Plppr4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plppr4
Entrez Gene ID	229791
Full Name	phospholipid phosphatase related 4
Synonyms	A330086D10,D3Bwg0562e,Lppr4,PRG-1,mKIAA0455
General protein information	Preferred Names phospholipid phosphatase related 4 Names phospholipid phosphatase-related protein type 4 brain-specific phosphatidic acid phosphatase-like protein 1 lipid phosphate phosphatase-related protein type 4 plasticity related gene 1 plasticity-related gene 1 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 G1\|3 50.57 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_177664.5	NP_808332.3	phospholipid phosphatase-related protein type 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC513388	XP_003585912.1
Homo sapiens (human)	LPPR4	NP_055654.2
Pan troglodytes (chimpanzee)	LOC469389	XP_524774.3
Rattus norvegicus (Norway rat)	Lppr4	NP_001001508.2
Gallus gallus (chicken)	LPPR4	XP_422319.2
Danio rerio (zebrafish)	lppr4a	XP_005163404.1
Xenopus tropicalis (tropical clawed frog)	LOC100489346	XP_002933836.2
Canis lupus familiaris (dog)	LOC490146	XP_003639142.1
Mus musculus (house mouse)	D3Bwg0562e	NP_808332.3

Gene Ontology
Bibliography

Related articles in PubMed

Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
Schneider P, Petzold S, Sommer A, Nitsch R, Schwegler H, Vogt J, Roskoden T
Behavioural brain research3361-7(2018 Jan)

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.
Vogt J, Kirischuk S, Unichenko P, Schl?ter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R
Cerebral cortex (New York, N.Y. : 1991)27(1)131-145(2017 Jan)

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Liu X, Huai J, Endle H, Schl?ter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J
Developmental cell38(3)275-90(2016 08)

Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.
Unichenko P, Kirischuk S, Yang JW, Baumgart J, Roskoden T, Schneider P, Sommer A, Horta G, Radyushkin K, Nitsch R, Vogt J, Luhmann HJ
Cerebral cortex (New York, N.Y. : 1991)26(7)3260-72(2016 07)

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Br?uer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R
Cell138(6)1222-35(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RG-1-deficient (KO) mice have deficits in sensorimotor integration and whisker-based sensory discrimination; genetic ablation of PRG-1 modulates postnatal day 16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4; data strongly indicate that PRG-1 is required for the developmental, activity-dependent fine-tuning of sensory cortex function
Title: Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.

Endogenous PRG3 promotes neurite shaft protrusion and therefore contributes to regulating filopodia formation in immature neurons.
Title: Plasticity-related gene 3 promotes neurite shaft protrusion.

PRG-1 as an important player in the modulatory control of hippocampal excitability dependent on presynaptic LPA(2) receptor signaling.
Title: Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.

The following Plppr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plppr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06620	NM_177664.5 Latest version!	Mus musculus phospholipid phosphatase related 4 (Plppr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plppr4 ( NM_177664.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808332.3 Mus musculus phospholipid phosphatase related 4 (Plppr4), mRNA.

Price & Availability↑

CloneID	OMu06620
Clone ID Related Accession (Same CDS sequence)	NM_177664.5
Accession Version	NM_177664.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2301bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	phospholipid phosphatase-related protein type 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165162.4. On Mar 19, 2008 this sequence version replaced NM_177664.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF541279.1, AK129149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCGCG CTGGTTCCAG CGGTGCCCGC GGGGAATGTG ACATCAGCGG CGCCGGGCGC 
TTGCGGCTGG AGCAGGCAGC TCGCCTCGGT GGCCGCACGG TGCACACCTC GCCCGGGGGA 
GGACTTGGAG CCCGGCAGGC GGCCGGGATG TCGGCGAAGG AGAGGCCAAA GGGCAAAGTG 
ATCAAGGACA GCGTCACCCT CCTGCCCTGT TTTTATTTCG TTGAGTTGCC TATATTGGCA 
TCATCAGTGG TTAGCCTCTA CTTCTTGGAA CTCACAGATG TCTTCAAACC TGTGCACTCT 
GGATTCAGTT GCTATGATAG GAGTCTTAGC ATGCCGTACA TTGAGCCAAC CCAGGAGGCC 
ATACCATTCC TTATGTTGCT TAGCTTGGCT TTTGCTGGAC CTGCAATTAC GATCATGGTG 
GGTGAAGGGA TTCTATACTG CTGCCTCTCC AAAAGAAGAA ACGGAGCTGG ATTGGAGCCT 
AACATCAACG CCGGAGGCTG CAACTTCAAC TCCTTTCTCA GGAGAGCCGT CAGATTCGTT 
GGTGTCCATG TGTTTGGACT GTGCTCCACA GCTCTCATTA CAGATATCAT ACAGCTCTCC 
ACAGGATATC AGGCACCATA CTTTCTGACT GTGTGCAAGC CAAACTATAC CTCTCTGAAT 
GTATCCTGCA AAGAAAACTC CTACATCGTG GAAGATATTT GTTCAGGATC TGACCTTACA 
GTCATCAACA GTGGCAGAAA GTCATTCCCA TCCCAACATG CGACCCTCGC TGCCTTTGCC 
GCTGTGTATG TGTCCATGTA CTTCAATTCC ACATTAACCG ATTCCTCTAA GCTCCTGAAA 
CCTCTCTTGG TCTTCACATT TATCATCTGT GGGATCATCT GCGGACTAAC ACGGATAACT 
CAATATAAGA ACCATCCAGT CGATGTCTAT TGTGGCTTTT TAATAGGAGG AGGAATCGCA 
CTATATTTGG GCCTGTATGC TGTAGGGAAT TTTCTGCCTA GTGAAGACAG TATGCTTCAG 
CACAGAGATG CCCTCAGGTC ACTGACAGAC CTCAATCAAG ACCCCAGCAG GGTTTTATCA 
GCTAAAAATG GTAGCAGTGG TGATGGAATT GCTCACACAG AGGGTATCCT CAACCGAAAC 
CACAGGGATG CAAGCTCCTT GACAAATCTC AAGAGGGCCA ACGCTGACGT AGAAATCATC 
ACTCCTAGGA GCCCCATGGG GAAGGAAAGC ATGGTGACCT TCAGCAACAC GCTGCCCAGG 
GCCAACACCC CCTCCGTGGA AGACCCAGTG AGAAGAAATG CGAGCATCCA TGCCTCTATG 
GATTCTGCCC GGTCCAAACA GCTCCTTACC CAGTGGAAGA GCAAGAATGA GAGTCGTAAG 
ATGTCCCTAC AGGTTATGGA CACTGAACCA GAAGGCCAGT CACCACCCAG GTCCATAGAA 
ATGAGGTCCA GCTCAGAGCC CTCGAGGGTG GGGGTGAACG GAGATCACCA TGTCCCGGGC 
AATCAGTACC TCAAGATACA GCCTGGCACA GTCCCCGGGT GCAACAATAG TATGCCGGGA 
GGGCCACGCG TGTCCATCCA GTCCCGCCCT GGCTCTTCCC AATTGGTGCA CATCCCCGAG 
GAGACCCAGG AAAACATAAG CACCTCGCCC AAGAGCAGTT CTGCGCGAGC CAAGTGGCTG 
AAAGCAGCTG AGAAGACCGT GGCCTGTAAC CGGAGCAACA ACCAGCCACG CATCATGCAG 
GTCATCGCCA TGTCCAAGCA GCAGGGCGTG CTGCAGAGCA GCCCCAAGAA TGCCGAAGGT 
AGCACTGTCA CCTGCACAGG CTCCATCCGC TACAAAACCC TGACTGACCA TGAGCCCAGC 
GGCATCGTGC GAGTGGAGGC TCATCCCGAG AACAACAGGC CCATCATTCA GATCCCGTCG 
TCCACTGAGG GTGAAGGCAG CGGCTCCTGG AAGTGGAAAG CTCCGGAGAA AAGTAGTCTG 
CGCCAAACCT ATGAGCTCAA CGACCTCAAC AGGGACTCAG AAAGCTGTGA GTCCCTCAAA 
GACAGCTTTG GTTCTGGAGA TCGCAAAAGA AGCAACATCG ACAGCAATGA GCACCACCAC 
CACGGCATCA CCACCATCCG AGTGACCCCG GTGGAGGGCA GCGAGATAGG CTCAGAGACG 
CTGTCCGTGT CCTCCTCACG CGACTCCACC CTGCGCAGGA AGGGCAACAT CATCTTGATC 
CCGGAAAGAA GCAACAGCCC TGAAAACACA AGAAACATCT TCTACAAAGG AACCTCCCCC 
ACGCGGGCTT ATAAGGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808332.3
CDS	629..2929
Translation	MQRAGSSGARGECDISGAGRLRLEQAARLGGRTVHTSPGGGLGARQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEDSMLQHRDALRSLTDLNQDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKESMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLTQWKSKNESRKMSLQVMDTEPEGQSPPRSIEMRSSSEPSRVGVNGDHHVPGNQYLKIQPGTVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKTVACNRSNNQPRIMQVIAMSKQQGVLQSSPKNAEGSTVTCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSLRQTYELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSVSSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD

Target ORF information:

RefSeq Version	NM_177664.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipid phosphatase related 4 (Plppr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177664.5

ORF Insert Sequence:

ATGCAGCGCG CTGGTTCCAG CGGTGCCCGC GGGGAATGTG ACATCAGCGG CGCCGGGCGC 
TTGCGGCTGG AGCAGGCAGC TCGCCTCGGT GGCCGCACGG TGCACACCTC GCCCGGGGGA 
GGACTTGGAG CCCGGCAGGC GGCCGGGATG TCGGCGAAGG AGAGGCCAAA GGGCAAAGTG 
ATCAAGGACA GCGTCACCCT CCTGCCCTGT TTTTATTTCG TTGAGTTGCC TATATTGGCA 
TCATCAGTGG TTAGCCTCTA CTTCTTGGAA CTCACAGATG TCTTCAAACC TGTGCACTCT 
GGATTCAGTT GCTATGATAG GAGTCTTAGC ATGCCGTACA TTGAGCCAAC CCAGGAGGCC 
ATACCATTCC TTATGTTGCT TAGCTTGGCT TTTGCTGGAC CTGCAATTAC GATCATGGTG 
GGTGAAGGGA TTCTATACTG CTGCCTCTCC AAAAGAAGAA ACGGAGCTGG ATTGGAGCCT 
AACATCAACG CCGGAGGCTG CAACTTCAAC TCCTTTCTCA GGAGAGCCGT CAGATTCGTT 
GGTGTCCATG TGTTTGGACT GTGCTCCACA GCTCTCATTA CAGATATCAT ACAGCTCTCC 
ACAGGATATC AGGCACCATA CTTTCTGACT GTGTGCAAGC CAAACTATAC CTCTCTGAAT 
GTATCCTGCA AAGAAAACTC CTACATCGTG GAAGATATTT GTTCAGGATC TGACCTTACA 
GTCATCAACA GTGGCAGAAA GTCATTCCCA TCCCAACATG CGACCCTCGC TGCCTTTGCC 
GCTGTGTATG TGTCCATGTA CTTCAATTCC ACATTAACCG ATTCCTCTAA GCTCCTGAAA 
CCTCTCTTGG TCTTCACATT TATCATCTGT GGGATCATCT GCGGACTAAC ACGGATAACT 
CAATATAAGA ACCATCCAGT CGATGTCTAT TGTGGCTTTT TAATAGGAGG AGGAATCGCA 
CTATATTTGG GCCTGTATGC TGTAGGGAAT TTTCTGCCTA GTGAAGACAG TATGCTTCAG 
CACAGAGATG CCCTCAGGTC ACTGACAGAC CTCAATCAAG ACCCCAGCAG GGTTTTATCA 
GCTAAAAATG GTAGCAGTGG TGATGGAATT GCTCACACAG AGGGTATCCT CAACCGAAAC 
CACAGGGATG CAAGCTCCTT GACAAATCTC AAGAGGGCCA ACGCTGACGT AGAAATCATC 
ACTCCTAGGA GCCCCATGGG GAAGGAAAGC ATGGTGACCT TCAGCAACAC GCTGCCCAGG 
GCCAACACCC CCTCCGTGGA AGACCCAGTG AGAAGAAATG CGAGCATCCA TGCCTCTATG 
GATTCTGCCC GGTCCAAACA GCTCCTTACC CAGTGGAAGA GCAAGAATGA GAGTCGTAAG 
ATGTCCCTAC AGGTTATGGA CACTGAACCA GAAGGCCAGT CACCACCCAG GTCCATAGAA 
ATGAGGTCCA GCTCAGAGCC CTCGAGGGTG GGGGTGAACG GAGATCACCA TGTCCCGGGC 
AATCAGTACC TCAAGATACA GCCTGGCACA GTCCCCGGGT GCAACAATAG TATGCCGGGA 
GGGCCACGCG TGTCCATCCA GTCCCGCCCT GGCTCTTCCC AATTGGTGCA CATCCCCGAG 
GAGACCCAGG AAAACATAAG CACCTCGCCC AAGAGCAGTT CTGCGCGAGC CAAGTGGCTG 
AAAGCAGCTG AGAAGACCGT GGCCTGTAAC CGGAGCAACA ACCAGCCACG CATCATGCAG 
GTCATCGCCA TGTCCAAGCA GCAGGGCGTG CTGCAGAGCA GCCCCAAGAA TGCCGAAGGT 
AGCACTGTCA CCTGCACAGG CTCCATCCGC TACAAAACCC TGACTGACCA TGAGCCCAGC 
GGCATCGTGC GAGTGGAGGC TCATCCCGAG AACAACAGGC CCATCATTCA GATCCCGTCG 
TCCACTGAGG GTGAAGGCAG CGGCTCCTGG AAGTGGAAAG CTCCGGAGAA AAGTAGTCTG 
CGCCAAACCT ATGAGCTCAA CGACCTCAAC AGGGACTCAG AAAGCTGTGA GTCCCTCAAA 
GACAGCTTTG GTTCTGGAGA TCGCAAAAGA AGCAACATCG ACAGCAATGA GCACCACCAC 
CACGGCATCA CCACCATCCG AGTGACCCCG GTGGAGGGCA GCGAGATAGG CTCAGAGACG 
CTGTCCGTGT CCTCCTCACG CGACTCCACC CTGCGCAGGA AGGGCAACAT CATCTTGATC 
CCGGAAAGAA GCAACAGCCC TGAAAACACA AGAAACATCT TCTACAAAGG AACCTCCCCC 
ACGCGGGCTT ATAAGGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
Behavioural brain research3361-7(2018 Jan)
Schneider P,Petzold S,Sommer A,Nitsch R,Schwegler H,Vogt J,Roskoden T

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.
Cerebral cortex (New York, N.Y. : 1991)27(1)131-145(2017 Jan)
Vogt J,Kirischuk S,Unichenko P,Schl?ter L,Pelosi A,Endle H,Yang JW,Schmarowski N,Cheng J,Thalman C,Strauss U,Prokudin A,Bharati BS,Aoki J,Chun J,Lutz B,Luhmann HJ,Nitsch R

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Developmental cell38(3)275-90(2016 08)
Liu X,Huai J,Endle H,Schl?ter L,Fan W,Li Y,Richers S,Yurugi H,Rajalingam K,Ji H,Cheng H,Rister B,Horta G,Baumgart J,Berger H,Laube G,Schmitt U,Schmeisser MJ,Boeckers TM,Tenzer S,Vlachos A,Deller T,Nitsch R,Vogt J

Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.
Cerebral cortex (New York, N.Y. : 1991)26(7)3260-72(2016 07)
Unichenko P,Kirischuk S,Yang JW,Baumgart J,Roskoden T,Schneider P,Sommer A,Horta G,Radyushkin K,Nitsch R,Vogt J,Luhmann HJ

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell138(6)1222-35(2009 Sep)
Trimbuch T,Beed P,Vogt J,Schuchmann S,Maier N,Kintscher M,Breustedt J,Schuelke M,Streu N,Kieselmann O,Brunk I,Laube G,Strauss U,Battefeld A,Wende H,Birchmeier C,Wiese S,Sendtner M,Kawabe H,Kishimoto-Suga M,Brose N,Baumgart J,Geist B,Aoki J,Savaskan NE,Br?uer AU,Chun J,Ninnemann O,Schmitz D,Nitsch R

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Plppr4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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