C4orf46 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C4orf46
Entrez Gene ID	201725
Full Name	chromosome 4 open reading frame 46
Synonyms	RCDG1
General protein information	Preferred Names chromosome 4 open reading frame 46 Names renal cancer differentiation gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q32.1
Summary	This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Disorder MIM:	616210

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008393.3	NP_001008394.1	renal cancer differentiation gene 1 protein
NM_001008393.4	NP_001008394.1	renal cancer differentiation gene 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C4H4orf46	XP_001145854.1
	C5H4orf46	XP_001097337.1
Homo sapiens (human)	C4orf46	NP_001008394.1
Bos taurus (cattle)	C17H4orf46	NP_001071581.1
Mus musculus (house mouse)	4930579G24Rik	NP_083758.1
Rattus norvegicus (Norway rat)	RGD1560010	NP_001101155.1
Canis lupus familiaris (dog)	C15H4orf46	XP_855397.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer?associated gene.
Yu Z, Ni L, Chen D, Su Z, Yu W, Zhang Q, Wang Y, Li C, Gui Y, Lai Y
Molecular medicine reports10(3)1583-9(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A reduction in RCDG1 expression may be associated with the oncogenesis of renal cell carcinoma and the differentiation of clear cell renal cell carcinoma.
Title: Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer?associated gene.

The following C4orf46 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C4orf46 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21174	NM_001008393.4 Latest version!	Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21174	NM_001008393.3	Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C4orf46 ( NM_001008393.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008394.1 Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21174
Clone ID Related Accession (Same CDS sequence)	NM_001008393.3 , NM_001008393.4
Accession Version	NM_001008393.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	renal cancer differentiation gene 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB289388.1, BC094775.1, AC107219.5 and BU688970.1. This sequence is a reference standard in the RefSeqGene project. On Feb 28, 2013 this sequence version replaced NM_001008393.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DB289388.1, BC094775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGACC CTGAGGAGTT GCAGGTTTCT TCGCCGCCCC CGCCGCCTCC CTCTTCTCCC 
TCCTCTTCAG ACGCCTCTGC AGCATCTTCC CCGGGCGGCC CAGTGAGTTT GGGCTGGCCA 
GTTCCGAGCA GGAGCAGCGG CCCAACGGTG GACCAGCTGG AGGAAGTGGA GCTGCAGATC 
GGAGACGCAG CCTTTTCATT AACCAAACTT CTTGAAGCCA CATCTGCAGT ATCAGCTCAA 
GTGGAAGAAC TTGCCTTCAA ATGTACAGAA AATGCACGTT TCCTTAAAAC GTGGCGGGAC 
CTCTTGAAAG AAGGCTATGA TTCTTTGAAA CCTGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008394.1
CDS	250..591
Translation	MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDAAFSLTKLLEATSAVSAQVEELAFKCTENARFLKTWRDLLKEGYDSLKPDD

Target ORF information:

RefSeq Version	NM_001008393.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008393.3

ORF Insert Sequence:

ATGGCCGACC CTGAGGAGTT GCAGGTTTCT TCGCCGCCCC CGCCGCCTCC CTCTTCTCCC 
TCCTCTTCAG ACGCCTCTGC AGCATCTTCC CCGGGCGGCC CAGTGAGTTT GGGCTGGCCA 
GTTCCGAGCA GGAGCAGCGG CCCAACGGTG GACCAGCTGG AGGAAGTGGA GCTGCAGATC 
GGAGACGCAG CCTTTTCATT AACCAAACTT CTTGAAGCCA CATCTGCAGT ATCAGCTCAA 
GTGGAAGAAC TTGCCTTCAA ATGTACAGAA AATGCACGTT TCCTTAAAAC GTGGCGGGAC 
CTCTTGAAAG AAGGCTATGA TTCTTTGAAA CCTGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C4orf46 ( NM_001008393.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008394.1 Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21174
Clone ID Related Accession (Same CDS sequence)	NM_001008393.3 , NM_001008393.4
Accession Version	NM_001008393.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	renal cancer differentiation gene 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC094775.1, AC107219.5 and BU688970.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001008393.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DB137547.1, AK074948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379205.5/ ENSP00000368503.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGACC CTGAGGAGTT GCAGGTTTCT TCGCCGCCCC CGCCGCCTCC CTCTTCTCCC 
TCCTCTTCAG ACGCCTCTGC AGCATCTTCC CCGGGCGGCC CAGTGAGTTT GGGCTGGCCA 
GTTCCGAGCA GGAGCAGCGG CCCAACGGTG GACCAGCTGG AGGAAGTGGA GCTGCAGATC 
GGAGACGCAG CCTTTTCATT AACCAAACTT CTTGAAGCCA CATCTGCAGT ATCAGCTCAA 
GTGGAAGAAC TTGCCTTCAA ATGTACAGAA AATGCACGTT TCCTTAAAAC GTGGCGGGAC 
CTCTTGAAAG AAGGCTATGA TTCTTTGAAA CCTGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008394.1
CDS	87..428
Translation	MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDAAFSLTKLLEATSAVSAQVEELAFKCTENARFLKTWRDLLKEGYDSLKPDD

Target ORF information:

RefSeq Version	NM_001008393.4
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008393.4

ORF Insert Sequence:

ATGGCCGACC CTGAGGAGTT GCAGGTTTCT TCGCCGCCCC CGCCGCCTCC CTCTTCTCCC 
TCCTCTTCAG ACGCCTCTGC AGCATCTTCC CCGGGCGGCC CAGTGAGTTT GGGCTGGCCA 
GTTCCGAGCA GGAGCAGCGG CCCAACGGTG GACCAGCTGG AGGAAGTGGA GCTGCAGATC 
GGAGACGCAG CCTTTTCATT AACCAAACTT CTTGAAGCCA CATCTGCAGT ATCAGCTCAA 
GTGGAAGAAC TTGCCTTCAA ATGTACAGAA AATGCACGTT TCCTTAAAAC GTGGCGGGAC 
CTCTTGAAAG AAGGCTATGA TTCTTTGAAA CCTGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer?associated gene.
Molecular medicine reports10(3)1583-9(2014 Sep)
Yu Z,Ni L,Chen D,Su Z,Yu W,Zhang Q,Wang Y,Li C,Gui Y,Lai Y