CRIPT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRIPT
Entrez Gene ID	9419
Full Name	CXXC repeat containing interactor of PDZ3 domain
Synonyms	HSPC139,SSMDF
General protein information	Preferred Names CXXC repeat containing interactor of PDZ3 domain Names cysteine-rich PDZ-binding protein cysteine-rich interactor of PDZ three cysteine-rich interactor of PDZ3 postsynaptic protein CRIPT
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014].
Disorder MIM:	604594
Disorder Html:	Short stature with microcephaly and distinctive facies, 615789 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014171.6	NP_054890.1	cysteine-rich PDZ-binding protein
NM_014171.5	NP_054890.1	cysteine-rich PDZ-binding protein

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT1G61780	NP_176371.1
Oryza sativa (rice)	Os08g0190800	NP_001061168.2
Mus musculus (house mouse)	Cript	NP_064320.1
Gallus gallus (chicken)	CRIPT	NP_001026225.1
	LOC715323	XP_001112532.1
Canis lupus familiaris (dog)	CRIPT	XP_851904.1
Rattus norvegicus (Norway rat)	Cript	NP_063972.1
Drosophila melanogaster (fruit fly)	CG4537	NP_001097135.1
Xenopus tropicalis (tropical clawed frog)	cript	NP_001016794.1
Homo sapiens (human)	CRIPT	NP_054890.1
Pan troglodytes (chimpanzee)	CRIPT	XP_515452.3
Bos taurus (cattle)	CRIPT	NP_001029975.1
Danio rerio (zebrafish)	cript	NP_001017893.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010721	XP_311435.4

Gene Ontology
Bibliography

Related articles in PubMed

CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities.
Leduc MS, Niu Z, Bi W, Zhu W, Miloslavskaya I, Chiang T, Streff H, Seavitt JR, Murray SA, Eng C, Chan A, Yang Y, Lalani SR
American journal of medical genetics. Part A170(8)2206-11(2016 Aug)

Genomic analysis of primordial dwarfism reveals novel disease genes.
Shaheen R, Faqeih E, Ansari S, Abdel-Salam G, Al-Hassnan ZN, Al-Shidi T, Alomar R, Sogaty S, Alkuraya FS
Genome research24(2)291-9(2014 Feb)

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Simino J, Sung YJ, Kume R, Schwander K, Rao DC
Frontiers in genetics4277(2013)

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Str?mgaard K, R?nn LC, Gether U
Proceedings of the National Academy of Sciences of the United States of America107(1)413-8(2010 Jan)

A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
Saro D, Li T, Rupasinghe C, Paredes A, Caspers N, Spaller MR
Biochemistry46(21)6340-52(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we describe a third patient with defects in the CRIPT gene responsible for short stature, microcephaly, and distinctive facies [MIM:615789]. The clinical presentation of our patient expands the phenotype of CRIPT mutations to include postnatal growth delay, distinct from primordial dwarfism.
Title: CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities.

Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

The following CRIPT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRIPT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27876	NM_014171.6 Latest version!	Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27876	NM_014171.5	Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRIPT ( NM_014171.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_054890.1 Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.

Price & Availability↑

CloneID	OHu27876
Clone ID Related Accession (Same CDS sequence)	NM_014171.6 , NM_014171.5
Accession Version	NM_014171.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cysteine-rich PDZ-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291298.1 and AC018682.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014171.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.2652604.1, SRR5189655.140977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238892.4/ ENSP00000238892.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGTGCG AAAAATGTGA AAAGAAACTT GGTACTGTTA TCACTCCAGA TACATGGAAA 
GATGGTGCTA GGAATACCAC AGAAAGTGGT GGAAGAAAGC TGAATGAAAA TAAAGCTTTG 
ACTTCAAAAA AAGCAAGATT TGATCCATAT GGAAAGAATA AGTTCTCCAC TTGTAGAATT 
TGTAAAAGTT CTGTGCACCA ACCAGGTTCT CATTACTGCC AGGGCTGTGC CTACAAAAAA 
GGCATCTGTG CGATGTGTGG AAAAAAGGTT TTGGATACCA AAAACTACAA GCAAACATCT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054890.1
CDS	69..374
Translation	MVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV

Target ORF information:

RefSeq Version	NM_014171.6
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014171.6

ORF Insert Sequence:

ATGGTGTGCG AAAAATGTGA AAAGAAACTT GGTACTGTTA TCACTCCAGA TACATGGAAA 
GATGGTGCTA GGAATACCAC AGAAAGTGGT GGAAGAAAGC TGAATGAAAA TAAAGCTTTG 
ACTTCAAAAA AAGCAAGATT TGATCCATAT GGAAAGAATA AGTTCTCCAC TTGTAGAATT 
TGTAAAAGTT CTGTGCACCA ACCAGGTTCT CATTACTGCC AGGGCTGTGC CTACAAAAAA 
GGCATCTGTG CGATGTGTGG AAAAAAGGTT TTGGATACCA AAAACTACAA GCAAACATCT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRIPT ( NM_014171.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_054890.1 Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.

Price & Availability↑

CloneID	OHu27876
Clone ID Related Accession (Same CDS sequence)	NM_014171.6 , NM_014171.5
Accession Version	NM_014171.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	cysteine-rich PDZ-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU603377.1, AK291298.1 and AC018682.4. This sequence is a reference standard in the RefSeqGene project. On Dec 11, 2013 this sequence version replaced NM_014171.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.409376.1, BC018653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGTGCG AAAAATGTGA AAAGAAACTT GGTACTGTTA TCACTCCAGA TACATGGAAA 
GATGGTGCTA GGAATACCAC AGAAAGTGGT GGAAGAAAGC TGAATGAAAA TAAAGCTTTG 
ACTTCAAAAA AAGCAAGATT TGATCCATAT GGAAAGAATA AGTTCTCCAC TTGTAGAATT 
TGTAAAAGTT CTGTGCACCA ACCAGGTTCT CATTACTGCC AGGGCTGTGC CTACAAAAAA 
GGCATCTGTG CGATGTGTGG AAAAAAGGTT TTGGATACCA AAAACTACAA GCAAACATCT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054890.1
CDS	112..417
Translation	MVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV

Target ORF information:

RefSeq Version	NM_014171.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC repeat containing interactor of PDZ3 domain (CRIPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014171.5

ORF Insert Sequence:

ATGGTGTGCG AAAAATGTGA AAAGAAACTT GGTACTGTTA TCACTCCAGA TACATGGAAA 
GATGGTGCTA GGAATACCAC AGAAAGTGGT GGAAGAAAGC TGAATGAAAA TAAAGCTTTG 
ACTTCAAAAA AAGCAAGATT TGATCCATAT GGAAAGAATA AGTTCTCCAC TTGTAGAATT 
TGTAAAAGTT CTGTGCACCA ACCAGGTTCT CATTACTGCC AGGGCTGTGC CTACAAAAAA 
GGCATCTGTG CGATGTGTGG AAAAAAGGTT TTGGATACCA AAAACTACAA GCAAACATCT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities.
American journal of medical genetics. Part A170(8)2206-11(2016 Aug)
Leduc MS,Niu Z,Bi W,Zhu W,Miloslavskaya I,Chiang T,Streff H,Seavitt JR,Murray SA,Eng C,Chan A,Yang Y,Lalani SR

Genomic analysis of primordial dwarfism reveals novel disease genes.
Genome research24(2)291-9(2014 Feb)
Shaheen R,Faqeih E,Ansari S,Abdel-Salam G,Al-Hassnan ZN,Al-Shidi T,Alomar R,Sogaty S,Alkuraya FS

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Frontiers in genetics4277(2013)
Simino J,Sung YJ,Kume R,Schwander K,Rao DC

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Proceedings of the National Academy of Sciences of the United States of America107(1)413-8(2010 Jan)
Thorsen TS,Madsen KL,Rebola N,Rathje M,Anggono V,Bach A,Moreira IS,Stuhr-Hansen N,Dyhring T,Peters D,Beuming T,Huganir R,Weinstein H,Mulle C,Str?mgaard K,R?nn LC,Gether U

A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
Biochemistry46(21)6340-52(2007 May)
Saro D,Li T,Rupasinghe C,Paredes A,Caspers N,Spaller MR