GPSM3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPSM3
Entrez Gene ID	63940
Full Name	G protein signaling modulator 3
Synonyms	AGS4,C6orf9,G18,G18.1a,G18.1b,G18.2,NG1
General protein information	Preferred Names G protein signaling modulator 3 Names G-protein-signaling modulator 3 G-protein signaling modulator 3 (AGS3-like, C. elegans) G-protein signalling modulator 3 (AGS3-like, C. elegans) activator of G-protein signaling 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32

mRNA and Protein(s)

mRNA	Protein	Name
NM_022107.1	NP_071390.1	G-protein-signaling modulator 3
NM_001276501.2	NP_001263430.1	G-protein-signaling modulator 3
NM_001276501.1	NP_001263430.1	G-protein-signaling modulator 3
NM_022107.2	NP_071390.1	G-protein-signaling modulator 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gpsm3	NP_598877.1
Bos taurus (cattle)	GPSM3	XP_002697418.2
Homo sapiens (human)	GPSM3	NP_001263430.1
Rattus norvegicus (Norway rat)	Gpsm3	NP_001003974.1
Pan troglodytes (chimpanzee)	GPSM3	XP_518379.2
	GPSM3	XP_001114953.1
Canis lupus familiaris (dog)	GPSM3	XP_849551.1

Gene Ontology
Bibliography

Related articles in PubMed

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.
Gall BJ, Schroer AB, Gross JD, Setola V, Siderovski DP
Genes and immunity17(6)321-7(2016 Sep)

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.
Gall BJ, Wilson A, Schroer AB, Gross JD, Stoilov P, Setola V, Watkins CM, Siderovski DP
Genes and immunity17(2)139-47(2016 Mar)

G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.
Gigu?re PM, Gall BJ, Ezekwe EA Jr, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA
The Journal of biological chemistry289(48)33245-57(2014 Nov)

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, R?der MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, , , , , , Kote-Jarai Z, Easton DF
Nature genetics45(4)385-91, 391e1-2(2013 Apr)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis
Title: Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.

Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance.
Title: Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.

findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function.
Title: G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.

Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization
Title: Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein.

GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits.
Title: G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with G? and G?i protein subunits.

The following GPSM3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPSM3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04144	NM_022107.2 Latest version!	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04144	NM_001276501.2 Latest version!	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04144	NM_001276501.1	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04144	NM_022107.1	Homo sapiens G-protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPSM3 ( NM_022107.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_071390.1 Homo sapiens G-protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04144
Clone ID Related Accession (Same CDS sequence)	NM_022107.1 , NM_001276501.2 , NM_001276501.1 , NM_022107.2
Accession Version	NM_022107.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	G-protein-signaling modulator 3
Comment

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071390.1
Translation	MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC

Target ORF information:

RefSeq Version	NM_022107.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens G-protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022107.1

ORF Insert Sequence:

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPSM3 ( NM_001276501.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263430.1 Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04144
Clone ID Related Accession (Same CDS sequence)	NM_022107.1 , NM_001276501.2 , NM_001276501.1 , NM_022107.2
Accession Version	NM_001276501.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	G-protein-signaling modulator 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA979033.1 and BC018724.1. On Nov 23, 2018 this sequence version replaced NM_001276501.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.618232.1, SRR1163657.19409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2149876 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375040.8/ ENSP00000364180.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263430.1
CDS	131..613
Translation	MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC

Target ORF information:

RefSeq Version	NM_001276501.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276501.2

ORF Insert Sequence:

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPSM3 ( NM_001276501.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263430.1 Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04144
Clone ID Related Accession (Same CDS sequence)	NM_022107.1 , NM_001276501.2 , NM_001276501.1 , NM_022107.2
Accession Version	NM_001276501.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	G-protein-signaling modulator 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA979033.1 and BC018724.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.82104.1, SRR1163655.258754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2149876 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263430.1
CDS	403..885
Translation	MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC

Target ORF information:

RefSeq Version	NM_001276501.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276501.1

ORF Insert Sequence:

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPSM3 ( NM_022107.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071390.1 Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04144
Clone ID Related Accession (Same CDS sequence)	NM_022107.1 , NM_001276501.2 , NM_001276501.1 , NM_022107.2
Accession Version	NM_022107.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	G-protein-signaling modulator 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ243937.1 and AL662884.11. On Dec 12, 2015 this sequence version replaced NM_022107.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243937.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071390.1
CDS	374..856
Translation	MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC

Target ORF information:

RefSeq Version	NM_022107.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein signaling modulator 3 (GPSM3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022107.2

ORF Insert Sequence:

ATGGAGGCTG AGAGACCCCA GGAAGAAGAG GATGGTGAGC AGGGCCCCCC TCAGGATGAG 
GAAGGCTGGC CCCCTCCAAA CTCCACCACT CGGCCTTGGC GATCTGCTCC TCCATCCCCT 
CCTCCTCCAG GGACCCGCCA CACAGCCCTG GGACCCCGCT CGGCCTCCCT GCTCTCCCTG 
CAGACTGAAC TCCTTCTGGA CCTGGTGGCT GAAGCCCAGT CCCGCCGCCT GGAGGAGCAG 
AGGGCCACCT TCTACACCCC CCAAAACCCC TCAAGCCTAG CCCCTGCCCC ACTCCGTCCT 
CTCGAGGACA GAGAACAGCT TTACAGCACT ATCCTCAGTC ACCAGTGCCA GCGGATGGAA 
GCCCAGCGGT CAGAGCCTCC CCTCCCTCCA GGGGGGCAAG AGCTCCTGGA GTTGCTGCTG 
AGAGTTCAGG GTGGGGGTCG AATGGAGGAG CAAAGGTCCC GGCCCCCCAC ACACACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.
Genes and immunity17(6)321-7(2016 Sep)
Gall BJ,Schroer AB,Gross JD,Setola V,Siderovski DP

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.
Genes and immunity17(2)139-47(2016 Mar)
Gall BJ,Wilson A,Schroer AB,Gross JD,Stoilov P,Setola V,Watkins CM,Siderovski DP

G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.
The Journal of biological chemistry289(48)33245-57(2014 Nov)
Gigu?re PM,Gall BJ,Ezekwe EA Jr,Laroche G,Buckley BK,Kebaier C,Wilson JE,Ting JP,Siderovski DP,Duncan JA

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Nature genetics45(4)385-91, 391e1-2(2013 Apr)
Eeles RA,Olama AA,Benlloch S,Saunders EJ,Leongamornlert DA,Tymrakiewicz M,Ghoussaini M,Luccarini C,Dennis J,Jugurnauth-Little S,Dadaev T,Neal DE,Hamdy FC,Donovan JL,Muir K,Giles GG,Severi G,Wiklund F,Gronberg H,Haiman CA,Schumacher F,Henderson BE,Le Marchand L,Lindstrom S,Kraft P,Hunter DJ,Gapstur S,Chanock SJ,Berndt SI,Albanes D,Andriole G,Schleutker J,Weischer M,Canzian F,Riboli E,Key TJ,Travis RC,Campa D,Ingles SA,John EM,Hayes RB,Pharoah PD,Pashayan N,Khaw KT,Stanford JL,Ostrander EA,Signorello LB,Thibodeau SN,Schaid D,Maier C,Vogel W,Kibel AS,Cybulski C,Lubinski J,Cannon-Albright L,Brenner H,Park JY,Kaneva R,Batra J,Spurdle AB,Clements JA,Teixeira MR,Dicks E,Lee A,Dunning AM,Baynes C,Conroy D,Maranian MJ,Ahmed S,Govindasami K,Guy M,Wilkinson RA,Sawyer EJ,Morgan A,Dearnaley DP,Horwich A,Huddart RA,Khoo VS,Parker CC,Van As NJ,Woodhouse CJ,Thompson A,Dudderidge T,Ogden C,Cooper CS,Lophatananon A,Cox A,Southey MC,Hopper JL,English DR,Aly M,Adolfsson J,Xu J,Zheng SL,Yeager M,Kaaks R,Diver WR,Gaudet MM,Stern MC,Corral R,Joshi AD,Shahabi A,Wahlfors T,Tammela TL,Auvinen A,Virtamo J,Klarskov P,Nordestgaard BG,R?der MA,Nielsen SF,Bojesen SE,Siddiq A,Fitzgerald LM,Kolb S,Kwon EM,Karyadi DM,Blot WJ,Zheng W,Cai Q,McDonnell SK,Rinckleb AE,Drake B,Colditz G,Wokolorczyk D,Stephenson RA,Teerlink C,Muller H,Rothenbacher D,Sellers TA,Lin HY,Slavov C,Mitev V,Lose F,Srinivasan S,Maia S,Paulo P,Lange E,Cooney KA,Antoniou AC,Vincent D,Bacot F,Tessier DC,,,,,,Kote-Jarai Z,Easton DF

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

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GPSM3 cDNA ORF clone, Homo sapiens(human)

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