Gsdmc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gsdmc
Entrez Gene ID	83492
Full Name	gasdermin C
Synonyms	Gsdmc1,Mlze
General protein information	Preferred Names gasdermin C Names gasdermin-C gasdermin C1 melanoma-derived leucine zipper, extra-nuclear factor melanoma-derived leucine zipper-containing extranuclear factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_031378.3	NP_113555.1	gasdermin-C

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gsdmc	NP_001127967.1
Pan troglodytes (chimpanzee)	GSDMC	XP_001153860.1
	GSDMC	XP_001083863.1
Canis lupus familiaris (dog)	LOC609825	XP_852261.2
Homo sapiens (human)	GSDMC	NP_113603.1
Mus musculus (house mouse)	Gsdmc	NP_113555.1
Mus musculus (house mouse)	Gsdmc2	NP_808580.2
Bos taurus (cattle)	LOC508492	NP_001039469.1
Mus musculus (house mouse)	Gsdmc4	NP_083268.1
Mus musculus (house mouse)	Gsdmc3	NP_899017.2

Gene Ontology
Bibliography

Related articles in PubMed

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor ? Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, Shigeyasu K, Tanakaya K, Kitadai Y, Sentani K, Oue N, Yasui W, Ohdan H
PloS one11(11)e0166422(2016)

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.
Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F
Nature genetics46(7)753-8(2014 Jul)

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP
Development (Cambridge, England)139(10)1863-73(2012 May)

Atlas of gene expression in the developing kidney at microanatomic resolution.
Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS
Developmental cell15(5)781-91(2008 Nov)

Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, Sumiyama K, Sagai T, Shiroishi T
Genomics89(5)618-29(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc, promoting colorectal cancer cell proliferation.
Title: Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor ? Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.

The following Gsdmc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gsdmc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08554	NM_031378.3 Latest version!	Mus musculus gasdermin C (Gsdmc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gsdmc ( NM_031378.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_113555.1 Mus musculus gasdermin C (Gsdmc), mRNA.

Price & Availability↑

CloneID	OMu08554
Clone ID Related Accession (Same CDS sequence)	NM_031378.3
Accession Version	NM_031378.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	gasdermin-C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK137662.1. On Apr 6, 2007 this sequence version replaced NM_031378.2. ##Evidence-Data-START## Transcript exon combination :: AK137662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGTCCTACA CATTTGACTG GCTTAGCAAG GATGTGGTTA AAAAGCTTCA AGGAAGAGAT 
CTGAGGCCTG TCAAATGCCT GTCAGATGCA ACCAAATTCT GCCTGTTTAA CATACTTCAG 
GAAACTTCTT CCCGGTTGGC TTTGAAAACT GAATATATTC CAGTTGGATT TACCCTTCTG 
CATCTCTTGG AGCCCAATAT TCCTGTTCCA GAGCCTGAAG TGTCAGCTCC CATCCCCCTT 
AAACACACCA TATCCCAGAA ACTGAAGGCT GACCTGGATG TCGAAACCAT TGCAGGAGGA 
GAAGCAGGGT TTGTTAAGTC CTGTGGATAT GACATCGAGG TTCAGAGTAA GAGCATCCCA 
AATCCAAAAC TGGAAAGTCT TCAAAACAGA AAACTGTTGG ATCAGTTGCC CACATTTATG 
AAGACTTGCT GGAAGGATGG AAAGAACCTG TATGTGGTGA CAGAGGCCTA TGAAGTGACC 
AAGGATACTG TGCTGGAAGG CACAAGCAAT AGCAAATTTG CAATCAAAGG GATCATCAAC 
CAGCTTGTCA AGGTTGGAGG CAGTGGACAG TGGCAAACAG AGAAAACAGA TTCAATACCT 
ATCCAAAAGG GTTCAGTGTT GGCCTACAAG AAGCAGCAAT TGGTCATTGA GGATAACACT 
TGTGTTATTC TCACTTCTGC TAACACTAAG AAGAAGATGA CCTTTCCAAT GAGATTTGTG 
GGAATGTCTG GACATCTAAG ATATCAGGAT CTAGTCATTG AGACAGGCTC GTGGATAAAT 
GACATCGATC CAATTGGAAC AATTAAGGAG CCCACCCATC TAGATTTCAT GTGCCTACAA 
AATGAAGTTT CTGAACAAAC ACGGCTACTG GCTGAACTCT CAAAGGATGT TCAAGAAGTT 
GTGTTCTCCA GTTTCCTGCA CATGCTCTGT GACAGGGATG TTCTGTATGA CCTGATGAAA 
ATGCTGGAGT TGAATCAGTT GGGGCATATG GATGGCCCAG GTGGCAAAAT CCTGGATGAG 
CTTCGAAAGG ACTCGAGCCT TTCATGGATT AACCTAAAGG ACCTCATTCT TTATCTCCTT 
CAAGCCCTGA TGGTGCTGAG TGATACCCAA CTCTGTCTGC TGGCCCTGTC TGTGGAGATG 
CGGCTCCTCC CGCACCAAGT GGAGCTGGTA AAGAGCATCT TACAGCCAAA CTTCAAGTAT 
CCCTGGAACA TTCCCTTCAC ACTCCAGCCT CAGCTTCTTG CCCCACTCCA GGGTGAGGGC 
TTGGCCATTA CTTATGAATT GCTGGAGGAG TGTGGTCTGA AGATGGAGCT GAATAATCCC 
AGGTCAACTT GGGATTTGGA AGCCAAGATG CCCCTGTCTG CTCTCTATGG AAGCCTGTCA 
TTTTTACAGC AACTTTCAGA AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113555.1
CDS	270..1676
Translation	MSYTFDWLSKDVVKKLQGRDLRPVKCLSDATKFCLFNILQETSSRLALKTEYIPVGFTLLHLLEPNIPVPEPEVSAPIPLKHTISQKLKADLDVETIAGGEAGFVKSCGYDIEVQSKSIPNPKLESLQNRKLLDQLPTFMKTCWKDGKNLYVVTEAYEVTKDTVLEGTSNSKFAIKGIINQLVKVGGSGQWQTEKTDSIPIQKGSVLAYKKQQLVIEDNTCVILTSANTKKKMTFPMRFVGMSGHLRYQDLVIETGSWINDIDPIGTIKEPTHLDFMCLQNEVSEQTRLLAELSKDVQEVVFSSFLHMLCDRDVLYDLMKMLELNQLGHMDGPGGKILDELRKDSSLSWINLKDLILYLLQALMVLSDTQLCLLALSVEMRLLPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLSEA

Target ORF information:

RefSeq Version	NM_031378.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus gasdermin C (Gsdmc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031378.3

ORF Insert Sequence:

ATGTCCTACA CATTTGACTG GCTTAGCAAG GATGTGGTTA AAAAGCTTCA AGGAAGAGAT 
CTGAGGCCTG TCAAATGCCT GTCAGATGCA ACCAAATTCT GCCTGTTTAA CATACTTCAG 
GAAACTTCTT CCCGGTTGGC TTTGAAAACT GAATATATTC CAGTTGGATT TACCCTTCTG 
CATCTCTTGG AGCCCAATAT TCCTGTTCCA GAGCCTGAAG TGTCAGCTCC CATCCCCCTT 
AAACACACCA TATCCCAGAA ACTGAAGGCT GACCTGGATG TCGAAACCAT TGCAGGAGGA 
GAAGCAGGGT TTGTTAAGTC CTGTGGATAT GACATCGAGG TTCAGAGTAA GAGCATCCCA 
AATCCAAAAC TGGAAAGTCT TCAAAACAGA AAACTGTTGG ATCAGTTGCC CACATTTATG 
AAGACTTGCT GGAAGGATGG AAAGAACCTG TATGTGGTGA CAGAGGCCTA TGAAGTGACC 
AAGGATACTG TGCTGGAAGG CACAAGCAAT AGCAAATTTG CAATCAAAGG GATCATCAAC 
CAGCTTGTCA AGGTTGGAGG CAGTGGACAG TGGCAAACAG AGAAAACAGA TTCAATACCT 
ATCCAAAAGG GTTCAGTGTT GGCCTACAAG AAGCAGCAAT TGGTCATTGA GGATAACACT 
TGTGTTATTC TCACTTCTGC TAACACTAAG AAGAAGATGA CCTTTCCAAT GAGATTTGTG 
GGAATGTCTG GACATCTAAG ATATCAGGAT CTAGTCATTG AGACAGGCTC GTGGATAAAT 
GACATCGATC CAATTGGAAC AATTAAGGAG CCCACCCATC TAGATTTCAT GTGCCTACAA 
AATGAAGTTT CTGAACAAAC ACGGCTACTG GCTGAACTCT CAAAGGATGT TCAAGAAGTT 
GTGTTCTCCA GTTTCCTGCA CATGCTCTGT GACAGGGATG TTCTGTATGA CCTGATGAAA 
ATGCTGGAGT TGAATCAGTT GGGGCATATG GATGGCCCAG GTGGCAAAAT CCTGGATGAG 
CTTCGAAAGG ACTCGAGCCT TTCATGGATT AACCTAAAGG ACCTCATTCT TTATCTCCTT 
CAAGCCCTGA TGGTGCTGAG TGATACCCAA CTCTGTCTGC TGGCCCTGTC TGTGGAGATG 
CGGCTCCTCC CGCACCAAGT GGAGCTGGTA AAGAGCATCT TACAGCCAAA CTTCAAGTAT 
CCCTGGAACA TTCCCTTCAC ACTCCAGCCT CAGCTTCTTG CCCCACTCCA GGGTGAGGGC 
TTGGCCATTA CTTATGAATT GCTGGAGGAG TGTGGTCTGA AGATGGAGCT GAATAATCCC 
AGGTCAACTT GGGATTTGGA AGCCAAGATG CCCCTGTCTG CTCTCTATGG AAGCCTGTCA 
TTTTTACAGC AACTTTCAGA AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor ? Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
PloS one11(11)e0166422(2016)
Miguchi M,Hinoi T,Shimomura M,Adachi T,Saito Y,Niitsu H,Kochi M,Sada H,Sotomaru Y,Ikenoue T,Shigeyasu K,Tanakaya K,Kitadai Y,Sentani K,Oue N,Yasui W,Ohdan H

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.
Nature genetics46(7)753-8(2014 Jul)
Uslu VV,Petretich M,Ruf S,Langenfeld K,Fonseca NA,Marioni JC,Spitz F

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
Development (Cambridge, England)139(10)1863-73(2012 May)
Yu J,Valerius MT,Duah M,Staser K,Hansard JK,Guo JJ,McMahon J,Vaughan J,Faria D,Georgas K,Rumballe B,Ren Q,Krautzberger AM,Junker JP,Thiagarajan RD,Machanick P,Gray PA,van Oudenaarden A,Rowitch DH,Stiles CD,Ma Q,Grimmond SM,Bailey TL,Little MH,McMahon AP

Atlas of gene expression in the developing kidney at microanatomic resolution.
Developmental cell15(5)781-91(2008 Nov)
Brunskill EW,Aronow BJ,Georgas K,Rumballe B,Valerius MT,Aronow J,Kaimal V,Jegga AG,Yu J,Grimmond S,McMahon AP,Patterson LT,Little MH,Potter SS

Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
Genomics89(5)618-29(2007 May)
Tamura M,Tanaka S,Fujii T,Aoki A,Komiyama H,Ezawa K,Sumiyama K,Sagai T,Shiroishi T