LRRC26 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRRC26
Entrez Gene ID	389816
Full Name	leucine rich repeat containing 26
Synonyms	CAPC,bA350O14.10
General protein information	Preferred Names leucine rich repeat containing 26 Names leucine-rich repeat-containing protein 26 BK channel auxiliary gamma subunit LRRC26 BK channel auxilliary gamma subunit LRRC26 cytokeratin associated protein cytokeratin-associated protein in cancer
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.3
Disorder MIM:	613505

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013653.2	NP_001013675.1	leucine-rich repeat-containing protein 26 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LRRC26	XP_002691732.1
Pan troglodytes (chimpanzee)	LRRC26	XP_520644.2
	LRRC26	XP_001090425.1
Canis lupus familiaris (dog)	LRRC26	XP_848545.2
Homo sapiens (human)	LRRC26	NP_001013675.1
Gallus gallus (chicken)	LRRC26	XP_004945818.1
Mus musculus (house mouse)	Lrrc26	NP_666229.1
Rattus norvegicus (Norway rat)	Lrrc26	NP_001014075.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary ? subunits.
Li Q, Fan F, Kwak HR, Yan J
The Journal of general physiology145(6)543-54(2015 Jun)

Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.
Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T
The Journal of general physiology145(4)331-43(2015 Apr)

Functional regulation of BK potassium channels by ?1 auxiliary subunits.
Gonzalez-Perez V, Xia XM, Lingle CJ
Proceedings of the National Academy of Sciences of the United States of America111(13)4868-73(2014 Apr)

BK potassium channel modulation by leucine-rich repeat-containing proteins.
Yan J, Aldrich RW
Proceedings of the National Academy of Sciences of the United States of America109(20)7917-22(2012 May)

CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis.
Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I
Oncogene31(13)1673-82(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest that BK channel modulation by auxiliary gamma subunits depends on intra- and/or juxta-membrane mechanisms.
Title: Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary ? subunits.

Regulation of the Ca(2+)- and voltage-activated large conductance Ca(2+)-activated K(+) (BK) channel by associated gamma1-subunits, was investigated.
Title: Functional regulation of BK potassium channels by ?1 auxiliary subunits.

The role of CAPC in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment.
Title: CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis.

in non-excitable LNCaP prostate cancer cells, BK channels can be activated at negative voltages without rises in [Ca(2+)](i) through their complex with an auxiliary protein, leucine-rich repeat (LRR)-containing protein 26 (LRRC26)
Title: LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.

CAPC transcripts have differential expression in cancer cell lines, and that S-CAPC is translated into a 7.5 kDa protein using a non-AUG start codon.
Title: Non-AUG translational initiation of a short CAPC transcript generating protein isoform.

The following LRRC26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRC26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu08993	NM_001013653.2 Latest version!	Homo sapiens leucine rich repeat containing 26 (LRRC26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRRC26 ( NM_001013653.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001013675.1 Homo sapiens leucine rich repeat containing 26 (LRRC26), mRNA.

Price & Availability↑

CloneID	OHu08993
Clone ID Related Accession (Same CDS sequence)	NM_001013653.2
Accession Version	NM_001013653.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 26 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN996987.1, DQ355157.1 and CB160046.1. On Jun 22, 2007 this sequence version replaced NM_001013653.1. ##Evidence-Data-START## Transcript exon combination :: ERR279825.777.1, BC140911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCGGGGCC CTTCCTGGTC GCGGCCTCGG CCGCTGCTGC TGCTGTTGCT GCTGCTGTCG 
CCTTGGCCTG TCTGGGCCCA GGTGTCGGCC ACGGCCTCGC CCTCGGGGTC CCTGGGCGCC 
CCGGACTGCC CCGAGGTGTG CACGTGCGTG CCGGGAGGCC TGGCCAGCTG CTCGGCACTC 
TCGCTGCCCG CCGTGCCCCC GGGCCTGAGC CTGCGCCTGC GCGCGCTGCT GCTGGACCAC 
AACCGCGTCC GTGCGCTGCC GCCAGGTGCC TTCGCGGGAG CGGGCGCGCT ACAGCGCCTG 
GACCTGCGCG AGAACGGGCT GCACTCGGTG CATGTGCGAG CCTTCTGGGG CCTGGGCGCG 
CTGCAGCTGC TGGACCTGAG CGCCAACCAG CTGGAAGCAC TGGCACCAGG GACTTTCGCG 
CCGCTGCGCG CGCTGCGCAA CCTCTCATTG GCCGGCAACC GGCTGGCGCG CCTGGAGCCC 
GCGGCGCTAG GCGCGCTCCC GCTGCTGCGC TCACTCAGCC TGCAGGACAA CGAGCTGGCG 
GCACTCGCGC CGGGGCTGCT GGGCCGCCTG CCCGCTCTAG ACGCGCTGCA CCTGCGCGGC 
AACCCTTGGG GCTGCGGGTG CGCGCTGCGC CCGCTCTGCG CCTGGCTGCG CCGGCACCCG 
CTGCCCGCGT CAGAGGCCGA GACGGTGCTC TGCGTGTGGC CGGGACGCCT GACGCTCAGC 
CCCCTGACTG CCTTTTCCGA CGCCGCCTTT AGCCATTGCG CGCAGCCGCT CGCCCTGCGG 
GACCTGGCCG TGGTTTACAC GCTCGGGCCG GCCTCCTTCC TCGTCAGCCT GGCTTCCTGC 
CTGGCGCTGG GCTCTGGGCT CACCGCCTGC CGTGCGCGCC GCCGCCGCCT CCGCACCGCC 
GCCCTCCGCC CGCCGAGACC GCCAGACCCG AACCCCGATC CCGACCCCCA CGGCTGTGCC 
TCGCCCGCGG ACCCGGGGAG CCCCGCCGCT GCCGCCCAAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013675.1
CDS	97..1101
Translation	MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTAALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA

Target ORF information:

RefSeq Version	NM_001013653.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 26 (LRRC26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013653.2

ORF Insert Sequence:

ATGCGGGGCC CTTCCTGGTC GCGGCCTCGG CCGCTGCTGC TGCTGTTGCT GCTGCTGTCG 
CCTTGGCCTG TCTGGGCCCA GGTGTCGGCC ACGGCCTCGC CCTCGGGGTC CCTGGGCGCC 
CCGGACTGCC CCGAGGTGTG CACGTGCGTG CCGGGAGGCC TGGCCAGCTG CTCGGCACTC 
TCGCTGCCCG CCGTGCCCCC GGGCCTGAGC CTGCGCCTGC GCGCGCTGCT GCTGGACCAC 
AACCGCGTCC GTGCGCTGCC GCCAGGTGCC TTCGCGGGAG CGGGCGCGCT ACAGCGCCTG 
GACCTGCGCG AGAACGGGCT GCACTCGGTG CATGTGCGAG CCTTCTGGGG CCTGGGCGCG 
CTGCAGCTGC TGGACCTGAG CGCCAACCAG CTGGAAGCAC TGGCACCAGG GACTTTCGCG 
CCGCTGCGCG CGCTGCGCAA CCTCTCATTG GCCGGCAACC GGCTGGCGCG CCTGGAGCCC 
GCGGCGCTAG GCGCGCTCCC GCTGCTGCGC TCACTCAGCC TGCAGGACAA CGAGCTGGCG 
GCACTCGCGC CGGGGCTGCT GGGCCGCCTG CCCGCTCTAG ACGCGCTGCA CCTGCGCGGC 
AACCCTTGGG GCTGCGGGTG CGCGCTGCGC CCGCTCTGCG CCTGGCTGCG CCGGCACCCG 
CTGCCCGCGT CAGAGGCCGA GACGGTGCTC TGCGTGTGGC CGGGACGCCT GACGCTCAGC 
CCCCTGACTG CCTTTTCCGA CGCCGCCTTT AGCCATTGCG CGCAGCCGCT CGCCCTGCGG 
GACCTGGCCG TGGTTTACAC GCTCGGGCCG GCCTCCTTCC TCGTCAGCCT GGCTTCCTGC 
CTGGCGCTGG GCTCTGGGCT CACCGCCTGC CGTGCGCGCC GCCGCCGCCT CCGCACCGCC 
GCCCTCCGCC CGCCGAGACC GCCAGACCCG AACCCCGATC CCGACCCCCA CGGCTGTGCC 
TCGCCCGCGG ACCCGGGGAG CCCCGCCGCT GCCGCCCAAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary ? subunits.
The Journal of general physiology145(6)543-54(2015 Jun)
Li Q,Fan F,Kwak HR,Yan J

Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.
The Journal of general physiology145(4)331-43(2015 Apr)
Tian Y,Ullrich F,Xu R,Heinemann SH,Hou S,Hoshi T

Functional regulation of BK potassium channels by ?1 auxiliary subunits.
Proceedings of the National Academy of Sciences of the United States of America111(13)4868-73(2014 Apr)
Gonzalez-Perez V,Xia XM,Lingle CJ

BK potassium channel modulation by leucine-rich repeat-containing proteins.
Proceedings of the National Academy of Sciences of the United States of America109(20)7917-22(2012 May)
Yan J,Aldrich RW

CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis.
Oncogene31(13)1673-82(2012 Mar)
Liu XF,Xiang L,Zhang Y,Becker KG,Bera TK,Pastan I