC GGTCACCTCA 
CATTCGCTCA CTGCCAGGGA AGTAATGAGC ACGCCTGTGA CCTGCCTGAG GAGGAGAGAG 
AAGGTTGGCA TCATCGTGGA TGTCCTAAGT GACACAGCGT CTAATCACAA TGGGTTCCCT 
GTGGTGGAGG ATGTAGGAGA CACCCAGCCA GCCAGACTCC AAGGCCTAAT CCTGCGTTCC 
CAGCTCATCG TGCTCCTGAA GCACAAGGTG TTTGTGGAGA GGTCCAACAT GGGTTTGGTG 
CAGCGGAGAC TGAGGCTGAA AGACTTTCGC GATGCCTACC CACGCTTCCC CCCAATCCAG 
TCCATCCACG TATCCCAGGA TGAGCGGGAG TGCACCATGG ACCTTTCTGA GTTCATGAAC 
CCTTCTCCCT ACACTGTGCC ACAGGAGGCA TCTCTTCCTC GAGTGTTCAA GCTGTTCCGG 
GCTCTGGGCC TGAGGCACCT GGTCGTAGTA GACAACCACA ATCAGGTGGT CGGGCTGGTG 
ACCAGGAAGG ACCTAGCAAG ATACCGCCTA GGAAAAGGAG GCCTAGAAGA GCTTTCACTG 
GCCCAGACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113756.1
CDS	68..2479
Translation	MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGARQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT

Target ORF information:

RefSeq Version	NM_031568.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031568.2

ORF Insert Sequence:

ATGGCCAACG TTTCTAAGAA AGTGTCTTGG TCCGGCCGAG ATCGCGATGA CGAGGAGGGG 
GCGCCGCTGC TTCGAAGGAC GGGGCAACCT GACGAGGAGA CGCCGCTGCT GAACGGAGCC 
GGGCCGGGCG CGCGCCAGTC TCATTCTGCA CTTTTCCGAA TTGGACAGAT GAACAACGTG 
GAGCTGGATG ATGAACTCCT GGACCCGGAA GTGGACCCTC CTCACACCTT CCCCAAGGAG 
ATTCCACACA ACGAGAAGCT CCTCTCCCTC AAGTATGAGA GCCTGGACTA TGACAATAGT 
GAGAATCAGC TCTTCCTGGA GGAGGAAAGA CGAATCAACC ACACGGCTTT CCGGACAGTG 
GAGATCAAGC GCTGGGTTAT CTGTGCCCTC ATTGGAATCC TCACAGGCCT AGTAGCCTGC 
TTCATTGACA TTGTAGTGGA GAACCTGGCA GGCCTCAAGT ACCGAGTCAT CAAGGACAAC 
ATCGACAAGT TCACAGAGAA GGGCGGCCTG TCCTTCTCCC TCCTGCTGTG GGCCACACTG 
AACTCTGCCT TCGTGCTCGT GGGGTCTGTG ATTGTGGCCT TCATAGAGCC AGTTGCTGCT 
GGCAGCGGAA TCCCTCAGAT CAAGTGCTTC CTCAATGGGG TGAAGATCCC CCACGTGGTG 
CGGCTCAAGA CGCTGGTGAT CAAGGTGTCT GGCGTGATTC TGTCTGTGGT AGGGGGACTG 
GCTGTGGGAA AGGAAGGGCC AATGATCCAC TCAGGATCCG TGATTGCTGC AGGGATTTCA 
CAGGGAAGGT CGACGTCACT CAAGCGAGAT TTTAAGATCT TTGAATATTT CCGCAGAGAT 
ACAGAGAAGC GGGATTTTGT CTCAGCTGGA GCTGCAGCTG GAGTGTCTGC TGCGTTTGGA 
GCACCTGTGG GTGGGGTCCT GTTCAGCCTG GAAGAGGGCG CCTCCTTCTG GAATCAGTTC 
CTGACATGGA GAATTTTCTT TGCTTCCATG ATTTCGACCT TTACACTGAA TTTTGTTCTG 
AGCATCTACC ATGGAAACAT GTGGGACCTG TCCAGCCCTG GCCTCATAAA TTTTGGAAGA 
TTCGACTCAG AGAAAATGGC CTACACAATC CATGAGATTC CTGTCTTCAT CGCCATGGGT 
GTGGTGGGTG GCATTCTTGG AGCCGTGTTC AATGCCTTGA ATTACTGGCT AACTATGTTT 
CGAATCAGGT ACATCCACCG GCCCTGCCTC CAAGTGATTG AGGCCATGCT GGTGGCAGCT 
GTCACAGCCA CAGTTGCATT TGTCTTGATT TACTCGTCTC GAGATTGCCA GCCCCTGCAG 
GGGAGCTCCA TGTCCTACCC ACTCCAGCTC TTCTGTGCAG ATGGCGAATA CAACTCAATG 
GCCGCAGCCT TCTTTAACAC CCCTGAGAAG AGCGTCGTCA GCCTGTTCCA CGACCCACCA 
GGCTCCTATA ATCCCATGAC TCTCGGCCTG TTCACCCTGG TCTACTTCTT CCTGGCCTGC 
TGGACCTATG GCCTCACAGT ATCTGCTGGT GTCTTCATCC CATCCCTGCT CATTGGGGCT 
GCCTGGGGCC GACTCTTTGG CATCTCCATG TCCTACCTCA CAGGAGCAGC GATCTGGGCA 
GATCCGGGTA AATACGCCCT GATGGGAGCT GCTGCTCAGC TTGGTGGGAT CGTGAGGATG 
ACCCTTAGCC TGACAGTCAT CATGATGGAG GCCACCAGCA ACGTGACCTA CGGTTTTCCC 
ATCATGTTGG TGCTGATGAC TGCCAAGATT GTGGGTGATG TCTTCATTGA GGGCCTCTAT 
GACATGCACA TCCAGCTGCA AAGTGTGCCC TTCCTACACT GGGAAGCCCC GGTCACCTCA 
CATTCGCTCA CTGCCAGGGA AGTAATGAGC ACGCCTGTGA CCTGCCTGAG GAGGAGAGAG 
AAGGTTGGCA TCATCGTGGA TGTCCTAAGT GACACAGCGT CTAATCACAA TGGGTTCCCT 
GTGGTGGAGG ATGTAGGAGA CACCCAGCCA GCCAGACTCC AAGGCCTAAT CCTGCGTTCC 
CAGCTCATCG TGCTCCTGAA GCACAAGGTG TTTGTGGAGA GGTCCAACAT GGGTTTGGTG 
CAGCGGAGAC TGAGGCTGAA AGACTTTCGC GATGCCTACC CACGCTTCCC CCCAATCCAG 
TCCATCCACG TATCCCAGGA TGAGCGGGAG TGCACCATGG ACCTTTCTGA GTTCATGAAC 
CCTTCTCCCT ACACTGTGCC ACAGGAGGCA TCTCTTCCTC GAGTGTTCAA GCTGTTCCGG 
GCTCTGGGCC TGAGGCACCT GGTCGTAGTA GACAACCACA ATCAGGTGGT CGGGCTGGTG 
ACCAGGAAGG ACCTAGCAAG ATACCGCCTA GGAAAAGGAG GCCTAGAAGA GCTTTCACTG 
GCCCAGACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clcn7 ( XM_017597168.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452657.1 Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57273
Clone ID Related Accession (Same CDS sequence)	XM_017597168.1
Accession Version	XM_017597168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	H(+)/Cl(-) exchange transporter 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGGCA TTCTTACAGG CCCATTTTGG GGATCGCCAC CAGAGACGCC TCCTCCCTCA 
GCAGAGGAGG GACCTCAGTC TCATTCTGCA CTTTTCCGAA TTGGACAGAT GAACAACGTG 
GAGCTGGATG ATGAACTCCT GGACCCGGAA GTGGACCCTC CTCACACCTT CCCCAAGGAG 
ATTCCACACA ACGAGAAGCT CCTCTCCCTC AAGTATGAGA GCCTGGACTA TGACAATAGT 
GAGAATCAGC TCTTCCTGGA GGAGGAAAGA CGAATCAACC ACACGGCTTT CCGGACAGTG 
GAGATCAAGC GCTGGGTTAT CTGTGCCCTC ATTGGAATCC TCACAGGCCT AGTAGCCTGC 
TTCATTGACA TTGTAGTGGA GAACCTGGCA GGCCTCAAGT ACCGAGTCAT CAAGGACAAC 
ATCGACAAGT TCACAGAGAA GGGCGGCCTG TCCTTCTCCC TCCTGCTGTG GGCCACACTG 
AACTCTGCCT TCGTGCTCGT GGGGTCTGTG ATTGTGGCCT TCATAGAGCC AGTTGCTGCT 
GGCAGCGGAA TCCCTCAGAT CAAGTGCTTC CTCAATGGGG TGAAGATCCC CCACGTGGTG 
CGGCTCAAGA CGCTGGTGAT CAAGGTGTCT GGCGTGATTC TGTCTGTGGT AGGGGGACTG 
GCTGTGGGAA AGGAAGGGCC AATGATCCAC TCAGGATCCG TGATTGCTGC AGGGATTTCA 
CAGGGAAGGT CGACGTCACT CAAGCGAGAT TTTAAGATCT TTGAATATTT CCGCAGAGAT 
ACAGAGAAGC GGGATTTTGT CTCAGCTGGA GCTGCAGCTG GAGTGTCTGC TGCGTTTGGA 
GCACCTGTGG GTGGGGTCCT GTTCAGCCTG GAAGAGGGCG CCTCCTTCTG GAATCAGTTC 
CTGACATGGA GAATTTTCTT TGCTTCCATG ATTTCGACCT TTACACTGAA TTTTGTTCTG 
AGCATCTACC ATGGAAACAT GTGGGACCTG TCCAGCCCTG GCCTCATAAA TTTTGGAAGA 
TTCGACTCAG AGAAAATGGC CTACACAATC CATGAGATTC CTGTCTTCAT CGCCATGGGT 
GTGGTGGGTG GCATTCTTGG AGCCGTGTTC AATGCCTTGA ATTACTGGCT AACTATGTTT 
CGAATCAGGT ACATCCACCG GCCCTGCCTC CAAGTGATTG AGGCCATGCT GGTGGCAGCT 
GTCACAGCCA CAGTTGCATT TGTCTTGATT TACTCGTCTC GAGATTGCCA GCCCCTGCAG 
GGGAGCTCCA TGTCCTACCC ACTCCAGCTC TTCTGTGCAG ATGGCGAATA CAACTCAATG 
GCCGCAGCCT TCTTTAACAC CCCTGAGAAG AGCGTCGTCA GCCTGTTCCA CGACCCACCA 
GGCTCCTATA ATCCCATGAC TCTCGGCCTG TTCACCCTGG TCTACTTCTT CCTGGCCTGC 
TGGACCTATG GCCTCACAGT ATCTGCTGGT GTCTTCATCC CATCCCTGCT CATTGGGGCT 
GCCTGGGGCC GACTCTTTGG CATCTCCATG TCCTACCTCA CAGGAGCAGC GATCTGGGCA 
GATCCGGGTA AATACGCCCT GATGGGAGCT GCTGCTCAGC TTGGTGGGAT CGTGAGGATG 
ACCCTTAGCC TGACAGTCAT CATGATGGAG GCCACCAGCA ACGTGACCTA CGGTTTTCCC 
ATCATGTTGG TGCTGATGAC TGCCAAGATT GTGGGTGATG TCTTCATTGA GGGCCTCTAT 
GACATGCACA TCCAGCTGCA AAGTGTGCCC TTCCTACACT GGGAAGCCCC GGTCACCTCA 
CATTCGCTCA CTGCCAGGGA AGTAATGAGC ACGCCTGTGA CCTGCCTGAG GAGGAGAGAG 
AAGGTTGGCA TCATCGTGGA TGTCCTAAGT GACACAGCGT CTAATCACAA TGGGTTCCCT 
GTGGTGGAGG ATGTAGGAGA CACCCAGCCA GCCAGACTCC AAGGCCTAAT CCTGCGTTCC 
CAGCTCATCG TGCTCCTGAA GCACAAGGTG TTTGTGGAGA GGTCCAACAT GGGTTTGGTG 
CAGCGGAGAC TGAGGCTGAA AGACTTTCGC GATGCCTACC CACGCTTCCC CCCAATCCAG 
TCCATCCACG TATCCCAGGA TGAGCGGGAG TGCACCATGG ACCTTTCTGA GTTCATGAAC 
CCTTCTCCCT ACACTGTGCC ACAGGAGGCA TCTCTTCCTC GAGTGTTCAA GCTGTTCCGG 
GCTCTGGGCC TGAGGCACCT GGTCGTAGTA GACAACCACA ATCAGGTGGT CGGGCTGGTG 
ACCAGGAAGG ACCTAGCAAG ATACCGCCTA GGAAAAGGAG GCCTAGAAGA GCTTTCACTG 
GCCCAGACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452657.1
CDS	36..2387
Translation	MQGILTGPFWGSPPETPPPSAEEGPQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT

Target ORF information:

RefSeq Version	XM_017597168.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597168.1

ORF Insert Sequence:

ATGCAGGGCA TTCTTACAGG CCCATTTTGG GGATCGCCAC CAGAGACGCC TCCTCCCTCA 
GCAGAGGAGG GACCTCAGTC TCATTCTGCA CTTTTCCGAA TTGGACAGAT GAACAACGTG 
GAGCTGGATG ATGAACTCCT GGACCCGGAA GTGGACCCTC CTCACACCTT CCCCAAGGAG 
ATTCCACACA ACGAGAAGCT CCTCTCCCTC AAGTATGAGA GCCTGGACTA TGACAATAGT 
GAGAATCAGC TCTTCCTGGA GGAGGAAAGA CGAATCAACC ACACGGCTTT CCGGACAGTG 
GAGATCAAGC GCTGGGTTAT CTGTGCCCTC ATTGGAATCC TCACAGGCCT AGTAGCCTGC 
TTCATTGACA TTGTAGTGGA GAACCTGGCA GGCCTCAAGT ACCGAGTCAT CAAGGACAAC 
ATCGACAAGT TCACAGAGAA GGGCGGCCTG TCCTTCTCCC TCCTGCTGTG GGCCACACTG 
AACTCTGCCT TCGTGCTCGT GGGGTCTGTG ATTGTGGCCT TCATAGAGCC AGTTGCTGCT 
GGCAGCGGAA TCCCTCAGAT CAAGTGCTTC CTCAATGGGG TGAAGATCCC CCACGTGGTG 
CGGCTCAAGA CGCTGGTGAT CAAGGTGTCT GGCGTGATTC TGTCTGTGGT AGGGGGACTG 
GCTGTGGGAA AGGAAGGGCC AATGATCCAC TCAGGATCCG TGATTGCTGC AGGGATTTCA 
CAGGGAAGGT CGACGTCACT CAAGCGAGAT TTTAAGATCT TTGAATATTT CCGCAGAGAT 
ACAGAGAAGC GGGATTTTGT CTCAGCTGGA GCTGCAGCTG GAGTGTCTGC TGCGTTTGGA 
GCACCTGTGG GTGGGGTCCT GTTCAGCCTG GAAGAGGGCG CCTCCTTCTG GAATCAGTTC 
CTGACATGGA GAATTTTCTT TGCTTCCATG ATTTCGACCT TTACACTGAA TTTTGTTCTG 
AGCATCTACC ATGGAAACAT GTGGGACCTG TCCAGCCCTG GCCTCATAAA TTTTGGAAGA 
TTCGACTCAG AGAAAATGGC CTACACAATC CATGAGATTC CTGTCTTCAT CGCCATGGGT 
GTGGTGGGTG GCATTCTTGG AGCCGTGTTC AATGCCTTGA ATTACTGGCT AACTATGTTT 
CGAATCAGGT ACATCCACCG GCCCTGCCTC CAAGTGATTG AGGCCATGCT GGTGGCAGCT 
GTCACAGCCA CAGTTGCATT TGTCTTGATT TACTCGTCTC GAGATTGCCA GCCCCTGCAG 
GGGAGCTCCA TGTCCTACCC ACTCCAGCTC TTCTGTGCAG ATGGCGAATA CAACTCAATG 
GCCGCAGCCT TCTTTAACAC CCCTGAGAAG AGCGTCGTCA GCCTGTTCCA CGACCCACCA 
GGCTCCTATA ATCCCATGAC TCTCGGCCTG TTCACCCTGG TCTACTTCTT CCTGGCCTGC 
TGGACCTATG GCCTCACAGT ATCTGCTGGT GTCTTCATCC CATCCCTGCT CATTGGGGCT 
GCCTGGGGCC GACTCTTTGG CATCTCCATG TCCTACCTCA CAGGAGCAGC GATCTGGGCA 
GATCCGGGTA AATACGCCCT GATGGGAGCT GCTGCTCAGC TTGGTGGGAT CGTGAGGATG 
ACCCTTAGCC TGACAGTCAT CATGATGGAG GCCACCAGCA ACGTGACCTA CGGTTTTCCC 
ATCATGTTGG TGCTGATGAC TGCCAAGATT GTGGGTGATG TCTTCATTGA GGGCCTCTAT 
GACATGCACA TCCAGCTGCA AAGTGTGCCC TTCCTACACT GGGAAGCCCC GGTCACCTCA 
CATTCGCTCA CTGCCAGGGA AGTAATGAGC ACGCCTGTGA CCTGCCTGAG GAGGAGAGAG 
AAGGTTGGCA TCATCGTGGA TGTCCTAAGT GACACAGCGT CTAATCACAA TGGGTTCCCT 
GTGGTGGAGG ATGTAGGAGA CACCCAGCCA GCCAGACTCC AAGGCCTAAT CCTGCGTTCC 
CAGCTCATCG TGCTCCTGAA GCACAAGGTG TTTGTGGAGA GGTCCAACAT GGGTTTGGTG 
CAGCGGAGAC TGAGGCTGAA AGACTTTCGC GATGCCTACC CACGCTTCCC CCCAATCCAG 
TCCATCCACG TATCCCAGGA TGAGCGGGAG TGCACCATGG ACCTTTCTGA GTTCATGAAC 
CCTTCTCCCT ACACTGTGCC ACAGGAGGCA TCTCTTCCTC GAGTGTTCAA GCTGTTCCGG 
GCTCTGGGCC TGAGGCACCT GGTCGTAGTA GACAACCACA ATCAGGTGGT CGGGCTGGTG 
ACCAGGAAGG ACCTAGCAAG ATACCGCCTA GGAAAAGGAG GCCTAGAAGA GCTTTCACTG 
GCCCAGACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.
PloS one5(9)e12585(2010 Sep)
Schulz P,Werner J,Stauber T,Henriksen K,Fendler K

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Integral and associated lysosomal membrane proteins.
Traffic (Copenhagen, Denmark)8(12)1676-86(2007 Dec)
Schr?der B,Wrocklage C,Pan C,J?ger R,K?sters B,Sch?fer H,Els?sser HP,Mann M,Hasilik A

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells.
The Journal of biological chemistry278(21)19230-6(2003 May)
Auzanneau C,Thoreau V,Kitzis A,Becq F

Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis.
Biochemical and biophysical research communications291(2)421-4(2002 Feb)
Diewald L,Rupp J,Dreger M,Hucho F,Gillen C,Nawrath H

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Clcn7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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