CMTR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CMTR1
Entrez Gene ID	23070
Full Name	cap methyltransferase 1
Synonyms	FTSJD2,KIAA0082,MTr1,hMTr1
General protein information	Preferred Names cap methyltransferase 1 Names cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 FtsJ methyltransferase domain containing 2 ISG95 S-adenosyl-L-methionine-dependent methyltransferase FTSJD2 cap1 2'O-ribose methyltransferase 1 ftsJ methyltransferase domain-containing protein 2 interferon-stimulated gene 95 kDa protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.2
Disorder MIM:	616189

mRNA and Protein(s)

mRNA	Protein	Name
XM_005248955.4	XP_005249012.1	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1
NM_015050.2	NP_055865.1	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
XM_005248955.3	XP_005249012.1	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1
NM_015050.3	NP_055865.1	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CMTR1	NP_055865.1
	FTSJD2	XP_002803764.1
Mus musculus (house mouse)	Cmtr1	NP_083067.1
Canis lupus familiaris (dog)	FTSJD2	XP_003431766.1
Gallus gallus (chicken)	FTSJD2	XP_004935442.1
Danio rerio (zebrafish)	cmtr1	NP_956427.1
Drosophila melanogaster (fruit fly)	CG6379	NP_572148.2
Pan troglodytes (chimpanzee)	FTSJD2	XP_527377.3
Bos taurus (cattle)	CMTR1	NP_001075899.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000826	XP_316791.5
Rattus norvegicus (Norway rat)	Cmtr1	NP_001014053.1
Caenorhabditis elegans (roundworm)	CELE_Y53F4B.13	NP_001254457.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation and function of CMTR1-dependent mRNA cap methylation.
Inesta-Vaquera F, Cowling VH
Wiley interdisciplinary reviews. RNA8(6)(2017 Nov)

Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Smietanski M, Werner M, Purta E, Kaminska KH, Stepinski J, Darzynkiewicz E, Nowotny M, Bujnicki JM
Nature communications53004(2014)

2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
Nucleic acids research39(11)4756-68(2011 Jun)

Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.
B?langer F, Stepinski J, Darzynkiewicz E, Pelletier J
The Journal of biological chemistry285(43)33037-44(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Crystal structures of the active CMTr1 catalytic domain in complex with a methyl group donor and a capped oligoribonucleotide are examined, thereby revealing the mechanism of specific recognition of capped RNA.
Title: Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.

hMTr1 catalyzes specific methylation of the 2'-O-ribose of the first nucleotide of a capped RNA transcript.
Title: Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.

The results presented in this work indicate that ISG95 is part of the interferon response pathway and functions in the pre-mRNA processing events mediated by the C-terminal domain of the RNA polymerase II.
Title: The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.

The following CMTR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CMTR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06786	NM_015050.3 Latest version!	Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu40219	XM_005248955.4 Latest version!	Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu40219	XM_005248955.3	Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu06786	NM_015050.2	Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CMTR1 ( NM_015050.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055865.1 Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.

Price & Availability↑

CloneID	OHu06786
Clone ID Related Accession (Same CDS sequence)	NM_015050.2 , NM_015050.3
Accession Version	NM_015050.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2508bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-07
Organism	Homo sapiens(human)
Product	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA508836.1, BC031890.1 and BC010731.2. On Jul 30, 2008 this sequence version replaced NM_015050.1. ##Evidence-Data-START## Transcript exon combination :: BC031890.1, D43949.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACATTT GCTACTATGG CCGGCTCTTC 
TGGGAGTGGG GGGATGGCAT TCGTGTGCAT GACTCCCAGA AGCCCCAGGA CCAGGACAAG 
CTGTCCAAGG AGGACGTCCT CTCCTTCATC CAGATGCACA GGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055865.1
CDS	254..2761
Translation	MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA

Target ORF information:

RefSeq Version	NM_015050.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015050.2

ORF Insert Sequence:

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACATTT GCTACTATGG CCGGCTCTTC 
TGGGAGTGGG GGGATGGCAT TCGTGTGCAT GACTCCCAGA AGCCCCAGGA CCAGGACAAG 
CTGTCCAAGG AGGACGTCCT CTCCTTCATC CAGATGCACA GGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTR1 ( NM_015050.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055865.1 Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.

Price & Availability↑

CloneID	OHu06786
Clone ID Related Accession (Same CDS sequence)	NM_015050.2 , NM_015050.3
Accession Version	NM_015050.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2508bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Homo sapiens(human)
Product	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA508836.1, BC031890.1 and BC010731.2. On Nov 22, 2018 this sequence version replaced NM_015050.2. ##Evidence-Data-START## Transcript exon combination :: BC031890.1, D43949.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373451.9/ ENSP00000362550.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACATTT GCTACTATGG CCGGCTCTTC 
TGGGAGTGGG GGGATGGCAT TCGTGTGCAT GACTCCCAGA AGCCCCAGGA CCAGGACAAG 
CTGTCCAAGG AGGACGTCCT CTCCTTCATC CAGATGCACA GGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055865.1
CDS	164..2671
Translation	MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA

Target ORF information:

RefSeq Version	NM_015050.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015050.3

ORF Insert Sequence:

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACATTT GCTACTATGG CCGGCTCTTC 
TGGGAGTGGG GGGATGGCAT TCGTGTGCAT GACTCCCAGA AGCCCCAGGA CCAGGACAAG 
CTGTCCAAGG AGGACGTCCT CTCCTTCATC CAGATGCACA GGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTR1 ( XM_005248955.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249012.1 Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu40219
Clone ID Related Accession (Same CDS sequence)	XM_005248955.4 , XM_005248955.3
Accession Version	XM_005248955.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005248955.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACCTCC CCAGCCTTGC CTGCCTGTCG 
AAGATGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249012.1
CDS	164..2575
Translation	MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHLPSLACLSKMD

Target ORF information:

RefSeq Version	XM_005248955.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248955.4

ORF Insert Sequence:

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACCTCC CCAGCCTTGC CTGCCTGTCG 
AAGATGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTR1 ( XM_005248955.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249012.1 Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu40219
Clone ID Related Accession (Same CDS sequence)	XM_005248955.4 , XM_005248955.3
Accession Version	XM_005248955.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005248955.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACCTCC CCAGCCTTGC CTGCCTGTCG 
AAGATGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249012.1
CDS	184..2595
Translation	MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHLPSLACLSKMD

Target ORF information:

RefSeq Version	XM_005248955.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cap methyltransferase 1 (CMTR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248955.3

ORF Insert Sequence:

ATGAAGAGGA GAACTGACCC AGAATGCACT GCCCCCATCA AGAAACAGAA AAAAAGAGTT 
GCAGAGCTTG CCCTGAGCCT CAGCTCCACG TCCGATGATG AACCTCCCTC CTCTGTCAGT 
CATGGAGCAA AAGCATCTAC TACAAGCCTT AGTGGGTCTG ATAGTGAGAC CGAGGGGAAA 
CAACACAGCT CTGACTCTTT TGACGATGCA TTCAAAGCAG ACTCTCTTGT GGAAGGAACT 
TCTTCTCGCT ATTCCATGTA TAATAGCGTC TCCCAGAAGC TTATGGCCAA GATGGGCTTC 
AGGGAAGGTG AAGGATTGGG TAAATACAGC CAGGGTCGGA AGGACATCGT TGAGGCTTCC 
AGTCAGAAAG GTCGAAGAGG CTTGGGTCTG ACACTCCGGG GCTTTGACCA GGAGCTGAAC 
GTGGACTGGC GAGATGAGCC AGAGCCCAGT GCTTGTGAGC AGGTGTCATG GTTTCCAGAA 
TGTACCACTG AAATTCCTGA CACTCAGGAA ATGAGCGATT GGATGGTGGT GGGAAAGAGA 
AAGATGATTA TTGAAGATGA AACAGAGTTT TGTGGGGAAG AGCTGCTTCA CAGTGTGTTG 
CAGTGTAAGA GCGTGTTTGA TGTCTTGGAT GGGGAAGAGA TGCGGCGAGC TCGGACTCGG 
GCCAATCCCT ATGAGATGAT CCGAGGAGTC TTCTTTCTAA ACAGGGCAGC AATGAAGATG 
GCTAACATGG ATTTTGTATT TGATCGCATG TTCACAAATC CGCGGGACTC TTATGGGAAG 
CCACTGGTGA AGGACCGGGA AGCTGAGCTT CTGTACTTTG CTGATGTCTG CGCAGGCCCA 
GGTGGCTTCT CAGAGTATGT GCTGTGGAGG AAGAAGTGGC ATGCAAAGGG CTTTGGAATG 
ACTTTGAAGG GCCCTAATGA CTTCAAGCTG GAGGACTTCT ACTCTGCTTC CAGTGAACTC 
TTCGAACCCT ACTATGGTGA GGGTGGGATT GATGGAGATG GAGATATCAC CCGCCCAGAG 
AACATCTCTG CTTTTCGGAA TTTTGTCCTG GATAACACAG ATCGCAAGGG TGTCCATTTT 
CTGATGGCTG ATGGGGGTTT CTCGGTGGAG GGGCAGGAGA ACCTGCAGGA GATCCTCAGC 
AAGCAGCTGC TTCTGTGTCA GTTCCTCATG GCGCTGTCCA TTGTCCGGAC AGGAGGCCAC 
TTCATCTGTA AAACCTTTGA CCTGTTCACA CCGTTTAGTG TGGGGCTTGT CTACCTGCTG 
TACTGCTGCT TTGAACGAGT TTGTCTCTTC AAGCCTATTA CCAGCCGTCC TGCCAACTCA 
GAGAGGTATG TGGTGTGCAA GGGCCTGAAG GTGGGCATAG ATGATGTTCG GGATTACCTC 
TTCGCAGTGA ATATTAAACT CAATCAGCTG CGGAACACGG ATTCCGACGT CAACTTGGTG 
GTCCCCCTGG AGGTGATCAA GGGAGACCAT GAATTTACTG ACTACATGAT ACGGTCCAAT 
GAGAGCCACT GTAGTCTGCA GATCAAAGCT CTGGCGAAAA TCCATGCCTT TGTTCAAGAC 
ACGACACTGA GTGAGCCTCG ACAGGCAGAG ATACGGAAGG AGTGCCTCCG ACTCTGGGGG 
ATCCCAGACC AGGCTCGTGT GGCTCCTTCT TCCTCCGACC CTAAATCGAA GTTCTTTGAG 
CTAATCCAGG GCACTGAGAT TGACATCTTC AGCTACAAGC CCACACTGCT CACCTCTAAA 
ACCCTGGAGA AGATCCGCCC TGTGTTTGAC TACCGCTGCA TGGTATCTGG CAGTGAGCAG 
AAGTTCCTCA TCGGCCTGGG GAAATCCCAG ATCTACACAT GGGATGGCCG CCAGTCAGAC 
CGCTGGATCA AGCTAGACCT GAAGACAGAG CTGCCCCGGG ACACTCTGCT ATCTGTGGAA 
ATTGTGCATG AGCTGAAAGG GGAGGGGAAG GCCCAGAGGA AGATCAGTGC CATCCACATC 
CTCGATGTCC TTGTGCTGAA TGGCACCGAC GTTCGGGAGC AGCACTTTAA CCAGCGAATT 
CAGCTTGCCG AGAAATTTGT GAAAGCCGTT TCCAAGCCTA GTCGGCCCGA CATGAATCCC 
ATCAGGGTGA AGGAGGTGTA CAGACTGGAA GAGATGGAGA AGATTTTTGT CAGGTTGGAG 
ATGAAGATCA TCAAGGGCTC CAGTGGCACC CCAAAGCTCA GCTACACAGG GCGTGATGAC 
CGGCACTTTG TACCCATGGG CCTCTACATC GTCAGGACAG TGAATGAGCC CTGGACTATG 
GGATTCAGCA AAAGCTTCAA GAAGAAGTTC TTCTACAACA AGAAAACCAA GGACTCTACT 
TTTGACCTCC CTGCAGACTC CATTGCCCCA TTTCACCTCC CCAGCCTTGC CTGCCTGTCG 
AAGATGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation and function of CMTR1-dependent mRNA cap methylation.
Wiley interdisciplinary reviews. RNA8(6)(2017 Nov)
Inesta-Vaquera F,Cowling VH

Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nature communications53004(2014)
Smietanski M,Werner M,Purta E,Kaminska KH,Stepinski J,Darzynkiewicz E,Nowotny M,Bujnicki JM

2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
Nucleic acids research39(11)4756-68(2011 Jun)
Werner M,Purta E,Kaminska KH,Cymerman IA,Campbell DA,Mittra B,Zamudio JR,Sturm NR,Jaworski J,Bujnicki JM

Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.
The Journal of biological chemistry285(43)33037-44(2010 Oct)
B?langer F,Stepinski J,Darzynkiewicz E,Pelletier J

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CMTR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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