Barx2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Barx2
Entrez Gene ID	12023
Full Name	BarH-like homeobox 2
Synonyms	2310006E12Rik,Barx2b
General protein information	Preferred Names BarH-like homeobox 2 Names homeobox protein BarH-like 2 homeodomain transcription factor BARX2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_013800.2	NP_038828.2	homeobox protein BarH-like 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	BARX2	NP_003649.2
Pan troglodytes (chimpanzee)	BARX2	XP_522247.2
Mus musculus (house mouse)	Barx2	NP_038828.2
Xenopus tropicalis (tropical clawed frog)	barx2	XP_002934925.2
Canis lupus familiaris (dog)	BARX2	XP_851519.1
Rattus norvegicus (Norway rat)	Barx2	XP_003750505.1
Danio rerio (zebrafish)	barx2	XP_001342044.1
	BARX2	XP_001113572.1
Bos taurus (cattle)	BARX2	NP_001094736.1
Gallus gallus (chicken)	BARX2	NP_990227.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with ?-Catenin and Chromatin Remodelling.
Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R
Stem cells (Dayton, Ohio)34(8)2169-82(2016 08)

The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea.
Gage PJ, Kuang C, Zacharias AL
Developmental dynamics : an official publication of the American Association of Anatomists243(11)1391-400(2014 Nov)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals.
Title: Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with ?-Catenin and Chromatin Remodelling.

antagonism between Barx2 and Pax7 in regulation of Wnt signaling may help mediate the switch from myoblast proliferation to differentiation.
Title: Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation.

Barx2 is an important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation.
Title: Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.

data suggest a functional network involving Barx2, Fgf10 and matrix metalloproteinases that plays an essential role in regulating branching morphogenesis of the ocular glands.
Title: Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling.

Study show that Barx2 regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation.
Title: The homeobox transcription factor Barx2 regulates plasticity of young primary myofibers.

The following Barx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Barx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09995	NM_013800.2 Latest version!	Mus musculus BarH-like homeobox 2 (Barx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Barx2 ( NM_013800.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038828.2 Mus musculus BarH-like homeobox 2 (Barx2), mRNA.

Price & Availability↑

CloneID	OMu09995
Clone ID Related Accession (Same CDS sequence)	NM_013800.2
Accession Version	NM_013800.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Mus musculus(house mouse)
Product	homeobox protein BarH-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT030724.7. On Aug 9, 2007 this sequence version replaced NM_013800.1. Sequence Note: This RefSeq record was created using genomic sequence from the reference strain C57BL/6J, because quality transcripts from the reference strain were not available for the full length of the gene. The genomic coordinates used for the transcript were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACTGCC ACGCGGAACT GAGGCTGAGC TCACCCGGCC AGCTCAAAGC AGCCAGGCGG 
CGCTACAAGA CTTTCATGAT CGATGAGATC CTCTCCAAGG AGACCTGCGA CTACTTTGAG 
AAACTTTCCC TCTACTCTGT GTGCCCGTCG CTGGTGGTGC GACCCAAGCC CCTGCACTCT 
TGTACCGGTT CCCCTTCCCT ACGGGCATAT CCTCTCCTGT CTGTGATCAC CCGGCAGCCC 
ACAGTCATCT CCCACCTGGT TCCCACCGGC TCGGGACTCA CCCCAGTGTT AACTCGCCAT 
CCAGTCGCCG CTGCGGAGGC GGCGGCTGCT GCTGCTGAGA CCCCTGGTGG TGAGGCGTTA 
GCCAGCAGCG AGTCAGAGAC AGAACAGCCC ACGCCCAGGC AGAAGAAACC ACGCAGAAGT 
CGCACCATCT TCACCGAGCT GCAGCTCATG GGCCTAGAGA AGAAATTCCA GAAGCAGAAG 
TATTTGTCTA CCCCAGACAG GTTGGACTTG GCCCAGTCTC TGGGACTCAC TCAGCTGCAA 
GTGAAGACTT GGTATCAGAA TCGCAGGATG AAATGGAAGA AGATGGTCCT TAAAGGTGGA 
CAGGAAGCAC CCACAAAACC TAAGGGGCGC CCTAAGAAGA ATTCCATTCC CACATCAGAG 
GAGATTGAAG CTGAAGAGAA GATGAACAGC CAGGCTCAGA GCCAGGAGCT GCTGGAATCC 
TCGGAGAGAC AGGAGGAGCC CTGTGATACC CAGGAGCCCA AAGCGTGCCT TGTCCCCTTG 
GAGGTGGCAG AACCTATTCA CCAGCCCCAG GAGTTATCAG AAGCTTCCTC TGAACCCCCA 
CCATTAAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038828.2
CDS	195..1046
Translation	MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPTGSGLTPVLTRHPVAAAEAAAAAAETPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQSQELLESSERQEEPCDTQEPKACLVPLEVAEPIHQPQELSEASSEPPPLS

Target ORF information:

RefSeq Version	NM_013800.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus BarH-like homeobox 2 (Barx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013800.2

ORF Insert Sequence:

ATGCACTGCC ACGCGGAACT GAGGCTGAGC TCACCCGGCC AGCTCAAAGC AGCCAGGCGG 
CGCTACAAGA CTTTCATGAT CGATGAGATC CTCTCCAAGG AGACCTGCGA CTACTTTGAG 
AAACTTTCCC TCTACTCTGT GTGCCCGTCG CTGGTGGTGC GACCCAAGCC CCTGCACTCT 
TGTACCGGTT CCCCTTCCCT ACGGGCATAT CCTCTCCTGT CTGTGATCAC CCGGCAGCCC 
ACAGTCATCT CCCACCTGGT TCCCACCGGC TCGGGACTCA CCCCAGTGTT AACTCGCCAT 
CCAGTCGCCG CTGCGGAGGC GGCGGCTGCT GCTGCTGAGA CCCCTGGTGG TGAGGCGTTA 
GCCAGCAGCG AGTCAGAGAC AGAACAGCCC ACGCCCAGGC AGAAGAAACC ACGCAGAAGT 
CGCACCATCT TCACCGAGCT GCAGCTCATG GGCCTAGAGA AGAAATTCCA GAAGCAGAAG 
TATTTGTCTA CCCCAGACAG GTTGGACTTG GCCCAGTCTC TGGGACTCAC TCAGCTGCAA 
GTGAAGACTT GGTATCAGAA TCGCAGGATG AAATGGAAGA AGATGGTCCT TAAAGGTGGA 
CAGGAAGCAC CCACAAAACC TAAGGGGCGC CCTAAGAAGA ATTCCATTCC CACATCAGAG 
GAGATTGAAG CTGAAGAGAA GATGAACAGC CAGGCTCAGA GCCAGGAGCT GCTGGAATCC 
TCGGAGAGAC AGGAGGAGCC CTGTGATACC CAGGAGCCCA AAGCGTGCCT TGTCCCCTTG 
GAGGTGGCAG AACCTATTCA CCAGCCCCAG GAGTTATCAG AAGCTTCCTC TGAACCCCCA 
CCATTAAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with ?-Catenin and Chromatin Remodelling.
Stem cells (Dayton, Ohio)34(8)2169-82(2016 08)
Hulin JA,Nguyen TD,Cui S,Marri S,Yu RT,Downes M,Evans RM,Makarenkova H,Meech R

The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea.
Developmental dynamics : an official publication of the American Association of Anatomists243(11)1391-400(2014 Nov)
Gage PJ,Kuang C,Zacharias AL

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Barx2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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