TREML4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TREML4
Entrez Gene ID	285852
Full Name	triggering receptor expressed on myeloid cells like 4
Synonyms	TLT-4,TLT4
General protein information	Preferred Names triggering receptor expressed on myeloid cells like 4 Names trem-like transcript 4 protein TREM like transcript 4 triggering receptor expressed on myeloid cells-like protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.1
Disorder MIM:	614664

mRNA and Protein(s)

mRNA	Protein	Name
NM_198153.2	NP_937796.1	trem-like transcript 4 protein precursor
NM_198153.3	NP_937796.1	trem-like transcript 4 protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TREML4	XP_001160496.2
Homo sapiens (human)	TREML4	NP_937796.1
Rattus norvegicus (Norway rat)	Treml4	XP_006244547.1

Gene Ontology
Bibliography

Related articles in PubMed

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK
Nature immunology16(5)495-504(2015 May)

Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.
Sen SK, Boelte KC, Barb JJ, Joehanes R, Zhao X, Cheng Q, Adams L, Teer JK, Accame DS, Chowdhury S, Singh LN, , , Kavousi M, Peyser PA, Quigley L, Priel DL, Lau K, Kuhns DB, Yoshimura T, Johnson AD, Hwang SJ, Chen MY, Arai AE, Green ED, Mullikin JC, Kolodgie FD, O'Donnell CJ, Virmani R, Munson PJ, McVicar DW, Biesecker LG
American journal of human genetics95(1)66-76(2014 Jul)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.
Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J
European journal of immunology33(2)567-77(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

determined by von Kossa staining that TREML4 colocalizes with areas of microcalcification within coronary plaques. Overall, we present integrative RNA, DNA, and protein evidence implicating TREML4 in coronary artery calcification
Title: Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following TREML4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TREML4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24471	NM_198153.3 Latest version!	Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24471	NM_198153.2	Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TREML4 ( NM_198153.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937796.1 Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.

Price & Availability↑

CloneID	OHu24471
Clone ID Related Accession (Same CDS sequence)	NM_198153.2 , NM_198153.3
Accession Version	NM_198153.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	trem-like transcript 4 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391903.15 and AY358271.1. On Nov 25, 2008 this sequence version replaced NM_198153.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY358271.1, BC101780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMN01820687 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTGGG GTGGGGTCCA CACCTGCTGC TTCCACCTGT GCTGCTGCTG CTCCTGGCCT 
CAGGGTGCTG TGCCTGAAGA ACTTCACAAA CACCCAGGAC AGACCCTCCT CCTGCAATGC 
CAGTACTCAC CCAAGAGAGG GCCCTATCAG CCCAAATCCT GGTGTCAGCA GACATCTCCA 
AGTCGGTGTA CCTTACTTGT CACCAGCTCC AAGCCCTGGA CAGCAGTTCA GAAGTCTCAT 
TACACAATCT GGGACAAGCC CAATGCTGGC TTCTTCAACA TCACCATGAT TCAGCTGACA 
CAGAATGACT CGGGATTCTA CTGGTGTGGA ATCTACAACG CTTCCGAAAA CATCATCACT 
GTTCTTAGAA ATATCAGCCT GGTGGTGTCT CCAGCCCCAA CCACGTCTCC TATGTGGACT 
CTTCCCTGGC TCCCAACAAG CACAGTTCTG ATCACTTCTC CAGAGGGGAC CTCTGGCCAT 
CCCTCCATCA ATGGCTCTGA GACCAGGAAA TCAAGAGCCC CTGCCTGCCT TGGCTCAGGT 
GGCCCCAGAT TCCTGGTCTT GGTGCTATGT GGACTCCTCC TGGCCAAGGG CCTGATGTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937796.1
CDS	105..707
Translation	MAWGGVHTCCFHLCCCCSWPQGAVPEELHKHPGQTLLLQCQYSPKRGPYQPKSWCQQTSPSRCTLLVTSSKPWTAVQKSHYTIWDKPNAGFFNITMIQLTQNDSGFYWCGIYNASENIITVLRNISLVVSPAPTTSPMWTLPWLPTSTVLITSPEGTSGHPSINGSETRKSRAPACLGSGGPRFLVLVLCGLLLAKGLML

Target ORF information:

RefSeq Version	NM_198153.2
Organism	Homo sapiens(human)
Definition	Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198153.2

ORF Insert Sequence:

ATGGCCTGGG GTGGGGTCCA CACCTGCTGC TTCCACCTGT GCTGCTGCTG CTCCTGGCCT 
CAGGGTGCTG TGCCTGAAGA ACTTCACAAA CACCCAGGAC AGACCCTCCT CCTGCAATGC 
CAGTACTCAC CCAAGAGAGG GCCCTATCAG CCCAAATCCT GGTGTCAGCA GACATCTCCA 
AGTCGGTGTA CCTTACTTGT CACCAGCTCC AAGCCCTGGA CAGCAGTTCA GAAGTCTCAT 
TACACAATCT GGGACAAGCC CAATGCTGGC TTCTTCAACA TCACCATGAT TCAGCTGACA 
CAGAATGACT CGGGATTCTA CTGGTGTGGA ATCTACAACG CTTCCGAAAA CATCATCACT 
GTTCTTAGAA ATATCAGCCT GGTGGTGTCT CCAGCCCCAA CCACGTCTCC TATGTGGACT 
CTTCCCTGGC TCCCAACAAG CACAGTTCTG ATCACTTCTC CAGAGGGGAC CTCTGGCCAT 
CCCTCCATCA ATGGCTCTGA GACCAGGAAA TCAAGAGCCC CTGCCTGCCT TGGCTCAGGT 
GGCCCCAGAT TCCTGGTCTT GGTGCTATGT GGACTCCTCC TGGCCAAGGG CCTGATGTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREML4 ( NM_198153.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_937796.1 Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.

Price & Availability↑

CloneID	OHu24471
Clone ID Related Accession (Same CDS sequence)	NM_198153.2 , NM_198153.3
Accession Version	NM_198153.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	trem-like transcript 4 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391903.15 and AY358271.1. On May 17, 2019 this sequence version replaced NM_198153.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY358271.1, BC105101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341495.7/ ENSP00000342570.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCTGGG GTGGGGTCCA CACCTGCTGC TTCCACCTGT GCTGCTGCTG CTCCTGGCCT 
CAGGGTGCTG TGCCTGAAGA ACTTCACAAA CACCCAGGAC AGACCCTCCT CCTGCAATGC 
CAGTACTCAC CCAAGAGAGG GCCCTATCAG CCCAAATCCT GGTGTCAGCA GACATCTCCA 
AGTCGGTGTA CCTTACTTGT CACCAGCTCC AAGCCCTGGA CAGCAGTTCA GAAGTCTCAT 
TACACAATCT GGGACAAGCC CAATGCTGGC TTCTTCAACA TCACCATGAT TCAGCTGACA 
CAGAATGACT CGGGATTCTA CTGGTGTGGA ATCTACAACG CTTCCGAAAA CATCATCACT 
GTTCTTAGAA ATATCAGCCT GGTGGTGTCT CCAGCCCCAA CCACGTCTCC TATGTGGACT 
CTTCCCTGGC TCCCAACAAG CACAGTTCTG ATCACTTCTC CAGAGGGGAC CTCTGGCCAT 
CCCTCCATCA ATGGCTCTGA GACCAGGAAA TCAAGAGCCC CTGCCTGCCT TGGCTCAGGT 
GGCCCCAGAT TCCTGGTCTT GGTGCTATGT GGACTCCTCC TGGCCAAGGG CCTGATGTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937796.1
CDS	80..682
Translation	MAWGGVHTCCFHLCCCCSWPQGAVPEELHKHPGQTLLLQCQYSPKRGPYQPKSWCQQTSPSRCTLLVTSSKPWTAVQKSHYTIWDKPNAGFFNITMIQLTQNDSGFYWCGIYNASENIITVLRNISLVVSPAPTTSPMWTLPWLPTSTVLITSPEGTSGHPSINGSETRKSRAPACLGSGGPRFLVLVLCGLLLAKGLML

Target ORF information:

RefSeq Version	NM_198153.3
Organism	Homo sapiens(human)
Definition	Homo sapiens triggering receptor expressed on myeloid cells like 4 (TREML4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198153.3

ORF Insert Sequence:

ATGGCCTGGG GTGGGGTCCA CACCTGCTGC TTCCACCTGT GCTGCTGCTG CTCCTGGCCT 
CAGGGTGCTG TGCCTGAAGA ACTTCACAAA CACCCAGGAC AGACCCTCCT CCTGCAATGC 
CAGTACTCAC CCAAGAGAGG GCCCTATCAG CCCAAATCCT GGTGTCAGCA GACATCTCCA 
AGTCGGTGTA CCTTACTTGT CACCAGCTCC AAGCCCTGGA CAGCAGTTCA GAAGTCTCAT 
TACACAATCT GGGACAAGCC CAATGCTGGC TTCTTCAACA TCACCATGAT TCAGCTGACA 
CAGAATGACT CGGGATTCTA CTGGTGTGGA ATCTACAACG CTTCCGAAAA CATCATCACT 
GTTCTTAGAA ATATCAGCCT GGTGGTGTCT CCAGCCCCAA CCACGTCTCC TATGTGGACT 
CTTCCCTGGC TCCCAACAAG CACAGTTCTG ATCACTTCTC CAGAGGGGAC CTCTGGCCAT 
CCCTCCATCA ATGGCTCTGA GACCAGGAAA TCAAGAGCCC CTGCCTGCCT TGGCTCAGGT 
GGCCCCAGAT TCCTGGTCTT GGTGCTATGT GGACTCCTCC TGGCCAAGGG CCTGATGTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Nature immunology16(5)495-504(2015 May)
Ramirez-Ortiz ZG,Prasad A,Griffith JW,Pendergraft WF 3rd,Cowley GS,Root DE,Tai M,Luster AD,El Khoury J,Hacohen N,Means TK

Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.
American journal of human genetics95(1)66-76(2014 Jul)
Sen SK,Boelte KC,Barb JJ,Joehanes R,Zhao X,Cheng Q,Adams L,Teer JK,Accame DS,Chowdhury S,Singh LN,,,Kavousi M,Peyser PA,Quigley L,Priel DL,Lau K,Kuhns DB,Yoshimura T,Johnson AD,Hwang SJ,Chen MY,Arai AE,Green ED,Mullikin JC,Kolodgie FD,O'Donnell CJ,Virmani R,Munson PJ,McVicar DW,Biesecker LG

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.
European journal of immunology33(2)567-77(2003 Feb)
Allcock RJ,Barrow AD,Forbes S,Beck S,Trowsdale J