Aqp6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aqp6
Entrez Gene ID	29170
Full Name	aquaporin 6
General protein information	Preferred Names aquaporin 6 Names aquaporin-6 AQP-6 aquaporin 6, kidney specific
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	may play a role in nitrate transport and cellular regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022181.1	NP_071517.1	aquaporin-6

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aqp6	NP_780296.1
Homo sapiens (human)	AQP6	NP_001643.2
Bos taurus (cattle)	AQP6	XP_002687325.1
Canis lupus familiaris (dog)	AQP6	XP_850452.1
Pan troglodytes (chimpanzee)	AQP6	XP_001157230.1
Rattus norvegicus (Norway rat)	Aqp6	NP_071517.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Aquaporin-6 in Rat Retinal Ganglion Cells.
Jang SY, Lee ES, Ohn YH, Park TK
Cellular and molecular neurobiology36(6)965-70(2016 Aug)

Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules.
Matsuki-Fukushima M, Fujita-Yoshigaki J, Murakami M, Katsumata-Kato O, Yokoyama M, Sugiya H
The Journal of membrane biology246(3)209-14(2013 Mar)

Expression of aquaporins in the retina of diabetic rats.
Hollborn M, Dukic-Stefanovic S, Pannicke T, Ulbricht E, Reichenbach A, Wiedemann P, Bringmann A, Kohen L
Current eye research36(9)850-6(2011 Sep)

Immunolocalization of aquaporin-6 in the rat retina.
Iandiev I, Dukic-Stefanovic S, Hollborn M, Pannicke T, H?rtig W, Wiedemann P, Reichenbach A, Bringmann A, Kohen L
Neuroscience letters490(2)130-4(2011 Feb)

Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine.
Laforenza U, Gastaldi G, Polimeni M, Tritto S, Tosco M, Ventura U, Scaffino MF, Yasui M
BMC physiology918(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

confirmed AQP6 expression in retinal ganglion cells and Muller cells in vitro
Title: Expression of Aquaporin-6 in Rat Retinal Ganglion Cells.

AQP6 is involved in osmoregulation to maintain both the acid-base and osmotic balance of parotid secretory granules.
Title: Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules.

AQP6 labeling of the outer plexiform layer was decreased in retinal slices from diabetic rats in comparison to slices from control rats.
Title: Expression of aquaporins in the retina of diabetic rats.

Aquaporin 6 is localized in glial membranes that surround the ribbon synapses in the outer plexiform layer of retina.
Title: Immunolocalization of aquaporin-6 in the rat retina.

aquaporin-6 is distributed throughout the gastrointestinal tract. Its localization at the apical pole of superficial epithelial cells and its upregulation by feeding suggest it may be involved in movements of water and anions through villi epithelium.
Title: Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine.

The following Aqp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aqp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05368	NM_022181.1 Latest version!	Rattus norvegicus aquaporin 6 (Aqp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aqp6 ( NM_022181.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071517.1 Rattus norvegicus aquaporin 6 (Aqp6), mRNA.

Price & Availability↑

CloneID	ORa05368
Clone ID Related Accession (Same CDS sequence)	NM_022181.1
Accession Version	NM_022181.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF083879.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF083879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642745 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCTG GGCTGTGTAA CAGGGCTTAC CTGCTGGTTG GCGGGCTTTG GACCGCCATC 
AGCAAGGCGC TTTTTGCTGA GTTCCTGGCC ACAGGGCTGT ACGTTTTCTT TGGTGTGGGC 
TCCGTCCTGC CCTGGCCCGT GGCGCTTCCC TCTGTGCTGC AGGTTGCCAT CACGTTCAAC 
CTGGCCACAG CCACAGCTGT GCAGATCTCC TGGAAGACCA GCGGGGCCCA CGCCAACCCC 
GCTGTGACCC TGGCCTACCT CGTGGGATCC CACATCTCTC TGCCCCGGGC TGTGGCCTAC 
ATAGCTGCTC AGCTGGCTGG GGCTACAGTT GGGGCTGCTC TTCTTTATGG GGTAACTCCA 
GGAGGTGTCC GAGAGACCCT TGGAGTCAAC GTGGTCCACA ACAGCACCTC GACTGGCCAG 
GCGGTGGCCG TGGAGCTGGT TCTGACGCTG CAGTTGGTTC TCTGTGTCTT TGCTTCCATG 
GACAGTCGGC AGACCTTGGG CTCCCCAGCT GCCATGATTG GGACCTCTGT GGCACTGGGC 
CATCTCATTG GGATCTACTT CACTGGCTGT TCCATGAACC CAGCTCGCTC CTTCGGCCCT 
GCGGTCATTG TTGGGAAGTT TGCAGTCCAT TGGATCTTCT GGGTAGGACC GCTCACAGGG 
GCTGTCCTGG CTTCGCTGAT CTACAACTTT ATCTTGTTTC CTGACACCAA GACCGTAGCC 
CAGCGATTGG CCATCCTTGT GGGTACCACA AAGGTGGAGA AAGTGGTAGA CCTGGAGCCC 
CAGAAGAAAG AATCACAGAC GAACTCAGAG GACACAGAAG TGAGCGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071517.1
CDS	142..972
Translation	MEPGLCNRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQVAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAVAYIAAQLAGATVGAALLYGVTPGGVRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDSRQTLGSPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTEVSV

Target ORF information:

RefSeq Version	NM_022181.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 6 (Aqp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022181.1

ORF Insert Sequence:

ATGGAGCCTG GGCTGTGTAA CAGGGCTTAC CTGCTGGTTG GCGGGCTTTG GACCGCCATC 
AGCAAGGCGC TTTTTGCTGA GTTCCTGGCC ACAGGGCTGT ACGTTTTCTT TGGTGTGGGC 
TCCGTCCTGC CCTGGCCCGT GGCGCTTCCC TCTGTGCTGC AGGTTGCCAT CACGTTCAAC 
CTGGCCACAG CCACAGCTGT GCAGATCTCC TGGAAGACCA GCGGGGCCCA CGCCAACCCC 
GCTGTGACCC TGGCCTACCT CGTGGGATCC CACATCTCTC TGCCCCGGGC TGTGGCCTAC 
ATAGCTGCTC AGCTGGCTGG GGCTACAGTT GGGGCTGCTC TTCTTTATGG GGTAACTCCA 
GGAGGTGTCC GAGAGACCCT TGGAGTCAAC GTGGTCCACA ACAGCACCTC GACTGGCCAG 
GCGGTGGCCG TGGAGCTGGT TCTGACGCTG CAGTTGGTTC TCTGTGTCTT TGCTTCCATG 
GACAGTCGGC AGACCTTGGG CTCCCCAGCT GCCATGATTG GGACCTCTGT GGCACTGGGC 
CATCTCATTG GGATCTACTT CACTGGCTGT TCCATGAACC CAGCTCGCTC CTTCGGCCCT 
GCGGTCATTG TTGGGAAGTT TGCAGTCCAT TGGATCTTCT GGGTAGGACC GCTCACAGGG 
GCTGTCCTGG CTTCGCTGAT CTACAACTTT ATCTTGTTTC CTGACACCAA GACCGTAGCC 
CAGCGATTGG CCATCCTTGT GGGTACCACA AAGGTGGAGA AAGTGGTAGA CCTGGAGCCC 
CAGAAGAAAG AATCACAGAC GAACTCAGAG GACACAGAAG TGAGCGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Aquaporin-6 in Rat Retinal Ganglion Cells.
Cellular and molecular neurobiology36(6)965-70(2016 Aug)
Jang SY,Lee ES,Ohn YH,Park TK

Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules.
The Journal of membrane biology246(3)209-14(2013 Mar)
Matsuki-Fukushima M,Fujita-Yoshigaki J,Murakami M,Katsumata-Kato O,Yokoyama M,Sugiya H

Expression of aquaporins in the retina of diabetic rats.
Current eye research36(9)850-6(2011 Sep)
Hollborn M,Dukic-Stefanovic S,Pannicke T,Ulbricht E,Reichenbach A,Wiedemann P,Bringmann A,Kohen L

Immunolocalization of aquaporin-6 in the rat retina.
Neuroscience letters490(2)130-4(2011 Feb)
Iandiev I,Dukic-Stefanovic S,Hollborn M,Pannicke T,H?rtig W,Wiedemann P,Reichenbach A,Bringmann A,Kohen L

Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine.
BMC physiology918(2009 Oct)
Laforenza U,Gastaldi G,Polimeni M,Tritto S,Tosco M,Ventura U,Scaffino MF,Yasui M