Hcrtr2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hcrtr2
Entrez Gene ID	387285
Full Name	hypocretin (orexin) receptor 2
Synonyms	OX2R,mOX2aR,mOX2bR,mOXR2
General protein information	Preferred Names hypocretin (orexin) receptor 2 Names orexin receptor type 2 hypocretin receptor type 2 orexin receptor type-2a ox-2-R ox2-R
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_198962.3	NP_945200.1	orexin receptor type 2
NM_198962.4	NP_945200.1	orexin receptor type 2 isoform 1
NM_001364551.1	NP_001351480.1	orexin receptor type 2 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	HCRTR2	NP_001517.2
	HCRTR2	XP_001109616.1
Xenopus tropicalis (tropical clawed frog)	hcrtr2	XP_002934896.2
Caenorhabditis elegans (roundworm)	npr-2	NP_501701.2
Pan troglodytes (chimpanzee)	HCRTR2	XP_518552.2
Bos taurus (cattle)	HCRTR2	NP_001179606.1
Mus musculus (house mouse)	Hcrtr2	NP_945200.1
Gallus gallus (chicken)	HCRTR2	NP_001019755.1
Canis lupus familiaris (dog)	HCRTR2	NP_001002933.1
Rattus norvegicus (Norway rat)	Hcrtr2	NP_037206.1
Danio rerio (zebrafish)	hcrtr2	NP_001073337.1
Caenorhabditis elegans (roundworm)	npr-1	NP_508816.1

Gene Ontology
Bibliography

Related articles in PubMed

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America114(22)5731-5736(2017 May)

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.
Yun S, Wennerholm M, Shelton JE, Bonaventure P, Letavic MA, Shireman BT, Lovenberg TW, Dugovic C
Frontiers in behavioral neuroscience1183(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrated that activation of the OX1 receptor in the ventrolateral periaqueductal gray of mice can initiate an endocannabinoid-CB1 receptor-mediated analgesia. Activation of the OX2 receptor in the ventrolateral periaqueductal gray was also antinociceptive but this antinociceptive effect is CB1 receptor-independent.
Title: Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.

Elevation levels of OX1R and OX2R following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.
Title: Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.

In an heart failure model, HCRTR2-deficient mice exhibited poorer cardiac function, worse treadmill exercise capacity, and greater myocardial scarring
Title: Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure.

orexin activation of OX2R in the brain centrally enhances bone formation by lowing circulating leptin level.
Title: Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.

Knocking down the Orx2 receptors in the basolateral amygdala increased anxious behavior as measured by reduced social preference and reduced time spent in the center of an open field.
Title: Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.

The following Hcrtr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hcrtr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu75169	NM_001364551.1 Latest version!	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu21656	NM_198962.4 Latest version!	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OMu21656	NM_198962.3	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hcrtr2 ( NM_001364551.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001351480.1 Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu75169
Clone ID Related Accession (Same CDS sequence)	NM_001364551.1
Accession Version	NM_001364551.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	orexin receptor type 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140311.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY336084.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849379 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001351480.1
CDS	120..1451
Translation	MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNW

Target ORF information:

RefSeq Version	NM_001364551.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364551.1

ORF Insert Sequence:

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hcrtr2 ( NM_198962.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_945200.1 Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), mRNA.

Price & Availability↑

CloneID	OMu21656
Clone ID Related Accession (Same CDS sequence)	NM_198962.3 , NM_198962.4
Accession Version	NM_198962.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Mus musculus(house mouse)
Product	orexin receptor type 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC140311.2. On May 2, 2007 this sequence version replaced NM_198962.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038551.1, AK079572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849379 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAGCA GGGAGTACCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_945200.1
CDS	75..1457
Translation	MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV

Target ORF information:

RefSeq Version	NM_198962.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198962.3

ORF Insert Sequence:

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAGCA GGGAGTACCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hcrtr2 ( NM_198962.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_945200.1 Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu21656
Clone ID Related Accession (Same CDS sequence)	NM_198962.3 , NM_198962.4
Accession Version	NM_198962.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	orexin receptor type 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140311.2. On Jun 21, 2018 this sequence version replaced NM_198962.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038551.1, AK048781.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849379 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAGCA GGGAGTACCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_945200.1
CDS	120..1502
Translation	MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV

Target ORF information:

RefSeq Version	NM_198962.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198962.4

ORF Insert Sequence:

ATGTCCAGCA CCAAACTGGA GGATTCCCTC TCTCGTCGCA ACTGGTCATC TGCTTCAGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAT CCCACGGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTTGT GGCTCTCATC GGGAACGTCC TGGTCTGTGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTTTC CCTAGCAGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCT ACCCTCGTTG TTGACATCAC TGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATT CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CGTTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGTGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTATGT GATGAACACT GGGGCGGTGA AGTTTACCCA 
AAGATGTACC ATATCTGCTT CTTTCTGGTG ACATACATGG CACCTCTGTG TCTTATGATA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCCGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCAGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CTCGGATTAG CGCTGTTGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTATTT GGGATGTTCA CACACACGGA AGACAGAGAG 
ACTGTCTATG CTTGGTTCAC TTTTTCTCAT TGGCTTGTAT ATGCCAACAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT TAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGTTGTCTTG GGGTTCATCA TCGCCAAGGA GACCGCCTCG CCAGGGGACG CACGAGCACA 
GAGAGCAGGA AGTCCCTGAC CACACAGATC AGCAACTTTG ACAATGTATC AAAACTCTCA 
GAGCACGTGG TGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAGCA GGGAGTACCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Proceedings of the National Academy of Sciences of the United States of America114(22)5731-5736(2017 May)
Irukayama-Tomobe Y,Ogawa Y,Tominaga H,Ishikawa Y,Hosokawa N,Ambai S,Kawabe Y,Uchida S,Nakajima R,Saitoh T,Kanda T,Vogt K,Sakurai T,Nagase H,Yanagisawa M

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.
Frontiers in behavioral neuroscience1183(2017)
Yun S,Wennerholm M,Shelton JE,Bonaventure P,Letavic MA,Shireman BT,Lovenberg TW,Dugovic C

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Hcrtr2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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