MCCD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCCD1
Entrez Gene ID	401250
Full Name	mitochondrial coiled-coil domain 1
General protein information	Preferred Names mitochondrial coiled-coil domain 1 Names mitochondrial coiled-coil domain protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Disorder MIM:	609624

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011700.3	NP_001011700.2	mitochondrial coiled-coil domain protein 1 precursor
NM_001011700.2	NP_001011700.2	mitochondrial coiled-coil domain protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCCD1	NP_001011700.2
	MCCD1	XP_001111754.1
Pan troglodytes (chimpanzee)	MCCD1	XP_001152701.1
Canis lupus familiaris (dog)	MCCD1	XP_848840.1
Bos taurus (cattle)	MCCD1	XP_002697394.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of tumor necrosis factor-? block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients.
Tan JH, Price P, Gut I, Stacey MC, Warrington NM, Wallace HJ
Human immunology71(12)1214-9(2010 Dec)

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS genetics5(10)e1000696(2009 Oct)

Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Leli?vre JD, L?vy Y, Therwath A, Sch?chter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF,
The Journal of infectious diseases199(3)419-26(2009 Feb)

The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature425(6960)805-11(2003 Oct)

A novel gene encoding a coiled-coil mitochondrial protein located at the telomeric end of the human MHC Class III region.
Semple JI, Ribas G, Hillyard G, Brown SE, Sanderson CM, Campbell RD
Gene31441-54(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Characterization of tumor necrosis factor-? block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

The following MCCD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCCD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30559	NM_001011700.3 Latest version!	Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30559	NM_001011700.2	Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCCD1 ( NM_001011700.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011700.2 Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.

Price & Availability↑

CloneID	OHu30559
Clone ID Related Accession (Same CDS sequence)	NM_001011700.3 , NM_001011700.2
Accession Version	NM_001011700.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	mitochondrial coiled-coil domain protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BN000141.1, AL663061.8 and AL662801.7. On Nov 23, 2018 this sequence version replaced NM_001011700.2. ##Evidence-Data-START## Transcript exon combination :: BN000141.1, BC132994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 14527716 MANE Ensembl match :: ENST00000376191.3/ ENSP00000365362.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCCTCC CTCTGCCCTG GCTCTCTCGG TACCATTTCC TTCGCCTCCT TCTGCCCTCC 
TGGTCCTTGG CACCCCAGGG CTCCCATGGG TGCTGCTCCC AAAACCCCAA AGCAAGCATG 
GAAGAGCAGA CCAGCTCCAG AGGAAATGGG AAGATGACGT CCCCTCCCAG GGGCCCTGGG 
ACCCACCGCA CAGCTGAGCT GGCCCGAGCT GAAGAGTTGT TGGAGCAGCA GCTGGAGCTG 
TACCAGGCCC TCCTTGAAGG GCAGGAGGGA GCCTGGGAGG CCCAAGCCCT GGTGCTCAAG 
ATCCAGAAGC TGAAGGAACA GATGAGGAGG CACCAAGAGA GCCTTGGAGG AGGCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011700.2
CDS	54..413
Translation	MVLPLPWLSRYHFLRLLLPSWSLAPQGSHGCCSQNPKASMEEQTSSRGNGKMTSPPRGPGTHRTAELARAEELLEQQLELYQALLEGQEGAWEAQALVLKIQKLKEQMRRHQESLGGGA

Target ORF information:

RefSeq Version	NM_001011700.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011700.3

ORF Insert Sequence:

ATGGTCCTCC CTCTGCCCTG GCTCTCTCGG TACCATTTCC TTCGCCTCCT TCTGCCCTCC 
TGGTCCTTGG CACCCCAGGG CTCCCATGGG TGCTGCTCCC AAAACCCCAA AGCAAGCATG 
GAAGAGCAGA CCAGCTCCAG AGGAAATGGG AAGATGACGT CCCCTCCCAG GGGCCCTGGG 
ACCCACCGCA CAGCTGAGCT GGCCCGAGCT GAAGAGTTGT TGGAGCAGCA GCTGGAGCTG 
TACCAGGCCC TCCTTGAAGG GCAGGAGGGA GCCTGGGAGG CCCAAGCCCT GGTGCTCAAG 
ATCCAGAAGC TGAAGGAACA GATGAGGAGG CACCAAGAGA GCCTTGGAGG AGGCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCCD1 ( NM_001011700.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011700.2 Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.

Price & Availability↑

CloneID	OHu30559
Clone ID Related Accession (Same CDS sequence)	NM_001011700.3 , NM_001011700.2
Accession Version	NM_001011700.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	mitochondrial coiled-coil domain protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BN000141.1, AL663061.8 and AL662801.7. On Aug 15, 2007 this sequence version replaced NM_001011700.1. ##Evidence-Data-START## Transcript exon combination :: BN000141.1, ERR279831.1637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 14527716 ##RefSeq-Attributes-END##

ATGGTCCTCC CTCTGCCCTG GCTCTCTCGG TACCATTTCC TTCGCCTCCT TCTGCCCTCC 
TGGTCCTTGG CACCCCAGGG CTCCCATGGG TGCTGCTCCC AAAACCCCAA AGCAAGCATG 
GAAGAGCAGA CCAGCTCCAG AGGAAATGGG AAGATGACGT CCCCTCCCAG GGGCCCTGGG 
ACCCACCGCA CAGCTGAGCT GGCCCGAGCT GAAGAGTTGT TGGAGCAGCA GCTGGAGCTG 
TACCAGGCCC TCCTTGAAGG GCAGGAGGGA GCCTGGGAGG CCCAAGCCCT GGTGCTCAAG 
ATCCAGAAGC TGAAGGAACA GATGAGGAGG CACCAAGAGA GCCTTGGAGG AGGCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011700.2
CDS	54..413
Translation	MVLPLPWLSRYHFLRLLLPSWSLAPQGSHGCCSQNPKASMEEQTSSRGNGKMTSPPRGPGTHRTAELARAEELLEQQLELYQALLEGQEGAWEAQALVLKIQKLKEQMRRHQESLGGGA

Target ORF information:

RefSeq Version	NM_001011700.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial coiled-coil domain 1 (MCCD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011700.2

ORF Insert Sequence:

ATGGTCCTCC CTCTGCCCTG GCTCTCTCGG TACCATTTCC TTCGCCTCCT TCTGCCCTCC 
TGGTCCTTGG CACCCCAGGG CTCCCATGGG TGCTGCTCCC AAAACCCCAA AGCAAGCATG 
GAAGAGCAGA CCAGCTCCAG AGGAAATGGG AAGATGACGT CCCCTCCCAG GGGCCCTGGG 
ACCCACCGCA CAGCTGAGCT GGCCCGAGCT GAAGAGTTGT TGGAGCAGCA GCTGGAGCTG 
TACCAGGCCC TCCTTGAAGG GCAGGAGGGA GCCTGGGAGG CCCAAGCCCT GGTGCTCAAG 
ATCCAGAAGC TGAAGGAACA GATGAGGAGG CACCAAGAGA GCCTTGGAGG AGGCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of tumor necrosis factor-? block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients.
Human immunology71(12)1214-9(2010 Dec)
Tan JH,Price P,Gut I,Stacey MC,Warrington NM,Wallace HJ

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
PLoS genetics5(10)e1000696(2009 Oct)
Barcellos LF,May SL,Ramsay PP,Quach HL,Lane JA,Nititham J,Noble JA,Taylor KE,Quach DL,Chung SA,Kelly JA,Moser KL,Behrens TW,Seldin MF,Thomson G,Harley JB,Gaffney PM,Criswell LA

Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
The Journal of infectious diseases199(3)419-26(2009 Feb)
Limou S,Le Clerc S,Coulonges C,Carpentier W,Dina C,Delaneau O,Labib T,Taing L,Sladek R,Deveau C,Ratsimandresy R,Montes M,Spadoni JL,Leli?vre JD,L?vy Y,Therwath A,Sch?chter F,Matsuda F,Gut I,Froguel P,Delfraissy JF,Hercberg S,Zagury JF,

The DNA sequence and analysis of human chromosome 6.
Nature425(6960)805-11(2003 Oct)
Mungall AJ,Palmer SA,Sims SK,Edwards CA,Ashurst JL,Wilming L,Jones MC,Horton R,Hunt SE,Scott CE,Gilbert JG,Clamp ME,Bethel G,Milne S,Ainscough R,Almeida JP,Ambrose KD,Andrews TD,Ashwell RI,Babbage AK,Bagguley CL,Bailey J,Banerjee R,Barker DJ,Barlow KF,Bates K,Beare DM,Beasley H,Beasley O,Bird CP,Blakey S,Bray-Allen S,Brook J,Brown AJ,Brown JY,Burford DC,Burrill W,Burton J,Carder C,Carter NP,Chapman JC,Clark SY,Clark G,Clee CM,Clegg S,Cobley V,Collier RE,Collins JE,Colman LK,Corby NR,Coville GJ,Culley KM,Dhami P,Davies J,Dunn M,Earthrowl ME,Ellington AE,Evans KA,Faulkner L,Francis MD,Frankish A,Frankland J,French L,Garner P,Garnett J,Ghori MJ,Gilby LM,Gillson CJ,Glithero RJ,Grafham DV,Grant M,Gribble S,Griffiths C,Griffiths M,Hall R,Halls KS,Hammond S,Harley JL,Hart EA,Heath PD,Heathcott R,Holmes SJ,Howden PJ,Howe KL,Howell GR,Huckle E,Humphray SJ,Humphries MD,Hunt AR,Johnson CM,Joy AA,Kay M,Keenan SJ,Kimberley AM,King A,Laird GK,Langford C,Lawlor S,Leongamornlert DA,Leversha M,Lloyd CR,Lloyd DM,Loveland JE,Lovell J,Martin S,Mashreghi-Mohammadi M,Maslen GL,Matthews L,McCann OT,McLaren SJ,McLay K,McMurray A,Moore MJ,Mullikin JC,Niblett D,Nickerson T,Novik KL,Oliver K,Overton-Larty EK,Parker A,Patel R,Pearce AV,Peck AI,Phillimore B,Phillips S,Plumb RW,Porter KM,Ramsey Y,Ranby SA,Rice CM,Ross MT,Searle SM,Sehra HK,Sheridan E,Skuce CD,Smith S,Smith M,Spraggon L,Squares SL,Steward CA,Sycamore N,Tamlyn-Hall G,Tester J,Theaker AJ,Thomas DW,Thorpe A,Tracey A,Tromans A,Tubby B,Wall M,Wallis JM,West AP,White SS,Whitehead SL,Whittaker H,Wild A,Willey DJ,Wilmer TE,Wood JM,Wray PW,Wyatt JC,Young L,Younger RM,Bentley DR,Coulson A,Durbin R,Hubbard T,Sulston JE,Dunham I,Rogers J,Beck S

A novel gene encoding a coiled-coil mitochondrial protein located at the telomeric end of the human MHC Class III region.
Gene31441-54(2003 Sep)
Semple JI,Ribas G,Hillyard G,Brown SE,Sanderson CM,Campbell RD