WBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WBP1
Entrez Gene ID	23559
Full Name	WW domain binding protein 1
Synonyms	WBP-1
General protein information	Preferred Names WW domain binding protein 1 Names WW domain-binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011].
Disorder MIM:	606961

mRNA and Protein(s)

mRNA	Protein	Name
NM_012477.4	NP_036609.1	WW domain-binding protein 1
NM_012477.3	NP_036609.1	WW domain-binding protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	WBP1	XP_852640.1
Mus musculus (house mouse)	Wbp1	NP_001077391.1
Danio rerio (zebrafish)	zgc:77391	NP_991197.1
Pan troglodytes (chimpanzee)	WBP1	XP_001159082.1
Homo sapiens (human)	WBP1	NP_036609.1
	LOC709202	XP_001109933.1
Rattus norvegicus (Norway rat)	Wbp1	NP_001100070.1
Bos taurus (cattle)	WBP1	NP_001029518.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation.
Tao H, Zhang M, Yang JJ, Shi KH
Heart, lung & circulation27(1)104-113(2018 Jan)

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.
Schuchardt BJ, Mikles DC, Hoang LM, Bhat V, McDonald CB, Sudol M, Farooq A
The FEBS journal281(24)5532-51(2014 Dec)

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
McDonald CB, McIntosh SK, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z, Farooq A
Biochemistry50(44)9616-27(2011 Nov)

Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.
Morishima N, Nakanishi K, Nakano A
The Journal of biological chemistry286(40)35227-35(2011 Oct)

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.
Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM
Oncogene23(29)5049-55(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP1 and WBP2 in a highly promiscuous and subtle manner.
Title: Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

Mcl-1 is a determinant of cell fate, and ATF6 mediates apoptosis via specific suppression of Mcl-1 through up-regulation of WBP1
Title: Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.

The following WBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55691	NM_012477.4 Latest version!	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu55691	NM_012477.3	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WBP1 ( NM_012477.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036609.1 Homo sapiens WW domain binding protein 1 (WBP1), mRNA.

Price & Availability↑

CloneID	OHu55691
Clone ID Related Accession (Same CDS sequence)	NM_012477.4 , NM_012477.3
Accession Version	NM_012477.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	WW domain-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN403791.1 and BC010012.2. On Nov 23, 2018 this sequence version replaced NM_012477.3. ##Evidence-Data-START## Transcript exon combination :: BC071626.1, BC010012.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233615.7/ ENSP00000233615.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGGG CCAGCAGCGG GAACGGCAGC GAGGAGGCCT GGGGGGCACT TCGGGCGCCG 
CAACAGCAGC TTCGAGAGCT GTGCCCAGGA GTGAACAACC AGCCCTACCT CTGTGAGAGT 
GGTCACTGCT GCGGGGAGAC TGGCTGCTGC ACCTACTACT ATGAGCTCTG GTGGTTCTGG 
CTGCTCTGGA CTGTCCTCAT CCTCTTTAGC TGCTGTTGCG CCTTCCGCCA CCGACGAGCT 
AAACTCAGGC TGCAACAACA GCAGCGGCAG CGTGAAATCA ACTTGTTGGC CTATCATGGG 
GCATGCCATG GGGCTGGTCC TTTCCCTACC GGTTCACTGC TTGACCTTCG CTTCCTCAGC 
ACCTTCAAGC CCCCAGCCTA CGAGGATGTG GTTCACCGCC CAGGCACACC ACCCCCCCCT 
TATACTGTGG CCCCAGGCCG CCCCTTGACT GCTTCCAGTG AACAAACCTG CTGTTCCTCC 
TCATCCAGCT GCCCTGCCCA CTTTGAAGGA ACAAATGTGG AAGGTGTTTC CTCCCACCAG 
AGTGCCCCCC CTCATCAGGA GGGTGAGCCC GGGGCAGGGG TGACCCCTGC CTCCACACCC 
CCCTCCTGCC GCTATCGCCG TTTAACTGGC GACTCCGGTA TTGAGCTCTG CCCTTGTCCT 
GCCTCCGGTG AGGGTGAGCC AGTCAAGGAG GTGAGGGTTA GTGCCACCCT GCCAGATCTG 
GAGGACTACT CCCCGTGTGC ACTACCCCCA GAGTCTGTAC CGCAGATCTT TCCCATGGGG 
CTGTCTTCCA GTGAAGGGGA CATCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036609.1
CDS	166..975
Translation	MARASSGNGSEEAWGALRAPQQQLRELCPGVNNQPYLCESGHCCGETGCCTYYYELWWFWLLWTVLILFSCCCAFRHRRAKLRLQQQQRQREINLLAYHGACHGAGPFPTGSLLDLRFLSTFKPPAYEDVVHRPGTPPPPYTVAPGRPLTASSEQTCCSSSSSCPAHFEGTNVEGVSSHQSAPPHQEGEPGAGVTPASTPPSCRYRRLTGDSGIELCPCPASGEGEPVKEVRVSATLPDLEDYSPCALPPESVPQIFPMGLSSSEGDIP

Target ORF information:

RefSeq Version	NM_012477.4
Organism	Homo sapiens(human)
Definition	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012477.4

ORF Insert Sequence:

ATGGCTCGGG CCAGCAGCGG GAACGGCAGC GAGGAGGCCT GGGGGGCACT TCGGGCGCCG 
CAACAGCAGC TTCGAGAGCT GTGCCCAGGA GTGAACAACC AGCCCTACCT CTGTGAGAGT 
GGTCACTGCT GCGGGGAGAC TGGCTGCTGC ACCTACTACT ATGAGCTCTG GTGGTTCTGG 
CTGCTCTGGA CTGTCCTCAT CCTCTTTAGC TGCTGTTGCG CCTTCCGCCA CCGACGAGCT 
AAACTCAGGC TGCAACAACA GCAGCGGCAG CGTGAAATCA ACTTGTTGGC CTATCATGGG 
GCATGCCATG GGGCTGGTCC TTTCCCTACC GGTTCACTGC TTGACCTTCG CTTCCTCAGC 
ACCTTCAAGC CCCCAGCCTA CGAGGATGTG GTTCACCGCC CAGGCACACC ACCCCCCCCT 
TATACTGTGG CCCCAGGCCG CCCCTTGACT GCTTCCAGTG AACAAACCTG CTGTTCCTCC 
TCATCCAGCT GCCCTGCCCA CTTTGAAGGA ACAAATGTGG AAGGTGTTTC CTCCCACCAG 
AGTGCCCCCC CTCATCAGGA GGGTGAGCCC GGGGCAGGGG TGACCCCTGC CTCCACACCC 
CCCTCCTGCC GCTATCGCCG TTTAACTGGC GACTCCGGTA TTGAGCTCTG CCCTTGTCCT 
GCCTCCGGTG AGGGTGAGCC AGTCAAGGAG GTGAGGGTTA GTGCCACCCT GCCAGATCTG 
GAGGACTACT CCCCGTGTGC ACTACCCCCA GAGTCTGTAC CGCAGATCTT TCCCATGGGG 
CTGTCTTCCA GTGAAGGGGA CATCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WBP1 ( NM_012477.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036609.1 Homo sapiens WW domain binding protein 1 (WBP1), mRNA.

Price & Availability↑

CloneID	OHu55691
Clone ID Related Accession (Same CDS sequence)	NM_012477.4 , NM_012477.3
Accession Version	NM_012477.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	WW domain-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN403791.1, BC010012.2 and AA635803.1. On Feb 11, 2011 this sequence version replaced NM_012477.2. ##Evidence-Data-START## Transcript exon combination :: AF087888.1, SRR1163657.493434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGGG CCAGCAGCGG GAACGGCAGC GAGGAGGCCT GGGGGGCACT TCGGGCGCCG 
CAACAGCAGC TTCGAGAGCT GTGCCCAGGA GTGAACAACC AGCCCTACCT CTGTGAGAGT 
GGTCACTGCT GCGGGGAGAC TGGCTGCTGC ACCTACTACT ATGAGCTCTG GTGGTTCTGG 
CTGCTCTGGA CTGTCCTCAT CCTCTTTAGC TGCTGTTGCG CCTTCCGCCA CCGACGAGCT 
AAACTCAGGC TGCAACAACA GCAGCGGCAG CGTGAAATCA ACTTGTTGGC CTATCATGGG 
GCATGCCATG GGGCTGGTCC TTTCCCTACC GGTTCACTGC TTGACCTTCG CTTCCTCAGC 
ACCTTCAAGC CCCCAGCCTA CGAGGATGTG GTTCACCGCC CAGGCACACC ACCCCCCCCT 
TATACTGTGG CCCCAGGCCG CCCCTTGACT GCTTCCAGTG AACAAACCTG CTGTTCCTCC 
TCATCCAGCT GCCCTGCCCA CTTTGAAGGA ACAAATGTGG AAGGTGTTTC CTCCCACCAG 
AGTGCCCCCC CTCATCAGGA GGGTGAGCCC GGGGCAGGGG TGACCCCTGC CTCCACACCC 
CCCTCCTGCC GCTATCGCCG TTTAACTGGC GACTCCGGTA TTGAGCTCTG CCCTTGTCCT 
GCCTCCGGTG AGGGTGAGCC AGTCAAGGAG GTGAGGGTTA GTGCCACCCT GCCAGATCTG 
GAGGACTACT CCCCGTGTGC ACTACCCCCA GAGTCTGTAC CGCAGATCTT TCCCATGGGG 
CTGTCTTCCA GTGAAGGGGA CATCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036609.1
CDS	204..1013
Translation	MARASSGNGSEEAWGALRAPQQQLRELCPGVNNQPYLCESGHCCGETGCCTYYYELWWFWLLWTVLILFSCCCAFRHRRAKLRLQQQQRQREINLLAYHGACHGAGPFPTGSLLDLRFLSTFKPPAYEDVVHRPGTPPPPYTVAPGRPLTASSEQTCCSSSSSCPAHFEGTNVEGVSSHQSAPPHQEGEPGAGVTPASTPPSCRYRRLTGDSGIELCPCPASGEGEPVKEVRVSATLPDLEDYSPCALPPESVPQIFPMGLSSSEGDIP

Target ORF information:

RefSeq Version	NM_012477.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012477.3

ORF Insert Sequence:

ATGGCTCGGG CCAGCAGCGG GAACGGCAGC GAGGAGGCCT GGGGGGCACT TCGGGCGCCG 
CAACAGCAGC TTCGAGAGCT GTGCCCAGGA GTGAACAACC AGCCCTACCT CTGTGAGAGT 
GGTCACTGCT GCGGGGAGAC TGGCTGCTGC ACCTACTACT ATGAGCTCTG GTGGTTCTGG 
CTGCTCTGGA CTGTCCTCAT CCTCTTTAGC TGCTGTTGCG CCTTCCGCCA CCGACGAGCT 
AAACTCAGGC TGCAACAACA GCAGCGGCAG CGTGAAATCA ACTTGTTGGC CTATCATGGG 
GCATGCCATG GGGCTGGTCC TTTCCCTACC GGTTCACTGC TTGACCTTCG CTTCCTCAGC 
ACCTTCAAGC CCCCAGCCTA CGAGGATGTG GTTCACCGCC CAGGCACACC ACCCCCCCCT 
TATACTGTGG CCCCAGGCCG CCCCTTGACT GCTTCCAGTG AACAAACCTG CTGTTCCTCC 
TCATCCAGCT GCCCTGCCCA CTTTGAAGGA ACAAATGTGG AAGGTGTTTC CTCCCACCAG 
AGTGCCCCCC CTCATCAGGA GGGTGAGCCC GGGGCAGGGG TGACCCCTGC CTCCACACCC 
CCCTCCTGCC GCTATCGCCG TTTAACTGGC GACTCCGGTA TTGAGCTCTG CCCTTGTCCT 
GCCTCCGGTG AGGGTGAGCC AGTCAAGGAG GTGAGGGTTA GTGCCACCCT GCCAGATCTG 
GAGGACTACT CCCCGTGTGC ACTACCCCCA GAGTCTGTAC CGCAGATCTT TCCCATGGGG 
CTGTCTTCCA GTGAAGGGGA CATCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation.
Heart, lung & circulation27(1)104-113(2018 Jan)
Tao H,Zhang M,Yang JJ,Shi KH

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.
The FEBS journal281(24)5532-51(2014 Dec)
Schuchardt BJ,Mikles DC,Hoang LM,Bhat V,McDonald CB,Sudol M,Farooq A

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
Biochemistry50(44)9616-27(2011 Nov)
McDonald CB,McIntosh SK,Mikles DC,Bhat V,Deegan BJ,Seldeen KL,Saeed AM,Buffa L,Sudol M,Nawaz Z,Farooq A

Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.
The Journal of biological chemistry286(40)35227-35(2011 Oct)
Morishima N,Nakanishi K,Nakano A

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.
Oncogene23(29)5049-55(2004 Jun)
Ludes-Meyers JH,Kil H,Bednarek AK,Drake J,Bedford MT,Aldaz CM