B3GNT2 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B3GNT2
Entrez Gene ID	10678
Full Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms	3-Gn-T1,3-Gn-T2,B3GN-T2,B3GNT,B3GNT-2,B3GNT1,BETA3GNT,BGNT2,BGnT-2,beta-1,beta3Gn-T1,beta3Gn-T2
General protein information	Preferred Names UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Names N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 beta-1,3-N-acetylglucosaminyltransferase bGnT-1 beta-1,3-N-acetylglucosaminyltransferase bGnT-2
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 2 Map Location: 2p15
Summary	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016].
Disorder MIM:	605581

mRNA and Protein(s)

mRNA	Protein	Name
NM_006577.6	NP_006568.2	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
NM_006577.5	NP_006568.2	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
NM_001319075.1	NP_001306004.1	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
XM_011532486.1	XP_011530788.1	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	B3GNT2	XP_005626201.1
Mus musculus (house mouse)	B3gnt2	NP_058584.3
Rattus norvegicus (Norway rat)	B3gnt2	NP_001100710.1
Gallus gallus (chicken)	B3GNT2	NP_001008457.1
Homo sapiens (human)	B3GNT2	NP_006568.2
Pan troglodytes (chimpanzee)	B3GNT2	XP_003309079.1
Danio rerio (zebrafish)	b3gnt2b	NP_991315.1
Xenopus tropicalis (tropical clawed frog)	b3gnt2	NP_001123810.1
Bos taurus (cattle)	B3GNT2	NP_001095967.1

Gene Ontology
Bibliography

Related articles in PubMed

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).
Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG, Leroux MR
PLoS genetics12(8)e1006235(2016 Aug)

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.
Venkitachalam S, Revoredo L, Varadan V, Fecteau RE, Ravi L, Lutterbaugh J, Markowitz SD, Willis JE, Gerken TA, Guda K
Scientific reports623642(2016 Mar)

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan.
Praissman JL, Live DH, Wang S, Ramiah A, Chinoy ZS, Boons GJ, Moremen KW, Wells L
eLife3(2014 Oct)

Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions.
Clark AT, Guimar?es da Costa VM, Bandeira Costa L, Bezerra Cavalcanti CL, De Melo R?go MJ, Beltr?o EI
European journal of histochemistry : EJH58(2)2334(2014 May)

B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells.
Qiu H, Duan WM, Shu J, Cheng HX, Wang WP, Huang XE, Chen HL
Asian Pacific journal of cancer prevention : APJCP15(24)10875-8(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we confirmed the involvement of BGNT-1.1 in ciliated sensory neuron function and morphogenesis. BGNT-1.1 functions at the trans-Golgi network of sheath cells (glia) to influence dye-filling and cilium length, in a cell non-autonomous manner. Notably, BGNT-1.1 is the orthologue of human B3GNT1/B4GAT1, a glycosyltransferase associated with Walker-Warburg syndrome (WWS).
Title: Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies.
Title: Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

data reveals beta3GnT2 and polyLacNAc may be involved in the progression of the pre-malignant lesions of human the uterine cervix.
Title: Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions.

High B3GNT2 expression is associated with hepatocellular carcinoma.
Title: B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells.

up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2.
Title: Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.

The following B3GNT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B3GNT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31051	NM_001319075.1 Latest version!	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu31051	NM_006577.6 Latest version!	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu31051	XM_011532486.1 Latest version!	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu31051	NM_006577.5	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B3GNT2 ( NM_006577.6 ) cDNA ORF clone, Homo sapiens(Human) -> NP_006568.2 Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31051
Clone ID Related Accession (Same CDS sequence)	NM_006577.6 , NM_006577.5 , NM_001319075.1 , XM_011532486.1
Accession Version	NM_006577.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018462.4, BC047933.1, BC030579.2 and AB049584.1. On Nov 22, 2018 this sequence version replaced NM_006577.5. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 3 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047933.1, SRR1660809.233184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301998.5/ ENSP00000305595.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006568.2
CDS	251..1444
Translation	MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC

Target ORF information:

RefSeq Version	NM_006577.6
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006577.6

ORF Insert Sequence:

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B3GNT2 ( NM_006577.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_006568.2 Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31051
Clone ID Related Accession (Same CDS sequence)	NM_006577.6 , NM_006577.5 , NM_001319075.1 , XM_011532486.1
Accession Version	NM_006577.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC047933.1, BC030579.2 and AB049584.1. On Apr 14, 2006 this sequence version replaced NM_006577.4. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 3 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047933.1, SRR1163655.155130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006568.2
CDS	239..1432
Translation	MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC

Target ORF information:

RefSeq Version	NM_006577.5
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006577.5

ORF Insert Sequence:

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B3GNT2 ( NM_001319075.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001306004.1 Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu31051
Clone ID Related Accession (Same CDS sequence)	NM_006577.6 , NM_006577.5 , NM_001319075.1 , XM_011532486.1
Accession Version	NM_001319075.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC030579.2, BC047933.1 and AC093401.4. On Jan 22, 2016 this sequence version replaced XM_011532486.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030579.2, BG721682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306004.1
CDS	105..1298
Translation	MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC

Target ORF information:

RefSeq Version	NM_001319075.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319075.1

ORF Insert Sequence:

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B3GNT2 ( XM_011532486.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011530788.1 Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant X1, mRNA.

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CloneID	OHu31051
Clone ID Related Accession (Same CDS sequence)	NM_006577.6 , NM_006577.5 , NM_001319075.1 , XM_011532486.1
Accession Version	XM_011532486.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1
Comment

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530788.1
Translation	MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC

Target ORF information:

RefSeq Version	XM_011532486.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532486.1

ORF Insert Sequence:

ATGAGTGTTG GACGTCGAAG AATAAAGTTG TTGGGTATCC TGATGATGGC AAATGTCTTC 
ATTTATTTTA TTATGGAAGT CTCCAAAAGC AGTAGCCAAG AAAAAAATGG AAAAGGGGAA 
GTAATAATAC CCAAAGAGAA GTTCTGGAAG ATATCTACCC CTCCCGAGGC ATACTGGAAC 
CGAGAGCAAG AGAAGCTGAA CCGGCAGTAC AACCCCATCC TGAGCATGCT GACCAACCAG 
ACGGGGGAGG CGGGCAGGCT CTCCAATATA AGCCATCTGA ACTACTGCGA ACCTGACCTG 
AGGGTCACGT CGGTGGTTAC GGGTTTTAAC AACTTGCCGG ACAGATTTAA AGACTTTCTG 
CTGTATTTGA GATGCCGCAA TTATTCACTG CTTATAGATC AGCCGGATAA GTGTGCAAAG 
AAACCTTTCT TGTTGCTGGC GATTAAGTCC CTCACTCCAC ATTTTGCCAG AAGGCAAGCA 
ATCCGGGAAT CCTGGGGCCA AGAAAGCAAC GCAGGGAACC AAACGGTGGT GCGAGTCTTC 
CTGCTGGGCC AGACACCCCC AGAGGACAAC CACCCCGACC TTTCAGATAT GCTGAAATTT 
GAGAGTGAGA AGCACCAAGA CATTCTTATG TGGAACTACA GAGACACTTT CTTCAACTTG 
TCTCTGAAGG AAGTGCTGTT TCTCAGGTGG GTAAGTACTT CCTGCCCAGA CACTGAGTTT 
GTTTTCAAGG GCGATGACGA TGTTTTTGTG AACACCCATC ACATCCTGAA TTACTTGAAT 
AGTTTATCCA AGACCAAAGC CAAAGATCTC TTCATAGGTG ATGTGATCCA CAATGCTGGA 
CCTCATCGGG ATAAGAAGCT GAAGTACTAC ATCCCAGAAG TTGTTTACTC TGGCCTCTAC 
CCACCCTATG CAGGGGGAGG GGGGTTCCTC TACTCCGGCC ACCTGGCCCT GAGGCTGTAC 
CATATCACTG ACCAGGTCCA TCTCTACCCC ATTGATGACG TTTATACTGG AATGTGCCTT 
CAGAAACTCG GCCTCGTTCC AGAGAAACAC AAAGGCTTCA GGACATTTGA TATCGAGGAG 
AAAAACAAAA ATAACATCTG CTCCTATGTA GATCTGATGT TAGTACATAG TAGAAAACCT 
CAAGAGATGA TTGATATTTG GTCTCAGTTG CAGAGTGCTC ATTTAAAATG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).
PLoS genetics12(8)e1006235(2016 Aug)
Timbers TA,Garland SJ,Mohan S,Flibotte S,Edgley M,Muncaster Q,Au V,Li-Leger E,Rosell FI,Cai J,Rademakers S,Jansen G,Moerman DG,Leroux MR

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.
Scientific reports623642(2016 Mar)
Venkitachalam S,Revoredo L,Varadan V,Fecteau RE,Ravi L,Lutterbaugh J,Markowitz SD,Willis JE,Gerken TA,Guda K

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan.
eLife3(2014 Oct)
Praissman JL,Live DH,Wang S,Ramiah A,Chinoy ZS,Boons GJ,Moremen KW,Wells L

Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions.
European journal of histochemistry : EJH58(2)2334(2014 May)
Clark AT,Guimar?es da Costa VM,Bandeira Costa L,Bezerra Cavalcanti CL,De Melo R?go MJ,Beltr?o EI

B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells.
Asian Pacific journal of cancer prevention : APJCP15(24)10875-8(2014)
Qiu H,Duan WM,Shu J,Cheng HX,Wang WP,Huang XE,Chen HL

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B3GNT2 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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