PLAC4 , Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLAC4
Entrez Gene ID	191585
Full Name	placenta specific 4
Synonyms	C21orf115,PRED78
General protein information	Preferred Names placenta specific 4
Gene Type	ncRNA
Organism	Homo sapiens(Human)
Genome	Chromosome: 21 Map Location: 21q22.2
Disorder MIM:	613770

mRNA and Protein(s)

mRNA	Protein	Name
NM_182832.2	NP_878252.2	placenta-specific protein 4

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Explore the dynamic alternation of gene PLAC4 mRNA expression levels in maternal plasma in second trimester for nonivasive detection of trisomy 21.
Yang L, Sun HY, Chen DZ, Lu MD, Tang Y, Xiao JP
Obstetrics & gynecology science58(4)261-7(2015 Jul)

Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21.
Yang L, Sun H, Chen D, Lu M, Wang J, Xu F, Hu L, Xiao J
Prenatal diagnosis34(2)139-44(2014 Feb)

PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia.
Tuohey L, Macintire K, Ye L, Palmer K, Skubisz M, Tong S, Kaitu'u-Lino TJ
Placenta34(3)256-60(2013 Mar)

Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21.
Tsui NB, Akolekar R, Chiu RW, Chow KC, Leung TY, Lau TK, Nicolaides KH, Lo YM
Clinical chemistry56(1)73-81(2010 Jan)

D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells.
Kido S, Sakuragi N, Bronner MP, Sayegh R, Berger R, Patterson D, Strauss JF 3rd
Genomics17(1)256-9(1993 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

For samples with heterozygous SNPs, PLAC4 RNA-SNP allelic ratio can be used for noninvasive prenatal detection of trisomy 21 by the multiplex SNaPshot assay. In Southeast China, PLAC4 Rs8130833 and Rs4818219 had higher frequency of heterozygosity.
Title: Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21.

PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia.
Title: PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

For prenatal screening of trisomy 21, the quantification of the total PLAC4 mRNA concentration can be used in a synergistic manner with the RNA-SNP allelic ratio approach
Title: Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following PLAC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLAC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu09003	NM_182832.2 Latest version!	Homo sapiens placenta specific 4 (PLAC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLAC4 ( NM_182832.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_878252.2 Homo sapiens placenta specific 4 (PLAC4), mRNA.

Price & Availability↑

CloneID	OHu09003
Clone ID Related Accession (Same CDS sequence)	NM_182832.2
Accession Version	NM_182832.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-08-24
Organism	Homo sapiens(Human)
Product	placenta-specific protein 4
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL773572.1. On Jan 12, 2007 this sequence version replaced NM_182832.1. COMPLETENESS: complete on the 3' end.

ATGAAAGAGT TGCTGCGCCT GAAGCACTGC AAACACCTCC TCACCACACA TGTGCACTCA 
CCCTGGACAC CCTCACTCAC CCTGACACCC TCACTCCTCA CCCTGGACAC CCTCACTCAC 
CCCAGACACC GTCACTCCTC ACCCTGGACA CCTCACTCTG CACCCTGGAC ACCCTCACTC 
ACCCTGGACA CGTTCACTCA CCCTGACACC CTCACTCACC CTGGACACCC TCACTCACCC 
TGGATACCCT CACTCCTCAC CCTGGACACC CTCACTCACC CTGGATACCC TCACTCCTCA 
CCCTGGACAC TCTCACTCAC CCTGACACCC TCAATCCTCA CCCTGGACTC CCTCACTCCT 
CACCCTGGAC TCCCTCACTC CTCACCCTGG ACACCCTCAC TCCTCATCCT GGACACCCTC 
ACTCAACCTG GACACCCTCA CTCCTCACCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_878252.2
CDS	5612..6064
Translation	MKELLRLKHCKHLLTTHVHSPWTPSLTLTPSLLTLDTLTHPRHRHSSPWTPHSAPWTPSLTLDTFTHPDTLTHPGHPHSPWIPSLLTLDTLTHPGYPHSSPWTLSLTLTPSILTLDSLTPHPGLPHSSPWTPSLLILDTLTQPGHPHSSP

Target ORF information:

RefSeq Version	NM_182832.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens placenta specific 4 (PLAC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182832.2

ORF Insert Sequence:

ATGAAAGAGT TGCTGCGCCT GAAGCACTGC AAACACCTCC TCACCACACA TGTGCACTCA 
CCCTGGACAC CCTCACTCAC CCTGACACCC TCACTCCTCA CCCTGGACAC CCTCACTCAC 
CCCAGACACC GTCACTCCTC ACCCTGGACA CCTCACTCTG CACCCTGGAC ACCCTCACTC 
ACCCTGGACA CGTTCACTCA CCCTGACACC CTCACTCACC CTGGACACCC TCACTCACCC 
TGGATACCCT CACTCCTCAC CCTGGACACC CTCACTCACC CTGGATACCC TCACTCCTCA 
CCCTGGACAC TCTCACTCAC CCTGACACCC TCAATCCTCA CCCTGGACTC CCTCACTCCT 
CACCCTGGAC TCCCTCACTC CTCACCCTGG ACACCCTCAC TCCTCATCCT GGACACCCTC 
ACTCAACCTG GACACCCTCA CTCCTCACCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Explore the dynamic alternation of gene PLAC4 mRNA expression levels in maternal plasma in second trimester for nonivasive detection of trisomy 21.
Obstetrics & gynecology science58(4)261-7(2015 Jul)
Yang L,Sun HY,Chen DZ,Lu MD,Tang Y,Xiao JP

Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21.
Prenatal diagnosis34(2)139-44(2014 Feb)
Yang L,Sun H,Chen D,Lu M,Wang J,Xu F,Hu L,Xiao J

PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia.
Placenta34(3)256-60(2013 Mar)
Tuohey L,Macintire K,Ye L,Palmer K,Skubisz M,Tong S,Kaitu'u-Lino TJ

Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21.
Clinical chemistry56(1)73-81(2010 Jan)
Tsui NB,Akolekar R,Chiu RW,Chow KC,Leung TY,Lau TK,Nicolaides KH,Lo YM

D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells.
Genomics17(1)256-9(1993 Jul)
Kido S,Sakuragi N,Bronner MP,Sayegh R,Berger R,Patterson D,Strauss JF 3rd