Hpx cDNA ORF clone, Mus musculus(house mouse)

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.
Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E
Free radical biology & medicine108452-464(2017 Jul)

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.
Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, N??ez G
Science immunology2(8)(2017 Feb)

Hemopexin plays a novel protective role in alleviating heme-induced oxidative stress, improving inflammatory properties of high-density lipoprotein, macrophage phenotype and function, and inhibiting the development of atherosclerosis in apoE(-/-) mice.
Title: Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.

This study demonstrated that Deletion of the hemopexin aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.

In models for sepsis or burns, mean plasma hemopexin levels were increased above baseline.
Title: Hemopexin in severe inflammation and infection: mouse models and human diseases.

negative regulatory role in Th17-mediated autoimmune inflammation
Title: Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

The findings suggest that hemopexin can modulate the role of hemoglobin in sterile and infectious inflammation
Title: Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation.