Mxd4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mxd4
Entrez Gene ID	17122
Full Name	Max dimerization protein 4
Synonyms	2810410A03Rik,Mad4,bHLHc12
General protein information	Preferred Names Max dimerization protein 4 Names max dimerization protein 4 max dimerizer 4 max-associated protein 4 max-interacting transcriptional repressor MAD4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 B2\|5 17.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010753.2	NP_034883.2	max dimerization protein 4

Pathways from BioSystems

Homologies

	LOC722345	XP_001118504.2
Danio rerio (zebrafish)	mxd4	XP_687970.6
Canis lupus familiaris (dog)	MXD4	XP_003639025.1
Mus musculus (house mouse)	Mxd4	NP_034883.2
Gallus gallus (chicken)	MXD4	NP_001006460.1
Homo sapiens (human)	MXD4	NP_006445.1
Bos taurus (cattle)	MXD4	NP_001069724.1
Pan troglodytes (chimpanzee)	MXD4	XP_517071.3
Xenopus tropicalis (tropical clawed frog)	mxd4	NP_001096239.1

Gene Ontology
Bibliography

Related articles in PubMed

The transcription factor Mxd4 controls the proliferation of the first blood precursors at?the onset of hematopoietic development in?vitro.
Boros K, Lacaud G, Kouskoff V
Experimental hematology39(11)1090-100(2011 Nov)

OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
Vasilevsky NA, Ruby CE, Hurlin PJ, Weinberg AD
European journal of immunology41(4)1024-34(2011 Apr)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Stevens JD, Roalson EH, Skinner MK
Differentiation; research in biological diversity76(9)1006-22(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

during embryonic hematopoietic differentiation Mxd4 is an important player in the regulation of blood progenitor proliferation, and downregulation of its expression might be required for a proliferative burst preceding lineage specification.
Title: The transcription factor Mxd4 controls the proliferation of the first blood precursors at?the onset of hematopoietic development in?vitro.

Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.

regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc
Title: Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.

The following Mxd4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mxd4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06798	NM_010753.2 Latest version!	Mus musculus Max dimerization protein 4 (Mxd4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mxd4 ( NM_010753.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034883.2 Mus musculus Max dimerization protein 4 (Mxd4), mRNA.

Price & Availability↑

CloneID	OMu06798
Clone ID Related Accession (Same CDS sequence)	NM_010753.2
Accession Version	NM_010753.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	max dimerization protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC011303.1. On Jun 10, 2003 this sequence version replaced NM_010753.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011303.1, AK007824.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCTGA ACTCTCTGCT GCTGCTGTTG GAGGCGGCCG AGTACCTGGA GCGTAGGGAC 
CGAGAGGCCG AGCACGGCTA CGCCTCCGTG CTGCCCTTCG ACGGCGACTT CGCAAGGAAG 
AAAACAAAGA CGGCCGGCCT GGTGCGCAAG GCCCCGAACA ACAGGTCTTC ACACAACGAA 
CTAGAAAAGC ACAGACGAGC TAAACTCAGG CTCTACTTGG AGCAGCTCAA GCAGCTGGTA 
CCCCTGGGCC CTGACAGCAC ACGTCACACT ACTCTGAGCC TTCTGAAGCG TGCTAAGATG 
CACATCAAGA AACTGGAGGA GCAGGACCGC AGGGCACTGA GCATCAAGGA ACAGCTTCAG 
CGGGAACATC GCTTCCTAAA GAGACGTTTG GAGCAGCTAT CAGTGCAGAG TGTAGAGCGT 
GTGCGCACAG ACAGCACTGG CTCTGCTGTG TCCACAGATG ACTCAGAGCA AGAGGTGGAT 
ATAGAGGGCA TGGAGTTTGG CCCTGGGGAG CTGGACAGTG CTGGCAGCAG CAGTGATGCC 
GATGACCACT ACAGCCTACA GAGCAGTGGC TGCAGCGACA GCAGCTATGG GCACCCTTGC 
AGGCGGCCTG GCTGCCCTGG CCTTTCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034883.2
CDS	138..767
Translation	MELNSLLLLLEAAEYLERRDREAEHGYASVLPFDGDFARKKTKTAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQREHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVDIEGMEFGPGELDSAGSSSDADDHYSLQSSGCSDSSYGHPCRRPGCPGLS

Target ORF information:

RefSeq Version	NM_010753.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Max dimerization protein 4 (Mxd4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010753.2

ORF Insert Sequence:

ATGGAGCTGA ACTCTCTGCT GCTGCTGTTG GAGGCGGCCG AGTACCTGGA GCGTAGGGAC 
CGAGAGGCCG AGCACGGCTA CGCCTCCGTG CTGCCCTTCG ACGGCGACTT CGCAAGGAAG 
AAAACAAAGA CGGCCGGCCT GGTGCGCAAG GCCCCGAACA ACAGGTCTTC ACACAACGAA 
CTAGAAAAGC ACAGACGAGC TAAACTCAGG CTCTACTTGG AGCAGCTCAA GCAGCTGGTA 
CCCCTGGGCC CTGACAGCAC ACGTCACACT ACTCTGAGCC TTCTGAAGCG TGCTAAGATG 
CACATCAAGA AACTGGAGGA GCAGGACCGC AGGGCACTGA GCATCAAGGA ACAGCTTCAG 
CGGGAACATC GCTTCCTAAA GAGACGTTTG GAGCAGCTAT CAGTGCAGAG TGTAGAGCGT 
GTGCGCACAG ACAGCACTGG CTCTGCTGTG TCCACAGATG ACTCAGAGCA AGAGGTGGAT 
ATAGAGGGCA TGGAGTTTGG CCCTGGGGAG CTGGACAGTG CTGGCAGCAG CAGTGATGCC 
GATGACCACT ACAGCCTACA GAGCAGTGGC TGCAGCGACA GCAGCTATGG GCACCCTTGC 
AGGCGGCCTG GCTGCCCTGG CCTTTCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The transcription factor Mxd4 controls the proliferation of the first blood precursors at?the onset of hematopoietic development in?vitro.
Experimental hematology39(11)1090-100(2011 Nov)
Boros K,Lacaud G,Kouskoff V

OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
European journal of immunology41(4)1024-34(2011 Apr)
Vasilevsky NA,Ruby CE,Hurlin PJ,Weinberg AD

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Differentiation; research in biological diversity76(9)1006-22(2008 Nov)
Stevens JD,Roalson EH,Skinner MK