KRTAP4-8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRTAP4-8
Entrez Gene ID	728224
Full Name	keratin associated protein 4-8
Synonyms	KAP4.8,KRTAP4.8
General protein information	Preferred Names keratin associated protein 4-8 Names keratin-associated protein 4-8 keratin associated protein 4.8 ultrahigh sulfur keratin-associated protein 4.8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_031960.2	NP_114166.1	keratin-associated protein 4-8 isoform 1
NM_001322457.1	NP_001309386.1	keratin-associated protein 4-8 isoform 2
NM_031960.3	NP_114166.1	keratin-associated protein 4-8 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KRTAP4-9	XP_001169025.1
Homo sapiens (human)	KRTAP4-8	NP_114166.1
Rattus norvegicus (Norway rat)	LOC100361969	XP_006247510.1
	LOC703872	XP_001103508.1
Mus musculus (house mouse)	Gm11563	NP_001119792.1

Gene Ontology
Bibliography

Related articles in PubMed

Hair greying is associated with active hair growth.
Choi HI, Choi GI, Kim EK, Choi YJ, Sohn KC, Lee Y, Kim CD, Yoon TJ, Sohn HJ, Han SH, Kim S, Lee JH, Lee YH
The British journal of dermatology165(6)1183-9(2011 Dec)

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature440(7087)1045-9(2006 Apr)

Size polymorphisms in the human ultrahigh sulfur hair keratin-associated protein 4, KAP4, gene family.
Kariya N, Shimomura Y, Ito M
The Journal of investigative dermatology124(6)1111-8(2005 Jun)

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.
Rogers MA, Langbein L, Winter H, Ehmann C, Praetzel S, Korn B, Schweizer J
The Journal of biological chemistry276(22)19440-51(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRTAP4-8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRTAP4-8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01679	NM_031960.3 Latest version!	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu100461	NM_001322457.1 Latest version!	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu01679	NM_031960.2	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRTAP4-8 ( NM_031960.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_114166.1 Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01679
Clone ID Related Accession (Same CDS sequence)	NM_031960.2 , NM_031960.3
Accession Version	NM_031960.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	keratin-associated protein 4-8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100808.10. On or before Aug 27, 2009 this sequence version replaced XM_002343515.1, XM_002347748.1, NM_031960.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGTCGCCC CAGCTGCTGT GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC 
CAGTCTGTGT GCTGCCAGCC CACCTGCTGC CACCCTAGCT GCTGCATCTC CAGCTGCTGC 
CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCAACT GCTGCCGCCC CAGCTGCAGC ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT 
GAATCCAGCT GCTGCCGCCC CTGCTGCTGC CTGCGTCCAG TCTGTGGCCG AGTCTCCTGC 
CACACCACTT GCTATCGCCC AGCCTGTGTC ATCTCCACCT GCCCCCGCCC CGTGTGCTGC 
GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114166.1
CDS	40..597
Translation	MVNSCCGSVCSDQGCGQDLCQETCCCPSCCQTTCCRTTCYRPSYSVSCCCRPQCCQSVCCQPTCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCCISSCCRPSCCVSSCCKPQCCQSVCCQPNCCRPSCSISSCCRPSCCESSCCRPCCCLRPVCGRVSCHTTCYRPACVISTCPRPVCCASSCC

Target ORF information:

RefSeq Version	NM_031960.2
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031960.2

ORF Insert Sequence:

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGTCGCCC CAGCTGCTGT GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC 
CAGTCTGTGT GCTGCCAGCC CACCTGCTGC CACCCTAGCT GCTGCATCTC CAGCTGCTGC 
CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCAACT GCTGCCGCCC CAGCTGCAGC ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT 
GAATCCAGCT GCTGCCGCCC CTGCTGCTGC CTGCGTCCAG TCTGTGGCCG AGTCTCCTGC 
CACACCACTT GCTATCGCCC AGCCTGTGTC ATCTCCACCT GCCCCCGCCC CGTGTGCTGC 
GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRTAP4-8 ( NM_031960.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_114166.1 Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01679
Clone ID Related Accession (Same CDS sequence)	NM_031960.2 , NM_031960.3
Accession Version	NM_031960.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	keratin-associated protein 4-8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100808.10. On May 17, 2019 this sequence version replaced NM_031960.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333822.5/ ENSP00000328444.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGTCGCCC CAGCTGCTGT GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC 
CAGTCTGTGT GCTGCCAGCC CACCTGCTGC CACCCTAGCT GCTGCATCTC CAGCTGCTGC 
CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCAACT GCTGCCGCCC CAGCTGCAGC ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT 
GAATCCAGCT GCTGCCGCCC CTGCTGCTGC CTGCGTCCAG TCTGTGGCCG AGTCTCCTGC 
CACACCACTT GCTATCGCCC AGCCTGTGTC ATCTCCACCT GCCCCCGCCC CGTGTGCTGC 
GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114166.1
CDS	59..616
Translation	MVNSCCGSVCSDQGCGQDLCQETCCCPSCCQTTCCRTTCYRPSYSVSCCCRPQCCQSVCCQPTCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCCISSCCRPSCCVSSCCKPQCCQSVCCQPNCCRPSCSISSCCRPSCCESSCCRPCCCLRPVCGRVSCHTTCYRPACVISTCPRPVCCASSCC

Target ORF information:

RefSeq Version	NM_031960.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031960.3

ORF Insert Sequence:

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGTCGCCC CAGCTGCTGT GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC 
CAGTCTGTGT GCTGCCAGCC CACCTGCTGC CACCCTAGCT GCTGCATCTC CAGCTGCTGC 
CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCAACT GCTGCCGCCC CAGCTGCAGC ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT 
GAATCCAGCT GCTGCCGCCC CTGCTGCTGC CTGCGTCCAG TCTGTGGCCG AGTCTCCTGC 
CACACCACTT GCTATCGCCC AGCCTGTGTC ATCTCCACCT GCCCCCGCCC CGTGTGCTGC 
GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRTAP4-8 ( NM_001322457.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309386.1 Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100461
Clone ID Related Accession (Same CDS sequence)	NM_001322457.1
Accession Version	NM_001322457.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-28
Organism	Homo sapiens(human)
Product	keratin-associated protein 4-8 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC037482.14. Transcript Variant: This variant (2) represents an alternate allele located on the reference alternate locus, ALT_REF_LOCI_1.

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGCCGCCC CAGATGCTGC ATCTCCAGCT GCTGTCGCCC CAGCTGCTGT 
GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC CAGTCTGTGT GCTGCCAGCC CACCTGCTGC 
CACCCTAGCT GCTGCATCTC CAGCTGCTGC CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC 
AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC CAGCCCACCT GCTGCCACCC TAGCTGCAGC 
ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT GAATCCAGCT GCTGCCGCCC CTGCTGCTGC 
GTGCGTCCAG TCTGTGGCCG AGTCTCCTGC CACACCACTT GCTATCGCCC AACCTGTGTC 
ATCTCCACCT GTCCCCGCCC CGTGTGCTGC GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309386.1
CDS	41..628
Translation	MVNSCCGSVCSDQGCGQDLCQETCCCPSCCQTTCCRTTCYRPSYSVSCCCRPQCCQSVCCQPTCCRPRCCISSCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCCISSCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCSISSCCRPSCCESSCCRPCCCVRPVCGRVSCHTTCYRPTCVISTCPRPVCCASSCC

Target ORF information:

RefSeq Version	NM_001322457.1
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322457.1

ORF Insert Sequence:

ATGGTCAACT CCTGTTGTGG CTCCGTGTGC TCTGACCAAG GCTGTGGCCA AGACCTCTGC 
CAGGAGACCT GCTGCTGCCC CAGCTGCTGT CAGACCACCT GCTGCAGGAC CACCTGCTAC 
CGCCCCAGCT ACAGTGTGTC CTGCTGCTGC AGACCCCAGT GCTGCCAGTC TGTGTGCTGC 
CAGCCCACCT GCTGCCGCCC CAGATGCTGC ATCTCCAGCT GCTGTCGCCC CAGCTGCTGT 
GTGTCCAGCT GCTGCAAGCC CCAGTGCTGC CAGTCTGTGT GCTGCCAGCC CACCTGCTGC 
CACCCTAGCT GCTGCATCTC CAGCTGCTGC CGCCCCAGCT GCTGTGTGTC CAGCTGCTGC 
AAGCCCCAGT GCTGCCAGTC TGTGTGCTGC CAGCCCACCT GCTGCCACCC TAGCTGCAGC 
ATCTCCAGCT GCTGCCGCCC CTCTTGCTGT GAATCCAGCT GCTGCCGCCC CTGCTGCTGC 
GTGCGTCCAG TCTGTGGCCG AGTCTCCTGC CACACCACTT GCTATCGCCC AACCTGTGTC 
ATCTCCACCT GTCCCCGCCC CGTGTGCTGC GCCTCCTCTT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hair greying is associated with active hair growth.
The British journal of dermatology165(6)1183-9(2011 Dec)
Choi HI,Choi GI,Kim EK,Choi YJ,Sohn KC,Lee Y,Kim CD,Yoon TJ,Sohn HJ,Han SH,Kim S,Lee JH,Lee YH

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature440(7087)1045-9(2006 Apr)
Zody MC,Garber M,Adams DJ,Sharpe T,Harrow J,Lupski JR,Nicholson C,Searle SM,Wilming L,Young SK,Abouelleil A,Allen NR,Bi W,Bloom T,Borowsky ML,Bugalter BE,Butler J,Chang JL,Chen CK,Cook A,Corum B,Cuomo CA,de Jong PJ,DeCaprio D,Dewar K,FitzGerald M,Gilbert J,Gibson R,Gnerre S,Goldstein S,Grafham DV,Grocock R,Hafez N,Hagopian DS,Hart E,Norman CH,Humphray S,Jaffe DB,Jones M,Kamal M,Khodiyar VK,LaButti K,Laird G,Lehoczky J,Liu X,Lokyitsang T,Loveland J,Lui A,Macdonald P,Major JE,Matthews L,Mauceli E,McCarroll SA,Mihalev AH,Mudge J,Nguyen C,Nicol R,O'Leary SB,Osoegawa K,Schwartz DC,Shaw-Smith C,Stankiewicz P,Steward C,Swarbreck D,Venkataraman V,Whittaker CA,Yang X,Zimmer AR,Bradley A,Hubbard T,Birren BW,Rogers J,Lander ES,Nusbaum C

Size polymorphisms in the human ultrahigh sulfur hair keratin-associated protein 4, KAP4, gene family.
The Journal of investigative dermatology124(6)1111-8(2005 Jun)
Kariya N,Shimomura Y,Ito M

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.
The Journal of biological chemistry276(22)19440-51(2001 Jun)
Rogers MA,Langbein L,Winter H,Ehmann C,Praetzel S,Korn B,Schweizer J