IFNE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNE
Entrez Gene ID	338376
Full Name	interferon epsilon
Synonyms	IFN-E,IFNE1,IFNT1,INFE1,PRO655
General protein information	Preferred Names interferon epsilon Names interferon epsilon IFN-epsilon interferon epsilon 1 interferon tau-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Disorder MIM:	615223

mRNA and Protein(s)

mRNA	Protein	Name
NM_176891.4	NP_795372.1	interferon epsilon precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ifne	XP_002729545.1
Pan troglodytes (chimpanzee)	IFNE	XP_528573.1
Gallus gallus (chicken)	LOC101750245	XP_004949189.1
Bos taurus (cattle)	IFNE	XP_005209958.1
Gallus gallus (chicken)	LOC101751725	XP_004950572.1
Mus musculus (house mouse)	Ifne	NP_796322.1
Homo sapiens (human)	IFNE	NP_795372.1

Gene Ontology
Bibliography

Related articles in PubMed

Interferon epsilon promotes HIV restriction at multiple steps of viral replication.
Garcia-Minambres A, Eid SG, Mangan NE, Pade C, Lim SS, Matthews AY, de Weerd NA, Hertzog PJ, Mak J
Immunology and cell biology95(5)478-483(2017 May)

IFN-
Tasker C, Subbian S, Gao P, Couret J, Levine C, Ghanny S, Soteropoulos P, Zhao X, Landau N, Lu W, Chang TL
JCI insight1(20)e88255(2016 Dec)

HIV-1-negative female sex workers sustain high cervical IFN?, low immune activation, and low expression of HIV-1-required host genes.
Abdulhaqq SA, Zorrilla C, Kang G, Yin X, Tamayo V, Seaton KE, Joseph J, Garced S, Tomaras GD, Linn KA, Foulkes AS, Azzoni L, VerMilyea M, Coutifaris C, Kossenkov AV, Showe L, Kraiselburd EN, Li Q, Montaner LJ
Mucosal immunology9(4)1027-38(2016 07)

T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-? is a risk factor for the development of intracerebral hemorrhage.
Kim SK, Park HJ, Kim JW, Chung JH, Yoo SD, Kim DH, Yun DH, Kim HS
Human immunology75(1)88-90(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

female sex workers decreased susceptibility to HIV-1 infection also have increased levels of IFNE gene and protein expression in the cervical epithelium
Title: HIV-1-negative female sex workers sustain high cervical IFN?, low immune activation, and low expression of HIV-1-required host genes.

T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.
Title: T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-? is a risk factor for the development of intracerebral hemorrhage.

Full-length IFN-epsilon 5'UTR markedly suppressed mRNA expression under basal conditions. It contains 2 stable stem-loop structures which associate with importin 9. Loop 1 is essential for regulation of mRNA expression.
Title: Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-? expression.

genetic polymorphism is related to onset time of vitiligo in Korean patients
Title: Association study between nonsense polymorphism (rs2039381, Gln71Stop) of interferon-? and susceptibility to vitiligo in Korean population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study.

The following IFNE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13948	NM_176891.4 Latest version!	Homo sapiens interferon epsilon (IFNE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNE ( NM_176891.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_795372.1 Homo sapiens interferon epsilon (IFNE), mRNA.

Price & Availability↑

CloneID	OHu13948
Clone ID Related Accession (Same CDS sequence)	NM_176891.4
Accession Version	NM_176891.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	interferon epsilon precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358570.1 and AL353732.14. On Jan 6, 2009 this sequence version replaced NM_176891.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY358570.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATTATCA AGCACTTCTT TGGAACTGTG TTGGTGCTGC TGGCCTCTAC CACTATCTTC 
TCTCTAGATT TGAAACTGAT TATCTTCCAG CAAAGACAAG TGAATCAAGA AAGTTTAAAA 
CTCTTGAATA AGTTGCAAAC CTTGTCAATT CAGCAGTGTC TACCACACAG GAAAAACTTT 
CTGCTTCCTC AGAAGTCTTT GAGTCCTCAG CAGTACCAAA AAGGACACAC TCTGGCCATT 
CTCCATGAGA TGCTTCAGCA GATCTTCAGC CTCTTCAGGG CAAATATTTC TCTGGATGGT 
TGGGAGGAAA ACCACACGGA GAAATTCCTC ATTCAACTTC ATCAACAGCT AGAATACCTA 
GAAGCACTCA TGGGACTGGA AGCAGAGAAG CTAAGTGGTA CTTTGGGTAG TGATAACCTT 
AGATTACAAG TTAAAATGTA CTTCCGAAGG ATCCATGATT ACCTGGAAAA CCAGGACTAC 
AGCACCTGTG CCTGGGCCAT TGTCCAAGTA GAAATCAGCC GATGTCTGTT CTTTGTGTTC 
AGTCTCACAG AAAAACTGAG CAAACAAGGA AGACCCTTGA ACGACATGAA GCAAGAGCTT 
ACTACAGAGT TTAGAAGCCC GAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795372.1
CDS	620..1246
Translation	MIIKHFFGTVLVLLASTTIFSLDLKLIIFQQRQVNQESLKLLNKLQTLSIQQCLPHRKNFLLPQKSLSPQQYQKGHTLAILHEMLQQIFSLFRANISLDGWEENHTEKFLIQLHQQLEYLEALMGLEAEKLSGTLGSDNLRLQVKMYFRRIHDYLENQDYSTCAWAIVQVEISRCLFFVFSLTEKLSKQGRPLNDMKQELTTEFRSPR

Target ORF information:

RefSeq Version	NM_176891.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon epsilon (IFNE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176891.4

ORF Insert Sequence:

ATGATTATCA AGCACTTCTT TGGAACTGTG TTGGTGCTGC TGGCCTCTAC CACTATCTTC 
TCTCTAGATT TGAAACTGAT TATCTTCCAG CAAAGACAAG TGAATCAAGA AAGTTTAAAA 
CTCTTGAATA AGTTGCAAAC CTTGTCAATT CAGCAGTGTC TACCACACAG GAAAAACTTT 
CTGCTTCCTC AGAAGTCTTT GAGTCCTCAG CAGTACCAAA AAGGACACAC TCTGGCCATT 
CTCCATGAGA TGCTTCAGCA GATCTTCAGC CTCTTCAGGG CAAATATTTC TCTGGATGGT 
TGGGAGGAAA ACCACACGGA GAAATTCCTC ATTCAACTTC ATCAACAGCT AGAATACCTA 
GAAGCACTCA TGGGACTGGA AGCAGAGAAG CTAAGTGGTA CTTTGGGTAG TGATAACCTT 
AGATTACAAG TTAAAATGTA CTTCCGAAGG ATCCATGATT ACCTGGAAAA CCAGGACTAC 
AGCACCTGTG CCTGGGCCAT TGTCCAAGTA GAAATCAGCC GATGTCTGTT CTTTGTGTTC 
AGTCTCACAG AAAAACTGAG CAAACAAGGA AGACCCTTGA ACGACATGAA GCAAGAGCTT 
ACTACAGAGT TTAGAAGCCC GAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interferon epsilon promotes HIV restriction at multiple steps of viral replication.
Immunology and cell biology95(5)478-483(2017 May)
Garcia-Minambres A,Eid SG,Mangan NE,Pade C,Lim SS,Matthews AY,de Weerd NA,Hertzog PJ,Mak J

IFN-
JCI insight1(20)e88255(2016 Dec)
Tasker C,Subbian S,Gao P,Couret J,Levine C,Ghanny S,Soteropoulos P,Zhao X,Landau N,Lu W,Chang TL

HIV-1-negative female sex workers sustain high cervical IFN?, low immune activation, and low expression of HIV-1-required host genes.
Mucosal immunology9(4)1027-38(2016 07)
Abdulhaqq SA,Zorrilla C,Kang G,Yin X,Tamayo V,Seaton KE,Joseph J,Garced S,Tomaras GD,Linn KA,Foulkes AS,Azzoni L,VerMilyea M,Coutifaris C,Kossenkov AV,Showe L,Kraiselburd EN,Li Q,Montaner LJ

T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-? is a risk factor for the development of intracerebral hemorrhage.
Human immunology75(1)88-90(2014 Jan)
Kim SK,Park HJ,Kim JW,Chung JH,Yoo SD,Kim DH,Yun DH,Kim HS