Cd7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd7
Entrez Gene ID	12516
Full Name	CD7 antigen
General protein information	Preferred Names CD7 antigen Names T-cell antigen CD7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 E2\|11 84.85 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009854.2	NP_033984.1	T-cell antigen CD7 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CD7	XP_001167912.1
Rattus norvegicus (Norway rat)	Cd7	NP_001100544.1
Mus musculus (house mouse)	Cd7	NP_033984.1
Homo sapiens (human)	CD7	NP_006128.1
Canis lupus familiaris (dog)	CD7	XP_849528.1
Bos taurus (cattle)	CD7	NP_001092392.1

Gene Ontology
Bibliography

Related articles in PubMed

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.
Gomes-Silva D, Srinivasan M, Sharma S, Lee CM, Wagner DL, Davis TH, Rouce RH, Bao G, Brenner MK, Mamonkin M
Blood130(3)285-296(2017 07)

Secreted and transmembrane 1A is a novel co-stimulatory ligand.
Howie D, Garcia Rueda H, Brown MH, Waldmann H
PloS one8(9)e73610(2013)

CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation.
Koh HS, Lee C, Lee KS, Ham CS, Seong RH, Kim SS, Jeon SH
Biochemical and biophysical research communications370(1)149-53(2008 May)

Murine CD7 shares antigenic cross-reactivity with HSP-60.
Howard BA, Sempowski GD, Scearce RM, Liao HX, Lee DM, Lam GK, Chen H, Fadden P, Haystead T, Haynes BF
Hybridoma (2005)27(2)81-9(2008 Apr)

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.
Hao QL, George AA, Zhu J, Barsky L, Zielinska E, Wang X, Price M, Ge S, Crooks GM
Blood111(3)1318-26(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD7 chimeric antigen receptor T cells have robust activity against T-cell malignancies in vitro and in vivo.
Title: CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.

Data indicate the tissue ligand SECTM1A (Secreted and transmembrane1A) as an alternative CD7 ligand.
Title: Secreted and transmembrane 1A is a novel co-stimulatory ligand.

The regulation of CD7 gene expression through NF-kappaB activation induced by TCR/CD28 might have significant implications for T-cell homeostasis.
Title: CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation.

Molecular mimicry of murine CD7 with HSP-60 is demonstrated; CD7 may regulate HSP-60 expression in mouse small intestine.
Title: Murine CD7 shares antigenic cross-reactivity with HSP-60.

differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor
Title: Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.

The following Cd7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04985	NM_009854.2 Latest version!	Mus musculus CD7 antigen (Cd7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd7 ( NM_009854.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033984.1 Mus musculus CD7 antigen (Cd7), mRNA.

Price & Availability↑

CloneID	OMu04985
Clone ID Related Accession (Same CDS sequence)	NM_009854.2
Accession Version	NM_009854.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	T-cell antigen CD7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL662887.13, AK136444.1 and AI852832.1. On Apr 5, 2011 this sequence version replaced NM_009854.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024376.1, AK154339.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849380, SAMN00849383 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCAGC AGGCAGTGCT GGCTTTGCTG CTTACACTGG CCGGAATCCT GCCTGGCCCC 
CTGGATGCCC AAGACGTACA CCAGTCCCCC CGACTCACGA TTGCCTCTGA GGGGGATTCT 
GTCAACATCA CCTGCTCTAC AAGAGGGCAC CTGGAAGGGA TCTTAATGAA GAAGATCTGG 
CCTCAGGCTT ACAATGTGAT TTACTTTGAA GACCGGCAGG AGCCCACAGT AGACAGGACC 
TTCTCAGGCC GAATTAATTT CTCTGGTTCC CAGAAGAACC TGACCATCAC CATAAGCTCC 
CTCCAGCTGG CAGACACTGG AGACTACACC TGCGAGGCTG TCAGGAAAGT CAGTGCCCGT 
GGCTTGTTCA CCACGGTTGT GGTGAAAGAA AAATCATCCC AAGAAGCATA CAGATCCCAG 
GAACCTCTGC AGACATCATT TTCCTTCCCA GCTGCCATTG CTGTAGGCTT CTTCTTCACC 
GGGCTGCTCC TTGGGGTGGT GTGCAGCATG CTGAGGAAGA TACAGATCAA GAAACTGTGT 
GCCTCAGGGA TTAAGGAATC TCCGTGCGTA GTGTATGAAG ACATGTCCTA CAGCAACCGC 
AAGACGCCAT GCATCCCCAA CCAGTACCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033984.1
CDS	114..746
Translation	MTQQAVLALLLTLAGILPGPLDAQDVHQSPRLTIASEGDSVNITCSTRGHLEGILMKKIWPQAYNVIYFEDRQEPTVDRTFSGRINFSGSQKNLTITISSLQLADTGDYTCEAVRKVSARGLFTTVVVKEKSSQEAYRSQEPLQTSFSFPAAIAVGFFFTGLLLGVVCSMLRKIQIKKLCASGIKESPCVVYEDMSYSNRKTPCIPNQYQ

Target ORF information:

RefSeq Version	NM_009854.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD7 antigen (Cd7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009854.2

ORF Insert Sequence:

ATGACTCAGC AGGCAGTGCT GGCTTTGCTG CTTACACTGG CCGGAATCCT GCCTGGCCCC 
CTGGATGCCC AAGACGTACA CCAGTCCCCC CGACTCACGA TTGCCTCTGA GGGGGATTCT 
GTCAACATCA CCTGCTCTAC AAGAGGGCAC CTGGAAGGGA TCTTAATGAA GAAGATCTGG 
CCTCAGGCTT ACAATGTGAT TTACTTTGAA GACCGGCAGG AGCCCACAGT AGACAGGACC 
TTCTCAGGCC GAATTAATTT CTCTGGTTCC CAGAAGAACC TGACCATCAC CATAAGCTCC 
CTCCAGCTGG CAGACACTGG AGACTACACC TGCGAGGCTG TCAGGAAAGT CAGTGCCCGT 
GGCTTGTTCA CCACGGTTGT GGTGAAAGAA AAATCATCCC AAGAAGCATA CAGATCCCAG 
GAACCTCTGC AGACATCATT TTCCTTCCCA GCTGCCATTG CTGTAGGCTT CTTCTTCACC 
GGGCTGCTCC TTGGGGTGGT GTGCAGCATG CTGAGGAAGA TACAGATCAA GAAACTGTGT 
GCCTCAGGGA TTAAGGAATC TCCGTGCGTA GTGTATGAAG ACATGTCCTA CAGCAACCGC 
AAGACGCCAT GCATCCCCAA CCAGTACCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.
Blood130(3)285-296(2017 07)
Gomes-Silva D,Srinivasan M,Sharma S,Lee CM,Wagner DL,Davis TH,Rouce RH,Bao G,Brenner MK,Mamonkin M

Secreted and transmembrane 1A is a novel co-stimulatory ligand.
PloS one8(9)e73610(2013)
Howie D,Garcia Rueda H,Brown MH,Waldmann H

CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation.
Biochemical and biophysical research communications370(1)149-53(2008 May)
Koh HS,Lee C,Lee KS,Ham CS,Seong RH,Kim SS,Jeon SH

Murine CD7 shares antigenic cross-reactivity with HSP-60.
Hybridoma (2005)27(2)81-9(2008 Apr)
Howard BA,Sempowski GD,Scearce RM,Liao HX,Lee DM,Lam GK,Chen H,Fadden P,Haystead T,Haynes BF

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.
Blood111(3)1318-26(2008 Feb)
Hao QL,George AA,Zhu J,Barsky L,Zielinska E,Wang X,Price M,Ge S,Crooks GM