TSPAN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSPAN6
Entrez Gene ID	7105
Full Name	tetraspanin 6
Synonyms	T245,TM4SF6,TSPAN-6
General protein information	Preferred Names tetraspanin 6 Names tetraspanin-6 A15 homolog putative NF-kappa-B-activating protein 321 tetraspan TM4SF tetraspanin TM4-D transmembrane 4 superfamily member 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.1
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013].
Disorder MIM:	300191

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278740.2	NP_001265669.1	tetraspanin-6 isoform b precursor
NM_003270.4	NP_003261.1	tetraspanin-6 isoform a
NM_001278741.1	NP_001265670.1	tetraspanin-6 isoform b precursor
NM_003270.3	NP_003261.1	tetraspanin-6 isoform a
NM_001278743.1	NP_001265672.1	tetraspanin-6 isoform d precursor
NM_001278742.1	NP_001265671.1	tetraspanin-6 isoform c precursor
XM_011531018.1	XP_011529320.1	tetraspanin-6 isoform X1
NM_001278740.1	NP_001265669.1	tetraspanin-6 isoform b precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tspan7	NP_999939.1
Homo sapiens (human)	TSPAN6	NP_003261.1
Rattus norvegicus (Norway rat)	Tspan6	NP_001094142.1
Gallus gallus (chicken)	TSPAN6	NP_001264532.1
	TSPAN6	XP_001091467.2
Drosophila melanogaster (fruit fly)	Tsp47F	NP_725044.1
Canis lupus familiaris (dog)	TSPAN6	XP_538102.1
Mus musculus (house mouse)	Tspan6	NP_062630.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005233	XP_314136.4
Pan troglodytes (chimpanzee)	TSPAN6	XP_529071.3
Bos taurus (cattle)	TSPAN6	NP_001033198.1
Xenopus tropicalis (tropical clawed frog)	tspan6	NP_001039117.1

Gene Ontology
Bibliography

Related articles in PubMed

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horr? K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, Tosi S, Munck S, Salas IH, Annaert W, De Strooper B
Molecular neurodegeneration12(1)25(2017 03)

Identification of genomic deletions spanning the PCDH19 gene in two unrelated girls with intellectual disability and seizures.
Vincent AK, Noor A, Janson A, Minassian BA, Ayub M, Vincent JB, Morel CF
Clinical genetics82(6)540-5(2012 Dec)

Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner.
Wang Y, Tong X, Omoregie ES, Liu W, Meng S, Ye X
The Journal of biological chemistry287(41)34626-34(2012 Oct)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results shows that TSPAN6 is a crucial player in Amyloid Precursor Protein-C-terminal fragment turnover
Title: Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.

TSPAN6 functions as a negative regulator of the RLR pathway by interacting with MAVS in a ubiquitination-dependent manner.
Title: Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner.

The following TSPAN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSPAN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07729	NM_001278740.2 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	Quote Price
OHu07729	NM_001278741.1 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	Quote Price
OHu07732	NM_001278743.1 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu07783	NM_001278742.1 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu20545	NM_003270.4 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	Quote Price
OHu07729	XM_011531018.1 Latest version!	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu20545	NM_003270.3	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu07729	NM_001278740.1	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSPAN6 ( NM_001278740.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265669.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07729
Clone ID Related Accession (Same CDS sequence)	NM_001278740.2 , NM_001278741.1 , XM_011531018.1 , NM_001278740.1
Accession Version	NM_001278740.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035608.11, DA147330.1, AK309581.1 and N64145.1. On May 31, 2019 this sequence version replaced NM_001278740.1. Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.270089.1, SRR1803611.233723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265669.1
CDS	794..1267
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_001278740.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278740.2

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_001278741.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265670.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07729
Clone ID Related Accession (Same CDS sequence)	NM_001278740.2 , NM_001278741.1 , XM_011531018.1 , NM_001278740.1
Accession Version	NM_001278741.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI458635.1, CX868833.1, AL035608.11 and N64145.1. Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.148815.1, SRR1803616.223050.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265670.1
CDS	490..963
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_001278741.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278741.1

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_001278740.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265669.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07729
Clone ID Related Accession (Same CDS sequence)	NM_001278740.2 , NM_001278741.1 , XM_011531018.1 , NM_001278740.1
Accession Version	NM_001278740.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA147330.1, AK309581.1, AL035608.11 and N64145.1. Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.124293.1, SRR1803616.270089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265669.1
CDS	720..1193
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_001278740.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278740.1

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_001278743.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265672.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu07732
Clone ID Related Accession (Same CDS sequence)	NM_001278743.1
Accession Version	NM_001278743.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform d precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI458635.1, DA038474.1, AB097016.1, AL035608.11 and N64145.1. Transcript Variant: This variant (5) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA ACTGATTGGA ATCTTTCTCG CCTACTGCCT CTCTCGTGCC 
ATAACAAATA ACCAGTATGA GATAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265672.1
CDS	490..879
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNELIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_001278743.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278743.1

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA ACTGATTGGA ATCTTTCTCG CCTACTGCCT CTCTCGTGCC 
ATAACAAATA ACCAGTATGA GATAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_001278742.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265671.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu07783
Clone ID Related Accession (Same CDS sequence)	NM_001278742.1
Accession Version	NM_001278742.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI458635.1, CN274931.1, AL035608.11 and N64145.1. Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an exon that results in an alternate 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and contains a distinct C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN274931.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAAGACAT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265671.1
CDS	490..903
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQDI

Target ORF information:

RefSeq Version	NM_001278742.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278742.1

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAAGACAT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_003270.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003261.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.

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CloneID	OHu20545
Clone ID Related Accession (Same CDS sequence)	NM_003270.4 , NM_003270.3
Accession Version	NM_003270.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX760536.1, AY358825.1, AL035608.11 and N64145.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003270.3. Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075072.1, SRR1803615.179220.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373020.9/ ENSP00000362111.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCC CGTCTCGGAG ACTGCAGACT AAACCAGTCA TTACTTGTTT CAAGAGCGTT 
CTGCTAATCT ACACTTTTAT TTTCTGGATC ACTGGCGTTA TCCTTCTTGC AGTTGGCATT 
TGGGGCAAGG TGAGCCTGGA GAATTACTTT TCTCTTTTAA ATGAGAAGGC CACCAATGTC 
CCCTTCGTGC TCATTGCTAC TGGTACCGTC ATTATTCTTT TGGGCACCTT TGGTTGTTTT 
GCTACCTGCC GAGCTTCTGC ATGGATGCTA AAACTGTATG CAATGTTTCT GACTCTCGTT 
TTTTTGGTCG AACTGGTCGC TGCCATCGTA GGATTTGTTT TCAGACATGA GATTAAGAAC 
AGCTTTAAGA ATAATTATGA GAAGGCTTTG AAGCAGTATA ACTCTACAGG AGATTATAGA 
AGCCATGCAG TAGACAAGAT CCAAAATACG TTGCATTGTT GTGGTGTCAC CGATTATAGA 
GATTGGACAG ATACTAATTA TTACTCAGAA AAAGGATTTC CTAAGAGTTG CTGTAAACTT 
GAAGATTGTA CTCCACAGAG AGATGCAGAC AAAGTAAACA ATGAAGGTTG TTTTATAAAG 
GTGATGACCA TTATAGAGTC AGAAATGGGA GTCGTTGCAG GAATTTCCTT TGGAGTTGCT 
TGCTTCCAAC TGATTGGAAT CTTTCTCGCC TACTGCCTCT CTCGTGCCAT AACAAATAAC 
CAGTATGAGA TAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003261.1
CDS	113..850
Translation	MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_003270.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003270.4

ORF Insert Sequence:

ATGGCGTCCC CGTCTCGGAG ACTGCAGACT AAACCAGTCA TTACTTGTTT CAAGAGCGTT 
CTGCTAATCT ACACTTTTAT TTTCTGGATC ACTGGCGTTA TCCTTCTTGC AGTTGGCATT 
TGGGGCAAGG TGAGCCTGGA GAATTACTTT TCTCTTTTAA ATGAGAAGGC CACCAATGTC 
CCCTTCGTGC TCATTGCTAC TGGTACCGTC ATTATTCTTT TGGGCACCTT TGGTTGTTTT 
GCTACCTGCC GAGCTTCTGC ATGGATGCTA AAACTGTATG CAATGTTTCT GACTCTCGTT 
TTTTTGGTCG AACTGGTCGC TGCCATCGTA GGATTTGTTT TCAGACATGA GATTAAGAAC 
AGCTTTAAGA ATAATTATGA GAAGGCTTTG AAGCAGTATA ACTCTACAGG AGATTATAGA 
AGCCATGCAG TAGACAAGAT CCAAAATACG TTGCATTGTT GTGGTGTCAC CGATTATAGA 
GATTGGACAG ATACTAATTA TTACTCAGAA AAAGGATTTC CTAAGAGTTG CTGTAAACTT 
GAAGATTGTA CTCCACAGAG AGATGCAGAC AAAGTAAACA ATGAAGGTTG TTTTATAAAG 
GTGATGACCA TTATAGAGTC AGAAATGGGA GTCGTTGCAG GAATTTCCTT TGGAGTTGCT 
TGCTTCCAAC TGATTGGAAT CTTTCTCGCC TACTGCCTCT CTCGTGCCAT AACAAATAAC 
CAGTATGAGA TAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( NM_003270.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003261.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.

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CloneID	OHu20545
Clone ID Related Accession (Same CDS sequence)	NM_003270.4 , NM_003270.3
Accession Version	NM_003270.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX760536.1, AY358825.1, AL035608.11 and N64145.1. This sequence is a reference standard in the RefSeqGene project. On Jul 13, 2013 this sequence version replaced NM_003270.2. Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.237398.1, SRR1803614.256243.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCC CGTCTCGGAG ACTGCAGACT AAACCAGTCA TTACTTGTTT CAAGAGCGTT 
CTGCTAATCT ACACTTTTAT TTTCTGGATC ACTGGCGTTA TCCTTCTTGC AGTTGGCATT 
TGGGGCAAGG TGAGCCTGGA GAATTACTTT TCTCTTTTAA ATGAGAAGGC CACCAATGTC 
CCCTTCGTGC TCATTGCTAC TGGTACCGTC ATTATTCTTT TGGGCACCTT TGGTTGTTTT 
GCTACCTGCC GAGCTTCTGC ATGGATGCTA AAACTGTATG CAATGTTTCT GACTCTCGTT 
TTTTTGGTCG AACTGGTCGC TGCCATCGTA GGATTTGTTT TCAGACATGA GATTAAGAAC 
AGCTTTAAGA ATAATTATGA GAAGGCTTTG AAGCAGTATA ACTCTACAGG AGATTATAGA 
AGCCATGCAG TAGACAAGAT CCAAAATACG TTGCATTGTT GTGGTGTCAC CGATTATAGA 
GATTGGACAG ATACTAATTA TTACTCAGAA AAAGGATTTC CTAAGAGTTG CTGTAAACTT 
GAAGATTGTA CTCCACAGAG AGATGCAGAC AAAGTAAACA ATGAAGGTTG TTTTATAAAG 
GTGATGACCA TTATAGAGTC AGAAATGGGA GTCGTTGCAG GAATTTCCTT TGGAGTTGCT 
TGCTTCCAAC TGATTGGAAT CTTTCTCGCC TACTGCCTCT CTCGTGCCAT AACAAATAAC 
CAGTATGAGA TAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003261.1
CDS	164..901
Translation	MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	NM_003270.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003270.3

ORF Insert Sequence:

ATGGCGTCCC CGTCTCGGAG ACTGCAGACT AAACCAGTCA TTACTTGTTT CAAGAGCGTT 
CTGCTAATCT ACACTTTTAT TTTCTGGATC ACTGGCGTTA TCCTTCTTGC AGTTGGCATT 
TGGGGCAAGG TGAGCCTGGA GAATTACTTT TCTCTTTTAA ATGAGAAGGC CACCAATGTC 
CCCTTCGTGC TCATTGCTAC TGGTACCGTC ATTATTCTTT TGGGCACCTT TGGTTGTTTT 
GCTACCTGCC GAGCTTCTGC ATGGATGCTA AAACTGTATG CAATGTTTCT GACTCTCGTT 
TTTTTGGTCG AACTGGTCGC TGCCATCGTA GGATTTGTTT TCAGACATGA GATTAAGAAC 
AGCTTTAAGA ATAATTATGA GAAGGCTTTG AAGCAGTATA ACTCTACAGG AGATTATAGA 
AGCCATGCAG TAGACAAGAT CCAAAATACG TTGCATTGTT GTGGTGTCAC CGATTATAGA 
GATTGGACAG ATACTAATTA TTACTCAGAA AAAGGATTTC CTAAGAGTTG CTGTAAACTT 
GAAGATTGTA CTCCACAGAG AGATGCAGAC AAAGTAAACA ATGAAGGTTG TTTTATAAAG 
GTGATGACCA TTATAGAGTC AGAAATGGGA GTCGTTGCAG GAATTTCCTT TGGAGTTGCT 
TGCTTCCAAC TGATTGGAAT CTTTCTCGCC TACTGCCTCT CTCGTGCCAT AACAAATAAC 
CAGTATGAGA TAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPAN6 ( XM_011531018.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529320.1 Homo sapiens tetraspanin 6 (TSPAN6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu07729
Clone ID Related Accession (Same CDS sequence)	NM_001278740.2 , NM_001278741.1 , XM_011531018.1 , NM_001278740.1
Accession Version	XM_011531018.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tetraspanin-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529320.1
CDS	230..703
Translation	MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV

Target ORF information:

RefSeq Version	XM_011531018.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 6 (TSPAN6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531018.1

ORF Insert Sequence:

ATGCTAAAAC TGTATGCAAT GTTTCTGACT CTCGTTTTTT TGGTCGAACT GGTCGCTGCC 
ATCGTAGGAT TTGTTTTCAG ACATGAGATT AAGAACAGCT TTAAGAATAA TTATGAGAAG 
GCTTTGAAGC AGTATAACTC TACAGGAGAT TATAGAAGCC ATGCAGTAGA CAAGATCCAA 
AATACGTTGC ATTGTTGTGG TGTCACCGAT TATAGAGATT GGACAGATAC TAATTATTAC 
TCAGAAAAAG GATTTCCTAA GAGTTGCTGT AAACTTGAAG ATTGTACTCC ACAGAGAGAT 
GCAGACAAAG TAAACAATGA AGGTTGTTTT ATAAAGGTGA TGACCATTAT AGAGTCAGAA 
ATGGGAGTCG TTGCAGGAAT TTCCTTTGGA GTTGCTTGCT TCCAACTGAT TGGAATCTTT 
CTCGCCTACT GCCTCTCTCG TGCCATAACA AATAACCAGT ATGAGATAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Molecular neurodegeneration12(1)25(2017 03)
Guix FX,Sannerud R,Berditchevski F,Arranz AM,Horr? K,Snellinx A,Thathiah A,Saido T,Saito T,Rajesh S,Overduin M,Kumar-Singh S,Radaelli E,Corthout N,Colombelli J,Tosi S,Munck S,Salas IH,Annaert W,De Strooper B

Identification of genomic deletions spanning the PCDH19 gene in two unrelated girls with intellectual disability and seizures.
Clinical genetics82(6)540-5(2012 Dec)
Vincent AK,Noor A,Janson A,Minassian BA,Ayub M,Vincent JB,Morel CF

Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner.
The Journal of biological chemistry287(41)34626-34(2012 Oct)
Wang Y,Tong X,Omoregie ES,Liu W,Meng S,Ye X

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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TSPAN6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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電話

FAX

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