Caml cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Caml
Entrez Gene ID	12328
Full Name	calcium modulating ligand
Synonyms	AI385748,Camlg
General protein information	Preferred Names calcium modulating ligand Names calcium signal-modulating cyclophilin ligand
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 B1\|13 30.06 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007596.2	NP_031622.2	calcium signal-modulating cyclophilin ligand

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CAMLG	XP_518170.2
Rattus norvegicus (Norway rat)	Camlg	NP_445786.1
Danio rerio (zebrafish)	camlg	NP_996973.2
Homo sapiens (human)	CAMLG	NP_001736.1
Bos taurus (cattle)	CAMLG	NP_001032714.1
	CAMLG	XP_001109668.1
Mus musculus (house mouse)	Caml	NP_031622.2
Gallus gallus (chicken)	CAMLG	NP_990293.1
Xenopus tropicalis (tropical clawed frog)	camlg	NP_001016600.2
Canis lupus familiaris (dog)	CAMLG	XP_531910.2

Gene Ontology
Bibliography

Related articles in PubMed

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ
Journal of immunology (Baltimore, Md. : 1950)197(12)4529-4534(2016 Dec)

Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.
Chan SL, Lindquist LD, Hansen MJ, Girtman MA, Pease LR, Bram RJ
Journal of immunology (Baltimore, Md. : 1950)195(12)5648-56(2015 Dec)

Essential role for CAML in follicular B cell survival and homeostasis.
Zane NA, Gundelach JH, Lindquist LD, Bram RJ
Journal of immunology (Baltimore, Md. : 1950)188(7)3009-18(2012 Apr)

Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.
Bryda EC, Johnson NT, Ohlemiller KK, Besch-Williford CL, Moore E, Bram RJ
Mammalian genome : official journal of the International Mammalian Genome Society23(3-4)270-6(2012 Apr)

Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
Zhang W, Savelieva KV, Suwanichkul A, Small DL, Kirkpatrick LL, Xu N, Lanthorn TH, Ye GL
PloS one5(6)e11261(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis
Title: Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

supports T cell survival and cell division downstream of T cell activation
Title: Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.

Conditional deletion of CAML in CD19-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Title: Essential role for CAML in follicular B cell survival and homeostasis.

Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Title: Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.

results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
Title: Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.

The following Caml gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Caml cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00441	NM_007596.2 Latest version!	Mus musculus calcium modulating ligand (Caml), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Caml ( NM_007596.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031622.2 Mus musculus calcium modulating ligand (Caml), mRNA.

Price & Availability↑

CloneID	OMu00441
Clone ID Related Accession (Same CDS sequence)	NM_007596.2
Accession Version	NM_007596.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	calcium signal-modulating cyclophilin ligand
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002895.1, CF915604.1 and BY632386.1. On Oct 26, 2005 this sequence version replaced NM_007596.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK002895.1, BC005688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCGG TGCCTGCGGC CACGGACGGC GGGGAAAGAC CCGCGACGCC GTCGGGCCTG 
TCGGCTTCTC AGCGGCGAGC GGAGCTGCGG AGGAGAAAGC TGCTCATGAA CTCCGAGCAA 
CGCATCAACC GGATCATGGG CTTTCACAGG CCCGGGAGCG GCTCGGAAGA AGAAAATCAA 
ACAAAATCAA AGCCACAGGA CAGTGACAAA CTGAACTCCC TCAGCATCCC TTCAGTTTCA 
AAGAGGGTAG TGCTTGGTGA TTCAGTCGAT GGAGGAGGAG CTGACCAGCT CGGTGGTGTG 
GCAGAAGTCA GGGGAACCCA GCTGGGAGAC AAACTGGACT CATTCATTAA AGCACCAGAG 
TGCAGTAGTA AGGATGGAGC TGAGCTCCGG CAGCGGACCA GAGGTGACCT GACAGCAGAC 
CCGGCCCAGA GGGCTTCTCA CCACGGCCTA GAACAGTACC TTTCCAGATT CGAAGAAGCG 
ATGAAGTTGC GCAAACAGCT GATCAGCGAG AAACCCAGCC AGGAAGATGG AAGTACCGCG 
GAAGAGTTTG ACTCTTTTCG AATATTTCGA TTGGTGGGGT GCGCTCTGCT CGCTCTTGGC 
GTCAGAGCCT TTGTTTGCAA ATATTTGTCT ATATTCGCTC CATTTCTCAC TTTGCAGCTT 
GCATACATGG GACTATACAA ATATTTTCCT AAGGGCGAGA AGAAGGTGAA GACGACGGTG 
CTGACAGCTG CGCTGTTGCT GTCTGGGATT CCCGCTGAGG TGATCAACCG GTCCATGGAC 
ACCTACAGCA AGATGGGCGA GGTCTTCACG GACCTCTGCG TCTACTTCTT CACCTTCATT 
TTCTGTCATG AACTGCTTGA TTACTGGGGT CCTGAAGTAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031622.2
CDS	87..971
Translation	MEPVPAATDGGERPATPSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGSEEENQTKSKPQDSDKLNSLSIPSVSKRVVLGDSVDGGGADQLGGVAEVRGTQLGDKLDSFIKAPECSSKDGAELRQRTRGDLTADPAQRASHHGLEQYLSRFEEAMKLRKQLISEKPSQEDGSTAEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKGEKKVKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGPEVP

Target ORF information:

RefSeq Version	NM_007596.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium modulating ligand (Caml), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007596.2

ORF Insert Sequence:

ATGGAGCCGG TGCCTGCGGC CACGGACGGC GGGGAAAGAC CCGCGACGCC GTCGGGCCTG 
TCGGCTTCTC AGCGGCGAGC GGAGCTGCGG AGGAGAAAGC TGCTCATGAA CTCCGAGCAA 
CGCATCAACC GGATCATGGG CTTTCACAGG CCCGGGAGCG GCTCGGAAGA AGAAAATCAA 
ACAAAATCAA AGCCACAGGA CAGTGACAAA CTGAACTCCC TCAGCATCCC TTCAGTTTCA 
AAGAGGGTAG TGCTTGGTGA TTCAGTCGAT GGAGGAGGAG CTGACCAGCT CGGTGGTGTG 
GCAGAAGTCA GGGGAACCCA GCTGGGAGAC AAACTGGACT CATTCATTAA AGCACCAGAG 
TGCAGTAGTA AGGATGGAGC TGAGCTCCGG CAGCGGACCA GAGGTGACCT GACAGCAGAC 
CCGGCCCAGA GGGCTTCTCA CCACGGCCTA GAACAGTACC TTTCCAGATT CGAAGAAGCG 
ATGAAGTTGC GCAAACAGCT GATCAGCGAG AAACCCAGCC AGGAAGATGG AAGTACCGCG 
GAAGAGTTTG ACTCTTTTCG AATATTTCGA TTGGTGGGGT GCGCTCTGCT CGCTCTTGGC 
GTCAGAGCCT TTGTTTGCAA ATATTTGTCT ATATTCGCTC CATTTCTCAC TTTGCAGCTT 
GCATACATGG GACTATACAA ATATTTTCCT AAGGGCGAGA AGAAGGTGAA GACGACGGTG 
CTGACAGCTG CGCTGTTGCT GTCTGGGATT CCCGCTGAGG TGATCAACCG GTCCATGGAC 
ACCTACAGCA AGATGGGCGA GGTCTTCACG GACCTCTGCG TCTACTTCTT CACCTTCATT 
TTCTGTCATG AACTGCTTGA TTACTGGGGT CCTGAAGTAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)197(12)4529-4534(2016 Dec)
Jackson SW,Scharping NE,Jacobs HM,Wang S,Chait A,Rawlings DJ

Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)195(12)5648-56(2015 Dec)
Chan SL,Lindquist LD,Hansen MJ,Girtman MA,Pease LR,Bram RJ

Essential role for CAML in follicular B cell survival and homeostasis.
Journal of immunology (Baltimore, Md. : 1950)188(7)3009-18(2012 Apr)
Zane NA,Gundelach JH,Lindquist LD,Bram RJ

Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.
Mammalian genome : official journal of the International Mammalian Genome Society23(3-4)270-6(2012 Apr)
Bryda EC,Johnson NT,Ohlemiller KK,Besch-Williford CL,Moore E,Bram RJ

Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
PloS one5(6)e11261(2010 Jun)
Zhang W,Savelieva KV,Suwanichkul A,Small DL,Kirkpatrick LL,Xu N,Lanthorn TH,Ye GL