ITM2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITM2A
Entrez Gene ID	9452
Full Name	integral membrane protein 2A
Synonyms	BRICD2A,E25A
General protein information	Preferred Names integral membrane protein 2A Names integral membrane protein 2A BRICHOS domain containing 2A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Disorder MIM:	300222

mRNA and Protein(s)

mRNA	Protein	Name
NM_004867.5	NP_004858.1	integral membrane protein 2A isoform 1
NM_004867.4	NP_004858.1	integral membrane protein 2A isoform 1
NM_001171581.1	NP_001165052.1	integral membrane protein 2A isoform 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	itm2a	NP_001004833.1
Rattus norvegicus (Norway rat)	Itm2a	NP_001020883.1
Gallus gallus (chicken)	ITM2A	NP_001012589.1
Homo sapiens (human)	ITM2A	NP_004858.1
	ITM2A	XP_001102547.1
Bos taurus (cattle)	ITM2A	XP_003588196.1
Pan troglodytes (chimpanzee)	ITM2A	XP_001145755.2
Mus musculus (house mouse)	Itm2a	NP_032435.2

Gene Ontology
Bibliography

Related articles in PubMed

ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis.
Ye XP, Yuan FF, Zhang LL, Ma YR, Zhang MM, Liu W, Sun F, Wu J, Lu M, Xue LQ, Shi JY, Zhao SX, Song HD, Liang J, Zheng CX,
The Journal of clinical endocrinology and metabolism102(2)652-660(2017 Feb)

Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.
Nguyen TM, Shin IW, Lee TJ, Park J, Kim JH, Park MS, Lee EJ
Gynecologic oncology140(3)545-53(2016 Mar)

Meta-analysis of differentially expressed genes in ankylosing spondylitis.
Lee YH, Song GG
Genetics and molecular research : GMR14(2)5161-70(2015 May)

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
Namkoong S, Lee KI, Lee JI, Park R, Lee EJ, Jang IS, Park J
Autophagy11(5)756-68(2015)

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
Tukiainen T, Pirinen M, Sarin AP, Ladenvall C, Kettunen J, Lehtim?ki T, Lokki ML, Perola M, Sinisalo J, Vlachopoulou E, Eriksson JG, Groop L, Jula A, J?rvelin MR, Raitakari OT, Salomaa V, Ripatti S
PLoS genetics10(2)e1004127(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ITM2A might be a susceptibility gene for Graves disease in the Xq21.1 locus, and environmental factors, such as viral and bacterial infections, probably contribute to GD pathogenesis by interacting with the risk SNP rs3827440 mediating the regulation of ITM2A expression.
Title: ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis.

ITM2A is a new biomarker of poor prognosis in ovarian cancer and a novel tumor suppressor that induces cell cycle arrest, acts as a chemosensitizer, and has therapeutic potential for ovarian cancer.
Title: Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.

The upregulated gene with the largest effect size in ankylosing spondylitis was ITM2A, which plays a role in activation of T cells. (Meta-analysis)
Title: Meta-analysis of differentially expressed genes in ankylosing spondylitis.

ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase.
Title: The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.

our results show one of the first links between phenotypic variation in a population sample and an XCI-escaping locus and pinpoint ITM2A as a potential contributor to the sexual dimorphism in height
Title: Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.

The following ITM2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITM2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18395	NM_004867.5 Latest version!	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04355	NM_001171581.1 Latest version!	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18395	NM_004867.4	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITM2A ( NM_004867.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004858.1 Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18395
Clone ID Related Accession (Same CDS sequence)	NM_004867.5 , NM_004867.4
Accession Version	NM_004867.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	integral membrane protein 2A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA365726.1, BC040437.1, BM561934.1 and AY359051.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004867.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034485.1, SRR3476690.1175785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373298.7/ ENSP00000362395.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GGAGCTCCGA 
GTTGCCACCC AGGAAAAAGA GGGCTCCTCT GGGAGATGTA TGCTTACTCT CTTAGGCCTT 
TCATTCATCT TGGCAGGACT TATTGTTGGT GGAGCCTGCA TTTACAAGTA CTTCATGCCC 
AAGAGCACCA TTTACCGTGG AGAGATGTGC TTTTTTGATT CTGAGGATCC TGCAAATTCC 
CTTCGTGGAG GAGAGCCTAA CTTCCTGCCT GTGACTGAGG AGGCTGACAT TCGTGAGGAT 
GACAACATTG CAATCATTGA TGTGCCTGTC CCCAGTTTCT CTGATAGTGA CCCTGCAGCA 
ATTATTCATG ACTTTGAAAA GGGAATGACT GCTTACCTGG ACTTGTTGCT GGGGAACTGC 
TATCTGATGC CCCTCAATAC TTCTATTGTT ATGCCTCCAA AAAATCTGGT AGAGCTCTTT 
GGCAAACTGG CGAGTGGCAG ATATCTGCCT CAAACTTATG TGGTTCGAGA AGACCTAGTT 
GCTGTGGAGG AAATTCGTGA TGTTAGTAAC CTTGGCATCT TTATTTACCA ACTTTGCAAT 
AACAGAAAGT CCTTCCGCCT TCGTCGCAGA GACCTCTTGC TGGGTTTCAA CAAACGTGCC 
ATTGATAAAT GCTGGAAGAT TAGACACTTC CCCAACGAAT TTATTGTTGA GACCAAGATC 
TGTCAAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004858.1
CDS	120..911
Translation	MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGLSFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE

Target ORF information:

RefSeq Version	NM_004867.5
Organism	Homo sapiens(human)
Definition	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004867.5

ORF Insert Sequence:

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GGAGCTCCGA 
GTTGCCACCC AGGAAAAAGA GGGCTCCTCT GGGAGATGTA TGCTTACTCT CTTAGGCCTT 
TCATTCATCT TGGCAGGACT TATTGTTGGT GGAGCCTGCA TTTACAAGTA CTTCATGCCC 
AAGAGCACCA TTTACCGTGG AGAGATGTGC TTTTTTGATT CTGAGGATCC TGCAAATTCC 
CTTCGTGGAG GAGAGCCTAA CTTCCTGCCT GTGACTGAGG AGGCTGACAT TCGTGAGGAT 
GACAACATTG CAATCATTGA TGTGCCTGTC CCCAGTTTCT CTGATAGTGA CCCTGCAGCA 
ATTATTCATG ACTTTGAAAA GGGAATGACT GCTTACCTGG ACTTGTTGCT GGGGAACTGC 
TATCTGATGC CCCTCAATAC TTCTATTGTT ATGCCTCCAA AAAATCTGGT AGAGCTCTTT 
GGCAAACTGG CGAGTGGCAG ATATCTGCCT CAAACTTATG TGGTTCGAGA AGACCTAGTT 
GCTGTGGAGG AAATTCGTGA TGTTAGTAAC CTTGGCATCT TTATTTACCA ACTTTGCAAT 
AACAGAAAGT CCTTCCGCCT TCGTCGCAGA GACCTCTTGC TGGGTTTCAA CAAACGTGCC 
ATTGATAAAT GCTGGAAGAT TAGACACTTC CCCAACGAAT TTATTGTTGA GACCAAGATC 
TGTCAAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITM2A ( NM_004867.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004858.1 Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18395
Clone ID Related Accession (Same CDS sequence)	NM_004867.5 , NM_004867.4
Accession Version	NM_004867.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	integral membrane protein 2A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA365726.1, BC040437.1, BM561934.1 and AY359051.1. This sequence is a reference standard in the RefSeqGene project. On Jan 20, 2010 this sequence version replaced NM_004867.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034485.1, SRR1660803.55429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GGAGCTCCGA 
GTTGCCACCC AGGAAAAAGA GGGCTCCTCT GGGAGATGTA TGCTTACTCT CTTAGGCCTT 
TCATTCATCT TGGCAGGACT TATTGTTGGT GGAGCCTGCA TTTACAAGTA CTTCATGCCC 
AAGAGCACCA TTTACCGTGG AGAGATGTGC TTTTTTGATT CTGAGGATCC TGCAAATTCC 
CTTCGTGGAG GAGAGCCTAA CTTCCTGCCT GTGACTGAGG AGGCTGACAT TCGTGAGGAT 
GACAACATTG CAATCATTGA TGTGCCTGTC CCCAGTTTCT CTGATAGTGA CCCTGCAGCA 
ATTATTCATG ACTTTGAAAA GGGAATGACT GCTTACCTGG ACTTGTTGCT GGGGAACTGC 
TATCTGATGC CCCTCAATAC TTCTATTGTT ATGCCTCCAA AAAATCTGGT AGAGCTCTTT 
GGCAAACTGG CGAGTGGCAG ATATCTGCCT CAAACTTATG TGGTTCGAGA AGACCTAGTT 
GCTGTGGAGG AAATTCGTGA TGTTAGTAAC CTTGGCATCT TTATTTACCA ACTTTGCAAT 
AACAGAAAGT CCTTCCGCCT TCGTCGCAGA GACCTCTTGC TGGGTTTCAA CAAACGTGCC 
ATTGATAAAT GCTGGAAGAT TAGACACTTC CCCAACGAAT TTATTGTTGA GACCAAGATC 
TGTCAAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004858.1
CDS	338..1129
Translation	MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGLSFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE

Target ORF information:

RefSeq Version	NM_004867.4
Organism	Homo sapiens(human)
Definition	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004867.4

ORF Insert Sequence:

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GGAGCTCCGA 
GTTGCCACCC AGGAAAAAGA GGGCTCCTCT GGGAGATGTA TGCTTACTCT CTTAGGCCTT 
TCATTCATCT TGGCAGGACT TATTGTTGGT GGAGCCTGCA TTTACAAGTA CTTCATGCCC 
AAGAGCACCA TTTACCGTGG AGAGATGTGC TTTTTTGATT CTGAGGATCC TGCAAATTCC 
CTTCGTGGAG GAGAGCCTAA CTTCCTGCCT GTGACTGAGG AGGCTGACAT TCGTGAGGAT 
GACAACATTG CAATCATTGA TGTGCCTGTC CCCAGTTTCT CTGATAGTGA CCCTGCAGCA 
ATTATTCATG ACTTTGAAAA GGGAATGACT GCTTACCTGG ACTTGTTGCT GGGGAACTGC 
TATCTGATGC CCCTCAATAC TTCTATTGTT ATGCCTCCAA AAAATCTGGT AGAGCTCTTT 
GGCAAACTGG CGAGTGGCAG ATATCTGCCT CAAACTTATG TGGTTCGAGA AGACCTAGTT 
GCTGTGGAGG AAATTCGTGA TGTTAGTAAC CTTGGCATCT TTATTTACCA ACTTTGCAAT 
AACAGAAAGT CCTTCCGCCT TCGTCGCAGA GACCTCTTGC TGGGTTTCAA CAAACGTGCC 
ATTGATAAAT GCTGGAAGAT TAGACACTTC CCCAACGAAT TTATTGTTGA GACCAAGATC 
TGTCAAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITM2A ( NM_001171581.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001165052.1 Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04355
Clone ID Related Accession (Same CDS sequence)	NM_001171581.1
Accession Version	NM_001171581.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	integral membrane protein 2A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA365726.1, AK303238.1, BM561934.1 and AY359051.1. Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking a 44 aa protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.567601.1, SRR1660803.381431.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GAGCACCATT 
TACCGTGGAG AGATGTGCTT TTTTGATTCT GAGGATCCTG CAAATTCCCT TCGTGGAGGA 
GAGCCTAACT TCCTGCCTGT GACTGAGGAG GCTGACATTC GTGAGGATGA CAACATTGCA 
ATCATTGATG TGCCTGTCCC CAGTTTCTCT GATAGTGACC CTGCAGCAAT TATTCATGAC 
TTTGAAAAGG GAATGACTGC TTACCTGGAC TTGTTGCTGG GGAACTGCTA TCTGATGCCC 
CTCAATACTT CTATTGTTAT GCCTCCAAAA AATCTGGTAG AGCTCTTTGG CAAACTGGCG 
AGTGGCAGAT ATCTGCCTCA AACTTATGTG GTTCGAGAAG ACCTAGTTGC TGTGGAGGAA 
ATTCGTGATG TTAGTAACCT TGGCATCTTT ATTTACCAAC TTTGCAATAA CAGAAAGTCC 
TTCCGCCTTC GTCGCAGAGA CCTCTTGCTG GGTTTCAACA AACGTGCCAT TGATAAATGC 
TGGAAGATTA GACACTTCCC CAACGAATTT ATTGTTGAGA CCAAGATCTG TCAAGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165052.1
CDS	338..997
Translation	MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE

Target ORF information:

RefSeq Version	NM_001171581.1
Organism	Homo sapiens(human)
Definition	Homo sapiens integral membrane protein 2A (ITM2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171581.1

ORF Insert Sequence:

ATGGTGAAAA TCGCCTTCAA TACCCCTACC GCCGTGCAAA AGGAGGAGGC GCGGCAAGAC 
GTGGAGGCCC TCCTGAGCCG CACGGTCAGA ACTCAGATAC TGACCGGCAA GAGCACCATT 
TACCGTGGAG AGATGTGCTT TTTTGATTCT GAGGATCCTG CAAATTCCCT TCGTGGAGGA 
GAGCCTAACT TCCTGCCTGT GACTGAGGAG GCTGACATTC GTGAGGATGA CAACATTGCA 
ATCATTGATG TGCCTGTCCC CAGTTTCTCT GATAGTGACC CTGCAGCAAT TATTCATGAC 
TTTGAAAAGG GAATGACTGC TTACCTGGAC TTGTTGCTGG GGAACTGCTA TCTGATGCCC 
CTCAATACTT CTATTGTTAT GCCTCCAAAA AATCTGGTAG AGCTCTTTGG CAAACTGGCG 
AGTGGCAGAT ATCTGCCTCA AACTTATGTG GTTCGAGAAG ACCTAGTTGC TGTGGAGGAA 
ATTCGTGATG TTAGTAACCT TGGCATCTTT ATTTACCAAC TTTGCAATAA CAGAAAGTCC 
TTCCGCCTTC GTCGCAGAGA CCTCTTGCTG GGTTTCAACA AACGTGCCAT TGATAAATGC 
TGGAAGATTA GACACTTCCC CAACGAATTT ATTGTTGAGA CCAAGATCTG TCAAGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis.
The Journal of clinical endocrinology and metabolism102(2)652-660(2017 Feb)
Ye XP,Yuan FF,Zhang LL,Ma YR,Zhang MM,Liu W,Sun F,Wu J,Lu M,Xue LQ,Shi JY,Zhao SX,Song HD,Liang J,Zheng CX,

Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.
Gynecologic oncology140(3)545-53(2016 Mar)
Nguyen TM,Shin IW,Lee TJ,Park J,Kim JH,Park MS,Lee EJ

Meta-analysis of differentially expressed genes in ankylosing spondylitis.
Genetics and molecular research : GMR14(2)5161-70(2015 May)
Lee YH,Song GG

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
Autophagy11(5)756-68(2015)
Namkoong S,Lee KI,Lee JI,Park R,Lee EJ,Jang IS,Park J

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
PLoS genetics10(2)e1004127(2014 Feb)
Tukiainen T,Pirinen M,Sarin AP,Ladenvall C,Kettunen J,Lehtim?ki T,Lokki ML,Perola M,Sinisalo J,Vlachopoulou E,Eriksson JG,Groop L,Jula A,J?rvelin MR,Raitakari OT,Salomaa V,Ripatti S

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ITM2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム