Tm4sf4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tm4sf4
Entrez Gene ID	116467
Full Name	transmembrane 4 L six family member 4
Synonyms	Lrtm4
General protein information	Preferred Names transmembrane 4 L six family member 4 Names transmembrane 4 L6 family member 4 transmembrane 4 superfamily member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q26
Summary	member of tetraspanin superfamily; may mediate cell proliferation and liver regeneration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053785.1	NP_446237.1	transmembrane 4 L6 family member 4

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tm4sf4	NP_001003489.1
Mus musculus (house mouse)	Tm4sf4	NP_663514.2
Rattus norvegicus (Norway rat)	Tm4sf4	NP_446237.1
Xenopus tropicalis (tropical clawed frog)	tm4sf4	NP_988958.1
Homo sapiens (human)	TM4SF4	NP_004608.1
	TM4SF4	XP_001108653.1
Canis lupus familiaris (dog)	TM4SF4	XP_854442.1
Gallus gallus (chicken)	TM4SF4	XP_001234023.1
Pan troglodytes (chimpanzee)	TM4SF4	XP_001170324.1
Bos taurus (cattle)	TM4SF4	NP_001029478.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.
Qiu J, Liu Z, Da L, Li Y, Xuan H, Lin Q, Li F, Wang Y, Li Z, Zhao M
Journal of hepatology46(2)266-75(2007 Feb)

Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1).
Liu Z, Zhao M, Yokoyama KK, Li T
Biochimica et biophysica acta1518(1-2)183-9(2001 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rat TM4SF4 is overexpressed in acutely injured liver induced by CCl4 and plays a crucial role in accelerating liver injury, which may be mediated by the TNF-alpha and HGF/c-met signaling pathways.
Title: Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.

The following Tm4sf4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tm4sf4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10647	NM_053785.1 Latest version!	Rattus norvegicus transmembrane 4 L six family member 4 (Tm4sf4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tm4sf4 ( NM_053785.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446237.1 Rattus norvegicus transmembrane 4 L six family member 4 (Tm4sf4), mRNA.

Price & Availability↑

CloneID	ORa10647
Clone ID Related Accession (Same CDS sequence)	NM_053785.1
Accession Version	NM_053785.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	transmembrane 4 L6 family member 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF205717.1. ##Evidence-Data-START## Transcript exon combination :: AF205717.1, BC091131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGTGTACTG GGGGCTGTGC CAGGTGCCTG GGGGGCACCC TCATTCCCTT GGCTGTGTTT 
GCCGTCCTGG CAAATATCCT GTTGTTTTTT CCTGGAGGAA AAGTGGTGGA TGACAACAGC 
CACCTTTCAG ATGAGGTCTG GTACTTCGGA GGAATACTGG GAAGTGGAGT CTTGATGATC 
TTCCCTGCGC TGGTGTTCTT GGGCCTGCAG AACAATGACT GCTGCGGATG CTGTGGTAAT 
GAGAGCTGTG GGAAGCGATT TGCGATGTTC ACCTCCACGT TGTTTGCTGT GGTTGGCTTC 
TTGGGTGCTG CATACTCATT TATCGTCTCA GCCGTTTCCA TCAACAAGGG TCCTAAATGC 
TTCATGACCA ATAACACCTG GGGATACCCC TTCCACGATG GTGATTATCT TAATGACCAA 
GCCTTGTGGA GCAAGTGCGA AGAACCCCGC GATGTGGTCC CTTGGAATCT CACCCTTTTC 
TCCATTCTGC TGGTCATCGG AGGGATCCAG ATGGTTCTCT GTGCCATCCA GGTGATCAAT 
GGCCTCCTGG GAACTCTCTG TGGAGACTGC CAGTGCTGTG GCTGCTGTGG GGGTGATAGA 
CCAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446237.1
CDS	335..943
Translation	MCTGGCARCLGGTLIPLAVFAVLANILLFFPGGKVVDDNSHLSDEVWYFGGILGSGVLMIFPALVFLGLQNNDCCGCCGNESCGKRFAMFTSTLFAVVGFLGAAYSFIVSAVSINKGPKCFMTNNTWGYPFHDGDYLNDQALWSKCEEPRDVVPWNLTLFSILLVIGGIQMVLCAIQVINGLLGTLCGDCQCCGCCGGDRPV

Target ORF information:

RefSeq Version	NM_053785.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane 4 L six family member 4 (Tm4sf4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053785.1

ORF Insert Sequence:

ATGTGTACTG GGGGCTGTGC CAGGTGCCTG GGGGGCACCC TCATTCCCTT GGCTGTGTTT 
GCCGTCCTGG CAAATATCCT GTTGTTTTTT CCTGGAGGAA AAGTGGTGGA TGACAACAGC 
CACCTTTCAG ATGAGGTCTG GTACTTCGGA GGAATACTGG GAAGTGGAGT CTTGATGATC 
TTCCCTGCGC TGGTGTTCTT GGGCCTGCAG AACAATGACT GCTGCGGATG CTGTGGTAAT 
GAGAGCTGTG GGAAGCGATT TGCGATGTTC ACCTCCACGT TGTTTGCTGT GGTTGGCTTC 
TTGGGTGCTG CATACTCATT TATCGTCTCA GCCGTTTCCA TCAACAAGGG TCCTAAATGC 
TTCATGACCA ATAACACCTG GGGATACCCC TTCCACGATG GTGATTATCT TAATGACCAA 
GCCTTGTGGA GCAAGTGCGA AGAACCCCGC GATGTGGTCC CTTGGAATCT CACCCTTTTC 
TCCATTCTGC TGGTCATCGG AGGGATCCAG ATGGTTCTCT GTGCCATCCA GGTGATCAAT 
GGCCTCCTGG GAACTCTCTG TGGAGACTGC CAGTGCTGTG GCTGCTGTGG GGGTGATAGA 
CCAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.
Journal of hepatology46(2)266-75(2007 Feb)
Qiu J,Liu Z,Da L,Li Y,Xuan H,Lin Q,Li F,Wang Y,Li Z,Zhao M

Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1).
Biochimica et biophysica acta1518(1-2)183-9(2001 Mar)
Liu Z,Zhao M,Yokoyama KK,Li T