Hspb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspb1
Entrez Gene ID	24471
Full Name	heat shock protein family B (small) member 1
Synonyms	Hsp25,Hsp27
General protein information	Preferred Names heat shock protein family B (small) member 1 Names heat shock protein beta-1 HSP 27 heat shock 27 kDa protein 1 heat shock 27kDa protein 1 heat shock protein B1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	putative heat shock protein; human homolog may suppress polyglutamine-mediated cell death and mutations in human gene are associated with various neuropathies and some forms of Charcot-Marie-Tooth disease [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031970.4	NP_114176.4	heat shock protein beta-1

Pathways from BioSystems

Homologies

	HSPB1	XP_001109274.1
Canis lupus familiaris (dog)	HSPB1	NP_001003295.1
Danio rerio (zebrafish)	hspb1	NP_001008615.2
Mus musculus (house mouse)	Hspb1	NP_038588.2
Homo sapiens (human)	HSPB1	NP_001531.1
Bos taurus (cattle)	HSPB1	NP_001020740.1
Gallus gallus (chicken)	HSPB1	NP_990621.1
Pan troglodytes (chimpanzee)	HSPB1	XP_003951106.1
Rattus norvegicus (Norway rat)	Hspb1	NP_114176.3
Xenopus tropicalis (tropical clawed frog)	hspb1	NP_001072817.1

Gene Ontology
Bibliography

Related articles in PubMed

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.
Kennedy D, Mnich K, Oommen D, Chakravarthy R, Almeida-Souza L, Krols M, Saveljeva S, Doyle K, Gupta S, Timmerman V, Janssens S, Gorman AM, Samali A
Cell death & disease8(8)e3026(2017 Aug)

Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/?B-crystallin after transient middle cerebral artery occlusion in rats.
Bartelt-Kirbach B, Slowik A, Beyer C, Golenhofen N
Cell stress & chaperones22(4)653-663(2017 Jul)

Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model.
Chien CC, Huang CJ, Tien LT, Cheng YC, Ke CY, Lee YJ
Investigative ophthalmology & visual science58(7)3107-3117(2017 Jun)

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Echaniz-Laguna A, Geuens T, Petiot P, P?r?on Y, Adriaenssens E, Haidar M, Capponi S, Maisonobe T, Fournier E, Dubourg O, Degos B, Salachas F, Lenglet T, Eymard B, Delmont E, Pouget J, Juntas Morales R, Goizet C, Latour P, Timmerman V, Stojkovic T
Human mutation38(5)556-568(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HSP27 suppression may initiate a protective effect for retinal cells, particularly photoreceptors, from light-induced retinal degeneration.
Title: Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model.

Exercise-related elevations of body temperature could be the only factor for the inductions of adrenal Hsp72 and Hsp25 expression.
Title: Short-term treadmill exercise in a cold environment does not induce adrenal Hsp72 and Hsp25 expression.

activation of the A1 adenosine receptor by N(6)-cyclohexyladenosine could prevent intracerebral hemorrhage-induced secondary brain injury via the P38-MAPKAP2-Hsp27 pathway.
Title: A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway.

These results were confirmed by analysis with STRING 9.1 software, which indicated that Hsp27 and aB-crystallin are co-expressed in rat myocardial cells
Title: Expression profiles of heat shock protein 27 and ?B-crystallin and their effects on heat-stressed rat myocardial cells in vitro and in vivo.

data suggest that HspB1 and HspB5 might be of protective value for retinal ganglion cells after optic nerve injury and that this process might be regulated by phosphorylation at serine 86 of HspB1 and serine 19 and serine 45 of HspB5.
Title: Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/?B-crystallin in the rat retina upon optic nerve injury.

The following Hspb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42911	NM_031970.4 Latest version!	Rattus norvegicus heat shock protein family B (small) member 1 (Hspb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspb1 ( NM_031970.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114176.4 Rattus norvegicus heat shock protein family B (small) member 1 (Hspb1), mRNA.

Price & Availability↑

CloneID	ORa42911
Clone ID Related Accession (Same CDS sequence)	NM_031970.4
Accession Version	NM_031970.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	heat shock protein beta-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07035823.1 and FM035762.1. On Feb 5, 2015 this sequence version replaced NM_031970.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF109657.1, FQ221491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGAGC GCCGCGTGCC CTTCTCGCTA CTGCGGAGCC CCAGCTGGGA GCCGTTCCGG 
GACTGGTACC CTGCCCACAG CCGCCTCTTC GATCAAGCTT TCGGGGTGCC TCGGTTTCCC 
GATGAGTGGT CTCAGTGGTT CAGCTCCGCT GGTTGGCCCG GCTATGTGCG CCCTCTGCCC 
GCCGCGACCG CCGAGGGCCC CGCAGCAGTG ACCCTGGCCG CGCCCGCCTT CAGCCGGGCG 
CTCAACCGGC AACTCAGCAG CGGTGTCTCA GAGATCCGAC AGACGGCCGA TCGCTGGCGC 
GTGTCCCTGG ACGTCAACCA CTTCGCTCCT GAGGAGCTCA CAGTTAAGAC CAAGGAAGGC 
GTGGTGGAGA TCACTGGCAA GCACGAAGAA AGGCAGGATG AACATGGCTA CATCTCTCGG 
TGCTTCACCC GGAAATACAC GCTCCCTCCA GGTGTGGACC CCACCCTGGT GTCCTCTTCC 
CTGTCCCCTG AGGGCACACT CACCGTGGAG GCTCCGCTGC CCAAAGCAGT CACACAATCA 
GCGGAGATCA CCATTCCGGT CACTTTCGAG GCCCGTGCCC AAATTGGAGG CCCAGAGTCG 
GAACAGTCTG GAGCCAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114176.4
CDS	135..755
Translation	MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRFPDEWSQWFSSAGWPGYVRPLPAATAEGPAAVTLAAPAFSRALNRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPESEQSGAK

Target ORF information:

RefSeq Version	NM_031970.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein family B (small) member 1 (Hspb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031970.4

ORF Insert Sequence:

ATGACCGAGC GCCGCGTGCC CTTCTCGCTA CTGCGGAGCC CCAGCTGGGA GCCGTTCCGG 
GACTGGTACC CTGCCCACAG CCGCCTCTTC GATCAAGCTT TCGGGGTGCC TCGGTTTCCC 
GATGAGTGGT CTCAGTGGTT CAGCTCCGCT GGTTGGCCCG GCTATGTGCG CCCTCTGCCC 
GCCGCGACCG CCGAGGGCCC CGCAGCAGTG ACCCTGGCCG CGCCCGCCTT CAGCCGGGCG 
CTCAACCGGC AACTCAGCAG CGGTGTCTCA GAGATCCGAC AGACGGCCGA TCGCTGGCGC 
GTGTCCCTGG ACGTCAACCA CTTCGCTCCT GAGGAGCTCA CAGTTAAGAC CAAGGAAGGC 
GTGGTGGAGA TCACTGGCAA GCACGAAGAA AGGCAGGATG AACATGGCTA CATCTCTCGG 
TGCTTCACCC GGAAATACAC GCTCCCTCCA GGTGTGGACC CCACCCTGGT GTCCTCTTCC 
CTGTCCCCTG AGGGCACACT CACCGTGGAG GCTCCGCTGC CCAAAGCAGT CACACAATCA 
GCGGAGATCA CCATTCCGGT CACTTTCGAG GCCCGTGCCC AAATTGGAGG CCCAGAGTCG 
GAACAGTCTG GAGCCAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.
Cell death & disease8(8)e3026(2017 Aug)
Kennedy D,Mnich K,Oommen D,Chakravarthy R,Almeida-Souza L,Krols M,Saveljeva S,Doyle K,Gupta S,Timmerman V,Janssens S,Gorman AM,Samali A

Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/?B-crystallin after transient middle cerebral artery occlusion in rats.
Cell stress & chaperones22(4)653-663(2017 Jul)
Bartelt-Kirbach B,Slowik A,Beyer C,Golenhofen N

Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model.
Investigative ophthalmology & visual science58(7)3107-3117(2017 Jun)
Chien CC,Huang CJ,Tien LT,Cheng YC,Ke CY,Lee YJ

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Human mutation38(5)556-568(2017 May)
Echaniz-Laguna A,Geuens T,Petiot P,P?r?on Y,Adriaenssens E,Haidar M,Capponi S,Maisonobe T,Fournier E,Dubourg O,Degos B,Salachas F,Lenglet T,Eymard B,Delmont E,Pouget J,Juntas Morales R,Goizet C,Latour P,Timmerman V,Stojkovic T

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Hspb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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