Tff3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tff3
Entrez Gene ID	21786
Full Name	trefoil factor 3, intestinal
Synonyms	ITF,mITF
General protein information	Preferred Names trefoil factor 3, intestinal Names trefoil factor 3 intestinal trefoil factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 A3.3\|17 15.8 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011575.2	NP_035705.1	trefoil factor 3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tff3	NP_035705.1
Rattus norvegicus (Norway rat)	Tff3	NP_037174.2
Pan troglodytes (chimpanzee)	TFF3	XP_531572.2
	LOC722463	XP_001118611.1
Gallus gallus (chicken)	TFF2	XP_004934640.1
Canis lupus familiaris (dog)	TFF3	NP_001002990.1
Bos taurus (cattle)	TFF3	NP_001107981.1
Homo sapiens (human)	TFF3	NP_003217.3

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating
Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE
Diabetes66(11)2789-2799(2017 11)

Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.
Bijeli? N, Belovari T, Tolu?i? Levak M, Baus Lon?ar M
Bosnian journal of basic medical sciences17(3)241-247(2017 Aug)

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
Manko A, Motta JP, Cotton JA, Feener T, Oyeyemi A, Vallance BA, Wallace JL, Buret AG
PloS one12(6)e0178647(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression.
Title: Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.(
Title: Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.

the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases
Title: Inducible gene modification in the gastric epithelium of Tff1-CreERT2, Tff2-rtTA, Tff3-luc mice.

TFF1 and TFF3 peptides might be involved in the complex processes of nervous system development and differentiation and brain plasticity.
Title: Trefoil factor family peptides TFF1 and TFF3 in the nervous tissues of developing mouse embryo.

TFF3 is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia.
Title: Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia.

The following Tff3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tff3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08408	NM_011575.2 Latest version!	Mus musculus trefoil factor 3, intestinal (Tff3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tff3 ( NM_011575.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035705.1 Mus musculus trefoil factor 3, intestinal (Tff3), mRNA.

Price & Availability↑

CloneID	OMu08408
Clone ID Related Accession (Same CDS sequence)	NM_011575.2
Accession Version	NM_011575.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	trefoil factor 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D38410.1 and AC167247.2. On Apr 18, 2009 this sequence version replaced NM_011575.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D38410.1, AK008538.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACCA GAGCCCTCTG GCTAATGCTG TTGGTGGTCC TGGTTGCTGG GTCCTCTGGG 
ATAGCTGCAG ATTACGTTGG CCTGTCTCCA AGCCAATGTA TGGTGCCGGC AAATGTCAGA 
GTGGACTGTG GCTACCCCTC TGTCACATCG GAGCAGTGTA ACAACCGTGG CTGCTGCTTT 
GACTCCAGTA TCCCAAATGT GCCCTGGTGC TTCAAACCTC TGCAGGAGAC AGAATGCACA 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035705.1
CDS	36..281
Translation	METRALWLMLLVVLVAGSSGIAADYVGLSPSQCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKPLQETECTF

Target ORF information:

RefSeq Version	NM_011575.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus trefoil factor 3, intestinal (Tff3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011575.2

ORF Insert Sequence:

ATGGAGACCA GAGCCCTCTG GCTAATGCTG TTGGTGGTCC TGGTTGCTGG GTCCTCTGGG 
ATAGCTGCAG ATTACGTTGG CCTGTCTCCA AGCCAATGTA TGGTGCCGGC AAATGTCAGA 
GTGGACTGTG GCTACCCCTC TGTCACATCG GAGCAGTGTA ACAACCGTGG CTGCTGCTTT 
GACTCCAGTA TCCCAAATGT GCCCTGGTGC TTCAAACCTC TGCAGGAGAC AGAATGCACA 
TTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating
Diabetes66(11)2789-2799(2017 11)
Zhu Y,Zhao S,Deng Y,Gordillo R,Ghaben AL,Shao M,Zhang F,Xu P,Li Y,Cao H,Zagnitko O,Scott DA,Gupta RK,Xing C,Zhang BB,Lin HV,Scherer PE

Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.
Bosnian journal of basic medical sciences17(3)241-247(2017 Aug)
Bijeli? N,Belovari T,Tolu?i? Levak M,Baus Lon?ar M

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
PloS one12(6)e0178647(2017)
Manko A,Motta JP,Cotton JA,Feener T,Oyeyemi A,Vallance BA,Wallace JL,Buret AG