Oas1g cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oas1g
Entrez Gene ID	23960
Full Name	2'-5' oligoadenylate synthetase 1G
Synonyms	AI449562,L2,Mmu-L,Mmu-L2,Oas1b,Oias-1,Oias1
General protein information	Preferred Names 2'-5' oligoadenylate synthetase 1G Names 2'-5' oligoadenylate synthetase 1G 2'-5' oligoadenylate synthetase 1A 2-5-oligoadenylate synthetase 1A ((2-5)oligo(A) synthetase 1A) (2-5A synthetase 1A) (p42 OAS)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 60.65 cM
Summary	This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011852.3	NP_035982.2	2'-5' oligoadenylate synthetase 1G

Pathways from BioSystems

Homologies

Homo sapiens (human)	OAS1	NP_058132.2
Bos taurus (cattle)	OAS1Y	NP_001035696.1
Mus musculus (house mouse)	Oas1a	NP_660212.2
Bos taurus (cattle)	OAS1Z	NP_001025017.1
Bos taurus (cattle)	OAS1X	NP_835209.1
Canis lupus familiaris (dog)	OAS1	NP_001041596.1
Mus musculus (house mouse)	Oas1g	NP_035982.2
Pan troglodytes (chimpanzee)	OAS1	XP_003952355.1
	OAS1	NP_001077418.1
Rattus norvegicus (Norway rat)	Oas1a	NP_620268.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research31(1)41-7(2011 Jan)

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S
Nature immunology6(1)49-56(2005 Jan)

Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.
Mashimo T, Glaser P, Lucas M, Simon-Chazottes D, Ceccaldi PE, Montagutelli X, Despr?s P, Gu?net JL
Genomics82(5)537-52(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Oas1g gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oas1g cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08991	NM_011852.3 Latest version!	Mus musculus 2'-5' oligoadenylate synthetase 1G (Oas1g), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oas1g ( NM_011852.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035982.2 Mus musculus 2'-5' oligoadenylate synthetase 1G (Oas1g), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08991
Clone ID Related Accession (Same CDS sequence)	NM_011852.3
Accession Version	NM_011852.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	2'-5' oligoadenylate synthetase 1G
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015535.11 and AF480417.1. On Nov 25, 2014 this sequence version replaced NM_011852.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACG GACTCAGGAG CATCCCAGCC TGGACGCTGG ACAAGTTCAT AGAGGATTAC 
CTCCTTCCCG ACACCACCTT TGGTGCTGAT GTCAAATCAG CCGTCAATGT CGTGTGTGAT 
TTCCTGAAGG AGAGATGCTT CCAAGGTGCT GCCCACCCAG TGAGGGTCTC CAAGGTGGTG 
AAGGGTGGCT CCTCAGGCAA AGGCACCACA CTCAAGGGCA GGTCAGACGC TGACCTGGTG 
GTGTTCCTTA ACAATCTCAC CAGCTTTGAG GATCAGTTAA ACCGACGGGG AGAGTTCATC 
AAGGAAATTA AGAAACAGCT GTACGAGGTT CAGCATGAGA GACGTTTTAG AGTCAAGTTT 
GAGGTCCAGA GTTCATGGTG GCCCAACGCC CGGTCTCTGA GCTTCAAGCT GAGCGCCCCC 
CATCTGCATC AGGAGGTGGA GTTTGATGTG CTTCCAGCCT TTGATGTCCT GGGTCATGGT 
AGTATCAATA AGAAGCCTAA TCCCTTAATC TACACCATCC TCATCTGGGA ATGTACCTCC 
CTGGGGAAGG ATGGCGAGTT CTCTACCTGC TTCACGGAGC TCCAGCGGAA CTTCCTGAAG 
CAGCGCCCAA CCAAGCTGAA GAGTCTCATC CGCCTGGTCA AACACTGGTA CCAACTGTGT 
AAGGAGAAGC TGGGGAAGCC ACTGCCCCCA CAGTATGCCC TGGAGCTACT CACTGTCTAT 
GCCTGGGAAC AGGGGAATGG ATGTAATGAG TTCAACACAG CCCAGGGCTT CCGGACCGTC 
TTGGAACTGG TCATCAATTA TCAGCATCTT CGAATCTACT GGACAAAGTA TTATGACTTT 
CAACACAAGG AGGTCTCCAA ATACCTGCAC AGACAGCTCA GAAAAGCCAG GCCTGTGATC 
CTGGACCCAG CTGACCCGAC AGGGAATGTG GCTGGTGGGA ACCCAGAGGG CTGGAGGCGG 
TTGGCTGAAG AGGCTGATGT GTGGCTGTGG TACCCATGTT TTATGAAAAA TGATGGTTCC 
CGAGTGAGCT CCTGGGATGT GCCGACGGTG GTTCCTGTAC CTTTTGAGCA GGTGGAGGAG 
AACTGGACAT GTATCCTGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035982.2
CDS	52..1155
Translation	MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKERCFQGAAHPVRVSKVVKGGSSGKGTTLKGRSDADLVVFLNNLTSFEDQLNRRGEFIKEIKKQLYEVQHERRFRVKFEVQSSWWPNARSLSFKLSAPHLHQEVEFDVLPAFDVLGHGSINKKPNPLIYTILIWECTSLGKDGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVYAWEQGNGCNEFNTAQGFRTVLELVINYQHLRIYWTKYYDFQHKEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRRLAEEADVWLWYPCFMKNDGSRVSSWDVPTVVPVPFEQVEENWTCILL

Target ORF information:

RefSeq Version	NM_011852.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus 2'-5' oligoadenylate synthetase 1G (Oas1g), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011852.3

ORF Insert Sequence:

ATGGAGCACG GACTCAGGAG CATCCCAGCC TGGACGCTGG ACAAGTTCAT AGAGGATTAC 
CTCCTTCCCG ACACCACCTT TGGTGCTGAT GTCAAATCAG CCGTCAATGT CGTGTGTGAT 
TTCCTGAAGG AGAGATGCTT CCAAGGTGCT GCCCACCCAG TGAGGGTCTC CAAGGTGGTG 
AAGGGTGGCT CCTCAGGCAA AGGCACCACA CTCAAGGGCA GGTCAGACGC TGACCTGGTG 
GTGTTCCTTA ACAATCTCAC CAGCTTTGAG GATCAGTTAA ACCGACGGGG AGAGTTCATC 
AAGGAAATTA AGAAACAGCT GTACGAGGTT CAGCATGAGA GACGTTTTAG AGTCAAGTTT 
GAGGTCCAGA GTTCATGGTG GCCCAACGCC CGGTCTCTGA GCTTCAAGCT GAGCGCCCCC 
CATCTGCATC AGGAGGTGGA GTTTGATGTG CTTCCAGCCT TTGATGTCCT GGGTCATGGT 
AGTATCAATA AGAAGCCTAA TCCCTTAATC TACACCATCC TCATCTGGGA ATGTACCTCC 
CTGGGGAAGG ATGGCGAGTT CTCTACCTGC TTCACGGAGC TCCAGCGGAA CTTCCTGAAG 
CAGCGCCCAA CCAAGCTGAA GAGTCTCATC CGCCTGGTCA AACACTGGTA CCAACTGTGT 
AAGGAGAAGC TGGGGAAGCC ACTGCCCCCA CAGTATGCCC TGGAGCTACT CACTGTCTAT 
GCCTGGGAAC AGGGGAATGG ATGTAATGAG TTCAACACAG CCCAGGGCTT CCGGACCGTC 
TTGGAACTGG TCATCAATTA TCAGCATCTT CGAATCTACT GGACAAAGTA TTATGACTTT 
CAACACAAGG AGGTCTCCAA ATACCTGCAC AGACAGCTCA GAAAAGCCAG GCCTGTGATC 
CTGGACCCAG CTGACCCGAC AGGGAATGTG GCTGGTGGGA ACCCAGAGGG CTGGAGGCGG 
TTGGCTGAAG AGGCTGATGT GTGGCTGTGG TACCCATGTT TTATGAAAAA TGATGGTTCC 
CGAGTGAGCT CCTGGGATGT GCCGACGGTG GTTCCTGTAC CTTTTGAGCA GGTGGAGGAG 
AACTGGACAT GTATCCTGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research31(1)41-7(2011 Jan)
Kristiansen H,Gad HH,Eskildsen-Larsen S,Despres P,Hartmann R

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Nature immunology6(1)49-56(2005 Jan)
Yoshida H,Okabe Y,Kawane K,Fukuyama H,Nagata S

Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.
Genomics82(5)537-52(2003 Nov)
Mashimo T,Glaser P,Lucas M,Simon-Chazottes D,Ceccaldi PE,Montagutelli X,Despr?s P,Gu?net JL