Mterf4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mterf4
Entrez Gene ID	69821
Full Name	mitochondrial transcription termination factor 4
Synonyms	1810059A23Rik,4933412H03Rik,Mterfd2
General protein information	Preferred Names mitochondrial transcription termination factor 4 Names transcription termination factor 4, mitochondrial MTERF domain containing 2 mTERF domain-containing protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_001310756.1	NP_001297685.1	transcription termination factor 4, mitochondrial isoform 2
NM_178051.4	NP_835152.1	transcription termination factor 4, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MTERFD2	XP_005642511.1
Pan troglodytes (chimpanzee)	MTERFD2	XP_003309628.1
	LOC717484	XP_001109015.2
Bos taurus (cattle)	MTERFD2	NP_001231155.1
Mus musculus (house mouse)	Mterfd2	NP_835152.1
Rattus norvegicus (Norway rat)	Mterfd2	NP_001032286.1
Xenopus tropicalis (tropical clawed frog)	mterfd2	XP_002933402.1
Homo sapiens (human)	MTERFD2	NP_872307.2
Danio rerio (zebrafish)	si:dkeyp-94h10.5	NP_001119940.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.
K?hl I, Miranda M, Atanassov I, Kuznetsova I, Hinze Y, Mourier A, Filipovska A, Larsson NG
eLife6(2017 Nov)

Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.
Wang XL, Liu Q, Chen GJ, Li ML, Ding YH
Biochemical and biophysical research communications482(4)928-934(2017 Jan)

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
C?mara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T, Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM, Larsson NG
Cell metabolism13(5)527-39(2011 May)

Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.
Xu Q, Zhang F, He H, Xu S, Li K, Liu S, Li Y, Wu Q
Genes & genetic systems86(4)269-75(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 mice, an animal model of Alzheimer's disease.
Title: Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.

Mterfd2 might have multiple roles in organogenesis.
Title: Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.

The following Mterf4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mterf4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05243	NM_178051.4 Latest version!	Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu70474	NM_001310756.1 Latest version!	Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mterf4 ( NM_178051.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_835152.1 Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05243
Clone ID Related Accession (Same CDS sequence)	NM_178051.4
Accession Version	NM_178051.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	transcription termination factor 4, mitochondrial isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK033043.1, DV058715.1 and AK077142.1. On Jul 18, 2015 this sequence version replaced NM_178051.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK077142.1, BC064709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGC TGGGAAGGCA GGTTCCTGAG TGGCATCGTC TACTGGCCCT CTCCTGGGCC 
TGTTTGGTTA GGCAGACCCC TCATCTCAGA GAACAGAAAC AGATGAGCCC TTCTTTGTCT 
TGCAAACTGA CTACAGTGCC CGGTAGAGGA AGCTTTCAAG AGTTTTCCAG CATTACACCC 
CAAAAGTACA TGCAGGAACC AGAAAACAGG ACACGACTTG TTCAGTGTCT TCATGAGGAA 
CAGAAGCCTT GTGTGGATCC TGAGTCCTTG GAGCCTGAAA AGGTCATCCG TTCCCTCCAG 
GACATGGGTT TTGCTGAAGC CCACATTCAC AGCTTGTTTA GTATACAGCC AAGTGTCCAT 
CCTCAACAGT TGCTGGGTAT AGTTTCAGAA CTCCTACTCT TGGGGTTGAA CCCAGAGCCT 
GTATTTAATG CCTTGAAGAA AAATCCCCAG TTGCTGAAAC TGTCTAGCAT GCAGATGAAG 
AGGCGTTCCA GTTACCTTCG GAAGCTTGGC CTTGGAGAAG GGAAACTGAA GCGGGTGCTG 
TCCGTTTGCC CTGAGGTTTT CACCATGCAT CAGCGGGACA TTGACCGAGT TGTGAAGGTC 
CTCAGGGAGA AGTGCTTGTT CACGGCACAG CACATCACAG ACGTTCTGCA CAGATGCCCC 
ACTGTTTTGC AGGAGGACCC CAACGAGCTA GAATACAAAT TCCAGTATGC ATATTTCAGG 
ATGGGACTCA CACATCTAGA CATAGTCAGG ACGAATTTCT TACAGTATTC AATAACCAAG 
ATCAAGCAGA GACACATTTA CCTGGAGCGC CTTGGACGGT ACCAGACCCC TGATAAGAAG 
GGGCAGACAC AGATCCCTAA TCCCTCACTG AGGAACATTC TCAGAGTTTC TGAAGCTGAG 
TTTTTGGCCA GGACAGCCTG TTCCTCTGTC GAGGAGTTTC AAGTTTTTAA AAAACTCTTG 
GATCAAGAGG AGGAGGAGGA GTCTGAGAGC CATGCATCTG AGGAGGAAGA GGAAGAGGAG 
GAAGAGGAGG AGCTACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835152.1
CDS	35..1075
Translation	MASLGRQVPEWHRLLALSWACLVRQTPHLREQKQMSPSLSCKLTTVPGRGSFQEFSSITPQKYMQEPENRTRLVQCLHEEQKPCVDPESLEPEKVIRSLQDMGFAEAHIHSLFSIQPSVHPQQLLGIVSELLLLGLNPEPVFNALKKNPQLLKLSSMQMKRRSSYLRKLGLGEGKLKRVLSVCPEVFTMHQRDIDRVVKVLREKCLFTAQHITDVLHRCPTVLQEDPNELEYKFQYAYFRMGLTHLDIVRTNFLQYSITKIKQRHIYLERLGRYQTPDKKGQTQIPNPSLRNILRVSEAEFLARTACSSVEEFQVFKKLLDQEEEEESESHASEEEEEEEEEEELL

Target ORF information:

RefSeq Version	NM_178051.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178051.4

ORF Insert Sequence:

ATGGCTTCGC TGGGAAGGCA GGTTCCTGAG TGGCATCGTC TACTGGCCCT CTCCTGGGCC 
TGTTTGGTTA GGCAGACCCC TCATCTCAGA GAACAGAAAC AGATGAGCCC TTCTTTGTCT 
TGCAAACTGA CTACAGTGCC CGGTAGAGGA AGCTTTCAAG AGTTTTCCAG CATTACACCC 
CAAAAGTACA TGCAGGAACC AGAAAACAGG ACACGACTTG TTCAGTGTCT TCATGAGGAA 
CAGAAGCCTT GTGTGGATCC TGAGTCCTTG GAGCCTGAAA AGGTCATCCG TTCCCTCCAG 
GACATGGGTT TTGCTGAAGC CCACATTCAC AGCTTGTTTA GTATACAGCC AAGTGTCCAT 
CCTCAACAGT TGCTGGGTAT AGTTTCAGAA CTCCTACTCT TGGGGTTGAA CCCAGAGCCT 
GTATTTAATG CCTTGAAGAA AAATCCCCAG TTGCTGAAAC TGTCTAGCAT GCAGATGAAG 
AGGCGTTCCA GTTACCTTCG GAAGCTTGGC CTTGGAGAAG GGAAACTGAA GCGGGTGCTG 
TCCGTTTGCC CTGAGGTTTT CACCATGCAT CAGCGGGACA TTGACCGAGT TGTGAAGGTC 
CTCAGGGAGA AGTGCTTGTT CACGGCACAG CACATCACAG ACGTTCTGCA CAGATGCCCC 
ACTGTTTTGC AGGAGGACCC CAACGAGCTA GAATACAAAT TCCAGTATGC ATATTTCAGG 
ATGGGACTCA CACATCTAGA CATAGTCAGG ACGAATTTCT TACAGTATTC AATAACCAAG 
ATCAAGCAGA GACACATTTA CCTGGAGCGC CTTGGACGGT ACCAGACCCC TGATAAGAAG 
GGGCAGACAC AGATCCCTAA TCCCTCACTG AGGAACATTC TCAGAGTTTC TGAAGCTGAG 
TTTTTGGCCA GGACAGCCTG TTCCTCTGTC GAGGAGTTTC AAGTTTTTAA AAAACTCTTG 
GATCAAGAGG AGGAGGAGGA GTCTGAGAGC CATGCATCTG AGGAGGAAGA GGAAGAGGAG 
GAAGAGGAGG AGCTACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mterf4 ( NM_001310756.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297685.1 Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu70474
Clone ID Related Accession (Same CDS sequence)	NM_001310756.1
Accession Version	NM_001310756.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	transcription termination factor 4, mitochondrial isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK033043.1, DV058715.1 and AK079098.1. On Jul 18, 2015 this sequence version replaced XM_011248070.1. Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK079098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGC TGGGAAGGCA GGTTCCTGAG TGGCATCGTC TACTGGCCCT CTCCTGGGCC 
TGTTTGGTTA GGCAGACCCC TCATCTCAGA GAACAGAAAC AGATGAGCCC TTCTTTGTCT 
TGCAAACTGA CTACAGTGCC CGGTAGAGGA AGCTTTCAAG AGTTTTCCAG CATTACACCC 
CAAAAGTACA TGCAGGAACC AGAAAACAGG ACACGACTTG TTCAGTGTCT TCATGAGGAA 
CAGAAGCCTT GTGTGGATCC TGAGTCCTTG GAGCCTGAAA AGGTCATCCG TTCCCTCCAG 
GACATGGGTT TTGCTGAAGC CCACATTCAC AGCTTGTTTA GTATACAGCC AAGTGTCCAT 
CCTCAACAGT TGCTGGGTAT AGTTTCAGAA CTCCTACTCT TGGGGTTGAA CCCAGAGCCT 
GTATTTAATG CCTTGAAGAA AAATCCCCAG TTGCTGAAAC TGTCTAGCAT GCAGATGAAG 
AGGCGTTCCA GTTACCTTCG GAAGCTTGGC CTTGGAGAAG GGAAACTGAA GCGGGTGCTG 
TCCGTTTGCC CTGAGGTTTT CACCATGCAT CAGCGGGACA TTGACCGAGT TGTGAAGGTC 
CTCAGGGAGA AGTGCTTGTT CACGGCACAG CACATCACAG ACGTTCTGCA CAGATGCCCC 
ACTGTTTTGC AGGAGGACCC CAACGAGCTA GAATACAAAT TCCAGCCTGT TCCTCTGTCG 
AGGAGTTTCA AGTTTTTAAA AAACTCTTGG ATCAAGAGGA GGAGGAGGAG TCTGAGAGCC 
ATGCATCTGA GGAGGAAGAG GAAGAGGAGG AAGAGGAGGA GCTACTGTGA CACAGCACTG 
GGGTGTCAGA GGTCATTCTC ATATTCTCGA AGTGCTGGGG ACCTTCACCT GGATCTTCTC 
AAGCACTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297685.1
CDS	35..946
Translation	MASLGRQVPEWHRLLALSWACLVRQTPHLREQKQMSPSLSCKLTTVPGRGSFQEFSSITPQKYMQEPENRTRLVQCLHEEQKPCVDPESLEPEKVIRSLQDMGFAEAHIHSLFSIQPSVHPQQLLGIVSELLLLGLNPEPVFNALKKNPQLLKLSSMQMKRRSSYLRKLGLGEGKLKRVLSVCPEVFTMHQRDIDRVVKVLREKCLFTAQHITDVLHRCPTVLQEDPNELEYKFQPVPLSRSFKFLKNSWIKRRRRSLRAMHLRRKRKRRKRRSYCDTALGCQRSFSYSRSAGDLHLDLLKHF

Target ORF information:

RefSeq Version	NM_001310756.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitochondrial transcription termination factor 4 (Mterf4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310756.1

ORF Insert Sequence:

ATGGCTTCGC TGGGAAGGCA GGTTCCTGAG TGGCATCGTC TACTGGCCCT CTCCTGGGCC 
TGTTTGGTTA GGCAGACCCC TCATCTCAGA GAACAGAAAC AGATGAGCCC TTCTTTGTCT 
TGCAAACTGA CTACAGTGCC CGGTAGAGGA AGCTTTCAAG AGTTTTCCAG CATTACACCC 
CAAAAGTACA TGCAGGAACC AGAAAACAGG ACACGACTTG TTCAGTGTCT TCATGAGGAA 
CAGAAGCCTT GTGTGGATCC TGAGTCCTTG GAGCCTGAAA AGGTCATCCG TTCCCTCCAG 
GACATGGGTT TTGCTGAAGC CCACATTCAC AGCTTGTTTA GTATACAGCC AAGTGTCCAT 
CCTCAACAGT TGCTGGGTAT AGTTTCAGAA CTCCTACTCT TGGGGTTGAA CCCAGAGCCT 
GTATTTAATG CCTTGAAGAA AAATCCCCAG TTGCTGAAAC TGTCTAGCAT GCAGATGAAG 
AGGCGTTCCA GTTACCTTCG GAAGCTTGGC CTTGGAGAAG GGAAACTGAA GCGGGTGCTG 
TCCGTTTGCC CTGAGGTTTT CACCATGCAT CAGCGGGACA TTGACCGAGT TGTGAAGGTC 
CTCAGGGAGA AGTGCTTGTT CACGGCACAG CACATCACAG ACGTTCTGCA CAGATGCCCC 
ACTGTTTTGC AGGAGGACCC CAACGAGCTA GAATACAAAT TCCAGCCTGT TCCTCTGTCG 
AGGAGTTTCA AGTTTTTAAA AAACTCTTGG ATCAAGAGGA GGAGGAGGAG TCTGAGAGCC 
ATGCATCTGA GGAGGAAGAG GAAGAGGAGG AAGAGGAGGA GCTACTGTGA CACAGCACTG 
GGGTGTCAGA GGTCATTCTC ATATTCTCGA AGTGCTGGGG ACCTTCACCT GGATCTTCTC 
AAGCACTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.
eLife6(2017 Nov)
K?hl I,Miranda M,Atanassov I,Kuznetsova I,Hinze Y,Mourier A,Filipovska A,Larsson NG

Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.
Biochemical and biophysical research communications482(4)928-934(2017 Jan)
Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
Cell metabolism13(5)527-39(2011 May)
C?mara Y,Asin-Cayuela J,Park CB,Metodiev MD,Shi Y,Ruzzenente B,Kukat C,Habermann B,Wibom R,Hultenby K,Franz T,Erdjument-Bromage H,Tempst P,Hallberg BM,Gustafsson CM,Larsson NG

Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.
Genes & genetic systems86(4)269-75(2011)
Xu Q,Zhang F,He H,Xu S,Li K,Liu S,Li Y,Wu Q