Scp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scp2
Entrez Gene ID	25541
Full Name	sterol carrier protein 2
Synonyms	NSLIPTR,SCPx
General protein information	Preferred Names sterol carrier protein 2 Names non-specific lipid-transfer protein NSL-TP SCP-2 SCP-X SCP-chi Sterol carrier protein 2, liver propanoyl-CoA C-acyltransferase sterol carrier protein X
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q34
Summary	may play a role in intracellular transport of cholesterol [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138508.4	NP_612517.2	non-specific lipid-transfer protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCP2	NP_002970.2
	LOC715765	XP_001106145.2
Mus musculus (house mouse)	Scp2	NP_035457.1
Drosophila melanogaster (fruit fly)	ScpX	NP_524715.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007921	XP_317563.2
Caenorhabditis elegans (roundworm)	daf-22	NP_496639.1
Magnaporthe oryzae (rice blast fungus)	MGG_02409	XP_003709194.1
Pan troglodytes (chimpanzee)	SCP2	XP_513413.3
Bos taurus (cattle)	SCP2	NP_001029162.2
Gallus gallus (chicken)	SCP2	XP_422482.4
Canis lupus familiaris (dog)	SCP2	XP_005620336.1
Xenopus tropicalis (tropical clawed frog)	scp2	NP_001015795.1
Rattus norvegicus (Norway rat)	Scp2	NP_612517.2
Danio rerio (zebrafish)	scp2a	NP_957159.1
Neurospora crassa	NCU03372	XP_956307.1

Gene Ontology
Bibliography

Related articles in PubMed

Type II Natural Killer T Cells that Recognize Sterol Carrier Protein 2 Are Implicated in Vascular Inflammation in the Rat Model of Systemic Connective Tissue Diseases.
Nishioka Y, Yamaguchi M, Kawakami A, Munehiro M, Masuda S, Tomaru U, Ishizu A
The American journal of pathology187(1)176-186(2017 Jan)

The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.
Williams CP, Schueller N, Thompson CA, van den Berg M, Van Haren SD, Erdmann R, Bond CS, Distel B, Schliebs W, Wilmanns M, Stanley WA
BMC biochemistry1212(2011 Mar)

A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.
Ghosh D, Berg JM
Journal of the American Chemical Society132(11)3973-9(2010 Mar)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI
The Journal of biological chemistry284(37)25334-42(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that type II natural killer T cells reactive with autologous SCP2 are implicated in vascular inflammation in the rat model.
Title: Type II Natural Killer T Cells that Recognize Sterol Carrier Protein 2 Are Implicated in Vascular Inflammation in the Rat Model of Systemic Connective Tissue Diseases.

These data are in agreement with the findings that diabetes, a medical condition characterized by high levels of fatty acids in an insulin deficient environment, enhances the hepatic expression of SCPx.
Title: Lauric acid dependent enhancement in hepatic SCPx protein requires an insulin deficient environment.

MLN64 has roles with StAR, and SCP-2 in regulating bile acid synthesis
Title: Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis.

Expression of the SCPx gene is regulated by PPARalpha; mechanism of this regulation occurs mainly through binding and activation of two peroxisomal-proliferator-response element motifs found in the promoter of the SCPx gene.
Title: Peroxisome proliferator-activated receptor alpha induces rat sterol carrier protein x promoter activity through two peroxisome proliferator-response elements.

The following Scp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01487	NM_138508.4 Latest version!	Rattus norvegicus sterol carrier protein 2 (Scp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scp2 ( NM_138508.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_612517.2 Rattus norvegicus sterol carrier protein 2 (Scp2), mRNA.

Price & Availability↑

CloneID	ORa01487
Clone ID Related Accession (Same CDS sequence)	NM_138508.4
Accession Version	NM_138508.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	non-specific lipid-transfer protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M57453.1. On Jul 18, 2004 this sequence version replaced NM_138508.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M57453.1, M62763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGCCTTCAG TCGCGTTGAA CTCTCCGCGC CTGCCGCGGG TGTTCGTGGT CGGAGTTGGC 
ATGACCAAGT TCATGAAGCC TGGAGGTGAG AATTCAAGAG ACTATCCTGA TTTGGCAAAA 
GAAGCAGGCC AGAAGGCATT GGCGGACCGG CAGATCCCTT ACTCCGCAGT GGAGCAGGCG 
TGCGTTGGCT ATGTGTACGG TGAATCCACC TGCGGGCAGA GGGCCATCTA TCACAGCCTG 
GGGCTGACTG GCATCCCTAT CATTAATGTC AACAATAACT GCTCTACCGG TTCTACTGCT 
TTGTTTATGG CCCAGCAACT GGTTCAGGGA GGTTTAGCAA ATTGCGTGTT AGCTCTTGGG 
TTTGAGAAGA TGGAAAAGGG ATCCCTTGGT ACCAAATATT CAGATCGGTC AAATCCACTG 
GAAAAACATA TTGACGTCTT GATCAATAAG TATGGAATGT CTGCCTGTCC ATTTGCTCCT 
CAGCTGTTTG GGAGCGCTGG GAAAGAACAT ATGGAAACAT ATGGAACAAA GGTTGAACAC 
TTTGCAAAAA TTGGATGGAA AAATCATAAA CACTCAGTTA ATAACCCGTA TTCCCAGTTC 
CAAGATGAAT ACAGCTTAGA TGAGATAATG AAATCAAGGC CAGTTTTCGA TTTTCTGACT 
GTCTTACAAT GCTGTCCCAC CTCAGATGGT GCCGCAGCAG CAATTGTGTC TAGTGAGGAG 
TTTGTGCAGA AGCATGGCCT GCAGTCCAAA GCTGTGGAAA TTGTGGCACA GGAGATGGTG 
ACTGACATGC CCACTACATT TGAAGAAAAA AGTGTTATTA AAATGGTTGG CTATGATATG 
AGTAAAGAAG CTGCCAGGAA GTGCTATGAG AAGTCCGGCC TGGGTCCCAG TGATGTCGAC 
GTGATAGAGC TTCACGATTG CTTCTCTACC AATGAACTCC TGACTTATGA AGCACTGGGG 
CTCTGTCCAG AAGGACAAGG TGGAGCACTG GTGGACAGAG GGGACAACAC TTACGGAGGA 
AAGTGGGTCA TAAACCCTAG TGGAGGCCTC ATCTCCAAGG GACACCCACT GGGTGCCACA 
GGTCTGGCTC AGTGCGCGGA GCTCTGCTGG CAGCTGAGAG GCGAAGCCGG AAAGAGGCAG 
GTTCCTGGGG CAAAGGTGGC TCTGCAGCAC AATTTAGGCC TTGGAGGAGC TGCTGTTGTC 
ACCCTCTACA GAATGGGTTT TCCCGAAGCT GCCAGCTCCT TCAGAACGCA CCAGATTTCA 
GCTGCTCCCA CCAGCTCTGC AGGGGATGGA TTCAAGGCAA ATCTCATTTT TAAGGAAATC 
GAGAAGAAGC TTGAAGAGGA AGGGGAAGAG TTCGTGAAGA AAATCGGTGG CATTTTTGCC 
TTCAAAGTGA AGGATGGCCC CGGGGGCAAA GAAGCTACGT GGGTGGTGGA CGTGAAGAAC 
GGCAAAGGAT CGGTGCTTCC GGATTCAGAT AAGAAGGCTG ACTGCACAAT CACCATGGCT 
GACTCAGACT TGCTGGCTTT GATGACTGGT AAAATGAACC CTCAGTCGGC CTTCTTTCAA 
GGTAAACTGA AAATTGCCGG TAACATGGGC CTGGCCATGA AACTGCAAAG CCTGCAGCTT 
CAGCCGGACA AAGCTAAGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612517.2
CDS	19..1662
Translation	MPSVALNSPRLPRVFVVGVGMTKFMKPGGENSRDYPDLAKEAGQKALADRQIPYSAVEQACVGYVYGESTCGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMAQQLVQGGLANCVLALGFEKMEKGSLGTKYSDRSNPLEKHIDVLINKYGMSACPFAPQLFGSAGKEHMETYGTKVEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEIMKSRPVFDFLTVLQCCPTSDGAAAAIVSSEEFVQKHGLQSKAVEIVAQEMVTDMPTTFEEKSVIKMVGYDMSKEAARKCYEKSGLGPSDVDVIELHDCFSTNELLTYEALGLCPEGQGGALVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAAVVTLYRMGFPEAASSFRTHQISAAPTSSAGDGFKANLIFKEIEKKLEEEGEEFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPDSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGLAMKLQSLQLQPDKAKL

Target ORF information:

RefSeq Version	NM_138508.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol carrier protein 2 (Scp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138508.4

ORF Insert Sequence:

ATGCCTTCAG TCGCGTTGAA CTCTCCGCGC CTGCCGCGGG TGTTCGTGGT CGGAGTTGGC 
ATGACCAAGT TCATGAAGCC TGGAGGTGAG AATTCAAGAG ACTATCCTGA TTTGGCAAAA 
GAAGCAGGCC AGAAGGCATT GGCGGACCGG CAGATCCCTT ACTCCGCAGT GGAGCAGGCG 
TGCGTTGGCT ATGTGTACGG TGAATCCACC TGCGGGCAGA GGGCCATCTA TCACAGCCTG 
GGGCTGACTG GCATCCCTAT CATTAATGTC AACAATAACT GCTCTACCGG TTCTACTGCT 
TTGTTTATGG CCCAGCAACT GGTTCAGGGA GGTTTAGCAA ATTGCGTGTT AGCTCTTGGG 
TTTGAGAAGA TGGAAAAGGG ATCCCTTGGT ACCAAATATT CAGATCGGTC AAATCCACTG 
GAAAAACATA TTGACGTCTT GATCAATAAG TATGGAATGT CTGCCTGTCC ATTTGCTCCT 
CAGCTGTTTG GGAGCGCTGG GAAAGAACAT ATGGAAACAT ATGGAACAAA GGTTGAACAC 
TTTGCAAAAA TTGGATGGAA AAATCATAAA CACTCAGTTA ATAACCCGTA TTCCCAGTTC 
CAAGATGAAT ACAGCTTAGA TGAGATAATG AAATCAAGGC CAGTTTTCGA TTTTCTGACT 
GTCTTACAAT GCTGTCCCAC CTCAGATGGT GCCGCAGCAG CAATTGTGTC TAGTGAGGAG 
TTTGTGCAGA AGCATGGCCT GCAGTCCAAA GCTGTGGAAA TTGTGGCACA GGAGATGGTG 
ACTGACATGC CCACTACATT TGAAGAAAAA AGTGTTATTA AAATGGTTGG CTATGATATG 
AGTAAAGAAG CTGCCAGGAA GTGCTATGAG AAGTCCGGCC TGGGTCCCAG TGATGTCGAC 
GTGATAGAGC TTCACGATTG CTTCTCTACC AATGAACTCC TGACTTATGA AGCACTGGGG 
CTCTGTCCAG AAGGACAAGG TGGAGCACTG GTGGACAGAG GGGACAACAC TTACGGAGGA 
AAGTGGGTCA TAAACCCTAG TGGAGGCCTC ATCTCCAAGG GACACCCACT GGGTGCCACA 
GGTCTGGCTC AGTGCGCGGA GCTCTGCTGG CAGCTGAGAG GCGAAGCCGG AAAGAGGCAG 
GTTCCTGGGG CAAAGGTGGC TCTGCAGCAC AATTTAGGCC TTGGAGGAGC TGCTGTTGTC 
ACCCTCTACA GAATGGGTTT TCCCGAAGCT GCCAGCTCCT TCAGAACGCA CCAGATTTCA 
GCTGCTCCCA CCAGCTCTGC AGGGGATGGA TTCAAGGCAA ATCTCATTTT TAAGGAAATC 
GAGAAGAAGC TTGAAGAGGA AGGGGAAGAG TTCGTGAAGA AAATCGGTGG CATTTTTGCC 
TTCAAAGTGA AGGATGGCCC CGGGGGCAAA GAAGCTACGT GGGTGGTGGA CGTGAAGAAC 
GGCAAAGGAT CGGTGCTTCC GGATTCAGAT AAGAAGGCTG ACTGCACAAT CACCATGGCT 
GACTCAGACT TGCTGGCTTT GATGACTGGT AAAATGAACC CTCAGTCGGC CTTCTTTCAA 
GGTAAACTGA AAATTGCCGG TAACATGGGC CTGGCCATGA AACTGCAAAG CCTGCAGCTT 
CAGCCGGACA AAGCTAAGCT GTGA