Cyp4a10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp4a10
Entrez Gene ID	13117
Full Name	cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms	AI647584,Cyp4a,D4Rp1,Msp-3,RP1
General protein information	Preferred Names cytochrome P450, family 4, subfamily a, polypeptide 10 Names cytochrome P450 4A10 CYPIVA10 cyp4a10 cytochrome P450, 4a10 cytochrome P450-LA-omega 1 cytochrome P452 lauric acid omega-hydroxylase long-chain fatty acid omega-monooxygenase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D1\|4 53.05 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010011.3	NP_034141.3	cytochrome P450 4A10

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYP4A11	NP_000769.2
Pan troglodytes (chimpanzee)	LOC739864	XP_001141506.2
Mus musculus (house mouse)	Cyp4a32	NP_001093651.1
Mus musculus (house mouse)	Cyp4a10	NP_034141.3
Rattus norvegicus (Norway rat)	Cyp4a1	NP_787031.1
Mus musculus (house mouse)	Cyp4a31	NP_964002.2

Gene Ontology
Bibliography

Related articles in PubMed

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X
EMBO reports18(5)841-857(2017 May)

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH
Proceedings of the National Academy of Sciences of the United States of America114(8)E1432-E1440(2017 02)

Peroxisome proliferator-activated receptor-? accelerates ?-chlorofatty acid catabolism.
Palladino EN, Wang WY, Albert CJ, Langhi C, Bald?n ?, Ford DA
Journal of lipid research58(2)317-324(2017 Feb)

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.
Creasy KT, Jiang J, Ren H, Peterson ML, Spear BT
Gene expression17(1)7-17(2016)

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Labialle S, Marty V, Bortolin-Cavaill? ML, Hoareau-Osman M, Prad?re JP, Valet P, Martin PG, Cavaill? J
The EMBO journal33(19)2216-30(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results implicate Cyp4a10 and Cyp4a14 in the regulation of the host inflammatory response to enteropathogenic bacterial infection but not to acute aseptic inflammation.
Title: Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.

High salt triggers possible A(2A)AR-induced relaxation through CYP epoxygenase in both eNOS(+/+) and eNOS(-/-).
Title: Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

Role of CYP4A in reactive oxygen species production ad apoptosis of podocytes in a mouse model of type 1 diabetes.
Title: Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

Results show that disruption of the murine cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10) gene causes a type of hypertension that is, like most human hypertension, dietary salt sensitive.
Title: Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

"Cytochromes P450 4A metabolize arachidonic acid into hydroxyeicosatetraenoic acids (HETEs) that exhibit potent actions on airway smooth muscle tone." p. 181
Title: Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

The following Cyp4a10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp4a10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05380	NM_010011.3 Latest version!	Mus musculus cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp4a10 ( NM_010011.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034141.3 Mus musculus cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10), mRNA.

Price & Availability↑

CloneID	OMu05380
Clone ID Related Accession (Same CDS sequence)	NM_010011.3
Accession Version	NM_010011.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	cytochrome P450 4A10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002528.1 and AI042822.1. On Apr 21, 2009 this sequence version replaced NM_010011.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK002528.1, BC051049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGTCT CTGCTCTAAG CCCAACCCGA TTTGCAGACA GCCTCTCTGG CTTCCTCCAA 
GTGGCCTCTG TGCTCGGTCT GCTCCTGCTG CTGGTGAAAG CTGTCCAGTT CTACCTCCAC 
AGGCAATGGC TACTCAAGGC TTTCCAGCAG TTCCCATCAC CTCCTTTTCA CTGGTTCTTT 
GGGCATGAGA AGTTCAAAGG TGACCAAGAA CTACAGGAAA TTGTGTCGTG CATAGAGAAC 
TTCCCAAGTG CCTTTCCTAG ATGGTTCTGG GGAAGCAAGG CCTACTTAAC TGTCTATGAC 
CCTGACTACA TGAAAGTGAT TCTGGGGCGA TCAGATCCAA AGGCTAATGG TGCGTACAGA 
TTGCTAGCTC CTTGGATTGG GTATGGTTTG CTCTTGTTGA ATGGACAGCC ATGGTTCCAG 
CACAGGAGGA TGCTAACCCC AGCCTTCCAC TATGACATTC TGAAACCCTA TGTGAAAAAC 
ATGGCCGACT CCATTCGATT GATGCTAGAC AAATGGGAAC GGCTGGCTGA TCAGGACTCC 
TCTATAGAGA TCTTTCAACA CATCTCCTTA ATGACCCTAG ACACTGTCAT GAAATGTGCC 
TTCAGCCACA AGGGCAGTGT TCAGGTAGAT GGAAATTACA GGACCTACCT CCAGGCCATT 
GGGGACTTGA ATAACCTATT TCACTCCCGT GTGAGGAATA TCTTTCATCA GAATGATACC 
ATCTACAAAC TTTCTTCCAA TGGCCGCTTG GCCAAACAAG CTTGTCAACT TGCCCATGAT 
CACACAGATG GAGTGATCAA GCTGAGAAAG GATCAGCTGC AGGATGAGGG AGAGCTGGAA 
AAGATCAAGA AGAAGAGACG TTTGGATTTT CTGGATATCC TTTTATTTGC CAGAATGGAG 
AATGGGGACA GCATGTCTGA CAAGGACCTA CGTGCTGAGG TGGACACATT CATGTTCGAG 
GGCCATGACA CCACAGCCAG TGGAGTCTCC TGGATCTTCT ATGCTCTGGC CACACACCCT 
GATCACCAAC AGAGATGCAG AGAGGAAGTT CAGAGCCTCC TGGGGGATGG ATCCTCTATC 
ACCTGGGATC ACCTAGACCA GATTCCCTAT ACCACAATGT GCATCAAGGA GGCCCTAAGG 
CTCTACCCAC CTGTCCCAGG CATTGTCAGA GAACTCAGTA CATCTGTCAC CTTCCCTGAT 
GGACGCTCTT TACCCAAAGG TGTCCAGGTC ACACTCTCCA TTTATGGTCT CCACCACAAC 
CCGAAGGTGT GGCCAAATCC AGAGGTGTTT GACCCTTCCA GGTTTGCACC AGACTCTCCC 
CGACACAGCC ACTCATTCCT GCCCTTCTCA GGAGGAGCCA GGAACTGCAT TGGGAAACAA 
TTTGCTATGA GTGAGCTGAA GGTGATTGTG GCCCTGACAC TGCTCCGCTT CGAACTACTG 
CCAGATCCTA CCAGGGTCCC CATGCCCTTA GCCCGACTTG TGCTGAAGTC CAAAAATGGG 
ATCTACCTAC ATCTCAAGAA GCTCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034141.3
CDS	36..1565
Translation	MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH

Target ORF information:

RefSeq Version	NM_010011.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010011.3

ORF Insert Sequence:

ATGAGTGTCT CTGCTCTAAG CCCAACCCGA TTTGCAGACA GCCTCTCTGG CTTCCTCCAA 
GTGGCCTCTG TGCTCGGTCT GCTCCTGCTG CTGGTGAAAG CTGTCCAGTT CTACCTCCAC 
AGGCAATGGC TACTCAAGGC TTTCCAGCAG TTCCCATCAC CTCCTTTTCA CTGGTTCTTT 
GGGCATGAGA AGTTCAAAGG TGACCAAGAA CTACAGGAAA TTGTGTCGTG CATAGAGAAC 
TTCCCAAGTG CCTTTCCTAG ATGGTTCTGG GGAAGCAAGG CCTACTTAAC TGTCTATGAC 
CCTGACTACA TGAAAGTGAT TCTGGGGCGA TCAGATCCAA AGGCTAATGG TGCGTACAGA 
TTGCTAGCTC CTTGGATTGG GTATGGTTTG CTCTTGTTGA ATGGACAGCC ATGGTTCCAG 
CACAGGAGGA TGCTAACCCC AGCCTTCCAC TATGACATTC TGAAACCCTA TGTGAAAAAC 
ATGGCCGACT CCATTCGATT GATGCTAGAC AAATGGGAAC GGCTGGCTGA TCAGGACTCC 
TCTATAGAGA TCTTTCAACA CATCTCCTTA ATGACCCTAG ACACTGTCAT GAAATGTGCC 
TTCAGCCACA AGGGCAGTGT TCAGGTAGAT GGAAATTACA GGACCTACCT CCAGGCCATT 
GGGGACTTGA ATAACCTATT TCACTCCCGT GTGAGGAATA TCTTTCATCA GAATGATACC 
ATCTACAAAC TTTCTTCCAA TGGCCGCTTG GCCAAACAAG CTTGTCAACT TGCCCATGAT 
CACACAGATG GAGTGATCAA GCTGAGAAAG GATCAGCTGC AGGATGAGGG AGAGCTGGAA 
AAGATCAAGA AGAAGAGACG TTTGGATTTT CTGGATATCC TTTTATTTGC CAGAATGGAG 
AATGGGGACA GCATGTCTGA CAAGGACCTA CGTGCTGAGG TGGACACATT CATGTTCGAG 
GGCCATGACA CCACAGCCAG TGGAGTCTCC TGGATCTTCT ATGCTCTGGC CACACACCCT 
GATCACCAAC AGAGATGCAG AGAGGAAGTT CAGAGCCTCC TGGGGGATGG ATCCTCTATC 
ACCTGGGATC ACCTAGACCA GATTCCCTAT ACCACAATGT GCATCAAGGA GGCCCTAAGG 
CTCTACCCAC CTGTCCCAGG CATTGTCAGA GAACTCAGTA CATCTGTCAC CTTCCCTGAT 
GGACGCTCTT TACCCAAAGG TGTCCAGGTC ACACTCTCCA TTTATGGTCT CCACCACAAC 
CCGAAGGTGT GGCCAAATCC AGAGGTGTTT GACCCTTCCA GGTTTGCACC AGACTCTCCC 
CGACACAGCC ACTCATTCCT GCCCTTCTCA GGAGGAGCCA GGAACTGCAT TGGGAAACAA 
TTTGCTATGA GTGAGCTGAA GGTGATTGTG GCCCTGACAC TGCTCCGCTT CGAACTACTG 
CCAGATCCTA CCAGGGTCCC CATGCCCTTA GCCCGACTTG TGCTGAAGTC CAAAAATGGG 
ATCTACCTAC ATCTCAAGAA GCTCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
EMBO reports18(5)841-857(2017 May)
Lu J,Xu Q,Ji M,Guo X,Xu X,Fargo DC,Li X

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
Proceedings of the National Academy of Sciences of the United States of America114(8)E1432-E1440(2017 02)
Chen S,Lu W,Yueh MF,Rettenmeier E,Liu M,Auwerx J,Yu RT,Evans RM,Wang K,Karin M,Tukey RH

Peroxisome proliferator-activated receptor-? accelerates ?-chlorofatty acid catabolism.
Journal of lipid research58(2)317-324(2017 Feb)
Palladino EN,Wang WY,Albert CJ,Langhi C,Bald?n ?,Ford DA

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.
Gene expression17(1)7-17(2016)
Creasy KT,Jiang J,Ren H,Peterson ML,Spear BT

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
The EMBO journal33(19)2216-30(2014 Oct)
Labialle S,Marty V,Bortolin-Cavaill? ML,Hoareau-Osman M,Prad?re JP,Valet P,Martin PG,Cavaill? J