Lage3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lage3
Entrez Gene ID	66192
Full Name	L antigen family, member 3
Synonyms	1110049G11Rik,Eso3,Itba2
General protein information	Preferred Names L antigen family, member 3 Names EKC/KEOPS complex subunit Lage3 ITBA2 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A7.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025410.2	NP_079686.1	EKC/KEOPS complex subunit Lage3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Lage3	NP_079686.1
Rattus norvegicus (Norway rat)	Lage3	NP_001099815.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nature genetics49(10)1529-1538(2017 Oct)

Pituitary tumorigenesis in prolactin gene-disrupted mice.
Cruz-Soto ME, Scheiber MD, Gregerson KA, Boivin GP, Horseman ND
Endocrinology143(11)4429-36(2002 Nov)

A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved.
Alpen B, G?re AO, Scanlan MJ, Old LJ, Chen YT
Gene297(1-2)141-9(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lage3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lage3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00418	NM_025410.2 Latest version!	Mus musculus L antigen family, member 3 (Lage3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lage3 ( NM_025410.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079686.1 Mus musculus L antigen family, member 3 (Lage3), mRNA.

Price & Availability↑

CloneID	OMu00418
Clone ID Related Accession (Same CDS sequence)	NM_025410.2
Accession Version	NM_025410.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	EKC/KEOPS complex subunit Lage3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK002539.1. On Apr 6, 2007 this sequence version replaced NM_025410.1. ##Evidence-Data-START## Transcript exon combination :: AK002539.1, DV065816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGCAGACAG CACACACAGG TTTAAGCCAC ACTGCAGATG GCGCCGATGG TCAGACTAGC 
CGCTGTTGTC CTGGTAATGC AGGCACAAAG GCAGTTATTC CCAGTGGAGC TCACCCTGTT 
GCAAGAGCAC TGGAAGCCTC CCGAAATTCC AGCAAAAGCA TGGTGCCTTT AACCCAAAGG 
CCTGGAACCC GACATCACAG ATTCTCCCTC TTCGTGCCTT TCCCGACCTC TTTGGAGGCA 
GAAATCGCCT GTGGGTCCCT AGTTCCAGAT GTCGAACCAC ATCGAGGACT GGTAGGGAAG 
GAGCTTAAAG TGAGCGGCTG CATGCTGGAG GTACGCTGGA TCGCGGAAGA TTCTCGCCTC 
CTCCGACTTT CCATCATCAA CTTTCTTGAC CAGCTTTCCC TAGTGGTGAA CACCATACAG 
CTCTTTGGGC CCCCAGTTTC CTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079686.1
CDS	92..538
Translation	MQTAHTGLSHTADGADGQTSRCCPGNAGTKAVIPSGAHPVARALEASRNSSKSMVPLTQRPGTRHHRFSLFVPFPTSLEAEIACGSLVPDVEPHRGLVGKELKVSGCMLEVRWIAEDSRLLRLSIINFLDQLSLVVNTIQLFGPPVSC

Target ORF information:

RefSeq Version	NM_025410.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus L antigen family, member 3 (Lage3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025410.2

ORF Insert Sequence:

ATGCAGACAG CACACACAGG TTTAAGCCAC ACTGCAGATG GCGCCGATGG TCAGACTAGC 
CGCTGTTGTC CTGGTAATGC AGGCACAAAG GCAGTTATTC CCAGTGGAGC TCACCCTGTT 
GCAAGAGCAC TGGAAGCCTC CCGAAATTCC AGCAAAAGCA TGGTGCCTTT AACCCAAAGG 
CCTGGAACCC GACATCACAG ATTCTCCCTC TTCGTGCCTT TCCCGACCTC TTTGGAGGCA 
GAAATCGCCT GTGGGTCCCT AGTTCCAGAT GTCGAACCAC ATCGAGGACT GGTAGGGAAG 
GAGCTTAAAG TGAGCGGCTG CATGCTGGAG GTACGCTGGA TCGCGGAAGA TTCTCGCCTC 
CTCCGACTTT CCATCATCAA CTTTCTTGAC CAGCTTTCCC TAGTGGTGAA CACCATACAG 
CTCTTTGGGC CCCCAGTTTC CTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Nature genetics49(10)1529-1538(2017 Oct)
Braun DA,Rao J,Mollet G,Schapiro D,Daugeron MC,Tan W,Gribouval O,Boyer O,Revy P,Jobst-Schwan T,Schmidt JM,Lawson JA,Schanze D,Ashraf S,Ullmann JFP,Hoogstraten CA,Boddaert N,Collinet B,Martin G,Liger D,Lovric S,Furlano M,Guerrera IC,Sanchez-Ferras O,Hu JF,Boschat AC,Sanquer S,Menten B,Vergult S,De Rocker N,Airik M,Hermle T,Shril S,Widmeier E,Gee HY,Choi WI,Sadowski CE,Pabst WL,Warejko JK,Daga A,Basta T,Matejas V,Scharmann K,Kienast SD,Behnam B,Beeson B,Begtrup A,Bruce M,Ch'ng GS,Lin SP,Chang JH,Chen CH,Cho MT,Gaffney PM,Gipson PE,Hsu CH,Kari JA,Ke YY,Kiraly-Borri C,Lai WM,Lemyre E,Littlejohn RO,Masri A,Moghtaderi M,Nakamura K,Ozaltin F,Praet M,Prasad C,Prytula A,Roeder ER,Rump P,Schnur RE,Shiihara T,Sinha MD,Soliman NA,Soulami K,Sweetser DA,Tsai WH,Tsai JD,Topaloglu R,Vester U,Viskochil DH,Vatanavicharn N,Waxler JL,Wierenga KJ,Wolf MTF,Wong SN,Leidel SA,Truglio G,Dedon PC,Poduri A,Mane S,Lifton RP,Bouchard M,Kannu P,Chitayat D,Magen D,Callewaert B,van Tilbeurgh H,Zenker M,Antignac C,Hildebrandt F

Pituitary tumorigenesis in prolactin gene-disrupted mice.
Endocrinology143(11)4429-36(2002 Nov)
Cruz-Soto ME,Scheiber MD,Gregerson KA,Boivin GP,Horseman ND

A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved.
Gene297(1-2)141-9(2002 Sep)
Alpen B,G?re AO,Scanlan MJ,Old LJ,Chen YT