Khsrp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Khsrp
Entrez Gene ID	16549
Full Name	KH-type splicing regulatory protein
Synonyms	6330409F21Rik,Fbp2,Fubp2,Ksrp
General protein information	Preferred Names KH-type splicing regulatory protein Names far upstream element-binding protein 2 FUSE-binding protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 D\|17 29.63 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010613.3	NP_034743.3	far upstream element-binding protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KHSRP	NP_003676.2
Rattus norvegicus (Norway rat)	Khsrp	NP_598286.1
Pan troglodytes (chimpanzee)	KHSRP	XP_512315.3
Danio rerio (zebrafish)	khsrp	NP_001082897.1
Xenopus tropicalis (tropical clawed frog)	khsrp	NP_001123831.2
Bos taurus (cattle)	KHSRP	XP_003586314.2
Mus musculus (house mouse)	Khsrp	NP_034743.3

Gene Ontology
Bibliography

Related articles in PubMed

Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
Li N, Cao M, Yi S, Cheng J, Wang L, Tao Y, Wu D, Peng J, Zhang M, Qi P, Zhao J
Biochemical and biophysical research communications495(2)1573-1579(2018 Jan)

KH-type splicing regulatory protein is a new component of chromatoid body.
Zhang H, Wang G, Liu L, Liang X, Lin Y, Lin YY, Chou CF, Liu MF, Huang H, Sun F
Reproduction (Cambridge, England)154(6)723-733(2017 Dec)

Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
K?fer R, Schrick K, Schmidtke L, Montermann E, Hobernik D, Bros M, Chen CY, Kleinert H, Pautz A
Molecular immunology87207-216(2017 Jul)

Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.
Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P
Biochimica et biophysica acta1860(3)291-298(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IFN-gamma production was increased in spleen cells of KSRP(-/-) mice.
Title: Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.
Title: Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.

KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression
Title: KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression.

This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR-150 expression.
Title: KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression.

This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR-145 expression.
Title: KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue.

The following Khsrp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Khsrp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15430	NM_010613.3 Latest version!	Mus musculus KH-type splicing regulatory protein (Khsrp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Khsrp ( NM_010613.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034743.3 Mus musculus KH-type splicing regulatory protein (Khsrp), mRNA.

Price & Availability↑

CloneID	OMu15430
Clone ID Related Accession (Same CDS sequence)	NM_010613.3
Accession Version	NM_010613.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2247bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	far upstream element-binding protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB645370.1, CB247078.1, BC108414.1 and BB258658.1. On Dec 28, 2007 this sequence version replaced NM_010613.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156541.1, AK077415.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGACT ACAACACCGG AGGTCCCCCG CCCGGCCCGC CGCCTCCCGC TGGCGGCGGA 
GGGGGAGCCG CGGGTGCGGG AGGAGGCCCT CCGCCGGGCC CGCCGGGCGC GGGAGACCGG 
GGCGGCGGAG GCCCTGGCGG CGGCGGCCCG GGTGGAGGAG GCGCGTCCGG GGGCCCCTCA 
CAGCCTCCCG GTGGCGGCGG CCCTGGGATC CGCAAGGACG CCTTCGCCGA CGCCGTGCAG 
CGGGCCCGCC AGATTGCAGC CAAAATCGGA GGTGATGCTG CTACCACCGT GAATAACAAC 
ACTCCTGATT TTGGCTTTGG GGGCCAAAAG AGACAGCTGG AAGATGGAGA CCAGCCAGAC 
AGCAAGAAAC TGGCTTCCCA GGGAGACTCG ATTGGTTCTC AACTGGGACC CATCCATCCT 
CCCCCCAGGA CCTCAATGAC AGAAGAGTAT AGGGTTCCGG ATGGCATGGT GGGCTTGATT 
ATTGGCAGAG GTGGTGAGCA GATAAACAAA ATCCAGCAGG ACTCAGGCTG CAAAGTTCAG 
ATCTCACCAG ATAGTGGTGG CCTCCCTGAG CGCAGCGTGT CTCTGACTGG AGCACCTGAG 
TCTGTCCAAA AGGCAAAGAT GATGCTGGAT GACATCGTGT CTCGGGGCCG TGGTGGCCCC 
CCAGGACAGT TTCACGACAA CGCCAATGGG GGTCAGAATG GCACAGTGCA GGAGATCATG 
ATCCCTGCTG GCAAGGCTGG CCTGGTCATT GGTAAAGGTG GAGAGACCAT CAAGCAGCTG 
CAGGAGCGGG CTGGGGTGAA GATGATTTTA ATTCAGGATG GCTCCCAGAA CACAAATGTG 
GACAAGCCAC TGCGGATTAT CGGGGACCCA TACAAAGTAC AGCAAGCCTG TGAGATGGTG 
ATGGACATCC TGCGAGAACG TGACCAAGGT GGCTTTGGGG ACCGCAATGA ATACGGATCT 
CGAGTTGGTG GAGGCATTGA TGTGCCTGTA CCCAGGCATT CAGTTGGTGT AGTCATTGGC 
CGGAGTGGAG AGATGATCAA GAAGATCCAG AATGATGCCG GTGTGCGCAT CCAGTTCAAG 
CAAGATGATG GGACCGGCCC TGAGAAGATT GCTCACATCA TGGGGCCTCC AGATCGGTGT 
GAACACGCAG CCCGGATCAT CAATGACCTC CTCCAGAGTC TTCGGAGTGG GCCCCCGGGT 
CCTCCAGGGG CCCCTGGCAT GCCCCCTGGG GGCAGGGGCC GGGGCCGAGG CCAAGGCAAC 
TGGGGCCCTC CTGGAGGGGA GATGACTTTC TCCATTCCTA CCCATAAGTG TGGGCTGGTC 
ATTGGCCGAG GCGGGGAGAA TGTGAAGGCC ATTAACCAGC AGACAGGCGC CTTTGTGGAA 
ATATCTCGGC AGCTGCCACC CAATGGGGAC CCCAATTTCA AGTTGTTTGT GATCCGGGGA 
TCGCCCCAGC AGATTGACCA TGCAAAGCAG CTCATTGAGG AGAAGATAGA GGGTCCCCTC 
TGCCCAGTTG GACCAGGCCC TGGGGGACCA GGCCCTGCTG GACCCATGGG GCCTTTCAAC 
CCTGGACCCT TCAACCAGGG GCCTCCAGGG GCACCCCCAC ATGCTGGTGG TCCCCCTCCT 
CACCAGTACC CGCCTCAGGG CTGGGGCAAT ACCTACCCCC AGTGGCAGCC ACCTGCCCCT 
CACGACCCAA ACAAAGCTGC TGCAGCGGCT ACAGATCCTA ATGCTGCCTG GGCTGCCTAC 
TACTCTCACT ACTACCAGCA ACCCCCAGGT CCTGTGCCAG GCCCTGCCCC AGCCCCTGCA 
GCCCCACCTG CACAGGGGGA ACCCCCCCAG CCTCCACCCA CTGGCCAATC AGACTACACC 
AAGGCTTGGG AAGAGTATTA CAAAAAAATT GGCCAGCAGC CCCAGCAGCC TGGGGCACCC 
CCACAGCAGG ACTACACCAA GGCCTGGGAG GAGTACTACA AGAAGCAAGC ACAAGTGGCC 
ACTGGTGGGG GTCCTGGAGC ACCCCCTGGC TCCCAGCCTG ATTACAGTGC TGCCTGGGCT 
GAGTATTACA GACAGCAGGC TGCTTACTAC GGACAGACCC CAGGCCCTGG TGGCCCACAG 
CCACCTCCCA CCCAGCAGGG ACAGCAGCAG GCAAGTGGGA ACTGCCACCC TCCTCCTCCT 
CCTTTCTCCT TCCAACCCCC GGCCACCGTC CATCCTGCCT TAGTGGGTAG CGCCGGAAAC 
CCTTTCCCCT GCGGGGTGTG CCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034743.3
CDS	109..2355
Translation	MSDYNTGGPPPGPPPPAGGGGGAAGAGGGPPPGPPGAGDRGGGGPGGGGPGGGGASGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNNTPDFGFGGQKRQLEDGDQPDSKKLASQGDSIGSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRVGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGAPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFVIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPNKAAAAATDPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQASGNCHPPPPPFSFQPPATVHPALVGSAGNPFPCGVCP

Target ORF information:

RefSeq Version	NM_010613.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus KH-type splicing regulatory protein (Khsrp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010613.3

ORF Insert Sequence:

ATGTCGGACT ACAACACCGG AGGTCCCCCG CCCGGCCCGC CGCCTCCCGC TGGCGGCGGA 
GGGGGAGCCG CGGGTGCGGG AGGAGGCCCT CCGCCGGGCC CGCCGGGCGC GGGAGACCGG 
GGCGGCGGAG GCCCTGGCGG CGGCGGCCCG GGTGGAGGAG GCGCGTCCGG GGGCCCCTCA 
CAGCCTCCCG GTGGCGGCGG CCCTGGGATC CGCAAGGACG CCTTCGCCGA CGCCGTGCAG 
CGGGCCCGCC AGATTGCAGC CAAAATCGGA GGTGATGCTG CTACCACCGT GAATAACAAC 
ACTCCTGATT TTGGCTTTGG GGGCCAAAAG AGACAGCTGG AAGATGGAGA CCAGCCAGAC 
AGCAAGAAAC TGGCTTCCCA GGGAGACTCG ATTGGTTCTC AACTGGGACC CATCCATCCT 
CCCCCCAGGA CCTCAATGAC AGAAGAGTAT AGGGTTCCGG ATGGCATGGT GGGCTTGATT 
ATTGGCAGAG GTGGTGAGCA GATAAACAAA ATCCAGCAGG ACTCAGGCTG CAAAGTTCAG 
ATCTCACCAG ATAGTGGTGG CCTCCCTGAG CGCAGCGTGT CTCTGACTGG AGCACCTGAG 
TCTGTCCAAA AGGCAAAGAT GATGCTGGAT GACATCGTGT CTCGGGGCCG TGGTGGCCCC 
CCAGGACAGT TTCACGACAA CGCCAATGGG GGTCAGAATG GCACAGTGCA GGAGATCATG 
ATCCCTGCTG GCAAGGCTGG CCTGGTCATT GGTAAAGGTG GAGAGACCAT CAAGCAGCTG 
CAGGAGCGGG CTGGGGTGAA GATGATTTTA ATTCAGGATG GCTCCCAGAA CACAAATGTG 
GACAAGCCAC TGCGGATTAT CGGGGACCCA TACAAAGTAC AGCAAGCCTG TGAGATGGTG 
ATGGACATCC TGCGAGAACG TGACCAAGGT GGCTTTGGGG ACCGCAATGA ATACGGATCT 
CGAGTTGGTG GAGGCATTGA TGTGCCTGTA CCCAGGCATT CAGTTGGTGT AGTCATTGGC 
CGGAGTGGAG AGATGATCAA GAAGATCCAG AATGATGCCG GTGTGCGCAT CCAGTTCAAG 
CAAGATGATG GGACCGGCCC TGAGAAGATT GCTCACATCA TGGGGCCTCC AGATCGGTGT 
GAACACGCAG CCCGGATCAT CAATGACCTC CTCCAGAGTC TTCGGAGTGG GCCCCCGGGT 
CCTCCAGGGG CCCCTGGCAT GCCCCCTGGG GGCAGGGGCC GGGGCCGAGG CCAAGGCAAC 
TGGGGCCCTC CTGGAGGGGA GATGACTTTC TCCATTCCTA CCCATAAGTG TGGGCTGGTC 
ATTGGCCGAG GCGGGGAGAA TGTGAAGGCC ATTAACCAGC AGACAGGCGC CTTTGTGGAA 
ATATCTCGGC AGCTGCCACC CAATGGGGAC CCCAATTTCA AGTTGTTTGT GATCCGGGGA 
TCGCCCCAGC AGATTGACCA TGCAAAGCAG CTCATTGAGG AGAAGATAGA GGGTCCCCTC 
TGCCCAGTTG GACCAGGCCC TGGGGGACCA GGCCCTGCTG GACCCATGGG GCCTTTCAAC 
CCTGGACCCT TCAACCAGGG GCCTCCAGGG GCACCCCCAC ATGCTGGTGG TCCCCCTCCT 
CACCAGTACC CGCCTCAGGG CTGGGGCAAT ACCTACCCCC AGTGGCAGCC ACCTGCCCCT 
CACGACCCAA ACAAAGCTGC TGCAGCGGCT ACAGATCCTA ATGCTGCCTG GGCTGCCTAC 
TACTCTCACT ACTACCAGCA ACCCCCAGGT CCTGTGCCAG GCCCTGCCCC AGCCCCTGCA 
GCCCCACCTG CACAGGGGGA ACCCCCCCAG CCTCCACCCA CTGGCCAATC AGACTACACC 
AAGGCTTGGG AAGAGTATTA CAAAAAAATT GGCCAGCAGC CCCAGCAGCC TGGGGCACCC 
CCACAGCAGG ACTACACCAA GGCCTGGGAG GAGTACTACA AGAAGCAAGC ACAAGTGGCC 
ACTGGTGGGG GTCCTGGAGC ACCCCCTGGC TCCCAGCCTG ATTACAGTGC TGCCTGGGCT 
GAGTATTACA GACAGCAGGC TGCTTACTAC GGACAGACCC CAGGCCCTGG TGGCCCACAG 
CCACCTCCCA CCCAGCAGGG ACAGCAGCAG GCAAGTGGGA ACTGCCACCC TCCTCCTCCT 
CCTTTCTCCT TCCAACCCCC GGCCACCGTC CATCCTGCCT TAGTGGGTAG CGCCGGAAAC 
CCTTTCCCCT GCGGGGTGTG CCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
Biochemical and biophysical research communications495(2)1573-1579(2018 Jan)
Li N,Cao M,Yi S,Cheng J,Wang L,Tao Y,Wu D,Peng J,Zhang M,Qi P,Zhao J

KH-type splicing regulatory protein is a new component of chromatoid body.
Reproduction (Cambridge, England)154(6)723-733(2017 Dec)
Zhang H,Wang G,Liu L,Liang X,Lin Y,Lin YY,Chou CF,Liu MF,Huang H,Sun F

Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
Molecular immunology87207-216(2017 Jul)
K?fer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.
Biochimica et biophysica acta1860(3)291-298(2017 03)
Moshiri A,Puppo M,Rossi M,Gherzi R,Briata P