AEN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AEN
Entrez Gene ID	64782
Full Name	apoptosis enhancing nuclease
Synonyms	ISG20L1,pp12744
General protein information	Preferred Names apoptosis enhancing nuclease Names apoptosis-enhancing nuclease interferon stimulated exonuclease gene 20kDa-like 1 interferon-stimulated 20 kDa exonuclease-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q26.1
Disorder MIM:	610177

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521905.2	XP_011520207.1	apoptosis-enhancing nuclease isoform X2
XM_006720645.3	XP_006720708.2	apoptosis-enhancing nuclease isoform X1
XM_017022489.1	XP_016877978.1	apoptosis-enhancing nuclease isoform X2
NM_022767.3	NP_073604.3	apoptosis-enhancing nuclease
XM_017022490.1	XP_016877979.1	apoptosis-enhancing nuclease isoform X1
NM_022767.4	NP_073604.3	apoptosis-enhancing nuclease
XM_005254967.1	XP_005255024.1	apoptosis-enhancing nuclease isoform X2
XM_005254966.1	XP_005255023.1	apoptosis-enhancing nuclease isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	AEN	NP_073604.3
Rattus norvegicus (Norway rat)	Aen	NP_001101957.1
Pan troglodytes (chimpanzee)	AEN	XP_510574.3
Gallus gallus (chicken)	AEN	XP_413869.3
Canis lupus familiaris (dog)	AEN	XP_545846.2
Mus musculus (house mouse)	Aen	NP_080807.3
Bos taurus (cattle)	AEN	XP_003587594.1
Xenopus tropicalis (tropical clawed frog)	aen	NP_001072399.2

Gene Ontology
Bibliography

Related articles in PubMed

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.
Eby KG, Rosenbluth JM, Mays DJ, Marshall CB, Barton CE, Sinha S, Johnson KN, Tang L, Pietenpol JA
Molecular cancer995(2010 Apr)

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.
Kawase T, Ichikawa H, Ohta T, Nozaki N, Tashiro F, Ohki R, Taya Y
Oncogene27(27)3797-810(2008 Jun)

Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis.
Lee JH, Koh YA, Cho CK, Lee SJ, Lee YS, Bae S
Biochemical and biophysical research communications337(1)39-47(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identification of ISG20L1 as a p53 family target and discovery that modulation of this target can regulate autophagic processes further strengthens the connection between p53 signaling and autophagy
Title: ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.

AEN is an important downstream mediator of p53 in apoptosis induction in cancer.
Title: p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.

The following AEN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AEN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31876	NM_022767.4 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31876	XM_005254967.1 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31876	XM_017022489.1 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31876	XM_011521905.2 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31876	XM_005254966.1 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu71472	XM_017022490.1 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu71472	XM_006720645.3 Latest version!	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu31876	NM_022767.3	Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AEN ( NM_022767.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073604.3 Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.

Price & Availability↑

CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	NM_022767.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC013489.17, BC020988.1 and CA441442.1. On Jul 12, 2008 this sequence version replaced NM_022767.2. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC020988.1, SRR1803612.130039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073604.3
CDS	152..1129
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	NM_022767.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022767.3

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( NM_022767.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_073604.3 Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.

Price & Availability↑

CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	NM_022767.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC013489.17. On Nov 23, 2018 this sequence version replaced NM_022767.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.198050.1, SRR1803616.258846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332810.4/ ENSP00000331944.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073604.3
CDS	108..1085
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	NM_022767.4
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022767.4

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_011521905.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520207.1 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	XM_011521905.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521905.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520207.1
CDS	506..1483
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	XM_011521905.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521905.2

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_017022489.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877978.1 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	XM_017022489.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877978.1
CDS	1129..2106
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	XM_017022489.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022489.1

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_005254967.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255024.1 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X4, mRNA.

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CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	XM_005254967.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255024.1
CDS	482..1459
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	XM_005254967.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254967.1

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_005254966.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255023.1 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X5, mRNA.

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CloneID	OHu31876
Clone ID Related Accession (Same CDS sequence)	XM_011521905.2 , XM_017022489.1 , NM_022767.3 , NM_022767.4 , XM_005254967.1 , XM_005254966.1
Accession Version	XM_005254966.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255023.1
CDS	342..1319
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN

Target ORF information:

RefSeq Version	XM_005254966.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254966.1

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GGTGGGCCAG CACGGGCACT CATCAGTAGA AGATGCCACG 
ACAGCCATGG AGCTCTACCG GCTGGTGGAG GTGCAGTGGG AACAGCAGGA GGCCCGCAGC 
CTCTGGACCT GCCCCGAGGA CAGAGAACCT GACAGCAGCA CAGACATGGA ACAGTACATG 
GAGGACCAGT ACTGGCCCGA TGACCTGGCC CACGGCAGCA GAGGAGGAGC CAGGGAGGCA 
CAGGACAGAA GGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_006720645.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006720708.2 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71472
Clone ID Related Accession (Same CDS sequence)	XM_006720645.3 , XM_017022490.1
Accession Version	XM_006720645.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006720645.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006720708.2
CDS	111..854
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQ

Target ORF information:

RefSeq Version	XM_006720645.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006720645.3

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AEN ( XM_017022490.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877979.1 Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu71472
Clone ID Related Accession (Same CDS sequence)	XM_006720645.3 , XM_017022490.1
Accession Version	XM_017022490.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis-enhancing nuclease isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877979.1
CDS	469..1212
Translation	MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQ

Target ORF information:

RefSeq Version	XM_017022490.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis enhancing nuclease (AEN), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022490.1

ORF Insert Sequence:

ATGGTACCCC GGGAGGCCCC TGAGTCTGCT CAGTGCCTGT GCCCTTCCCT CACCATCCCA 
AATGCCAAGG ATGTGCTTCG GAAGAGGCAC AAGAGAAGGA GCCGACAGCA CCAGCGGTTC 
ATGGCCCGGA AGGCCTTGCT GCAGGAGCAG GGGCTGCTGA GCATGCCTCC AGAACCAGGG 
TCCTCCCCAC TGCCCACCCC TTTCGGGGCA GCGACAGCAA CTGAAGCTGC CAGCAGTGGG 
AAGCAGTGTC TGAGGGCTGG ATCTGGCAGT GCCCCATGCA GCAGAAGGCC TGCTCCCGGG 
AAAGCCTCAG GGCCCTTGCC CAGCAAGTGT GTGGCTATCG ACTGTGAGAT GGTGGGCACG 
GGACCCCGAG GGCGGGTAAG CGAGCTGGCC CGCTGTTCCA TTGTGAGCTA CCATGGCAAT 
GTCCTCTATG ACAAGTACAT CAGGCCTGAG ATGCCCATCG CTGACTACCG TACCCGCTGG 
AGTGGCATCA CTCGGCAGCA CATGCGCAAG GCTGTCCCCT TCCAGGTGGC CCAGAAAGAG 
ATCCTTAAGC TCCTGAAGGG CAAGGTGGTG GTGGGGCACG CGCTGCACAA CGACTTCCAG 
GCGCTCAAGT ATGTCCACCC TCGGAGCCAG ACCCGGGATA CGACCTATGT CCCAAACTTC 
CTCAGCGAGC CCGGCCTCCA CACCCGGGCC CGGGTCTCTC TAAAGGACCT GGCCCTGCAG 
CTGCTGCACA AGAAGATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.
Molecular cancer995(2010 Apr)
Eby KG,Rosenbluth JM,Mays DJ,Marshall CB,Barton CE,Sinha S,Johnson KN,Tang L,Pietenpol JA

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.
Oncogene27(27)3797-810(2008 Jun)
Kawase T,Ichikawa H,Ohta T,Nozaki N,Tashiro F,Ohki R,Taya Y

Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis.
Biochemical and biophysical research communications337(1)39-47(2005 Nov)
Lee JH,Koh YA,Cho CK,Lee SJ,Lee YS,Bae S

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AEN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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