Ncr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ncr1
Entrez Gene ID	117547
Full Name	natural cytotoxicity triggering receptor 1
Synonyms	KILR-1,Ly94,Nk-p46,Nkp46
General protein information	Preferred Names natural cytotoxicity triggering receptor 1 Names natural cytotoxicity triggering receptor 1 NK receptor KILR-1 NK-p46) NKACTR activating receptor 1 lymphocyte antigen 94 homolog (activating NK-receptor lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46) natural killer cell p46-related protein rAR-1 rat-activating receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12
Summary	has similarity to immunoglobulins; expressed in NK cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057199.1	NP_476547.1	natural cytotoxicity triggering receptor 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NCR1	XP_854148.3
	NCR1	NP_001028063.1
Homo sapiens (human)	NCR1	NP_004820.2
Pan troglodytes (chimpanzee)	NCR1	NP_001164063.1
Bos taurus (cattle)	NCR1	NP_899209.1
Rattus norvegicus (Norway rat)	Ncr1	NP_476547.1
Mus musculus (house mouse)	Ncr1	NP_034876.2

Gene Ontology
Bibliography

Related articles in PubMed

Elucidating the mechanisms of influenza virus recognition by Ncr1.
Glasner A, Zurunic A, Meningher T, Lenac Rovis T, Tsukerman P, Bar-On Y, Yamin R, Meyers AF, Mandeboim M, Jonjic S, Mandelboim O
PloS one7(5)e36837(2012)

Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
Wai LE, Garcia JA, Martinez OM, Krams SM
Journal of immunology (Baltimore, Md. : 1950)186(1)222-9(2011 Jan)

Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages.
Aliahmad P, de la Torre B, Kaye J
Nature immunology11(10)945-52(2010 Oct)

Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.
Westgaard IH, Berg SF, Vaage JT, Wang LL, Yokoyama WM, Dissen E, Fossum S
Journal of leukocyte biology76(6)1200-6(2004 Dec)

Identification of the rat homologue of the human NKp46 triggering receptor.
Falco M, Cantoni C, Bottino C, Moretta A, Biassoni R
Immunology letters68(2-3)411-4(1999 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dendritic cells and hepatoma cell line McA stimulate interferon-gamma production from natural killer (NK) cells in a cell-cell contact-dependent manner via different NK-activating receptors, NKp46 and NKp30, respectively.
Title: Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.

NKp46 activates natural killer cell cytotoxicity by similar pathways as CD16.
Title: Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.

The following Ncr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ncr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11588	NM_057199.1 Latest version!	Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ncr1 ( NM_057199.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476547.1 Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA.

Price & Availability↑

CloneID	ORa11588
Clone ID Related Accession (Same CDS sequence)	NM_057199.1
Accession Version	NM_057199.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	natural cytotoxicity triggering receptor 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF082533.1. ##Evidence-Data-START## Transcript exon combination :: AF082533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689603 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCAA CACTCACTGC CCTACTCTGC CTTGGTCTAT GTCTGAGCCA AAGGATCAAC 
ACTGAAAAAC AGACTCTCCC AAAACCCATC ATCTGGGCCA AACCTAGTAT CATGGTCACA 
AAAGGAAACT CGGTGAACAT CTGGTGTCAG GGGGCTCAGA GTGCTTCTGA GTATCAACTG 
TACTTTGAAG GAAGCTTTTT TGCCTTGGAG AGACCAAAGT CATCGAGATC GATGAATAAA 
GTCAAGTTCT TCATTTCACA AATGACCTCA CATACTGCAG GGATCTACAC CTGCTTCTAT 
CAGAGTGGAG AGCTCTGGTC AGAGTCAAGC AACCCCCTGA AACTGGTGGT AACTGGTCTG 
TATGACACAC CCACCCTCTG GGTTCACCCA GGGCCTGAGG TAACCTTGGG GGAGAATGTT 
ACCTTCTCTT GCCATCTGAA GACTGCAACA AGCAAATTCT TTCTGCTCAA GGAGAGAGAA 
TCCAACCATA TCCAGCATAA ATATGGGAAC ATCCAAGCAG AGTTCCCCAT GGGCCCTGTG 
ACTAGAGCTC ACAGAGGGAC ATACAGATGT TTTGGCTCTT ACAACGACTA TGCATGGTCT 
TTTCCCAGTG AGCCTGTGAC ACTACTCATC ACAGGAGAGG TTGAGAACAC CAGCCTTGCA 
CCCACAGACC CTGTTTCTTC TCTTGATTAT TGGGAGTTTG ACCTTTCAAC CAAAGAATCA 
GGATTGCAGA AGGACTCTGC CTTCTGGGAT CACACAGCCC AGAATCTCAT TCGGATTGGC 
CTGGCATGCA TAATCGTGAT GGCTCTAGTA TGGCTTTTGG CTGAAGACTG GCTCAGCAGG 
AGGAAGGATC ATGAGAAGCT CAATAGATTA ACAAGTTGGG AATGCAGGGG AAGACGGAGA 
ATGCATCGTT ACCATGAAGA GGAGCAAAGA GATGCAATAT CTATGAGGGA ACTGAAGGCA 
ACTCCTGGGG ATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476547.1
CDS	11..988
Translation	MLPTLTALLCLGLCLSQRINTEKQTLPKPIIWAKPSIMVTKGNSVNIWCQGAQSASEYQLYFEGSFFALERPKSSRSMNKVKFFISQMTSHTAGIYTCFYQSGELWSESSNPLKLVVTGLYDTPTLWVHPGPEVTLGENVTFSCHLKTATSKFFLLKERESNHIQHKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGEVENTSLAPTDPVSSLDYWEFDLSTKESGLQKDSAFWDHTAQNLIRIGLACIIVMALVWLLAEDWLSRRKDHEKLNRLTSWECRGRRRMHRYHEEEQRDAISMRELKATPGDM

Target ORF information:

RefSeq Version	NM_057199.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057199.1

ORF Insert Sequence:

ATGCTGCCAA CACTCACTGC CCTACTCTGC CTTGGTCTAT GTCTGAGCCA AAGGATCAAC 
ACTGAAAAAC AGACTCTCCC AAAACCCATC ATCTGGGCCA AACCTAGTAT CATGGTCACA 
AAAGGAAACT CGGTGAACAT CTGGTGTCAG GGGGCTCAGA GTGCTTCTGA GTATCAACTG 
TACTTTGAAG GAAGCTTTTT TGCCTTGGAG AGACCAAAGT CATCGAGATC GATGAATAAA 
GTCAAGTTCT TCATTTCACA AATGACCTCA CATACTGCAG GGATCTACAC CTGCTTCTAT 
CAGAGTGGAG AGCTCTGGTC AGAGTCAAGC AACCCCCTGA AACTGGTGGT AACTGGTCTG 
TATGACACAC CCACCCTCTG GGTTCACCCA GGGCCTGAGG TAACCTTGGG GGAGAATGTT 
ACCTTCTCTT GCCATCTGAA GACTGCAACA AGCAAATTCT TTCTGCTCAA GGAGAGAGAA 
TCCAACCATA TCCAGCATAA ATATGGGAAC ATCCAAGCAG AGTTCCCCAT GGGCCCTGTG 
ACTAGAGCTC ACAGAGGGAC ATACAGATGT TTTGGCTCTT ACAACGACTA TGCATGGTCT 
TTTCCCAGTG AGCCTGTGAC ACTACTCATC ACAGGAGAGG TTGAGAACAC CAGCCTTGCA 
CCCACAGACC CTGTTTCTTC TCTTGATTAT TGGGAGTTTG ACCTTTCAAC CAAAGAATCA 
GGATTGCAGA AGGACTCTGC CTTCTGGGAT CACACAGCCC AGAATCTCAT TCGGATTGGC 
CTGGCATGCA TAATCGTGAT GGCTCTAGTA TGGCTTTTGG CTGAAGACTG GCTCAGCAGG 
AGGAAGGATC ATGAGAAGCT CAATAGATTA ACAAGTTGGG AATGCAGGGG AAGACGGAGA 
ATGCATCGTT ACCATGAAGA GGAGCAAAGA GATGCAATAT CTATGAGGGA ACTGAAGGCA 
ACTCCTGGGG ATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elucidating the mechanisms of influenza virus recognition by Ncr1.
PloS one7(5)e36837(2012)
Glasner A,Zurunic A,Meningher T,Lenac Rovis T,Tsukerman P,Bar-On Y,Yamin R,Meyers AF,Mandeboim M,Jonjic S,Mandelboim O

Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
Journal of immunology (Baltimore, Md. : 1950)186(1)222-9(2011 Jan)
Wai LE,Garcia JA,Martinez OM,Krams SM

Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages.
Nature immunology11(10)945-52(2010 Oct)
Aliahmad P,de la Torre B,Kaye J

Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.
Journal of leukocyte biology76(6)1200-6(2004 Dec)
Westgaard IH,Berg SF,Vaage JT,Wang LL,Yokoyama WM,Dissen E,Fossum S

Identification of the rat homologue of the human NKp46 triggering receptor.
Immunology letters68(2-3)411-4(1999 Jun)
Falco M,Cantoni C,Bottino C,Moretta A,Biassoni R