OR2J3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR2J3
Entrez Gene ID	442186
Full Name	olfactory receptor family 2 subfamily J member 3
Synonyms	6M1-3,C3HEXS,HS6M1-3,OR6-16,OR6-6,OR6.3.6,ORL671
General protein information	Preferred Names olfactory receptor family 2 subfamily J member 3 Names olfactory receptor 2J3 olfactory receptor 6-6 olfactory receptor OR6-16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013].
Disorder MIM:	615016
Disorder Html:	[C3HEX, ability to smell], 615082 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005216.3	NP_001005216.2	olfactory receptor 2J3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC471931	XP_527309.2
	OR2J3	XP_001101790.1
Homo sapiens (human)	OR2J3	NP_001005216.2
Bos taurus (cattle)	OR2J3	XP_002697487.1

Gene Ontology
Bibliography

Related articles in PubMed

Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line.
Kalbe B, Schulz VM, Schlimm M, Philippou S, Jovancevic N, Jansen F, Scholz P, L?bbert H, Jarocki M, Faissner A, Hecker E, Veitinger S, Tsai T, Osterloh S, Hatt H
European journal of cell biology96(1)34-46(2017 Jan)

Common variation contributes to the genetic architecture of social communication traits.
St Pourcain B, Whitehouse AJ, Ang WQ, Warrington NM, Glessner JT, Wang K, Timpson NJ, Evans DM, Kemp JP, Ring SM, McArdle WL, Golding J, Hakonarson H, Pennell CE, Smith GD
Molecular autism4(1)34(2013 Sep)

Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.
Garcia-Esparcia P, Schl?ter A, Carmona M, Moreno J, Ansoleaga B, Torrej?n-Escribano B, Gustincich S, Pujol A, Ferrer I
Journal of neuropathology and experimental neurology72(6)524-39(2013 Jun)

Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.
McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD
Chemical senses37(7)585-93(2012 Sep)

A probabilistic classifier for olfactory receptor pseudogenes.
Menashe I, Aloni R, Lancet D
BMC bioinformatics7393(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OR2J3 activation induces apoptosis and inhibits cell proliferation and migration in long-term stimulus experiments with helional.
Title: Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line.

Two amino acid substitutions, T113A and R226Q, impaired the ability of OR2J3 to respond to cis-3-hexen-1-ol, and together these two substitutions effectively abolished the response to the compound.
Title: Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

The following OR2J3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR2J3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21681	NM_001005216.3 Latest version!	Homo sapiens olfactory receptor family 2 subfamily J member 3 (OR2J3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR2J3 ( NM_001005216.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005216.2 Homo sapiens olfactory receptor family 2 subfamily J member 3 (OR2J3), mRNA.

Price & Availability↑

CloneID	OHu21681
Clone ID Related Accession (Same CDS sequence)	NM_001005216.3
Accession Version	NM_001005216.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	olfactory receptor 2J3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC136975.1. This sequence is a reference standard in the RefSeqGene project. On May 29, 2013 this sequence version replaced NM_001005216.2. ##Evidence-Data-START## Transcript is intronless :: BC136973.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAATGATG ATGGAAAAGT CAATGCTAGC TCTGAGGGGT ACTTTATTTT AGTTGGATTT 
TCTAATTGGC CTCATCTGGA AGTAGTTATC TTTGTGGTTG TCTTGATCTT CTACTTGATG 
ACACTGATAG GAAACCTGTT CATCATCATC CTGTCATACC TGGACTCCCA TCTGCACACA 
CCAATGTACT TCTTCCTTTC AAACCTCTCA TTTCTGGATC TCTGCTACAC CACCAGCTCT 
ATCCCTCAGT TGCTGGTCAA TCTCTGGGGC CCGGAAAAGA CCATCTCTTA TGCTGGTTGC 
ATGATTCAAC TTTACTTTGT TCTCGCACTG GGAACCACAG AGTGTGTCCT ACTGGTGGTG 
ATGTCCTATG ACCGTTATGC AGCTGTGTGT AGACCTTTGC ATTACACTGT CCTCATGCAC 
CCTCGTTTCT GCCACCTGCT GGCTGTGGCT TCTTGGGTAA GTGGTTTTAC CAACTCAGCA 
CTTCATTCCT CCTTCACCTT CTGGGTACCT CTGTGTGGAC ACCGCCAAGT AGATCACTTT 
TTCTGTGAAG TTCCAGCACT TCTGCGATTA TCGTGTGTTG ATACCCATGT CAATGAGCTG 
ACCCTCATGA TCACAAGCTC CATATTTGTT CTCATACCTC TCATCCTCAT TCTCACTTCT 
TATGGTGCCA TCGTCCGAGC TATACTGAGG ATGCAGTCAA CCACTGGGCT TCAGAAAGTG 
TTTGGAACAT GTGGAGCTCA TCTTATGGCT GTATCTCTCT TTTTCATTCC GGCCATGTGC 
ATGTATCTCC AGCCACCATC AGGAAATTCT CAAGATCAAG GCAAGTTCAT TGCCCTCTTT 
TATACTGTTG TCACACCTAG TCTTAACCCT CTAATCTACA CCCTCAGAAA CAAAGTTGTA 
AGAGGGGCAG TGAAGAGACT AATGGGGTGG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005216.2
CDS	82..1017
Translation	MNDDGKVNASSEGYFILVGFSNWPHLEVVIFVVVLIFYLMTLIGNLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCMIQLYFVLALGTTECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCHLLAVASWVSGFTNSALHSSFTFWVPLCGHRQVDHFFCEVPALLRLSCVDTHVNELTLMITSSIFVLIPLILILTSYGAIVRAILRMQSTTGLQKVFGTCGAHLMAVSLFFIPAMCMYLQPPSGNSQDQGKFIALFYTVVTPSLNPLIYTLRNKVVRGAVKRLMGWE

Target ORF information:

RefSeq Version	NM_001005216.3
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 2 subfamily J member 3 (OR2J3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005216.3

ORF Insert Sequence:

ATGAATGATG ATGGAAAAGT CAATGCTAGC TCTGAGGGGT ACTTTATTTT AGTTGGATTT 
TCTAATTGGC CTCATCTGGA AGTAGTTATC TTTGTGGTTG TCTTGATCTT CTACTTGATG 
ACACTGATAG GAAACCTGTT CATCATCATC CTGTCATACC TGGACTCCCA TCTGCACACA 
CCAATGTACT TCTTCCTTTC AAACCTCTCA TTTCTGGATC TCTGCTACAC CACCAGCTCT 
ATCCCTCAGT TGCTGGTCAA TCTCTGGGGC CCGGAAAAGA CCATCTCTTA TGCTGGTTGC 
ATGATTCAAC TTTACTTTGT TCTCGCACTG GGAACCACAG AGTGTGTCCT ACTGGTGGTG 
ATGTCCTATG ACCGTTATGC AGCTGTGTGT AGACCTTTGC ATTACACTGT CCTCATGCAC 
CCTCGTTTCT GCCACCTGCT GGCTGTGGCT TCTTGGGTAA GTGGTTTTAC CAACTCAGCA 
CTTCATTCCT CCTTCACCTT CTGGGTACCT CTGTGTGGAC ACCGCCAAGT AGATCACTTT 
TTCTGTGAAG TTCCAGCACT TCTGCGATTA TCGTGTGTTG ATACCCATGT CAATGAGCTG 
ACCCTCATGA TCACAAGCTC CATATTTGTT CTCATACCTC TCATCCTCAT TCTCACTTCT 
TATGGTGCCA TCGTCCGAGC TATACTGAGG ATGCAGTCAA CCACTGGGCT TCAGAAAGTG 
TTTGGAACAT GTGGAGCTCA TCTTATGGCT GTATCTCTCT TTTTCATTCC GGCCATGTGC 
ATGTATCTCC AGCCACCATC AGGAAATTCT CAAGATCAAG GCAAGTTCAT TGCCCTCTTT 
TATACTGTTG TCACACCTAG TCTTAACCCT CTAATCTACA CCCTCAGAAA CAAAGTTGTA 
AGAGGGGCAG TGAAGAGACT AATGGGGTGG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line.
European journal of cell biology96(1)34-46(2017 Jan)
Kalbe B,Schulz VM,Schlimm M,Philippou S,Jovancevic N,Jansen F,Scholz P,L?bbert H,Jarocki M,Faissner A,Hecker E,Veitinger S,Tsai T,Osterloh S,Hatt H

Common variation contributes to the genetic architecture of social communication traits.
Molecular autism4(1)34(2013 Sep)
St Pourcain B,Whitehouse AJ,Ang WQ,Warrington NM,Glessner JT,Wang K,Timpson NJ,Evans DM,Kemp JP,Ring SM,McArdle WL,Golding J,Hakonarson H,Pennell CE,Smith GD

Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.
Journal of neuropathology and experimental neurology72(6)524-39(2013 Jun)
Garcia-Esparcia P,Schl?ter A,Carmona M,Moreno J,Ansoleaga B,Torrej?n-Escribano B,Gustincich S,Pujol A,Ferrer I

Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.
Chemical senses37(7)585-93(2012 Sep)
McRae JF,Mainland JD,Jaeger SR,Adipietro KA,Matsunami H,Newcomb RD

A probabilistic classifier for olfactory receptor pseudogenes.
BMC bioinformatics7393(2006 Aug)
Menashe I,Aloni R,Lancet D