TSSK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSSK2
Entrez Gene ID	23617
Full Name	testis specific serine kinase 2
Synonyms	DGS-G,SPOGA2,STK22B,TSK2
General protein information	Preferred Names testis specific serine kinase 2 Names testis-specific serine/threonine-protein kinase 2 TSK-2 TSSK-2 diGeorge syndrome protein G serine/threonine kinase 22B (spermiogenesis associated) serine/threonine-protein kinase 22B spermiogenesis associated 2 testicular secretory protein Li 61 testis specific serine threonine kinase 2 testis-specific kinase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610710

mRNA and Protein(s)

mRNA	Protein	Name
NM_053006.4	NP_443732.3	testis-specific serine/threonine-protein kinase 2
NM_053006.5	NP_443732.3	testis-specific serine/threonine-protein kinase 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TSSK2	XP_850513.1
Bos taurus (cattle)	TSSK2	XP_005218362.1
Rattus norvegicus (Norway rat)	Tssk2	NP_001012019.1
Homo sapiens (human)	TSSK2	NP_443732.3
Pan troglodytes (chimpanzee)	TSSK2	XP_001165103.1
Mus musculus (house mouse)	Tssk2	NP_033462.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008765	XP_314887.4
	TSSK2	XP_001104572.1

Gene Ontology
Bibliography

Related articles in PubMed

Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.
Shetty J, Sinville R, Shumilin IA, Minor W, Zhang J, Hawkinson JE, Georg GI, Flickinger CJ, Herr JC
Protein expression and purification12188-96(2016 May)

Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Shang P, Hoogerbrugge J, Baarends WM, Grootegoed JA
Andrology1(1)160-8(2013 Jan)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.
Li Y, Sosnik J, Brassard L, Reese M, Spiridonov NA, Bates TC, Johnson GR, Anguita J, Visconti PE, Salicioni AM
Molecular human reproduction17(1)42-56(2011 Jan)

Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
Zhang H, Su D, Yang Y, Zhang W, Liu Y, Bai G, Ma M, Ma Y, Zhang S
Journal of andrology31(4)388-92(2010 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

n vitro phosphorylation experiments carried out with TSKS (isoform 1) fragments revealed particularly strong phosphorylation of a recombinant N-terminal region representing aa 1-150 of TSKS, indicating that the N-terminus of human TSKS is phosphorylated by human TSSK2.
Title: Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.

Report evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Title: Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.

Observational study of gene-disease association. (HuGE Navigator)
Title: Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.

Data show that human testis-specific serine/threonine (Ser/Thr) kinase (TSSK) 1 and 2 messages are expressed exclusively in the testis and suggest that this family of kinases might play a role in sperm function.
Title: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.

The following TSSK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSSK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31935	NM_053006.5 Latest version!	Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu31935	NM_053006.4	Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSSK2 ( NM_053006.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_443732.3 Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.

Price & Availability↑

CloneID	OHu31935
Clone ID Related Accession (Same CDS sequence)	NM_053006.4 , NM_053006.5
Accession Version	NM_053006.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	testis-specific serine/threonine-protein kinase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L77564.1 and BC037781.2. On Jul 17, 2008 this sequence version replaced NM_053006.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGACGATG CCACAGTCCT AAGGAAGAAG GGTTACATCG TAGGCATCAA TCTTGGCAAG 
GGTTCCTACG CAAAAGTCAA ATCTGCCTAC TCTGAGCGCC TCAAGTTCAA TGTGGCTGTC 
AAGATCATCG ACCGCAAGAA AACACCTACT GACTTTGTGG AGAGATTCCT TCCTCGGGAG 
ATGGACATCC TGGCAACTGT CAACCACGGC TCCATCATCA AGACTTACGA GATCTTTGAG 
ACCTCTGACG GACGGATCTA CATCATCATG GAGCTTGGCG TCCAGGGCGA CCTCCTCGAG 
TTCATCAAGT GCCAGGGAGC CCTGCATGAG GACGTGGCAC GCAAGATGTT CCGACAGCTC 
TCCTCCGCCG TCAAGTACTG CCACGACCTG GACATCGTCC ACCGGGACCT CAAGTGCGAG 
AACCTTCTCC TCGACAAGGA CTTCAACATC AAGCTGTCTG ACTTTGGCTT CTCCAAGCGC 
TGCCTGCGGG ACAGCAATGG GCGCATCATC CTCAGCAAGA CCTTCTGCGG GTCGGCAGCA 
TATGCAGCCC CCGAGGTGCT GCAGAGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 
AGCCTGGGCG TGATCCTGTA CATCATGGTC TGCGGCTCCA TGCCCTATGA CGACTCCGAC 
ATCAGGAAGA TGCTGCGTAT CCAGAAGGAG CACCGTGTGG ACTTCCCGCG CTCCAAGAAC 
CTGACCTGCG AGTGCAAGGA CCTCATCTAC CGCATGCTGC AGCCCGACGT CAGCCAGCGG 
CTCCACATCG ATGAGATCCT CAGCCACTCG TGGCTGCAGC CCCCCAAGCC CAAAGCCACG 
TCTTCTGCCT CCTTCAAGAG GGAGGGGGAG GGCAAGTACC GCGCTGAGTG CAAACTGGAC 
ACCAAGACAG GCTTGAGGCC CGACCACCGG CCCGACCACA AGCTTGGAGC CAAAACCCAG 
CACCGGCTGC TGGTGGTGCC CGAGAACGAG AACAGGATGG AGGACAGGCT GGCCGAGACC 
TCCAGGGCCA AAGACCATCA CATCTCCGGA GCTGAGGTGG GGAAAGCAAG CACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443732.3
CDS	593..1669
Translation	MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST

Target ORF information:

RefSeq Version	NM_053006.4
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053006.4

ORF Insert Sequence:

ATGGACGATG CCACAGTCCT AAGGAAGAAG GGTTACATCG TAGGCATCAA TCTTGGCAAG 
GGTTCCTACG CAAAAGTCAA ATCTGCCTAC TCTGAGCGCC TCAAGTTCAA TGTGGCTGTC 
AAGATCATCG ACCGCAAGAA AACACCTACT GACTTTGTGG AGAGATTCCT TCCTCGGGAG 
ATGGACATCC TGGCAACTGT CAACCACGGC TCCATCATCA AGACTTACGA GATCTTTGAG 
ACCTCTGACG GACGGATCTA CATCATCATG GAGCTTGGCG TCCAGGGCGA CCTCCTCGAG 
TTCATCAAGT GCCAGGGAGC CCTGCATGAG GACGTGGCAC GCAAGATGTT CCGACAGCTC 
TCCTCCGCCG TCAAGTACTG CCACGACCTG GACATCGTCC ACCGGGACCT CAAGTGCGAG 
AACCTTCTCC TCGACAAGGA CTTCAACATC AAGCTGTCTG ACTTTGGCTT CTCCAAGCGC 
TGCCTGCGGG ACAGCAATGG GCGCATCATC CTCAGCAAGA CCTTCTGCGG GTCGGCAGCA 
TATGCAGCCC CCGAGGTGCT GCAGAGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 
AGCCTGGGCG TGATCCTGTA CATCATGGTC TGCGGCTCCA TGCCCTATGA CGACTCCGAC 
ATCAGGAAGA TGCTGCGTAT CCAGAAGGAG CACCGTGTGG ACTTCCCGCG CTCCAAGAAC 
CTGACCTGCG AGTGCAAGGA CCTCATCTAC CGCATGCTGC AGCCCGACGT CAGCCAGCGG 
CTCCACATCG ATGAGATCCT CAGCCACTCG TGGCTGCAGC CCCCCAAGCC CAAAGCCACG 
TCTTCTGCCT CCTTCAAGAG GGAGGGGGAG GGCAAGTACC GCGCTGAGTG CAAACTGGAC 
ACCAAGACAG GCTTGAGGCC CGACCACCGG CCCGACCACA AGCTTGGAGC CAAAACCCAG 
CACCGGCTGC TGGTGGTGCC CGAGAACGAG AACAGGATGG AGGACAGGCT GGCCGAGACC 
TCCAGGGCCA AAGACCATCA CATCTCCGGA GCTGAGGTGG GGAAAGCAAG CACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSSK2 ( NM_053006.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_443732.3 Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.

Price & Availability↑

CloneID	OHu31935
Clone ID Related Accession (Same CDS sequence)	NM_053006.4 , NM_053006.5
Accession Version	NM_053006.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	testis-specific serine/threonine-protein kinase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L77564.1 and BC037781.2. On Nov 22, 2018 this sequence version replaced NM_053006.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR5189667.153170.1, SRR5189667.124858.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000399635.4/ ENSP00000382544.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGATG CCACAGTCCT AAGGAAGAAG GGTTACATCG TAGGCATCAA TCTTGGCAAG 
GGTTCCTACG CAAAAGTCAA ATCTGCCTAC TCTGAGCGCC TCAAGTTCAA TGTGGCTGTC 
AAGATCATCG ACCGCAAGAA AACACCTACT GACTTTGTGG AGAGATTCCT TCCTCGGGAG 
ATGGACATCC TGGCAACTGT CAACCACGGC TCCATCATCA AGACTTACGA GATCTTTGAG 
ACCTCTGACG GACGGATCTA CATCATCATG GAGCTTGGCG TCCAGGGCGA CCTCCTCGAG 
TTCATCAAGT GCCAGGGAGC CCTGCATGAG GACGTGGCAC GCAAGATGTT CCGACAGCTC 
TCCTCCGCCG TCAAGTACTG CCACGACCTG GACATCGTCC ACCGGGACCT CAAGTGCGAG 
AACCTTCTCC TCGACAAGGA CTTCAACATC AAGCTGTCTG ACTTTGGCTT CTCCAAGCGC 
TGCCTGCGGG ACAGCAATGG GCGCATCATC CTCAGCAAGA CCTTCTGCGG GTCGGCAGCA 
TATGCAGCCC CCGAGGTGCT GCAGAGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 
AGCCTGGGCG TGATCCTGTA CATCATGGTC TGCGGCTCCA TGCCCTATGA CGACTCCGAC 
ATCAGGAAGA TGCTGCGTAT CCAGAAGGAG CACCGTGTGG ACTTCCCGCG CTCCAAGAAC 
CTGACCTGCG AGTGCAAGGA CCTCATCTAC CGCATGCTGC AGCCCGACGT CAGCCAGCGG 
CTCCACATCG ATGAGATCCT CAGCCACTCG TGGCTGCAGC CCCCCAAGCC CAAAGCCACG 
TCTTCTGCCT CCTTCAAGAG GGAGGGGGAG GGCAAGTACC GCGCTGAGTG CAAACTGGAC 
ACCAAGACAG GCTTGAGGCC CGACCACCGG CCCGACCACA AGCTTGGAGC CAAAACCCAG 
CACCGGCTGC TGGTGGTGCC CGAGAACGAG AACAGGATGG AGGACAGGCT GGCCGAGACC 
TCCAGGGCCA AAGACCATCA CATCTCCGGA GCTGAGGTGG GGAAAGCAAG CACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443732.3
CDS	93..1169
Translation	MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST

Target ORF information:

RefSeq Version	NM_053006.5
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific serine kinase 2 (TSSK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053006.5

ORF Insert Sequence:

ATGGACGATG CCACAGTCCT AAGGAAGAAG GGTTACATCG TAGGCATCAA TCTTGGCAAG 
GGTTCCTACG CAAAAGTCAA ATCTGCCTAC TCTGAGCGCC TCAAGTTCAA TGTGGCTGTC 
AAGATCATCG ACCGCAAGAA AACACCTACT GACTTTGTGG AGAGATTCCT TCCTCGGGAG 
ATGGACATCC TGGCAACTGT CAACCACGGC TCCATCATCA AGACTTACGA GATCTTTGAG 
ACCTCTGACG GACGGATCTA CATCATCATG GAGCTTGGCG TCCAGGGCGA CCTCCTCGAG 
TTCATCAAGT GCCAGGGAGC CCTGCATGAG GACGTGGCAC GCAAGATGTT CCGACAGCTC 
TCCTCCGCCG TCAAGTACTG CCACGACCTG GACATCGTCC ACCGGGACCT CAAGTGCGAG 
AACCTTCTCC TCGACAAGGA CTTCAACATC AAGCTGTCTG ACTTTGGCTT CTCCAAGCGC 
TGCCTGCGGG ACAGCAATGG GCGCATCATC CTCAGCAAGA CCTTCTGCGG GTCGGCAGCA 
TATGCAGCCC CCGAGGTGCT GCAGAGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 
AGCCTGGGCG TGATCCTGTA CATCATGGTC TGCGGCTCCA TGCCCTATGA CGACTCCGAC 
ATCAGGAAGA TGCTGCGTAT CCAGAAGGAG CACCGTGTGG ACTTCCCGCG CTCCAAGAAC 
CTGACCTGCG AGTGCAAGGA CCTCATCTAC CGCATGCTGC AGCCCGACGT CAGCCAGCGG 
CTCCACATCG ATGAGATCCT CAGCCACTCG TGGCTGCAGC CCCCCAAGCC CAAAGCCACG 
TCTTCTGCCT CCTTCAAGAG GGAGGGGGAG GGCAAGTACC GCGCTGAGTG CAAACTGGAC 
ACCAAGACAG GCTTGAGGCC CGACCACCGG CCCGACCACA AGCTTGGAGC CAAAACCCAG 
CACCGGCTGC TGGTGGTGCC CGAGAACGAG AACAGGATGG AGGACAGGCT GGCCGAGACC 
TCCAGGGCCA AAGACCATCA CATCTCCGGA GCTGAGGTGG GGAAAGCAAG CACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.
Protein expression and purification12188-96(2016 May)
Shetty J,Sinville R,Shumilin IA,Minor W,Zhang J,Hawkinson JE,Georg GI,Flickinger CJ,Herr JC

Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Andrology1(1)160-8(2013 Jan)
Shang P,Hoogerbrugge J,Baarends WM,Grootegoed JA

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.
Molecular human reproduction17(1)42-56(2011 Jan)
Li Y,Sosnik J,Brassard L,Reese M,Spiridonov NA,Bates TC,Johnson GR,Anguita J,Visconti PE,Salicioni AM

Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
Journal of andrology31(4)388-92(2010 Jul-Aug)
Zhang H,Su D,Yang Y,Zhang W,Liu Y,Bai G,Ma M,Ma Y,Zhang S

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TSSK2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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