Fcnb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fcnb
Entrez Gene ID	114091
Full Name	ficolin B
Synonyms	Fcn2
General protein information	Preferred Names ficolin B Names ficolin-2 L-ficolin collagen/fibrinogen domain-containing protein 2 ficolin-beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p12
Summary	mouse homolog is similar to mouse plasma ficolin Fcna [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053634.1	NP_446086.1	ficolin-2 precursor

Pathways from BioSystems

Homologies

	FCN1	XP_001098002.1
Bos taurus (cattle)	FCN1	NP_001010996.1
Xenopus tropicalis (tropical clawed frog)	LOC100495637	XP_004917595.1
Pan troglodytes (chimpanzee)	FCN1	XP_001170643.1
Rattus norvegicus (Norway rat)	Fcnb	NP_446086.1
Gallus gallus (chicken)	FCN2	XP_004945800.1
Drosophila melanogaster (fruit fly)	CG5550	NP_611160.2
Xenopus tropicalis (tropical clawed frog)	MGC108470	XP_004917597.1
Xenopus tropicalis (tropical clawed frog)	MGC107908	XP_004917596.1
Canis lupus familiaris (dog)	LOC608247	XP_850307.1
Mus musculus (house mouse)	Fcnb	NP_034320.1
Xenopus tropicalis (tropical clawed frog)	LOC100491028	XP_002943934.2
Homo sapiens (human)	FCN1	NP_001994.2

Gene Ontology
Bibliography

Related articles in PubMed

Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL
Journal of immunology (Baltimore, Md. : 1950)189(5)2478-87(2012 Sep)

Carbohydrate recognition and complement activation by rat ficolin-B.
Girija UV, Mitchell DA, Roscher S, Wallis R
European journal of immunology41(1)214-23(2011 Jan)

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.
Zhang J, Yang L, Ang Z, Yoong SL, Tran TT, Anand GS, Tan NS, Ho B, Ding JL
Journal of immunology (Baltimore, Md. : 1950)185(11)6899-910(2010 Dec)

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.
Honor? C, R?rvig S, Hummelsh?j T, Skjoedt MO, Borregaard N, Garred P
Journal of leukocyte biology88(1)145-58(2010 Jul)

Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.
Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, Nakata M, Matsushita M
Immunogenetics57(11)837-44(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rat ficolin-B activated MASP-2 comparable to ficolin-A.
Title: Carbohydrate recognition and complement activation by rat ficolin-B.

The following Fcnb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fcnb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10147	NM_053634.1 Latest version!	Rattus norvegicus ficolin B (Fcnb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fcnb ( NM_053634.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446086.1 Rattus norvegicus ficolin B (Fcnb), mRNA.

Price & Availability↑

CloneID	ORa10147
Clone ID Related Accession (Same CDS sequence)	NM_053634.1
Accession Version	NM_053634.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	ficolin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB036792.1. ##Evidence-Data-START## Transcript exon combination :: AB036792.1, FQ220557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGTCCTGG GATCTGCTGC ACTATTCGTC TTGAGCCTGT GTGTCACTGA GCTGACCCTC 
CATGCTGCTG ACACCTGCCC AGAGGTGAAG GTCCTGGATC TGGAGGGCTC CAACAAACTC 
ACCATCCTTC AAGGCTGCCC TGGCTTGCCT GGAGCCCTGG GGCCCAAGGG AGAGGCTGGT 
GCCAAAGGAG ATAGAGGAGA GAGTGGCCTT CCTGGACACC CTGGAAAGGC GGGGCCAACT 
GGACCCAAAG GAGACCGAGG AGAGAAGGGA GTGCGTGGAG AAAAAGGAGA CACCGGGCCC 
TCCCAGTCAT GTGCTACAGG ACCTCGGACC TGCAAGGAGT TGCTCACCCG GGGCTACTTT 
CTCACTGGCT GGTATACCAT CTACCTGCCA GACTGCAGGC CCCTGACCGT GCTGTGTGAT 
ATGGACACAG ATGGTGGAGG CTGGACCGTC TTTCAGAGAA GGATCGACGG CACGGTGGAC 
TTCTTTCGGG ACTGGACCTC ATACAAGCAA GGCTTCGGCA GCCAGCTGGG GGAGTTCTGG 
CTGGGGAACG ATAACATCCA TGCTTTAACC ACCCAGGGAA CCAATGAGCT GCGGGTGGAT 
CTTGCAGACT TCGACGGCAA CCATGACTTT GCCAAGTACA GCTCCTTCCA GATCCAGGGA 
GAGGCCGAGA AATACAAGCT CATTCTGGGG AACTTCCTCG GTGGTGGTGC TGGTGACTCC 
CTGACTTCCC AAAACAACAT GCTTTTCTCC ACCAAAGACC AAGACAACGA CCAGGGATCC 
TCCAACTGTG CCGTGCGTTA CCATGGAGCC TGGTGGTACT CTGATTGTCA CACTTCCAAC 
CTGAATGGCC TCTACCTTAG GGGTCTCCAT AAGAGCTATG CAAACGGTGT CAATTGGAAG 
TCATGGAAAG GGTACAACTA CAGCTACAAG GTTTCTGAAA TGAAGGTGCG CCTCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446086.1
CDS	27..986
Translation	MVLGSAALFVLSLCVTELTLHAADTCPEVKVLDLEGSNKLTILQGCPGLPGALGPKGEAGAKGDRGESGLPGHPGKAGPTGPKGDRGEKGVRGEKGDTGPSQSCATGPRTCKELLTRGYFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRIDGTVDFFRDWTSYKQGFGSQLGEFWLGNDNIHALTTQGTNELRVDLADFDGNHDFAKYSSFQIQGEAEKYKLILGNFLGGGAGDSLTSQNNMLFSTKDQDNDQGSSNCAVRYHGAWWYSDCHTSNLNGLYLRGLHKSYANGVNWKSWKGYNYSYKVSEMKVRLI

Target ORF information:

RefSeq Version	NM_053634.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ficolin B (Fcnb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053634.1

ORF Insert Sequence:

ATGGTCCTGG GATCTGCTGC ACTATTCGTC TTGAGCCTGT GTGTCACTGA GCTGACCCTC 
CATGCTGCTG ACACCTGCCC AGAGGTGAAG GTCCTGGATC TGGAGGGCTC CAACAAACTC 
ACCATCCTTC AAGGCTGCCC TGGCTTGCCT GGAGCCCTGG GGCCCAAGGG AGAGGCTGGT 
GCCAAAGGAG ATAGAGGAGA GAGTGGCCTT CCTGGACACC CTGGAAAGGC GGGGCCAACT 
GGACCCAAAG GAGACCGAGG AGAGAAGGGA GTGCGTGGAG AAAAAGGAGA CACCGGGCCC 
TCCCAGTCAT GTGCTACAGG ACCTCGGACC TGCAAGGAGT TGCTCACCCG GGGCTACTTT 
CTCACTGGCT GGTATACCAT CTACCTGCCA GACTGCAGGC CCCTGACCGT GCTGTGTGAT 
ATGGACACAG ATGGTGGAGG CTGGACCGTC TTTCAGAGAA GGATCGACGG CACGGTGGAC 
TTCTTTCGGG ACTGGACCTC ATACAAGCAA GGCTTCGGCA GCCAGCTGGG GGAGTTCTGG 
CTGGGGAACG ATAACATCCA TGCTTTAACC ACCCAGGGAA CCAATGAGCT GCGGGTGGAT 
CTTGCAGACT TCGACGGCAA CCATGACTTT GCCAAGTACA GCTCCTTCCA GATCCAGGGA 
GAGGCCGAGA AATACAAGCT CATTCTGGGG AACTTCCTCG GTGGTGGTGC TGGTGACTCC 
CTGACTTCCC AAAACAACAT GCTTTTCTCC ACCAAAGACC AAGACAACGA CCAGGGATCC 
TCCAACTGTG CCGTGCGTTA CCATGGAGCC TGGTGGTACT CTGATTGTCA CACTTCCAAC 
CTGAATGGCC TCTACCTTAG GGGTCTCCAT AAGAGCTATG CAAACGGTGT CAATTGGAAG 
TCATGGAAAG GGTACAACTA CAGCTACAAG GTTTCTGAAA TGAAGGTGCG CCTCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Journal of immunology (Baltimore, Md. : 1950)189(5)2478-87(2012 Sep)
Verma A,White M,Vathipadiekal V,Tripathi S,Mbianda J,Ieong M,Qi L,Taubenberger JK,Takahashi K,Jensenius JC,Thiel S,Hartshorn KL

Carbohydrate recognition and complement activation by rat ficolin-B.
European journal of immunology41(1)214-23(2011 Jan)
Girija UV,Mitchell DA,Roscher S,Wallis R

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.
Journal of immunology (Baltimore, Md. : 1950)185(11)6899-910(2010 Dec)
Zhang J,Yang L,Ang Z,Yoong SL,Tran TT,Anand GS,Tan NS,Ho B,Ding JL

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.
Journal of leukocyte biology88(1)145-58(2010 Jul)
Honor? C,R?rvig S,Hummelsh?j T,Skjoedt MO,Borregaard N,Garred P

Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.
Immunogenetics57(11)837-44(2005 Dec)
Endo Y,Nakazawa N,Liu Y,Iwaki D,Takahashi M,Fujita T,Nakata M,Matsushita M