| Gene Symbol | KLKB1 |
| Entrez Gene ID | 3818 |
| Full Name | kallikrein B1 |
| Synonyms | KLK3,PKK,PKKD,PPK |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. |
| Disorder MIM: | |
| Disorder Html: | Fletcher factor (prekallikrein) deficiency, 612423 (3) |








































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