LSM11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM11
Entrez Gene ID	134353
Full Name	LSM11, U7 small nuclear RNA associated
General protein information	Preferred Names LSM11, U7 small nuclear RNA associated Names U7 snRNA-associated Sm-like protein LSm11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q33.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_173491.4	NP_775762.1	U7 snRNA-associated Sm-like protein LSm11
NM_173491.3	NP_775762.1	U7 snRNA-associated Sm-like protein LSm11

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LSM11	XP_001138531.1
Rattus norvegicus (Norway rat)	Lsm11	NP_001166855.1
Xenopus tropicalis (tropical clawed frog)	lsm11	XP_002939655.2
Homo sapiens (human)	LSM11	NP_775762.1
	LOC100429445	XP_002804651.1
Mus musculus (house mouse)	Lsm11	NP_082461.1
Gallus gallus (chicken)	LSM11	XP_414562.3
Bos taurus (cattle)	LSM11	XP_002707877.1

Gene Ontology
Bibliography

Related articles in PubMed

A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.
Yang XC, Sabath I, D?bski J, Kaus-Drobek M, Dadlez M, Marzluff WF, Dominski Z
Molecular and cellular biology33(1)28-37(2013 Jan)

Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.
Fu D, Collins K
Molecular cell28(5)773-85(2007 Dec)

ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase.
Wagner EJ, Marzluff WF
Molecular and cellular biology26(17)6702-12(2006 Sep)

Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein.
Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF
RNA (New York, N.Y.)12(7)1206-18(2006 Jul)

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.
Azzouz TN, Pillai RS, D?pp C, Chari A, Meister G, Kambach C, Fischer U, Sch?mperli D
The Journal of biological chemistry280(41)34435-40(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FLASH/Lsm11 complex bind a unique combination of polyadenylation factors
Title: A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.

The overexpression of Lsm10 and Lsm11 increases the cellular levels of U7 snRNP but has no effect on histone pre-mRNA processing.
Title: ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase.

Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 and SMN complexes
Title: Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

The following LSM11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu75738	NM_173491.4 Latest version!	Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
View Old Accession Versions >>
OHu75738	NM_173491.3	Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM11 ( NM_173491.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_775762.1 Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.

Price & Availability↑

CloneID	OHu75738
Clone ID Related Accession (Same CDS sequence)	NM_173491.4 , NM_173491.3
Accession Version	NM_173491.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	U7 snRNA-associated Sm-like protein LSm11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC126449.1, BC051353.1, AC026407.4 and AI271367.1. On Nov 22, 2018 this sequence version replaced NM_173491.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC051353.1, AK095592.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000286307.6/ ENSP00000286307.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGAGC GGGAGCGGGG GGCGAGGTCG GCTGGCGCCG GGAGCCCCGC GCGCCCGCCC 
AGCCCGCGGC TGGATGTCAG CTCTGACAGC TTCGACCCGC TGCTGGCCCT GTACGCGCCC 
CGCCTGCCTC CCATTCCCTA CCCCAATGCC CCCTGCTTCA ACAACGTGGC GGAGTACGAG 
AGCTTCCTCA GGACCGGAGT CCGGGGCGGC GGGCGCGGGC GCGGGCGGGC TCGGGGCGCG 
GCCGCGGGCT CTGGGGTTCC CGCCGCACCC GGGCCCTCGG GCAGGACTCG TCGCCGCCCG 
GACGCGCCCG CCCCGGACCC CGAGCGCATC CAGCGCCTCC GCCGTCTCAT GGTGGCCAAA 
GAGGAAGGGG ACGGGGCCGC AGGAGCGGGC CGGAGGGGTC CGGGTCGGAG CAGGAAGGCG 
CCACGCAACG TGCTCACGCG AATGCCCTTG CACGAAGGCA GCCCTCTGGG TGAACTCCAT 
CGCTGTATCC GTGAGGGGGT GAAGGTGAAT GTTCACATCC GCACTTTCAA GGGACTTCGG 
GGCGTCTGTA CAGGCTTCCT TGTTGCATTC GACAAGTTCT GGAATATGGC ACTTACTGAT 
GTGGATGAGA CCTACCGAAA ACCTGTCCTA GGCAAAGCAT ATGAACGGGA TTCTTCACTG 
ACTCTCACTA GGCTATTTGA TCGGCTGAAA CTTCAAGATT CCTCCAAGAA GGAAGCAGAT 
TCTAAGTCTG CAGTTGAAGA TTCCACTCTG TCTAGATACT CACAGACATC CACTTGGAAG 
TTGGCTTCAG TGTGGGGAAG AGCAGACACT GGCCGGGGCT CACACAAGCG TTCCCGCTCT 
GTCCCTTCTT CCCTGCAGGC CTCTGCAAGG GAGGAGTCCA GGTCAGAGCT GTCAGGGAGG 
ACTACACGGA CAGACGGCTC CAGTGTGGGA GGTACCTTTT CCAGGGCTAC CACCCTTTCC 
AGAGGCCAGT CCCGTAAGAA AAAGCGAAAG CCCAAAGTGG ATTACCAGCA GGTATTCACT 
CGACACATAA ATCAGATTTT CATTCGAGGC GAGAATGTCC TGCTGGTTCA TCTTGCACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775762.1
CDS	40..1122
Translation	MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHKRSRSVPSSLQASAREESRSELSGRTTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ

Target ORF information:

RefSeq Version	NM_173491.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173491.4

ORF Insert Sequence:

ATGGAGGAGC GGGAGCGGGG GGCGAGGTCG GCTGGCGCCG GGAGCCCCGC GCGCCCGCCC 
AGCCCGCGGC TGGATGTCAG CTCTGACAGC TTCGACCCGC TGCTGGCCCT GTACGCGCCC 
CGCCTGCCTC CCATTCCCTA CCCCAATGCC CCCTGCTTCA ACAACGTGGC GGAGTACGAG 
AGCTTCCTCA GGACCGGAGT CCGGGGCGGC GGGCGCGGGC GCGGGCGGGC TCGGGGCGCG 
GCCGCGGGCT CTGGGGTTCC CGCCGCACCC GGGCCCTCGG GCAGGACTCG TCGCCGCCCG 
GACGCGCCCG CCCCGGACCC CGAGCGCATC CAGCGCCTCC GCCGTCTCAT GGTGGCCAAA 
GAGGAAGGGG ACGGGGCCGC AGGAGCGGGC CGGAGGGGTC CGGGTCGGAG CAGGAAGGCG 
CCACGCAACG TGCTCACGCG AATGCCCTTG CACGAAGGCA GCCCTCTGGG TGAACTCCAT 
CGCTGTATCC GTGAGGGGGT GAAGGTGAAT GTTCACATCC GCACTTTCAA GGGACTTCGG 
GGCGTCTGTA CAGGCTTCCT TGTTGCATTC GACAAGTTCT GGAATATGGC ACTTACTGAT 
GTGGATGAGA CCTACCGAAA ACCTGTCCTA GGCAAAGCAT ATGAACGGGA TTCTTCACTG 
ACTCTCACTA GGCTATTTGA TCGGCTGAAA CTTCAAGATT CCTCCAAGAA GGAAGCAGAT 
TCTAAGTCTG CAGTTGAAGA TTCCACTCTG TCTAGATACT CACAGACATC CACTTGGAAG 
TTGGCTTCAG TGTGGGGAAG AGCAGACACT GGCCGGGGCT CACACAAGCG TTCCCGCTCT 
GTCCCTTCTT CCCTGCAGGC CTCTGCAAGG GAGGAGTCCA GGTCAGAGCT GTCAGGGAGG 
ACTACACGGA CAGACGGCTC CAGTGTGGGA GGTACCTTTT CCAGGGCTAC CACCCTTTCC 
AGAGGCCAGT CCCGTAAGAA AAAGCGAAAG CCCAAAGTGG ATTACCAGCA GGTATTCACT 
CGACACATAA ATCAGATTTT CATTCGAGGC GAGAATGTCC TGCTGGTTCA TCTTGCACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM11 ( NM_173491.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_775762.1 Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.

Price & Availability↑

CloneID	OHu75738
Clone ID Related Accession (Same CDS sequence)	NM_173491.4 , NM_173491.3
Accession Version	NM_173491.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	U7 snRNA-associated Sm-like protein LSm11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC126449.1, BC051353.1, AC026407.4 and AI271367.1. On Dec 23, 2014 this sequence version replaced NM_173491.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC126449.1, BC051353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGC GGGAGCGGGG GGCGAGGTCG GCTGGCGCCG GGAGCCCCGC GCGCCCGCCC 
AGCCCGCGGC TGGATGTCAG CTCTGACAGC TTCGACCCGC TGCTGGCCCT GTACGCGCCC 
CGCCTGCCTC CCATTCCCTA CCCCAATGCC CCCTGCTTCA ACAACGTGGC GGAGTACGAG 
AGCTTCCTCA GGACCGGAGT CCGGGGCGGC GGGCGCGGGC GCGGGCGGGC TCGGGGCGCG 
GCCGCGGGCT CTGGGGTTCC CGCCGCACCC GGGCCCTCGG GCAGGACTCG TCGCCGCCCG 
GACGCGCCCG CCCCGGACCC CGAGCGCATC CAGCGCCTCC GCCGTCTCAT GGTGGCCAAA 
GAGGAAGGGG ACGGGGCCGC AGGAGCGGGC CGGAGGGGTC CGGGTCGGAG CAGGAAGGCG 
CCACGCAACG TGCTCACGCG AATGCCCTTG CACGAAGGCA GCCCTCTGGG TGAACTCCAT 
CGCTGTATCC GTGAGGGGGT GAAGGTGAAT GTTCACATCC GCACTTTCAA GGGACTTCGG 
GGCGTCTGTA CAGGCTTCCT TGTTGCATTC GACAAGTTCT GGAATATGGC ACTTACTGAT 
GTGGATGAGA CCTACCGAAA ACCTGTCCTA GGCAAAGCAT ATGAACGGGA TTCTTCACTG 
ACTCTCACTA GGCTATTTGA TCGGCTGAAA CTTCAAGATT CCTCCAAGAA GGAAGCAGAT 
TCTAAGTCTG CAGTTGAAGA TTCCACTCTG TCTAGATACT CACAGACATC CACTTGGAAG 
TTGGCTTCAG TGTGGGGAAG AGCAGACACT GGCCGGGGCT CACACAAGCG TTCCCGCTCT 
GTCCCTTCTT CCCTGCAGGC CTCTGCAAGG GAGGAGTCCA GGTCAGAGCT GTCAGGGAGG 
ACTACACGGA CAGACGGCTC CAGTGTGGGA GGTACCTTTT CCAGGGCTAC CACCCTTTCC 
AGAGGCCAGT CCCGTAAGAA AAAGCGAAAG CCCAAAGTGG ATTACCAGCA GGTATTCACT 
CGACACATAA ATCAGATTTT CATTCGAGGC GAGAATGTCC TGCTGGTTCA TCTTGCACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775762.1
CDS	57..1139
Translation	MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHKRSRSVPSSLQASAREESRSELSGRTTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ

Target ORF information:

RefSeq Version	NM_173491.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173491.3

ORF Insert Sequence:

ATGGAGGAGC GGGAGCGGGG GGCGAGGTCG GCTGGCGCCG GGAGCCCCGC GCGCCCGCCC 
AGCCCGCGGC TGGATGTCAG CTCTGACAGC TTCGACCCGC TGCTGGCCCT GTACGCGCCC 
CGCCTGCCTC CCATTCCCTA CCCCAATGCC CCCTGCTTCA ACAACGTGGC GGAGTACGAG 
AGCTTCCTCA GGACCGGAGT CCGGGGCGGC GGGCGCGGGC GCGGGCGGGC TCGGGGCGCG 
GCCGCGGGCT CTGGGGTTCC CGCCGCACCC GGGCCCTCGG GCAGGACTCG TCGCCGCCCG 
GACGCGCCCG CCCCGGACCC CGAGCGCATC CAGCGCCTCC GCCGTCTCAT GGTGGCCAAA 
GAGGAAGGGG ACGGGGCCGC AGGAGCGGGC CGGAGGGGTC CGGGTCGGAG CAGGAAGGCG 
CCACGCAACG TGCTCACGCG AATGCCCTTG CACGAAGGCA GCCCTCTGGG TGAACTCCAT 
CGCTGTATCC GTGAGGGGGT GAAGGTGAAT GTTCACATCC GCACTTTCAA GGGACTTCGG 
GGCGTCTGTA CAGGCTTCCT TGTTGCATTC GACAAGTTCT GGAATATGGC ACTTACTGAT 
GTGGATGAGA CCTACCGAAA ACCTGTCCTA GGCAAAGCAT ATGAACGGGA TTCTTCACTG 
ACTCTCACTA GGCTATTTGA TCGGCTGAAA CTTCAAGATT CCTCCAAGAA GGAAGCAGAT 
TCTAAGTCTG CAGTTGAAGA TTCCACTCTG TCTAGATACT CACAGACATC CACTTGGAAG 
TTGGCTTCAG TGTGGGGAAG AGCAGACACT GGCCGGGGCT CACACAAGCG TTCCCGCTCT 
GTCCCTTCTT CCCTGCAGGC CTCTGCAAGG GAGGAGTCCA GGTCAGAGCT GTCAGGGAGG 
ACTACACGGA CAGACGGCTC CAGTGTGGGA GGTACCTTTT CCAGGGCTAC CACCCTTTCC 
AGAGGCCAGT CCCGTAAGAA AAAGCGAAAG CCCAAAGTGG ATTACCAGCA GGTATTCACT 
CGACACATAA ATCAGATTTT CATTCGAGGC GAGAATGTCC TGCTGGTTCA TCTTGCACAG 
TGA