LGALS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LGALS2
Entrez Gene ID	3957
Full Name	galectin 2
Synonyms	HL14
General protein information	Preferred Names galectin 2 Names galectin-2 S-Lac lectin 2 beta-galactoside-binding lectin L-14-II gal-2 lactose-binding lectin 2 lectin, galactoside-binding, soluble, 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008].
Disorder MIM:	150571
Disorder Html:	{Myocardial infarction, susceptibility to}, 608446 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006498.3	NP_006489.1	galectin-2
NM_006498.2	NP_006489.1	galectin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LGALS2	XP_525588.2
Homo sapiens (human)	LGALS2	NP_006489.1
Bos taurus (cattle)	LGALS2	NP_001244020.1
Rattus norvegicus (Norway rat)	Lgals2	NP_598283.1
Gallus gallus (chicken)	LGALS2	XP_001234400.2
Canis lupus familiaris (dog)	LGALS2	XP_531742.1
Mus musculus (house mouse)	Lgals2	NP_079898.2
Xenopus tropicalis (tropical clawed frog)	lgals2	NP_001116913.1

Gene Ontology
Bibliography

Related articles in PubMed

Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study.
Kazmi N, Gaunt TR, Relton C, Micali N
Clinical epigenetics9120(2017)

Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.
Si Y, Feng S, Gao J, Wang Y, Zhang Z, Meng Y, Zhou Y, Tai G, Su J
Acta biochimica et biophysica Sinica48(10)939-947(2016 Oct)

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).
Hutter S, Knabl J, Andergassen U, Hofmann S, Kuhn C, Mahner S, Arck P, Jeschke U
International journal of molecular sciences17(4)523(2016 Apr)

Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
Block M, M?lne J, Leffler H, B?rjesson L, Breimer ME
BioMed research international20165989128(2016)

PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.
Tian J, Hu S, Wang F, Yang X, Li Y, Huang C
International journal of clinical and experimental pathology8(3)3138-43(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that lactose binding to galectin-2 (Gal-2) stabilizes the lectin's conformation.
Title: Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.

Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas.
Title: Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).

Galectin-1 was undetectable in normal and ulcerative colitis colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed.
Title: Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.

Lower LGALS2 gene expression is associated with acute myeloid leukemia.
Title: Expression profiling of cancer-related galectins in acute myeloid leukemia.

PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease
Title: PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.

The following LGALS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LGALS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18546	NM_006498.3 Latest version!	Homo sapiens galectin 2 (LGALS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18546	NM_006498.2	Homo sapiens galectin 2 (LGALS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LGALS2 ( NM_006498.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006489.1 Homo sapiens galectin 2 (LGALS2), mRNA.

Price & Availability↑

CloneID	OHu18546
Clone ID Related Accession (Same CDS sequence)	NM_006498.3 , NM_006498.2
Accession Version	NM_006498.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	galectin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL022315.1, CD701729.1 and BC059782.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006498.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP303532.1, ERR279840.1904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215886.6/ ENSP00000215886.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGGGGG AACTTGAGGT TAAGAACATG GACATGAAGC CGGGGTCAAC CCTGAAGATC 
ACAGGCAGCA TCGCCGATGG CACTGATGGC TTTGTAATTA ATCTGGGCCA GGGGACAGAC 
AAGCTGAACC TGCATTTCAA CCCTCGCTTC AGCGAATCCA CCATTGTCTG CAACTCATTG 
GACGGCAGCA ACTGGGGGCA AGAACAACGG GAAGATCACC TGTGCTTCAG CCCAGGGTCA 
GAGGTCAAGT TCACAGTGAC CTTTGAGAGT GACAAATTCA AGGTGAAGCT GCCAGATGGG 
CACGAGCTGA CTTTTCCCAA CAGGCTGGGT CACAGCCACC TGAGCTACCT GAGCGTAAGG 
GGCGGGTTCA ACATGTCCTC TTTCAAGTTA AAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006489.1
CDS	183..581
Translation	MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE

Target ORF information:

RefSeq Version	NM_006498.3
Organism	Homo sapiens(human)
Definition	Homo sapiens galectin 2 (LGALS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006498.3

ORF Insert Sequence:

ATGACGGGGG AACTTGAGGT TAAGAACATG GACATGAAGC CGGGGTCAAC CCTGAAGATC 
ACAGGCAGCA TCGCCGATGG CACTGATGGC TTTGTAATTA ATCTGGGCCA GGGGACAGAC 
AAGCTGAACC TGCATTTCAA CCCTCGCTTC AGCGAATCCA CCATTGTCTG CAACTCATTG 
GACGGCAGCA ACTGGGGGCA AGAACAACGG GAAGATCACC TGTGCTTCAG CCCAGGGTCA 
GAGGTCAAGT TCACAGTGAC CTTTGAGAGT GACAAATTCA AGGTGAAGCT GCCAGATGGG 
CACGAGCTGA CTTTTCCCAA CAGGCTGGGT CACAGCCACC TGAGCTACCT GAGCGTAAGG 
GGCGGGTTCA ACATGTCCTC TTTCAAGTTA AAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LGALS2 ( NM_006498.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006489.1 Homo sapiens galectin 2 (LGALS2), mRNA.

Price & Availability↑

CloneID	OHu18546
Clone ID Related Accession (Same CDS sequence)	NM_006498.3 , NM_006498.2
Accession Version	NM_006498.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	galectin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD701729.1 and BC059782.1. This sequence is a reference standard in the RefSeqGene project. On Aug 12, 2004 this sequence version replaced NM_006498.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059782.1, ERR279840.1904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGGGGG AACTTGAGGT TAAGAACATG GACATGAAGC CGGGGTCAAC CCTGAAGATC 
ACAGGCAGCA TCGCCGATGG CACTGATGGC TTTGTAATTA ATCTGGGCCA GGGGACAGAC 
AAGCTGAACC TGCATTTCAA CCCTCGCTTC AGCGAATCCA CCATTGTCTG CAACTCATTG 
GACGGCAGCA ACTGGGGGCA AGAACAACGG GAAGATCACC TGTGCTTCAG CCCAGGGTCA 
GAGGTCAAGT TCACAGTGAC CTTTGAGAGT GACAAATTCA AGGTGAAGCT GCCAGATGGG 
CACGAGCTGA CTTTTCCCAA CAGGCTGGGT CACAGCCACC TGAGCTACCT GAGCGTAAGG 
GGCGGGTTCA ACATGTCCTC TTTCAAGTTA AAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006489.1
CDS	113..511
Translation	MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE

Target ORF information:

RefSeq Version	NM_006498.2
Organism	Homo sapiens(human)
Definition	Homo sapiens galectin 2 (LGALS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006498.2

ORF Insert Sequence:

ATGACGGGGG AACTTGAGGT TAAGAACATG GACATGAAGC CGGGGTCAAC CCTGAAGATC 
ACAGGCAGCA TCGCCGATGG CACTGATGGC TTTGTAATTA ATCTGGGCCA GGGGACAGAC 
AAGCTGAACC TGCATTTCAA CCCTCGCTTC AGCGAATCCA CCATTGTCTG CAACTCATTG 
GACGGCAGCA ACTGGGGGCA AGAACAACGG GAAGATCACC TGTGCTTCAG CCCAGGGTCA 
GAGGTCAAGT TCACAGTGAC CTTTGAGAGT GACAAATTCA AGGTGAAGCT GCCAGATGGG 
CACGAGCTGA CTTTTCCCAA CAGGCTGGGT CACAGCCACC TGAGCTACCT GAGCGTAAGG 
GGCGGGTTCA ACATGTCCTC TTTCAAGTTA AAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study.
Clinical epigenetics9120(2017)
Kazmi N,Gaunt TR,Relton C,Micali N

Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.
Acta biochimica et biophysica Sinica48(10)939-947(2016 Oct)
Si Y,Feng S,Gao J,Wang Y,Zhang Z,Meng Y,Zhou Y,Tai G,Su J

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).
International journal of molecular sciences17(4)523(2016 Apr)
Hutter S,Knabl J,Andergassen U,Hofmann S,Kuhn C,Mahner S,Arck P,Jeschke U

Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
BioMed research international20165989128(2016)
Block M,M?lne J,Leffler H,B?rjesson L,Breimer ME

PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.
International journal of clinical and experimental pathology8(3)3138-43(2015)
Tian J,Hu S,Wang F,Yang X,Li Y,Huang C